检索结果-南通市图书馆

Biomedical and Environmental Sciences 2021年第4期34卷 314-318页

作者： PANG Xiu Hong ZHENG Xiao yong LIN Yun ZHENG Hao XU Jun LIU Dong JIN Chun Yan ZHANG Lu Ping ZHANG Yu Ting CHU Jiu Sheng chai yong chuan YANG Tao Department of Otolaryngology-Head and Neck Surgery Taizhou People's Hospitalthe Fifth Affiliated Hospital of Nantong University&Clinical Hospital of Dalian Medical UniversityTaizhou 225300JiangsuChina Department of Dermatology Taizhou People's Hospitalthe Fifth Affiliated Hospital of Nantong UniversityTaizhou 225300JiangsuChina Department of Otolaryngology-Head and Neck Surgery the Ninth People's HospitalShanghai Jiaotong University School of MedicineShanghai 200011China Ear Institute Shanghai Jiaotong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases Shanghai 200011China Department of Clinical Medicine Medical School of Nantong UniversityNantong 226000JiangsuChina Life scientific School Neuroregenerative Key Laboratory of Jiangsu and Ministry of EducationNeuroregenerative Co-innovation CenterNantong UniversityNantong 226000JiangsuChina Department of Medical Genetics Taizhou People's Hospitalthe Fifth Affiliated Hospital of Nantong UniversityTaizhou 225300JiangsuChina Department of Otolaryngology-Head and Neck Surgery Affiliated Hospital of Nantong UniversityNantong 226000JiangsuChina

SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the *** SIX family includes six members(SIX1–SIX6),which share a homologous DNA-binding homeodomain(HD)and a highly conserved protein–protein interacting SIX domain(SD)[1].

关键词： SIX1 homeobox belongs

Stability and Stabilization of Sampled-Data Based LFC for Power Systems:A Data-Driven Method

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2025年第1期 291-293页

作者： Yu-Long Fan chuan-Ke Zhang yong He the School of Automation China University of Geosciences the Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems the Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education IEEE

Dear Editor,This letter is concerned with stability analysis and stabilization design for sampled-data based load frequency control(LFC) systems via a data-driven method. By describing the dynamic behavior of LFC systems based on a data-based representation, a stability criterion is derived to obtain the admissible maximum sampling interval(MSI) for a given controller and a design condition of the PI-type controller is further developed to meet the required MSI. Finally, the effectiveness of the proposed methods is verified by a case study.

关键词：

一个常染体显性非综合征型耳聋大家系的临床特征及79个已知耳聋基因的检测分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华耳鼻咽喉头颈外科杂志 2014年第8期49卷 654-658页

作者：林晓江陈东野吴皓杨涛张丹柴永川浙江省开化县人民医院耳鼻咽喉头颈外科 324300 上海交通大学医学院附属新华医院耳鼻咽喉头颈外科上海交通大学医学院耳科学研究所浙江大学医学院附属邵逸夫医院耳鼻咽喉头颈外科

目的分析探讨一个连续七代表现为常染色体显性遗传性非综合征型迟发性耳聋家系的临床表型及遗传学特征.方法 2011年8月对浙江省-耳聋家系成员进行病史采集、全身及听力学检查,绘制遗传图谱并进行遗传学特征分析.通过常规PCR扩增及Sange... 详细信息

目的分析探讨一个连续七代表现为常染色体显性遗传性非综合征型迟发性耳聋家系的临床表型及遗传学特征.方法 2011年8月对浙江省-耳聋家系成员进行病史采集、全身及听力学检查,绘制遗传图谱并进行遗传学特征分析.通过常规PCR扩增及Sanger测序方法筛查GJB2、MTRNRl （12SrRNA）、SLC26A4基因致病突变.使用定向捕获联合二代测序技术,对包括所有已知非综合征型耳聋的79个耳聋相关基因的外显子及其侧翼内含子序列进行筛查.结果该耳聋家系共七代,现存家系成员73人,符合常染色体显性遗传规律,参与本研究的22人中耳聋患者11人,除1人为语前聋外,其他患者均表现为迟发性、渐进性听力下降,发病年龄9～30岁,听力曲线多为平坦型.对常见耳聋基因GJB2、MTRNRl （12SrRNA）、SLC26A4进行筛查,排除了致病突变.使用定向捕获联合二代测序技术,先证者（Ⅴ：6）在发现的70个插入缺失标记（insertion-deletion,InDel）和591个单核苷酸基因多态性（single nucleotide polymorphism,SNP）中,经数据分析滤过后确定3个潜在致病突变位点：COL4A3（c.C1295T）、KCNQl（c.T1058C）和MYH14（c.G1295A）.但后续经测序验证,此3个可疑突变位点在家系中不与耳聋表型共分离,从而排除了致病可能.结论该常染色体显性非综合征型迟发性耳聋大家系基本排除了79个耳聋相关基因的点突变及小片段插入缺失突变的可能,其为新基因致病的可能性较大.

关键词：听觉丧失,感音神经性 DNA突变分析系谱

芯片检测结合测序技术在遗传性耳聋产前基因筛查与诊断中的应用

在线全文

学校读者我要写书评

暂无评论

中华耳鼻咽喉头颈外科杂志 2012年第12期47卷 991-995页

作者：孙莲花李磊王晓雯朱亚忠柴永川李晓华吴皓杨涛上海交通大学医学院附属新华医院耳鼻咽喉头颈外科上海交通大学医学院耳科学研究所 200092

目的探讨遗传性耳聋基因检测芯片在中国孕妇人群常见遗传性耳聋基因突变位点检测中的作用，并评估其在遗传性耳聋产前诊断中的应用。方法对3056例孕妇采集外周血并抽提DNA，采用遗传性耳聋基因芯片检测GJB2、SLC26A4、线粒体12SrRNA、C... 详细信息

目的探讨遗传性耳聋基因检测芯片在中国孕妇人群常见遗传性耳聋基因突变位点检测中的作用，并评估其在遗传性耳聋产前诊断中的应用。方法对3056例孕妇采集外周血并抽提DNA，采用遗传性耳聋基因芯片检测GJB2、SLC26A4、线粒体12SrRNA、CJB3等4个中国人群常见遗传性耳聋基因共9个突变热点。根据检测结果对有耳聋生育风险的夫妇提供遗传咨询与生育指导。结果3056例孕妇中，共检测到156例携带至少一种基因突变，占总抽查人数的5．11％。其中7例为线粒体12SrRNA突变，预测后代亦为此突变携带者，需终生避免使用氨基糖苷类抗生素。149例为另外三种隐性耳聋基因突变，对其中的124例生育配偶进行了相关基因的全序列测序分析，共有20对夫妇具有遗传性耳聋生育风险。5对夫妇要求进行耳聋产前诊断，4例产前诊断结果均为相应致病基因单杂合突变或野生型，出生后听力随访均未发现异常；1例为P．V37I／c．235delC复合杂合突变，有产生轻、中度耳聋的风险。结论利用遗传性耳聋基因芯片进行临床耳聋基因突变产前筛查具有高度可靠性和可操作性，结合产前诊断技术能有效预防先天性耳聋患儿的出生。

关键词：聋突变遗传筛查遗传咨询产前诊断寡核苷酸序列分析

舌下神经-面神经侧端吻合术治疗小脑脑桥角肿瘤术后面瘫

在线全文

学校读者我要写书评

暂无评论

中国耳鼻咽喉颅底外科杂志 2020年第1期26卷 28-31页

作者：陈哲王智立柴永川汪照炎上海交通大学医学院附属第九人民医院耳鼻咽喉头颈外科上海交通大学医学院耳科学研究所上海市耳鼻疾病转化医学重点实验室

目的探讨舌下神经-面神经侧端吻合术治疗小脑脑桥角肿瘤术后面瘫的效果。方法6例小脑脑桥角肿瘤切除术后面瘫患者均行舌下神经-面神经侧端吻合术。所有患者术后每3个月随访1次,评估House-Brackmann(H-B)分级和舌下神经功能。结果术后1年... 详细信息

目的探讨舌下神经-面神经侧端吻合术治疗小脑脑桥角肿瘤术后面瘫的效果。方法6例小脑脑桥角肿瘤切除术后面瘫患者均行舌下神经-面神经侧端吻合术。所有患者术后每3个月随访1次,评估House-Brackmann(H-B)分级和舌下神经功能。结果术后1年H-B III级2例,H-BⅣ级3例,H-B V级1例。静态面部张力4例患者在吻合术后6个月改善明显,1例患者在吻合术后9个月改善,1例患者在吻合术后1年改善。所有患者均未出现术侧舌肌瘫痪萎缩,发音和吞咽功能均正常。结论舌下神经-面神经侧端吻合术可改善小脑脑桥角肿瘤切除术后面瘫患者的面部张力和面肌功能,借助神经监护可尽量减小对舌肌功能的影响。

关键词：面神经头颈肿瘤面瘫修复舌下神经小脑脑桥角

在线全文

学校读者我要写书评

暂无评论

耳内镜下I型鼓室成形干湿耳手术疗效分析

中国耳鼻咽喉颅底外科杂志 2018年第1期24卷 24-28页

作者：柴永川杨洁朱伟栋汪照炎吴皓上海交通大学医学院附属第九人民医院耳鼻咽喉头颈外科上海交通大学医学院耳科学研究所上海耳鼻疾病转化医学重点实验室上海200092

目的探究耳内镜下I型鼓室成形术在干湿耳状态下手术的疗效差异。方法前瞻性纳入2017年7月~2017年9月于上海交通大学医学院附属第九人民医院耳鼻咽喉头颈外科收治的慢性化脓性中耳炎静止期患者,术前由2名耳内镜医师和1名临床医师独立判... 详细信息

目的探究耳内镜下I型鼓室成形术在干湿耳状态下手术的疗效差异。方法前瞻性纳入2017年7月~2017年9月于上海交通大学医学院附属第九人民医院耳鼻咽喉头颈外科收治的慢性化脓性中耳炎静止期患者,术前由2名耳内镜医师和1名临床医师独立判断鼓膜及鼓室黏膜情况,将45例患者分为干耳组和湿耳组。其中干耳患者29例,湿耳患者16例。I型鼓室成形术后3个月时的鼓膜愈合率和听力改善率。结果术后3个月时干耳患者中26例(89.6%)的患者鼓膜完全愈合,湿耳患者中14例(87.5%)鼓膜完全愈合,两组气骨导差均明显下降,干耳组气骨导差由术前(23.5±7.3)dB HL下降至(8.6±6.2)dB HL,湿耳组气骨导差由术前(25.1±7.6)dB HL下降至(10.5±8.0)dB HL。两组在鼓膜愈合率和听力改善率上差异均无统计学意义(P>0.05)。结论对于不伴有听骨链病变的静止期慢性化脓性中耳炎,术前湿耳状态并非手术禁忌证,其术后鼓膜愈合率以及听力改善率与干耳手术一致,且可以降低患者术前等待时间,减少抗生素使用和并发症发生,但这一结论仍需多中心、前瞻性队列研究进一步证实。

关键词：中耳炎湿耳鼓室成形术鼓膜穿孔耳内镜

Separability for Positive Operators on Tensor Product of Hilbert Spaces

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2021年第6期37卷 893-910页

作者： Jin chuan HOU Jin Fei chai College of Mathematics Taiyuan University of TechnologyTaiyuan 030024P.R.China

The separability and the entanglement(that is,inseparability)of the composite quantum states play important roles in quantum information ***,a quantum state is a trace-class positive operator with trace one acting on a complex separable Hilbert *** this paper,in more general frame,the notion of separability for quantum states is generalized to bounded positive operators acting on tensor product of Hilbert ***,not like the quantum state case,there are different kinds of separability for positive operators with different operator *** types of such separability are discussed;several criteria such as the finite rank entanglement witness criterion,the positive elementary operator criterion and PPT criterion to detect the separability of the positive operators are established;some methods to construct separable positive operators by operator matrices are *** may also make us to understand the separability and entanglement of quantum states better,and may be applied to find new separable quantum states.

关键词： Hilbert spaces tensor products positive operators separability entanglement

前庭导水管扩大耳聋人群中SLC26A4单等位基因突变的出现率及致病相关性研究

在线全文

学校读者我要写书评

暂无评论

中国听力语言康复科学杂志 2015年第3期13卷 190-194页

作者：庞秀红柴永川陈鹏辉孙莲花吴皓杨涛上海交通大学医学院附属新华医院耳鼻咽喉-头颈外科上海200092 上海交通大学耳科学研究所上海200092 上海耳鼻疾病转化医学重点实验室上海200092

目的：以SLC26A4基因热点突变c.919-2A＞G和p.H723R为对象，研究SLC26A4基因单等位基因突变在中国汉族非综合征大前庭导水管（enlarged vestibular aqueduct，EVA）耳聋人群中的出现频率，并通过与正常听力人群的比较评估该疾病SLC26A4... 详细信息

目的：以SLC26A4基因热点突变c.919-2A＞G和p.H723R为对象，研究SLC26A4基因单等位基因突变在中国汉族非综合征大前庭导水管（enlarged vestibular aqueduct，EVA）耳聋人群中的出现频率，并通过与正常听力人群的比较评估该疾病SLC26A4单等位基因突变的检出与疾病发生的相关性。方法通过Sanger测序对121例EVA耳聋患者进行SLC26A4基因的全部外显子及剪切位点的序列筛查，经耳聋基因突变检测芯片对3056例正常听力对照进行热点突变筛查，分别确定c.919-2A＞G和p.H723R单杂合突变在两组人群中的出现频率，利用统计软件SPSS 19.0分析其统计学差异。结果121例EVA耳聋患者中有78例样本检出SLC26A4基因双等位基因突变，12例样本检出单等位基因突变，其中6例为c.919-2A＞G单杂合突变，2例为p.H723R单杂合突变，共占患病人群的6.61%；3056例正常听力对照中发现33例c.919-2A＞G和9例p.H723R单杂合突变，占对照人群的1.37%；Fisher’s exact检验显示，SLC26A4基因c.919-2A＞G和p.H723R单杂合突变的出现率在EVA耳聋组与正常对照组之间存在显著差异（P=0.001）。结论 SLC26A4单等位基因突变在EVA耳聋患者中的出现率显著高于正常对照人群，提示携带SLC26A4单等位基因突变的EVA耳聋患者可能存在无法用常规外显子测序方法所检出的其它致病基因突变，需进一步研究，并在相关遗传咨询中加以注意。

关键词：前庭导水管扩大 SLC26A4 单等位基因突变遗传咨询

A Novel Rolling Bearing Vibration Impulsive Signals Detection Approach Based on Dictionary Learning

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2021年第6期8卷 1188-1198页

作者： chuan Sun Hongpeng Yin Yanxia Li Yi chai School of Big Data&Software Engineering Chongqing UniversityChongqing 401331China Key Laboratory of Complex System Safety and Control Ministry of EducationChongqing UniversityChongqing 400044China

The localized faults of rolling bearings can be diagnosed by its vibration impulsive ***,it is always a challenge to extract the impulsive feature under background noise and non-stationary *** paper investigates impulsive signals detection of a single-point defect rolling bearing and presents a novel data-driven detection approach based on dictionary *** overcome the effects harmonic and noise components,we propose an autoregressive-minimum entropy deconvolution model to separate harmonic and deconvolve the effect of the transmission *** address the shortcomings of conventional sparse representation under the changeable operation environment,we propose an approach that combines K-clustering with singular value decomposition(K-SVD)and split-Bregman to extract impulsive components *** experiments on synthetic signals and real run-to-failure signals,the excellent performance for different impulsive signals detection verifies the effectiveness and robustness of the proposed ***,a comparison with the state-of-the-art methods is illustrated,which shows that the proposed approach can provide more accurate detected impulsive signals.

关键词： Dictionary learning impulsive signals detection Kclustering with singular value decomposition(K-SVD) minimum entropy deconvolution rolling bearing signal processing

Searching for events in Chinese ancient records to explain the increase in ^(14)C from AD 774–775 and AD 993–994

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2015年第9期15卷 1504-1512页

作者： Ya-Ting chai Yuan-chuan Zou School of Physics Huazhong University of Science and Technology Department of Physics Hong Kong University

According to analysis of the ^14C content in two Japanese trees, that grew over a period of approximately 3000 years, with high time resolution, Miyake et al. found a rapid increase at AD 774-775 and another one at AD 993-994. These increases correspond to high-energy events that happened within those years and radi- ated ＂）,-ray energy of about 7x 1034 erg toward the Earth. The origin of these events is a mystery. Such strong events should have an unusual optical counterpart, and have been recorded in historical literatures. We searched Chinese historical materi- als around AD 744-775 and AD 993-994, but no remarkable event was found except for a violent thunderstorm in AD 775. However, the possibility of a thunderstorm containing so much energy is unlikely. We conclude that the events, which caused the 14C increase, are still unclear. These events most probably had no optical counterpart, and a short gamma-ray burst, giant flare of a soft gamma-ray repeater or a terrestrial γ-ray flash could all be candidates.

关键词： astroparticle -- ^14C -- gamma rays: general -- astronomical history --astrobiology