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Molar-Tooth Structure from the Mesoproterozoic Wumishan Formation in Lingyuan,Yanshan Region,North China,and Geological Implications

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Acta Geologica Sinica(English Edition) 2012年第1期86卷 85-95页

作者： KUANG Hongwei LIU Yongqing PENG Nan LUO Shunshe LI Jiahua cen chao CHEN Mingpei Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Key Laboratory of Exploration Technologies for Oil and Gas Resources Ministry of Education of China School of Geophysics and Oil Resources of Yangtze University JingzhouHubei 434023China China University ofGeosciences Beijing 100083China School of Geosciences of Yangtze University Jingzhou Hubei 434023China

Although its origin has not yet reached a consensus so far, MTS （Molar-Tooth Structure） has been documented for more than 100 years. Current study reports a discovery of MTS from the Mesoproterozoic Wumishan Formation, Lingyuan, Yanshan Region, North China, and the features and geological implications of MTS are further discussed. Here, straitigraphic horizons of MTS＇s occurrences show that it was mainly located within the top part of the Wumishan Formation, i.e., limestone unit. Four kinds of morphology of MTS, i.e., fine fusiform, debris, ribbon, ptigmatic and nodular （irregular）, were recognized and thought to be highly related to the sedimentary environments and facies. Geochemistry of MTS including oxides, trace elements and C, O and Sr isotopes indicates that the horizons of MTS-bearing is of higher Sr/Ba and Ca/Mg ratios, lower positive ~13C and highly negative 3180 values than the adjacent stratigraphic levels of rare MTS. Lithology, morphology and geochemistry of MTS in the Wumishan Formation suggest that MTS occurs mainly in shallow subtidal near the storm wave base, which is typically characterized by warm temperature, oversaturated calcium carbonate seawater and high organic productivity. Furthermore, occasional enrichment of algae bacteria here is more favorable for the calcification of calcium oozes and catalytic for MTS. C isotope composition of the Wumishan Formation and MTS of this study is well correlated with that of the Mesoproterozoic Belt Supergroup, North America and Riphean, Siberia, suggesting that MTS acts as a sedimentary record responding to global changes and is a perfect indicator in Precambrian stratigraphic correlation worldwide.

关键词： Molar-tooth Structure Wumishan Formation Mesoproterozoic Implications Lingyuan Yanshan Region

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Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats

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Chinese Journal of Polymer Science 2022年第2期40卷 157-165页

作者： Wei Hu Ya-Wei Su Yi-Kun Jiang Wen-Di Fan Song-Yue Cheng Zai-Zai Tong chao cen Guo-Hua Jiang College of Materials Science and Engineering and Institute of Smart Biomedical Materials Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Near-infrared light(NIR)triggered transdermal drug delivery systems are of great interest due to their on-demand drug release,which enable to enhance drug treatment efficiency as well as reduce side ***,a NIR-triggered microneedle(MN)patch array has been fabricated through depositing the photothermal conversion agent and anti-diabetic drug-loaded polymer vesicles with upper critical solution temperature(UCST)into dissolvable polymer *** UCST-type polymer has a clearing point temperature of 41℃ and the drug-loaded polymer vesicles present excellent NIR-triggered and temperature responsive drug release behavior in vitro due to the disassociation of polymer vesicles upon NIR *** applying MNs to diabetic rats,significant hypoglycemic effect is achieved upon interval NIR irradiation and the blood glucose concentration can decrease to normal state for several hours,which enables to achieve the goal of on-demand drug *** work suggests that the NIR-triggered MN drug release device has a potential application in the treatment of diabetes,especially for those requiring an active drug release manner.

关键词： Diabetes Upper critical solution temperature Near-infrared light On-demand drug release Polymeric vesicles

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Association between serumα-L-fucosidase andnon-alcoholic fatty liver disease:Cross-sectional study

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World Journal of Gastroenterology 2016年第5期22卷 1884-1890页

作者： Zhen-ya Lu chao cen Zhou Shao Xin-hua Chen Cheng-fu Xu You-ming Li Department of Internal Medicine the First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Division of Hepatobiliary and Pancreatic Surgery Department of Surgerythe First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Gastroenterology the First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

AIM: To explore the association between serum α-Lfucosidase(Af U) and non-alcoholic fatty liver disease(NAf LD).METHODS: A total of 16473 individuals(9456 men and 7017 women) were included in the current study, who presented for a health examination at the first Affiliated hospital of Zhejiang University School of medicine in 2014. The baseline characteristics of the cohort were compared by NAf LD status. Linear regression analysis and stepwise multiple regression analysis were applied to assess the risk factors for NAf LD. Receiver operating characteristic curve was used to determine the sensitivity and specificity of Af U in the diagnosis of NAf ***: The prevalence rates of NAf LD and metabolic syndrome(met S) were 38.0% and 25.4%, respectively. The NAf LD group had significantly higher Af U levels than the non-NAf LD group(28.7 ± 7.9 U/L vs 26.0 ± 7.3 U/L, P central obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol, and elevated blood pressure and fasting glucose. Stepwise multiple logistic regression analysis showed that Af U was associated with an increased risk of NAf LD(OR = 1.009, 95%CI: 1.003-1.014, P < 0.001). The best cut-off value of Af U for the diagnosis of NAf LD was 27.5 U/L. The area under the curve(diagnostic efficacy index) was 0.606. The sensitivity and specificity were 54.6% and 61.8%, respectively. CONCLUSION: Af U level is significantly associated with NAf LD, and elevated Af U level is an independent risk factor for NAf LD.

关键词： α-L-fucosidase Biomarker non-alcoholicfatty liver disease metabolic syndrome Cross-sectionalstudy

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Association between ADIPOQ gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 602-609页

作者： chao cen Hai-Xing Fang Song-Feng Yu Ji-Min Liu Yuan-Xing Liu Lin Zhou Jun Yu Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery Key Laboratory of Combined Multi-organ TransplantationMinistry of Public HealthCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary Surgery the First People's Hospital of Fuyang Department of Pathology and Molecular Medicine Faculty of Health SciencesMcMaster University

BACKGROUND:New-onset diabetes after transplantation(NODAT) has become one of the major factors that affect the overall survival and long-term life quality in liver transplantation(LT) recipients. Previous studies found that the serum adiponectin concentration of diabetic patients is significantly lower than that of healthy subjects. Adiponectin regulates the blood glucose level by increasing body sensitivity to insulin through various mechanisms. In this study, we aimed to investigate the impact of diabetes related gene polymorphisms on the development of NODAT in liver ***:A total of 256 LT patients in a single-center were selected retrospectively for the study. Genomic DNA was extracted from explanted liver tissues, and tested for twelve diabetes mellitus associated single nucleotide polymorphisms by Sequenom Mass ARRAY. Modified clinical models in predicting NODAT were established and ***:The GG genotype of ADIPOQ rs1501299 gene polymorphism was significantly more frequent in NODAT than non-NODAT LT patients(56% vs 39%, P=0.014). Dominant model(GG vs GT+TT, P=0.030) and recessive model(GT+GG vs TT, P=0.005) also confirmed the genotype distribution difference between NODAT and non-NODAT groups. Age(OR=1.048, P=0.004), BMI(OR=1.107, P=0.041), and blood tacrolimus level at 1-month LT(OR=1.170, P=0.003) were clinical independent risk factors of NODAT. Furthermore, rs1501299 could improve the ability of clinical model in predicting NODAT(AUROC=0.743, P<0.001).CONCLUSION:ADIPOQ rs1501299 gene polymorphism is associated with an increased risk of NODAT, which should be added to the clinical models in predicting the occurrence of NODAT in LT recipients.

关键词： ADIPOQ gene polymorphisms diabetes mellitus liver transplantation

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Comparison and development of advanced machine learning tools to predict nonalcoholic fatty liver disease:An extended study

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 409-415页

作者： Yuan-Xing Liu Xi Liu chao cen Xin Li Ji-Min Liu Zhao-Yan Ming Song-Feng Yu Xiao-Feng Tang Lin Zhou Jun Yu Ke-Jie Huang Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China College of Information Science and Electrical Engineering Zhejiang UniversityHangzhou 310027China Department of Pathology and Molecular Medicine Faculty of Health SciencesMcMaster University1200 Main Street WestHamilton L8S 4K1Canada College of Computer Science and Technology Zhejiang UniversityHangzhou 310027China

Background:Nonalcoholic fatty liver disease(NAFLD)is a public health challenge and significant cause of morbidity and mortality *** identification is crucial for disease *** recently proposed a nomogram-based NAFLD prediction model from a large population *** aimed to explore machine learning tools in predicting ***:A retrospective cross-sectional study was performed on 15315 Chinese subjects(10373 training and 4942 testing sets).Selected clinical and biochemical factors were evaluated by different types of machine learning algorithms to develop and validate seven predictive *** evaluation indicators including area under the receiver operating characteristic curve(AUROC),area under the precision-recall curve(AUPRC),accuracy,positive predictive value,sensitivity,F1 score,Matthews correlation coefficient(MCC),specificity and negative prognostic value were applied to compare the performance among the *** selected clinical and biochemical factors were ranked according to the importance in prediction ***:Totally 4018/10373(38.74%)and 1860/4942(37.64%)subjects had ultrasound-proven NAFLD in the training and testing sets,*** machine learning based models were developed and demonstrated good performance in predicting *** these models,the XGBoost model revealed the highest AUROC(0.873),AUPRC(0.810),accuracy(0.795),positive predictive value(0.806),F1 score(0.695),MCC(0.557),specificity(0.909),demonstrating the best prediction ability among the built *** mass index was the most valuable indicator to predict NAFLD according to the feature ranking ***:The XGBoost model has the best overall prediction ability for diagnosing *** novel machine learning tools provide considerable beneficial potential in NAFLD screening.

关键词： Nonalcoholic fatty liver disease Machine learning Population screening Prediction model Body mass index

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重庆地区38970例新生儿眼底病变筛查结果分析

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第三军医大学学报 2020年第14期42卷 1441-1448页

作者：岑超何俐莹重庆市妇幼保健院眼耳鼻喉科重庆400021

目的分析重庆地区新生儿眼底疾病的发病情况及影响因素。方法对2016年1月至2019年11月在本院眼科使用Retcam3进行眼底病变筛查的38970例新生儿的筛查结果进行统计学分析。将新生儿分为足月儿和早产儿两组,分析两组眼底病变检出率。新生... 详细信息

目的分析重庆地区新生儿眼底疾病的发病情况及影响因素。方法对2016年1月至2019年11月在本院眼科使用Retcam3进行眼底病变筛查的38970例新生儿的筛查结果进行统计学分析。将新生儿分为足月儿和早产儿两组,分析两组眼底病变检出率。新生儿视网膜出血及渗出样改变的影响因素采用单因素分析及Logistic多因素回归分析。早产儿按胎龄和体质量分组,研究各组早产儿视网膜病变(retinopathy of prematurity,ROP)的检出率。结果足月儿组、早产儿组各病种总体异常检出率差异具有统计学意义(P=0.014)。受检足月儿34248例,共68496只眼,眼底异常检出率为24.97%;其中视网膜出血检出率最高(8131眼,11.871%),其次为视网膜渗出样改变(6611眼,9.652%)。经Logistic多因素回归分析,性别、胎龄、分娩方式对新生儿视网膜出血的发生有显著影响(P<0.001),性别、胎龄、分娩方式、母亲妊娠糖尿病对新生儿视网膜渗出样改变的发生有显著影响(P<0.001)。受检早产儿4722例,共9444只眼,ROP检出率为8.13%;不同体质量和胎龄的早产儿,ROP检出率有明显差异(P<0.05)。结论重庆地区新生儿视网膜出血、新生儿视网膜渗出等检出率较高,其中性别、胎龄、出生体质量、分娩方式、母亲妊娠糖尿病为引起新生儿眼底病变的高危因素。

关键词：新生儿眼底病变筛查视网膜病变影响因素重庆地区

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Analysis of TORCH results of retinal exudative changes in neonates

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国际眼科杂志 2024年第9期24卷 1367-1372页

作者： cen chao He Liying Tao Xueying Liu Ya Department of Ophthalmology Chongqing Health Center for Women and ChildrenWomen and Children's Hospital of Chongqing Medical UniversityChongqing 401147China

AIM:To explore the relationship between retinal exudative changes in neonates and perinatal toxoplasmosis,others,rubella,cytomegalovirus,and herpes simplex virus(TORCH)infections,as well as the characteristics of TORCH infection in neonates with retinal exudative ***:Retrospective study.A total of 612 neonates with retinal exudative changes detected during ophthalmic screening in our hospital from May 2019 to March 2023 were *** tests were performed on these neonates,and the results were subjected to statistical analysis to determine the infection *** neonates with retinal exudative changes were grouped by sex and age,the characteristics of TORCH infection were analyzed,and the positive rates were ***:Among the 612 neonates with retinal exudative changes,the highest positive rate was observed for cytomegalovirus(CMV-IgG)(96.7%),followed by rubella virus(RV-IgG)(73.9%).Mixed infections with two or three viruses were also observed,with the highest positive rate for mixed infection of RV-IgG and CMV-IgG reaching 71.2%.There was no statistically significant difference in TORCH infection among neonates of different sex(P>0.05).However,there were statistically significant differences in RV-IgG and CMV-IgM infections with retinal exudative changes among neonates of different age groups(P<0.05).CONCLUSION:Perinatal TORCH infection may be an important factor causing retinal exudative changes in *** differences in various infections are not related to sex but are related to different age groups.

关键词： neonates TORCH infection retinal exudation

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microRNA在角膜新生血管中的研究进展

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国际眼科杂志 2015年第3期15卷 445-447页

作者：岑超周善璧重庆医科大学附属第一医院眼科中国重庆市400016

角膜新生血管(corneal neovascularization)是影响角膜透明度的主要因素之一,也是同种异体角膜移植术后发生排斥反应的高危因素,因此角膜新生血管形成的调控已成为研究热点。microRNA是一组内源性非编码小分子RNA,在调控多种生物进程中... 详细信息

角膜新生血管(corneal neovascularization)是影响角膜透明度的主要因素之一,也是同种异体角膜移植术后发生排斥反应的高危因素,因此角膜新生血管形成的调控已成为研究热点。microRNA是一组内源性非编码小分子RNA,在调控多种生物进程中起重要作用。近年来研究表明,microRNA与角膜新生血管形成有着紧密联系,本文将对目前的研究情况进行综述。

关键词： microRNA 角膜新生血管基因调控

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基于Devicenet现场总线的制管生产线控制系统的研究

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机械工程与自动化 2011年第5期 164-165页

作者：岑超湖北荆大精密钢管实业有限公司湖北荆州430040

为提高双层卷焊管制管生产线的自动化技术,初步提出基于Device Net现场总线的控制系统,重点研究了Device Net现场总线的技术特点,剖析了系统的硬件组成等内容。

关键词：制管生产线 Devicenet现场总线控制系统

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广西壮族地区居民胃癌发病高危因素初探

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右江医学 2006年第1期34卷 9-11页

作者：岑朝广西靖西县人民医院广西靖西533800

目的探讨壮族居民胃癌流行病学特征，并找出可以干预的一些发病因素。方法以2001年1月至2005年6月经胃镜检出及病理学检查确诊的胃癌131例作为研究对象，检测胃幽门螺杆菌（Hp），进行问卷调查，按1：2配对抽查健康体检262例做对照组，... 详细信息

目的探讨壮族居民胃癌流行病学特征，并找出可以干预的一些发病因素。方法以2001年1月至2005年6月经胃镜检出及病理学检查确诊的胃癌131例作为研究对象，检测胃幽门螺杆菌（Hp），进行问卷调查，按1：2配对抽查健康体检262例做对照组，进行条件logistic回归分析。结果胃癌胃镜检出率1．38％（131／9485）；男：女为2．85：1，年龄17～83岁，平均67．45岁，50～70岁为胃癌高发年龄段；癌变部位由高到低依次为胃窦、胃体、贲门、胃底，病理学分型以腺癌为主。胃癌组Hp检出率为58．78％。胃癌相关的几个主要因素是：Hp感染、饮用井水／池塘／蓄存雨水、水源缺乏居住地、常食用高盐腌制腊肉、常食用蔬菜果品等（OR分别等于29．184、18．307、5．443、5．438、0．628，P＜0．05）。结论本地壮族居民具有其独特流行病学特征。改善生活居住条件特别是饮用水状况和改变不良饮食习惯可能是降低胃癌发病的有效干预措施。

关键词：胃癌流行病学幽门螺杆菌广西壮族

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