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Integra.ion of multiple flexible electrodes for rea.time detection of ba.rier forma.ion with spa.ia. resolution in a.gut-on-chip system

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Microsystems & Na.oengineering 2024年第1期10卷 105-114页

作者： Ma.a.Lucchetti Ga.riel Werr Sofia.Joha.sson La.rent Ba.be Léa.Gra.dmougin Pa.l Wilmes maria Tenje Luxembourg Centre for Systems Biomedicine(LCSB) University of LuxembourgEsch-sur-Alzette L-4362Luxembourg Division of Biomedica. Engineering Department of Materials Science and EngineeringScience for Life LaboratoryUppsala University75121 UppsalaSweden Depa.tment of Life Sciences a.d Medicine Faculty of ScienceTechnology and MedicineUniversity of LuxembourgEsch-sur-Alzette L-4362Luxembourg

In hea.thy individua.s,the intestina. epithelium forms a.tight ba.rier to prevent gut ba.teria.from rea.hing blood *** study the effect of probiotics,dieta.y compounds a.d drugs on gut ba.rier forma.ion a.d disruption,huma. gut epithelia. a.d ba.teria. cells ca. be cocultured in a. in vitro model ca.led the huma. microbia. crossta.k(HuMiX)gut-on-a.chip ***,we present the design,fa.rica.ion a.d integra.ion of thin-film electrodes into the HuMiX pla.form to mea.ure tra.sepithelia. electrica. resista.ce(TEER)a. a.direct rea.out on ba.rier tightness in *** va.ious a.pects of the HuMiX pla.form ha.e a.rea.y been set in their design,such a. multiple compressible la.ers,uneven surfa.es a.d nontra.spa.ent ma.eria.s,a.novel fa.rica.ion method wa. developed whereby thin-film meta. electrodes were first deposited on flexible substra.es a.d sequentia.ly integra.ed with the HuMiX system via.a.tra.sfer-ta.e ***,to mea.ure loca.ized TEER a.ong the cell culture cha.ber,we integra.ed multiple electrodes tha. were connected to a. impeda.ce a.a.yzer via.a.*** further developed a.dyna.ic norma.iza.ion method beca.se the a.tive mea.urement a.ea.depends on the mea.ured TEER *** fa.rica.ion process a.d system setup ca. be a.plica.le to other ba.rier-on-chip *** a.proof-of-concept,we mea.ured the ba.rier forma.ion of a.ca.cerous Ca.o-2 cell line in rea.-time,which wa. ma.ped a. four spa.ia.ly sepa.a.ed positions a.ong the HuMiX culture a.ea.

关键词： ba.rier system multiple

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Clima.e cha.ge a.d huma. hea.th: La.t ca.l to a.ms for us

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World Journa. of Clinica. Ca.es 2024年第11期12卷 1870-1874页

作者： a.tonio Corrente maria Ca.erina.Pa.e Ma.co Fiore Depa.tment of a.a.sthesiology a.d Intensive Ca.e Medicine The Anastasia Guerriero HospitalMarcianise 81025CasertaItaly Depa.tment of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy

Clima.e cha.ge,now the foremost globa. hea.th ha.a.d,poses multifa.eted cha.lenges to huma. *** editoria. elucida.es the extensive impa.t of clima.e cha.ge on hea.th,empha.ising the increa.ing burden of disea.es a.d the exa.erba.ion of hea.th *** highlights the critica. role of the hea.thca.e sector,pa.ticula.ly a.a.sthesia.in both contributing to a.d mitiga.ing clima.e *** is a.ca.l to a.tion for the medica. community to recognise a.d respond to the hea.th cha.lenges posed by clima.e cha.ge.

关键词： Clima.e cha.ge Ca.bon footprint Susta.na.ility Greenhouse ga.es a.a.sthetic ga.es Environmenta. impa.t Disposa.le la.yngoscope bla.es

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a.Ra.id Pa.a.eter of Enzyme-Trea.ed Cellulosic Ma.eria. Revea.ed by Reducing Suga. Relea.e

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Journa. of Renewa.le Ma.eria.s 2024年第3期12卷 539-551页

作者： Verônica.Távilla.Ferreira.Silva.a.ria.e maria Ferreira.Mila.res Depa.ta.ento de Biotecnologia Escola de Engenharia de LorenaUniversidade de São PauloLorenaSP12602-810Brazil

This study wa. conducted to eva.ua.e the effectiveness of enzymes in purifying a.d reducing the degree of polymeriza.ion of cellulose for the production of dissolving *** goa. wa. to determine the contributions of xyla.a.e(X)a.d endogluca.a.e(EG)in the trea.ment of pulp,specifica.ly by qua.tifying the forma.ion of soluble a.d insoluble reducing suga.s using the dinitrosa.ycilic a.id(DNS)***,the relea.e of soluble reducing suga.s(RSSol)wa. enha.ced a.ter xyla.a.e trea.ment,while endogluca.a.e(EG)trea.ment led to cha.ges in insoluble reducing suga.s(RSIns).The ma.imum synergism wa. observed for RSIns when a.high ra.io of endogluca.a.e to xyla.a.e(320EG:5X/g pulp)wa. *** rela.ive contribution of endogluca.a.e to RSins wa. determined to be 15.6%of the tota. reducing *** viscosity of pulps trea.ed with xyla.a.e decrea.ed only by 7%,wherea. endogluca.a.e trea.ment significa.tly reduced viscosity by 45%.Modifica.ions in the pa.ticle size were observed a.ter pulp trea.ment with the combina.ion of endogluca.a.e a.d *** summa.y,the DNS test is a.ra.id a.d effective method for eva.ua.ing the efficiency of enzyme trea.ments on *** mea.urement of RSIns correla.es with cha.ges in pulp viscosity to different extents,providing va.ua.le insights into the effectiveness of enzyme trea.ments.

关键词： Endogluca.a.e xyla.a.e cellulose fiber pulp synergism

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MIS 5e sea.surfa.e tempera.ure estima.ion;a.multi-proxy a.proa.h using a.ma.ine ma.rofossil a.sembla.e(Ma. Piccolo,Gulf of Ta.a.to,Southern Ita.y)

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Journa. of Pa.a.ogeogra.hy 2024年第2期13卷 327-350页

作者： Pierluigi Sa.ta.a.i Edoa.do Perri maria Pia.Berna.coni Ma.io Borrelli Sa.va.ore Guerrieri Sa.va.ore Critelli Dipa.timento di Biologia Ecologia e Scienze della TerraUniversita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly Dipa.timento di Ingegneria.a.bienta.e Universita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly

It is reported a.multi-proxy pa.a.oclima.ic study conducted on a.MIS 5e ca.ca.enite from the Ma. Piccolo Ba.in(MP),Gulf of Ta.a.to(GT)(Centra. Mediterra.ea.).The ca.ca.enite returned a.rich ma.a.ofa.na.consisting of 120 exta.t species,including four of the tropica. Senega.ese Fa.na.toda. a.sent in the *** biogeogra.hic-clima.ic a.finity of the a.sembla.e shows,compa.ed to toda.,a.double percenta.e of wa.m a.finity species,while the cold a.finity species a.e nea.ly equa.ly represented,indica.ing a.wa.mer but not strictly tropica. *** is confirmed by the most recurring preferred SST ra.ges of the a.sembla.e,indica.ing a. a.era.e of 20℃.The skeleta. compositions of five well-preserved mollusca. a.d cora. specimens were a.a.yzed for tra.e elements a.d sta.le isotopes for further mea. SST *** the compa.ison of the results of severa. equa.ions a.a.la.le in litera.ure,it a.pea.s tha. only some SST estima.ions a.e rea.istic,converging into simila. va.ues of,on a.era.e,20.8±0.9℃.Considering a.l the used proxies,the MIS 5e SST difference compa.ed to toda. fa.ls in the ra.ge 1.2—2.0℃for the GT(being a.more rea.ona.le scena.io)a.d 2.0—2.8℃for the *** is not a.firmly tropica.-like SST setting a. suggested by the sole Senega.ese fa.na.indica.ing a. lea.t 2.7℃—3.5℃more tha. toda.’s GT a.d MP,*** a.proxima.ions a.d a.sumptions ma.e for obta.ning SST va.ues with a.y single proxy indica.e the need of a.multi-proxy a.proa.h to define the best SST estima.ion.

关键词： MiS 5e Sea.surfa.e tempera.ure Pa.a.oclima.e proxy Fossil fa.na Gulf of Ta.a.to

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Ta.geted na.opore sequencing for the identifica.ion of novel PRMT1 circRNa. unveils a.diverse tra.scriptiona. profile of this gene in brea.t ca.cer cells

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Genes & Disea.es 2024年第2期11卷 589-592页

作者： maria Pa.a.sirou a.drea. Scorila. Dia.a.tis C.Sideris Christos K.Kontos Depa.tment of Biochemistry a.d Molecula. Biology National and Kapodistrian University of AthensPanepistimiopolisAthens GR 15701Greece

Long-rea. sequencing with na.opore technology ha. been widely utilized for the identifica.ion of the full-length sequence of RNa.molecules."It is especia.ly suita.le for the identifica.ion of circula. RNa.(circRNa.),which a.e regula.ory molecules tha. a.e rega.ded a. promising non-inva.ive bioma.kers for va.ious huma. ma.igna.cies,including brea.t ca.cer.2 The impa.t of circRNa. derived from the protein a.ginine methyltra.sfera.e 1(PRMT1)gene ha. not been cla.ified yet,even though the effect of PRMT1-media.ed methyla.ion on brea.t ca.cer cell cha.a.teristics ha. been well esta.lished.

关键词： PRMT1 brea.t ca.cer

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Ja.ques Touret(1936-2024)

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Geoscience Frontiers 2024年第4期15卷 518-520页

作者： maria Luce Frezzotti Da.iel Ha.lov Ja. Ma.ten Huizenga.a.fons va. den Kerkhof Universitàdegli Studi di Mila.o-Bicocca MilanoItaly Geo Forschungs Zentrum Potsda. TelegrafenbergPotsdamGermany Norwegia. University of Life Sciences ÅsNorway Georg-a.gust Universität Göttingen GöttingenGermany

Ja.ques Touret(Fig.1)pa.sed a.a. on 11 Ma.ch 2024 in Pa.is a. the a.e of 88 a.ter a.long *** is survived by his wife Lydie Touret,four children,a.d 14 *** wa. a.pioneer in the field of fluid inclusions a.d its a.plica.ions in high-gra.e meta.orphic *** his retrospective pa.er in Geoscience Frontiers(Touret,2014),Ja.ques described himself a. someone who dedica.ed"...a.grea. pa.t of my scientifiic life to the study of minute bubbles in rocks issued from the most extreme depths of our mother Ea.th".He will be remembered a. a.very a.ia.le person a.d his infectious enthusia.m for fluid inclusions.

关键词： someone remember mother

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Boston type I kera.oprosthesis

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a.na.s of Eye Science 2024年第2期9卷 12-23页

作者： Ka.en Hu Ima.e Ta.ib maria Soleda. Cortina Depa.tment of Ophtha.mology a.d Visua. Sciences University of Illinois at ChicagoChicagoILUSA

Successful cornea. solid tissue tra.spla.ta.ion,beginning with penetra.ing kera.opla.ty(PKP),a.d evolving to include contempora.y la.ella. a.d endothelia. kera.opla.ty,ha. been a.tremendous a.va.cement in the struggle to comba. cornea. ***,there rema.n pa.ients with high-risk fea.ures predictive of tra.spla.t fa.lure,for whom donor kera.opla.ty is not a.via.le *** cornea. ha.e therefore been developed in order to meet the needs of these *** Boston type I kera.oprosthesis(BKPro)is the most widely used prosthetic cornea.in the trea.ment of cornea. *** the yea.s since the BKPro’s introduction,refinement of surgica. technique a.d clinica. ma.a.ement a. well a. improvements in prosthetic design ha.e contributed to promising pa.ient outcomes,pa.ticula.ly in the short *** such,pa.ients with kera.oprosthesis impla.ts continue to grow in number,a.d the indica.ions for the BKPro ha.e commensura.ely ***,risks of perma.ently blinding complica.ions a.ter impla.ta.ion persist over a.l sta.es of *** the foreseea.le future,the success of kera.oprosthesis(KPro)impla.ta.ion will continue to depend on refined pa.ient selection,preopera.ive optimiza.ion,a.d incisive postopera.ive *** we explore indica.ions,surgica. technique a.d postopera.ive outcomes a. well a. severa. core tena.ts in the ma.a.ement of BKPro pa.ients:limiting gla.coma.ous progression,controlling infla.ma.ion,a.d optimizing the ocula. *** exquisite sensitivity of the BKPro-impla.ted eye to perturba.ions in a.y one of these a.ea. showca.es the intima.e rela.ionship between the prosthetic device a.d its surrounding environment.

关键词： Kera.oprosthesis cornea. tra.spla.t Boston type I kera.oprosthesis(BKPro) kera.oprosthesis(KPro)

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How to identify ea.ly complica.ions in pa.ients undergoing dista. ga.trectomy?

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World Journa. of Ga.trointestina. Surgery 2024年第4期16卷 974-981页

作者： Giuseppe Tropea.o maria Michela.Chia.ello Va.eria.Fico Giuseppe Brisinda Emergency Surgery a.d Tra.ma.Center Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Depa.tment of Surgery Azienda Sanitaria Provinciale di CosenzaCosenza 87100Italy Depa.tment of Medica. a.d Surgica. Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy

In this editoria. we comment on the a.ticle by Zha.g et a. published in a.recent issue of the World Journa. of Ga.trointestina. *** with a.propria.e lymph node dissection is still sta.da.d cura.ive trea.ment in loca.ly a.va.ced ga.tric *** studies point out tha. ga.tric ca.cer surgery is a.complex procedure tha. lea.s to a.high risk of morbidity a.d *** fa.tors ca. contribute to the onset of complica.ions with consequent effects on prognosis a.d increa.ed *** complica.ions ca. be divided in complica.ions rela.ed to a.a.tomosis,to motility a.d to surgica. site *** study presented by Zha.g B et a. represent a. interesting a.a.ysis on the possibility to prevent postopera.ive *** study wa. performed on 131 pa.ients with dista. ga.tric ca.cer who underwent ga.trectomy with D2 lymph node *** these pa.ients,16%developed ea.ly postopera.ive *** univa.ia.e a.a.ysis showed tha. prea.bumin level,hypertension,dia.etes,history of a.domina. surgery,R0 resection,a.d blood tra.sfusion were fa.tors influencing ea.ly postopera.ive complica.ions a.ter dista. ***,the inclusion of the a.ove significa.t va.ia.les in the logistic regression a.a.ysis revea.ed tha. hypertension,dia.etes,a.history of a.domina. surgery,a.d blood tra.sfusion were independent predictors of postopera.ive *** conclusion,preopera.ive a.d intra.pera.ive fa.tors ca. be used to esta.lish a. ea.ly postopera.ive nomogra. *** results of the study presented by Zha.g et a. suggest tha. the prediction model ca. be used to guide the detection of postopera.ive complica.ions a.d ha. clinica. reference va.ue.

关键词： Ga.tric ca.cer Ga.trectomy Lymph node dissection Morbidity Morta.ity Surgica. site infections

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Unra.eling the gut-bra.n a.is:the impa.t of steroid hormones a.d nutrition on Pa.kinson's disea.e

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Neura. Regenera.ion Resea.ch 2024年第10期19卷 2219-2228页

作者： Pa.la.maria Neufeld Ra.f a.Nettersheim Veronika.Ma.schke Ma.thia. Vorgerd Sa.a. Sta.lke Ca.sten Theiss Depa.tment of Cytology Institute of AnatomyMedical FacultyRuhr-University BochumBochumGermany Depa.tment of Viscera. Surgery University Hospital BergmannsheilRuhr-University BochumBochumGermany Depa.tment of Neurology Heimer Institute for Muscle ResearchUniversity Hospital BergmannsheilRuhr-University BochumBochumGermany

This comprehensive review explores the intrica.e rela.ionship between nutrition,the gut microbiome,steroid hormones,a.d Pa.kinson's disea.e within the context of the gut-bra.n *** gut-bra.n a.is pla.s a.pivota. role in neurodegenera.ive disea.es like Pa.kinson's disea.e,encompa.sing diverse components such a. the gut microbiota.immune system,meta.olism,a.d neura. *** gut microbiome,profoundly influenced by dieta.y fa.tors,emerges a. a.key *** during the first 1000 da.s of life sha.es the gut microbiota.composition,influencing immune responses a.d impa.ting both child development a.d a.ult ***-fa.,high-suga. diets ca. disrupt this delica.e ba.a.ce,contributing to infla.ma.ion a.d immune *** nutritiona. stra.egies,the Mediterra.ea. diet's a.ti-infla.ma.ory a.d a.tioxida.t properties show promise in reducing Pa.kinson's disea.e ***-ta.geted dieta.y a.proa.hes a.d the ketogenic diet hold the potentia. in improving bra.n *** nutrition,emerging resea.ch uncovers potentia. intera.tions between steroid hormones,nutrition,a.d Pa.kinson's ***,with its a.ti-infla.ma.ory properties a.d presence in the nervous system,offers a.novel option for Pa.kinson's disea.e *** a.ility to enha.ce neuroprotection within the enteric nervous system presents exciting *** review a.dresses the hypothesis tha.α-synuclein a.grega.es origina.e from the gut a.d ma. enter the bra.n via.the va.us *** symptoms preceding motor symptoms support this *** gut-bra.n signa.ing during gut dysbiosis contributes to infla.ma.ion a.d neurotra.smitter imba.a.ces,empha.izing the potentia. of microbiota.ba.ed *** summa.y,this review uncovers the complex web of intera.tions between nutrition,the gut microbiome,steroid hormones,a.d Pa.kinson's disea.e within the gut-bra.n a.is *** these connections not only offers novel thera.eutic insi

关键词： diet gut-bra.n a.is microbiome neurodegenera.ive disea.es nutrition Pa.kinson's disea.e progesterone steroid hormones

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Effect of low concentra.ion electrolytes on the forma.ion a.d corrosion resista.ce of PEO coa.ings on a.50 ma.nesium a.loy

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Journa. of Ma.nesium a.d a.loys 2024年第4期12卷 1386-1405页

作者： Peng Xie Ca.sten Bla.ert maria Serdechnova.Na.a.ia.Koncha.ova.Ta.sia.a.Shulha.Ting Wu Mikha.l L.Zheludkevich Institute of Surfa.e Science Helmholtz-Zentrum HereonMax-Planck Strasse 121502 GeesthachtGermany Institute for Ma.eria.s Science Faculty of EngineeringKiel UniversityKaiserstrasse 224143 KielGermany

In this pa.er,the forma.ion process,morphology,a.d electrochemica. performa.ce of PEO coa.ings on a.50 ma.nesium a.loy prepa.ed in low concentra.ion phospha.e,a.umina.e,a.d phospha.e-a.umina.e electrolytes were systema.ica.ly *** results show tha. the coa.ings prepa.ed from the phospha.e electrolytes ha.e a.higher thickness a.d better corrosion resista.ce properties compa.ed to the other *** coa.ings prepa.ed from low concentra.ion phospha.e-a.umina.e mixed electrolytes ha.e slightly thinner thickness,a.simila. coa.ing structure a.d a. order of ma.nitude lower va.ue of electrochemica. impeda.ce compa.ed with phospha.e electrolyte *** Coa.ings prepa.ed from low concentra.ion a.umina.e electrolytes ha.e the lowest thickness a.d the worst corrosion resista.ce properties which gets close to corrosion beha.ior of the ba.e a.50 under the sa.e test *** a.plica.ion,coa.ings prepa.ed from single low concentra.ion phospha.e electrolytes a.d low concentra.ion phospha.e-a.umina.e electrolytes ha.e grea.er potentia. tha. single low concentra.ion a.umina.e ***,reducing the electrolyte concentra.ions of coa.ing forming ions too much ha. nega.ive influence on the coa.ing growth ra.e.

关键词： Pla.ma.electrolytic oxida.ion Low concentra.ion electrolytes Corrosion resista.ce a.50 ma.nesium a.loy

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