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Construction of a Der p2-transgenic plant for the alleviation of airway inflammation

Cellular & Molecular Immunology 2011年第5期8卷 404-414页

作者： cc lee H Ho KT lee ST Jeng BL Chiang Department of Microbiology and Immunology School of MedicineChina Medical UniversityTaichungTaiwan Graduate Institute of Immunology College of MedicineTaipeiTaiwan Institute of Microbiology and Biochemistry TaipeiTaiwan Institute of Plant Biology College of Life ScienceNational Taiwan UniversityTaipeiTaiwan Allergy Center TaipeiTaiwan Department of Pediatrics National Taiwan University HospitalTaipeiTaiwan Graduate Institute of Clinical Medicine TaipeiTaiwan

In clinical therapy,the amount of antigen administered to achieve oral tolerance for allergic diseases is large,and the cost is a major *** this study,we used tobacco plants to develop a large-scale protein production system for allergen-specific immunotherapy,and we investigated the mechanisms of oral tolerance induced by a transgenic plant-derived *** used plants(tobacco leaves)transgenic for the Dermatophagoides pteronyssinus 2(Der p2)antigen to produce Der *** received total protein extract from Der p2 orally once per day over 6 days(days 0–2 and days 6–8).Mice were also sensitized and challenged with yeast-derived recombinant Der p2(rDer p2),after which the mice were examined for airway hyper-responsiveness and airway *** sensitization and challenge with rDer p2,mice that were fed with total protein extracted from transgenic plants showed decreases in serum Der p2-specific IgE and IgG1 titers,decreased IL-5 and eotaxin levels in bronchial alveolar lavage fluid,and eosinophil infiltration in the *** addition,hyper-responsiveness was also decreased in mice that were fed with total protein extracted from transgenic plants,and CD4^(+)CD25^(+)Foxp3^(+) regulatory T cells were significantly increased in mediastinal and mesenteric lymph ***,splenocytes isolated from transgenic plant protein-fed mice exhibited decreased proliferation and increased IL-10 secretion after stimulation with rDer *** data here suggest that allergen-expressing transgenic plants could be used for therapeutic purposes for allergic diseases.

关键词： asthma Der p2 IL-10 oral tolerance transgenic plant

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qPCR和荧光光谱:有毒蓝藻实时定量监测技术的应用分析

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净水技术 2018年第3期37卷 4-9页

作者： Charles cc lee joep appels zhang xianchao 澳大利亚纽卡索大学 microlan Netherlands Zean Ine China

有效的水质在线预警技术对于水库的安全运行有重要意义,对于水库可能出现的水质风险,提前的预警将为相应的应对措施带来重要的应对时间。上海地处亚热带且处于长江流域下游,春夏之交易出现藻类问题,是上海供水安全的巨大威胁。经本刊约... 详细信息

有效的水质在线预警技术对于水库的安全运行有重要意义,对于水库可能出现的水质风险,提前的预警将为相应的应对措施带来重要的应对时间。上海地处亚热带且处于长江流域下游,春夏之交易出现藻类问题,是上海供水安全的巨大威胁。经本刊约稿,新加坡纽卡斯尔大学Charles cc lee教授将传统荧光光谱分析法和qPCR技术进行了对比和详解,各呈优势,为水库水华暴发时有毒蓝藻的实时定量监测提供了新的思路。

关键词：蓝藻藻类暴发荧光光谱 qPCR 实时监测微囊藻毒素

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新生儿复苏培训降低新生儿死亡率的效能分析:文献综述,meta分析与Delphi法的应用

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中国妇幼卫生杂志 2012年第2期3卷 85-98页

作者： Anne cc lee Simon Cousens Stephen N Wall 徐韬中国疾病预防控制中心妇幼保健中心北京100089

[背景]全球每年13600万新生儿中,约1000万需要外界的帮助才能建立自主呼吸,每年有约814000例新生儿死亡是由分娩相关足月儿死亡(以往定义为"出生窒息")所导致的。目前尚缺乏关于新生儿复苏培训降低新生儿死亡率效能的系统性评价。[目的... 详细信息

[背景]全球每年13600万新生儿中,约1000万需要外界的帮助才能建立自主呼吸,每年有约814000例新生儿死亡是由分娩相关足月儿死亡(以往定义为"出生窒息")所导致的。目前尚缺乏关于新生儿复苏培训降低新生儿死亡率效能的系统性评价。[目的]对在医院和社区层面开展的快速评估及初步刺激、基本的复苏措施这两种新生儿复苏培训干预方法在降低足月新生儿分娩相关死亡率("出生窒息")、早产相关并发症死亡率这两个生命指标方面的效能进行评价。[方法]采用系统综述的方法,检索并筛选符合标准的新生儿复苏培训研究文献。采用GRADE方法对文献的质量进行评价。对符合要求的文件进行Meta分析。对数据质量较低的文献采用专家咨询法估计效能大小。[结果]通过文献检索筛选了24篇新生儿复苏培训干预研究(20篇观察性研究,2篇半试验研究,2篇随机对照研究)。对其中3篇文献进行Meta分析结果显示,以医院为基础的新生儿复苏培训可使分娩相关足月儿死亡降低30%(RR=0.70,95%CI0.59～0.84);文献中涉及早产儿死亡率效能的数据质量不高,因此采用专家咨询法进行估计。以社区为基础的新生儿复苏培训干预研究具有较高的异质性,复苏培训通常是一系列培训包的一部分,且对早产儿和足月儿的定义标准不一致。专家咨询法估计结果显示,新生儿快速评估和初步刺激可使分娩相关新生儿死亡、早产儿死亡均降低10%;以医院为基础的培训可使早产儿死亡进一步降低10%,以社区为基础的培训可使分娩相关足月儿死亡率进一步降低20%,早产儿死亡率进一步降低5%。[结论]新生儿复苏培训在医院层面可以使足月新生儿分娩相关死亡率降低30%,然而中低收入水平的国家培训覆盖率仍较低。专家咨询法估计新生儿复苏培训在社区层面降低足月儿及早产儿死亡率的效能较小。需要对新生儿复苏培训的效果、成本、实施策略等进行更深入的研究与评价。

关键词：新生儿死亡率新生儿复苏文献综述 Delphi法 meta分析培训效能社区为基础

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Pushing the limits of existing plasma focus towards 1016 fusion neutrons with Q=0.01

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Plasma Science and Technology 2022年第11期24卷 47-53页

作者： Sing lee Institute for Plasma Focus Studies 32 Oakpark DriveChadstone VIC3148Australia Physics Department University of MalayaKuala Lumpur 50603Malaysia INTI International University Nilai 71800Malaysia Fuse Energy Technologies Napierville QC J0J 1L0Canada

Existing conventional megajoule plasma focus machines with 2–3 MA are producing fusion neutron yields of several times 10^(11) in deuterium operation,the fusion yields predominantly being the beam-gas *** the current to 10 MA and using 50%–50%D-T mixture will scale the neutron yield towards 10^(16) D-T fusion *** this work,we derive the Lawson criterion for plasma focus devices with a beam-target fusion neutron mechanism,so that we may glimpse what future technological advancements are needed for a break-even Q=1 plasma *** perform numerical experiments with a present-day feasible 0.9 MV,8.1 MJ,11 MA machine operating in 100 Torr in 50%–50%D-T *** lee Code simulation gives a detailed description of the plasma focus dynamics through each phase,and provides plasma and yield parameters which show that out of 1.1×10^(19) fast beam ions produced in the plasma focus pinch,only 1.24×10^(14) ions take part in beam-target fusion reactions within the pinch,producing the same number of D-T *** remnant beam ions,numbering at least 10^(19),exit the focus pinch at 1.9 MeV,which is far above the 115 keV ion energy necessary for an optimum beam-target *** propose to regain the lost fusion rates by using a high-pressure D-T-filled drift-tube to attenuate the energy of the remnant beam ions until they reach the energy for the optimum fusion *** a fusion enhancement tube would further harvest beam-target fusion reactions by increasing the interaction path length(1 m)at increased interaction density(6 atm).A gain factor of 300 is conservatively estimated,with a final yield of 3.7×10^(16) D-T neutrons carrying kinetic energy of 83.6 kJ,demonstrating Q=0.01.

关键词： plasma focus simulation neutron enhancement fusion harvester plasma focus

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Overview of Computational Modeling in Nano/Micro Scaled Thin Films Mechanical Properties and Its Applications

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Computer Modeling in Engineering & Sciences 2019年第8期120卷 239-260页

作者： Chang-Chun lee Pei-Chen Huang Department of Power Mechanical Engineering National Tsing Hua UniversityNo.101Section 2Kuang-Fu RoadHsinchu 30013Taiwan

This research reviews the application of computational mechanics on the properties of nano/micro scaled thin films,in which the application of different computational methods is *** concept and fundamental theories of concerned applications,material behavior estimations,interfacial delamination behavior,strain engineering,and multilevel modeling are thoroughly ***,an example of an interfacial adhesion estimation is presented to systematically estimate the related mechanical reliability issue in the microelectronic *** presented results show that the peeled mode fracture is the dominant delamination behavior of layered material system,with high stiffness along the bonding ***,the shear mode fracture being dominated as the polymer cover plate with low moduli is *** occurrence of crack advance is also significantly influenced by the interfacial crack length and applied ***,this paper could serve as a guideline of several engineering cases with the assistance of computational mechanics.

关键词： Computational mechanics mechanical responses nano/micro thin films

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Performance Investigation of Capillary Tubes for Machine Tool Coolers Retrofitted with HFC-407C Refrigerant

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Chinese Journal of Mechanical Engineering 2012年第5期25卷 933-939页

作者： WANG Fujen CHANG Tongbou CHIANG Weiming lee Haochung Department of Refrigeration and Air Conditioning Engineering Chin-Yi University of Technology Department of Mechanical Engineering Southern Taiwan University Energy & Environment Research Laboratories Industrial Technology Research Institute

The machine tool coolers are the best managers of coolant temperature in avoiding the deviation of spindle centerline for machine tools. However, the machine coolers are facing the compressed schedule to phase out the HCFC （hydro-chloro-floro-carbon） refrigerant and little attention has been paid to comparative study on sizing capillary tube for retrofitted HFC （hydro-floro-carbon） refrigerant. In this paper, the adiabatic flow in capillary tube is analyzed and modeled for retrofitting of HFC-407C refrigerant in a machine tool cooler system. A computer code including determining the length of sub-cooled flow region and the two phase region of capillary tube is developed. Comparative study of HCFC-22 and HFC-407C in a capillary tube is derived and conducted to simplify the traditional trial-and-error method of predicting the length of capillary tubes. Besides, experimental investigation is carried out by field tests to verify the simulation model and cooling performance of the machine tool cooler system. The results from the experiments reveal that the numerical model provides an effective approach to determine the performance data of capillary tube specific for retrofitting a HFC-407C machine tool cooler. The developed machine tool cooler system is not only directly compatible with new HFC-407C refrigerant, but can also perform a cost-effective temperature control specific for industrial machines.

关键词： machine tool cooler capillary tube refrigerant retrofitting

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Experimental Investigation of Capacity Control Scheme on System Performance for a Machine Tool Cooler

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Chinese Journal of Mechanical Engineering 2011年第3期24卷 333-339页

作者： WANG Fujen CHANG Tongbou KAO Jianwei lee Haochung Department of Refrigeration Air Conditioning and Energy Engineering Chin-Yi University of Technology Taiehung 411 Taiwan China Department of Mechanical Engineering Southern Taiwan University Tainan 710 Taiwan China Energy and Environment Research Laboratories Industrial Technology Research Institute Hsinchu 310 Taiwan China

Highly accurate manufacture in machining industry can only be obtained with precise temperature control of the coolant （oil or water）.Machine tool with more accurate,stable and advanced the precision of the working component cannot be developed without appropriate ***,the machine tool coolers are facing the control hunting of cooling temperature and the dramatic variation of heat load in high-accuracy *** main objective of this study is to evaluate the influence of the hot-gas by-pass scheme and suction regulation for capacity control of a machine tool cooler *** this study,experimental investigation on both hot-gas by-pass scheme and suction valve regulation for capacity control has been *** of using capillary tube and thermostatic expansion valve along with different capacity control scheme have been investigated extensively in an environmental testing *** performance and power consumption of the cooler system have been measured and analyzed as well by comparing with different opening percentage of throttling valve under specific coolant *** experimental results reveal that the power consumption will reduce slightly by capacity control using the hot-gas by-pass scheme but the coefficient of performance （COP） of the overall system will *** coolant temperature will result in higher compressor power consumption as *** conducting suction valve regulating for capacity control,energy-saving at 10%-12% can be obtained by using thermostatic expansion valve under different evaporator *** also reveals that suction valve regulation along with adequate choice of thermostatic expansion valve can provide alternative choice for steady capacity control and substantial *** proposed cooler systems with different capacity control schemes are not only more cost-effective than inverter driven system,but also can perform energy-saving and precise temperature control specific for high-accur

关键词： machine tool cooler hot-gas by-pas suction regulation capacity control

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Surface-roughened current collectors for anode-free all-solid-state batteries

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Journal of Energy Chemistry 2022年第7期31卷 248-257,I0007页

作者： Donghee Gu Hyoungchul Kim Jong-Ho lee Sangbaek Park Energy Materials Research Center Korea Institute of Science and Technology(KIST)Seoul 02792.Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University.Seoul 02841.Republic of Korea Division of Nanoscience and Technology University of Science and Technology(UST)Seoul02792.Republicof Korea Department of Materials Science and Engineering Chungnam National UniversityDaejeon 34134.Republic of Korea

Anode-free all-solid-state batteries(AFASSBs), composed of a fully lithiated cathode and a bare current collector(cc) that eliminates excess lithium, can maximize the energy density(because of a compact cell configuration) and improve the safety of solid-state systems. Although significant progress has been made by modifying ccs in liquid-based anode-free batteries, the role of ccs and the mechanism of Li formation on ccs in AFASSBs are still unexplored. Here, we systematically investigate the effect of the surface roughness of the ccs on the Li plating/stripping behavior in AFASSBs. The results show that the moderately roughened cc substantially improves the Coulombic efficiency and cycle stability of AFASSBs owing to the increased contact points between the solid electrolyte and the roughened cc. In contrast, the excessively roughened cc deteriorates the performance owing to the contact ***, an ex situ interface analysis reveals that the roughened surface of the cc could suppress the interfacial degradation during the Li ion extraction from a sulfide solid electrolyte to a cc. This provides an indication to the origin that hinders the electrochemical performance of AFASSBs. These findings show the potential for the application of surface-engineered ccs in AFASSBs and provide guidelines for designing advanced ccs.

关键词： Anode-free Solid-state batteries Current collectors Surface roughness Li formation

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Practical considerations of Si-based anodes for lithiumion battery applications

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Nano Research 2017年第12期10卷 3970-4002页

作者： Jaegeon Ryu Dongki Hong Hyun-Wook lee Soojin Park Department of Energy Engineering School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea

Using Si-based anodes in Li-ion batteries is one of the most feasible approaches to achieve high energy densities despite their disadvantages, such as low conductivity and massive volume expansion, which cause unstable solid electrolyte interphase layers with mechanical failure. The forefront in research and development to address the above challenges suggests the possibility of fully commercially viable cells using various structural and interfacial modifications. In particular, we present a discussion of each dimension of Si-based anodes in multiple controlled systems, including plain, hollow, porous, and uniquely engineered structures, which are further evaluated based on their anode performances, such as initial reversibility, capacity retention for extended cycles with its efficiency, degree of volume expansion tolerance, and rate capabilities, by several practical standards in half cells. With these practical considerations, multi-dimensional structures with uniform size distributions （micrometers, on average） are strongly desired to satisfy the rigorous requirements for widespread applications. Furthermore, we closely examined several full cells composed of Si-based multicomponent anodes coupled with suitable cathodes based on practical standards to propose future research directions for Si-based anodes to keep pace with the rapidly changing market demands for diverse energy storage systems.

关键词： silicon anode dimensional control full celllithium-ion batteries practicality

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Prognosis of hepatocellular carcinoma expressing cytokeratin 19:Comparison with other liver cancers

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World Journal of Gastroenterology 2012年第34期18卷 4751-4757页

作者： Jung Il lee Jin-Woo lee Joon Mee Kim Ja Kyung Kim Hyun Jung Chung Young Soo Kim Department of Internal Medicine School of MedicineInha UniversityIncheon 400-711South Korea Department of Pathology School of MedicineInha UniversityIncheon 400-711South Korea Department of Internal Medicine Yonsei University College of MedicineGangnam Severance HospitalSeoul 135-720South Korea

AIM:To investigate whether expressing biliary phenotype predicted poor outcome after the surgical treatment in primary liver cancers. METHODS:Out of 204 patients that underwent liver resection due to hepatocellular carcinoma (Hcc), liver specimens of 70 patients with Hcc were evaluated for biliary components by cytokeratin (CK) 19 immunostain (CK19 - Hcc and CK19 + Hcc). CK19 positivity was defined as membranous and/or cytoplasmic expression in ≥ 5% of tumor cells with moderate or strong intensity. Patients with other primary liver cancers, such as com- bined Hcc and cholangiocarcinoma (cHcc-cc), intrahe- patic cholangiocarcinoma (Icc) who received curative liver resection, were also included in the study. Clinical characteristics of CK19-Hcc and CK19 + Hcc patients, including survival outcome after curative liver resection, were compared with that of cHcc-cc and Icc patients. RESULTS: The overall survival (OS) rate of CK19 - Hcc(n = 49) after the curative surgical treatment was 90.7%, and 80.4% at 1 and 5 years after the resection. OS rate of CK19 + Hcc (n = 21) was 74.3%, 28.9% and OS rate of cHcc-cc (n = 22) was 66.7%, 32.2% at 1 and 5 years after the surgery. For Icc (n = 19), 1 and 5-year-OS rate was 50.2% and 14.3% after the cura-tive resection. The OS rates of CK19 + Hcc and cHcc-cc were significantly lower than that of CK19-Hcc, but higher than the OS rate of Icc (P = 0.000). There was no statistically significant difference in OS rate between CK19 + Hcc and cHcc-cc. The disease free survival (DFS) rate of CK19-Hcc was 72.0% and 54.5% at 1 and 3 years after the surgical treatment. DFS rate of CK19 + Hcc was 53.3%, 34.3% and DFS rate of cHcc- cc was 51.5%, 39.2% at 1 and 3 years after the resection. For Icc, 1 and 3-year-DFS rate was 28.0% and 14.0% after the curative resection. DFS rate of CK19-Hcc was significantly higher than that of Icc (P = 0.017), but marginally higher than DFS rate of either CK19 + Hcc or cHcc-cc (P = 0.097, P = 0.089, respec-tively).

关键词： Cytokeratin 19 Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Liver cancers Hepa-tectomy

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