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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria jim.nez carretero IrisÁlvarez-Merz Jorge Hernández-campano Sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y cajal Institute for Health Research(IRYcIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

control of tendon cell fate in the embryonic limb: A molecular perspective

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BIOcELL 2023年第3期47卷 465-471页

作者： JESSIcA cRISTINA MARÍN-LLERA carlos amaury jim.nez-cárdenas JESÚS cHIMAL-MONROY Departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de México Ciudad UniversitariaApartado Postal 70228MéxicoDF 04510México

The molecular cascade underlying tendon formation starts when progenitor cells begin to express the Scleraxis(Scx)*** knockout mice develop some but not all tendons,suggesting that additional factors are necessary for tendon commitment,maintenance,and *** transcription factors,such as Mohawk(Mkx)or early growth response(Egr),maintain Scx expression and extracellular matrix formation during *** inhibition of wingless and int-related protein signaling is necessary and sufficient to induce the expression of *** the commitment of tenogenic lineage occurs,transforming growth factor-beta(TGFβ)induces the Scx gene expression,becoming involved in the maintenance of tendon cell *** this point of view,we discussed two phases of the tenogenic process during limb development:dependent and independent of mechanical ***,we highlight the importance of understanding embryonic tendon development to improve therapeutic strategies in regenerative medicines for tendons.

关键词： Tendon differentiation Tenocyte Scleraxis Mohawk Early growth response Tendon development WNT TGFβ

Visual function,performance,and processing of basketball players *** individuals

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Journal of Sport and Health Science 2020年第6期9卷 587-594页

作者： Jesús Vera Raimundo jim.nez David cárdenas Beatriz Redondo José Antonio García Department of Optics Faculty of ScienceUniversity of GranadaGranada 18071Spain Department of Physical Education and Sport Faculty of Sport ScienceUniversity of GranadaGranada 18071Spain Sport and Health University Mixed Institute University of GranadaGranada 18071Spain

Background:Athletes tend to have better visuo-motor performance than do sedentary ***,several basic visual-function and perceptual parameters remain unexplored to *** this study,we investigated whether differences exist in visual function,performance,and processing between basketball players and individuals without a sport-involvement ***:A total of 33 healthy men with no visual impairment or pathology were divided into 2 groups,depending on the involvement in sport(semi-professional basketball players and sedentary individuals).We tested their baseline heart-rate variability in the resting position apart from subjective questionnaires to determine their physical fitness level,and we checked their visual function,performance,and processing through an extended battery of optometric ***:The 2 groups differed in resting heart-rate variability parameters(pconfirming their dissimilarities in regular time practising sports per *** basketball players showed a closer breakpoint and recovery nearpoint of convergence,a higher fusional-vergence rate,better discriminability halos,and better eye-hand coordination(all p valuesconclusion:These results show evidence that athletes,basketball players in this case,exhibit better performance in several visual abilities in comparison to a group of individuals without sporting backgrounds,suggesting an improvement due to the systematic involvement of those skills during basketball practice.

关键词： Exercise Fitness level Health Heart rate variability Visual skills Team sport

Processing of Aerosol Particles in convective cumulus clouds:cases Study in the Mexican East Pacific

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Advances in Atmospheric Sciences 2010年第6期27卷 1331-1343页

作者： José c.jim.nez-EScALONA Oscar PERALTA ESIME UP Ticomán National Polytechnic Institute chemistry Faculty National Autonomous University of MexicoCiudad Universitaria

In the Mexican Intertropical convergence Zone, particle size distributions within 500 m of cloud boundaries at altitudes of 1000, 2500, and 4200 m, were compared against size distributions at the same levels but 1500 m away from the clouds. The differences in the distributions near and far from the cloud are related to processes that may change particle properties inside the cloud. chemical changes in the aerosols are deduced from the particles＇ refractive index, as derived from comparisons with the scattering coeflcient measured by a nephelometer. An analysis of ten cloud systems indicates that vertical transport of cloud base aerosol followed by entrainment/detrainment is the cloud processing signature most frequently observed in the comparisons （65%）. changes in the chemical composition are observed in approximately 20% of the cases and another 20% of the cases showed removal by precipitation. About 5% of the comparisons showed clear evidence of changes by coalescence. The principal effect of these cloud-processed aerosols is observed in the increase of optical depth in the layer from 30 m to 4200 m in the near-cloud regions, in comparison with the atmosphere further from clouds.

关键词： cloud processing cloud interaction scattering redistribution entrainment

Effect of intensity and duration of anthropic noises on European mink locomotor activity and fecal cortisol metabolite levels

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current Zoology 2022年第6期68卷 688-699页

作者： Lorena ORTIZ-jimEnez carlos IGLESIAS-MERcHAN Alba Itzel MARTınez-SALAZAR Isabel BARJA Department of Biology Zoology UnitUniversidad Autonoma de MadridMadrid28049Spain Department of Forest and Environmental Engineering and Management Universidad Politecnica de MadridMadridSpain Geographic Information Systems Laboratory Institute of BiologyUniversidad Nacional Autonoma de MexicoMexico CityMexico Biodiversity and Global change Research centre(cIBc-UAM) Universidad Autonoma de MadridMadridSpain

Human activities involving noise emission can affect wild *** mink was exposed to road noise and human voice playbacks to analyze how sound intensity level and duration of both noises altered the time that individuals were active and if their fecal cortisol metabolite(FcM)levels varied.A Hierarchical Analysis cluster was performed to establish 2 mink groups with respect to both noise source type:short duration/low intensity(SL)and long duration/high intensity(LH).We performed general linear mixed models to evaluate the variation in locomotor activity duration(s)and FcM(nanogram per gram)levels,*** results showed both road noise and human voices decreased locomotor activity duration in SL more sharply compared with LH,and human voices were the triggers that induced the most pronounced response to both exposure ***(ng/g)levels increased in SL compared with LH during road noise while the opposite happened during human *** based on sex and age of individuals were *** conclusion,noise characteristics given by the sound type determined the variations in locomotor activity duration while noise exposure level determined the variations in FcM(ng/g)*** should be paid to noisy activities(e.g.,recreational activities for visitors in protected natural areas)and loud groups of people to conserve wildlife,especially noise sensitive species.

关键词： anthropic disturbances European mink fecal cortisol metabolites noise exposure locomotor activity behavioral response

Origin of light emission and enhanced Eu^(3+) photoluminescence in tin-containing glass

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Journal of Rare Earths 2015年第1期33卷 27-32页

作者： José A.jim.nez Esteban Rosim Fachini Department of chemistry University of North FloridaJacksonville FL 32224 USA Department of Physical Sciences General Studies Faculty University of Puerto RicoRío Piedras PR 00931 USA

A barium-phosphate glass matrix was co-doped with Sn O and Eu2O3 for investigating on material luminescent properties. Optical absorption and X-ray photoelectron spectroscopy（XPS） were employed in the characterization of tin species. The prevalence of divalent tin was indicated by the XPS data in accord with a conspicuous absorption band detected around 285 nm ascribed to twofold-coordinated Sn centers（isoelectronic with Sn^2＋）. Photoluminescence（PL） excitation spectra obtained by monitoring Eu^3＋ emission from the 5D0 state revealed a broad excitation band from about 250 to 340 nm, characteristic of donor/acceptor energy transfer. Under excitation of such at 290 nm, the co-doped material exhibited a bright whitish luminescence, and a four-fold enhanced Eu3＋ emission relative to a purely Eu-doped reference. Time-resolved PL spectra recorded under the excitation at 290 nm exposed a broad band characteristic of the twofold-coordinated Sn centers and emission bands of Eu^3＋ ions, which appeared well separated in time in accord with their emission decay dynamics. The data suggested that light absorption took place at the Sn centers（donors） followed by energy transfer to Eu^3＋ ions（acceptors） which resulted in populating the 5D0 emitting state. Energy transfer pathways likely resulting in the enhanced Eu3＋ photoluminescence and the consequential light emission were discussed.

关键词： energy transfer glasses luminescence optical materials rare earths

Non-ST elevation acute coronary syndrome in the elderly

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Journal of Geriatric cardiology 2020年第1期17卷 9-15页

作者： Pablo Díez-Villanueva césar jim.nez Méndez Fernando Alfonso cardiology Department Hospital Universitario La Princesa Universidad Autónoma de Madrid

1 Introduction Societies are ageing at an accelerated *** scenario is a well-known challenge for health care systems,as chronic diseases,multiple comorbidities and dependency are all entities that often converge in the ***,there is an issue regarding a reduction in the general incidence of acute coronary syndrome(AcS)together with a delayed in the age of presentation,which,in sum,lead to an increase in both incidence and prevalence of AcS with age,especially non-ST elevation myocardial infarction(NSTEMI).

关键词： Acute coronary syndrome Myocardial infarction The elderly

Heart failure in the elderly

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Journal of Geriatric cardiology 2021年第3期18卷 219-232页

作者： Pablo Díez-Villanueva césar jim.nez-Méndez Fernando Alfonso cardiology Department Hospital Universitario La PrincesaUniversidad Autónoma de MadridCIBER-CVMadridSpain

Heart failure(HF)is a clinical syndrome caused by structural and/or functional cardiac abnormalities,resulting in a reduced cardiac output and/or elevated intracardiac filling pressures at rest or during *** is a major public health problem with high prevalence and incidence,involving both high morbidity and mortality,but also high economic *** incidence of HF progressively increases with age,reaching around 20%among people over 75 years ***,HF represents the leading cause of hospitalization in patients older than 65 years in Western ***,some authors even consider HF a geriatric syndrome,entailing worse prognosis and high residual disability,and often associating some complex comorbidities,common in older population,that may further complicate the course of the *** the other hand,however,clinical course and prognosis may be often difficult to *** this article,main pathophysiological issues related to the aging heart are addressed,together with key aspects related to both diagnosis and prognosis in elderly patients with ***,main geriatric conditions,common in the elderly population,are reviewed,highlighting the importance of a comprehensive and multidisciplinary approach.

关键词： diagnosis elevated mortality

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Neural Regeneration Research 2021年第1期16卷 123-124页

作者： carlos Bueno Salvador Martínez Instituto de Neurociencias de Alicante(UMH-cSIc) San JuanAlicanteSpain

Human neurological disorders and spinal cord injuries are caused by a loss of neurons and glial cells in the brain or spinal *** proof-ofprinciple of cell therapy is that replacing damaged cells with new healthy ones will restore the lost *** and manipulating autologous neural stem cells(NScs)could provide an ideal source of cells for use in cell replacement and the transfer of genes to a diseased central nervous *** are immature cells present,not only during embryonic development,but also in the adult brain of all mammalian species,including *** presence of NScs in the adult mammalian brain has been described in two neurogenic niches,the ventricular-subventricular zone(V-SVZ)of the anterolateral ventricle wall and the subgranular zone of the hippocampal dentate ***,NScs are defined as self-renewing multipotent cells that can generate neurons,astrocytes and *** major barrier to isolating adult NScs in humans is the inaccessibility of living *** this reason,an enormous effort has been made to derive neurons from human adult stem cells isolated from various tissue sources.

关键词： injuries ventricular adult