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Progress in tumor vascular normalization for anticancer therapy:challenges and perspectives

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Frontiers of Medicine 2012年第1期6卷 67-78页

作者： Bingxue Shang zhifei cao Quansheng Zhou Cyrus Tang Hematology Center Jiangsu Institute of Hematologythe First Affiliated Hospital of Soochow UniversitySuzhou 215123China Key Laboratory of Thrombosis and Hemostasis Ministry of HealthSoochow UniversitySuzhou 215123China

Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in *** the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment,recent studies have shown that antiangiogenic therapy has transient and insufficient efficacy,resulting in tumor recurrence in patients after several months of *** of blood and oxygen supplies creates a hypoxic and acidic microenvironment in the tumor tissues,which fosters tumor cells to become more aggressive and *** 2001,Jain proposed tumor vascular normalization as an alternative approach to treating cancers based on the pioneering work on tumor blood vessels by several other *** present,normalizing the disorganized tumor vasculature,rather than disrupting or blocking them,has emerged as a new option for anticancer *** and clinical data have shown that tumor vascular normalization using monoclonal antibodies,proteins,peptides,small molecules,and pericytes resulted in decreased tumor size and reduced ***,current tumor vascular normalizing drugs display moderate anticancer *** data have shown that a variety of vasculogenic/angiogenic tumor cells and genes play important roles in tumor neovascularization,growth,and ***,multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor vascular *** this end,the combination of antiangiogenic drugs with tumor vascular normalizing therapeutics,as well as the integration ofWestern medicine with traditional Chinese medicine,may provide a good opportunity for discovering novel tumor vascular normalizing drugs for an effective anticancer therapy.

关键词： angiogenesis vasculogenesis neovascularization tumor vasculature normalization traditional Chinese medicine

A novel traditional Chinese medicine combination for radiation

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Radiation Medicine and Protection 2024年第1期5卷 37-42页

作者： Ming Shang Yicheng Ke Jiangyun Liu zhifei cao Liying Zhang Wenyang Zhang Weiwei Pei Guangming Zhou Yongqi Liu Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities Gansu University of Chinese MedicineLanzhou 730000China School of Radiation Medicine and Protection Medical College of Soochow UniversitySuzhou 215123China Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou 215123China College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Department of Pathology The Second Affiliated HospitalMedical College of Soochow UniversitySuzhou 215123China

Objective:To formulate an efficacious radioprotective combination of Chinese medicines with minimal ***:Aqueous and alcoholic extracts from 38 traditional Chinese herbs were *** produce drugcontaining sera,rats received six doses of each extract via oral gavage at 12-h ***,human lung epithelial BEAS-2B cells were cultured in these drug-containing *** cell viability was assessed after different doses of irradiation to identify the radioprotective effects of Chinese herbal *** efficacy of a selected Chinese herbal extract combination was further confirmed through cell viability analysis via in vitro colony formation and survival rate assessments in C57BL/6 mice ***:Extracts from Angelicae Sinensis Radix(ASR;two extracts),Citri Reticulatae Pericarpium(CRP),Platycladi Cacumen(PC),Schisandrae chinensis Fructus(SF),Scutellariae Radix(SR),and Glycyrrhizae Radix et Rhizome(GRR)demonstrated radioprotective *** combination of the seven Chinese herbal extracts notably increased the survival and viability of the BEAS-2B cells exposed to varying doses of ***,the group of mice receiving Chinese medicine combination and irradiation exhibited prolonged survival after exposure to 6.5 Gy Xrays with a median survival of(14=2)d compared to(11=2)d in the irradiated group without the herbal ***,the Chinese medicine combination group displayed a significantly higher 28 d survival rate(30%)compared to the irradiation-only group(16.6%,P<0.05).Conclusion:The novel combination of Chinese herbal extracts from ASR,CRP,PC,SF,SR,and GRR has the potential for radiation protection applications.

关键词： Radiation protection Acute radiation syndrome Chinese medicine Drug-containing serum

m^(6)A甲基化修饰在肾细胞癌中的研究进展

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中华病理学杂志 2024年第8期53卷 876-882页

作者：张源曹志飞张永胜苏州大学附属第二医院病理科苏州251004

m^(6)A甲基化修饰是RNA修饰中常见的修饰方式之一,这种修饰方式是受m^(6)A甲基转移酶、m^(6)A去甲基化酶和m^(6)A相关蛋白调控的动态、可逆的过程。m^(6)A甲基化修饰影响RNA的剪切、出核、翻译和稳定性等,在表观遗传水平上调控基因的表... 详细信息

m^(6)A甲基化修饰是RNA修饰中常见的修饰方式之一,这种修饰方式是受m^(6)A甲基转移酶、m^(6)A去甲基化酶和m^(6)A相关蛋白调控的动态、可逆的过程。m^(6)A甲基化修饰影响RNA的剪切、出核、翻译和稳定性等,在表观遗传水平上调控基因的表达,影响其生物学功能的发挥。近年来m^(6)A甲基化修饰相关因子在肾细胞癌中的异常表达获得关注。现有研究指出m^(6)A甲基化修饰在肾细胞癌的发生、发展中发挥重要作用,但仍有部分m^(6)A甲基化修饰相关因子在肾细胞癌中的机制未明。本文将讨论m^(6)A甲基化修饰在侵袭、转移等生物学行为,代谢重编程、上皮间质转化、程序性细胞死亡等潜在发生机制在肾细胞癌发生、发展中的作用,以及m^(6)A甲基化修饰在肾细胞癌的靶向药物耐药和预后评估中的作用,为肾细胞癌的研究和治疗策略提供新思路。

关键词：肾细胞癌上皮间质转化甲基化修饰程序性细胞死亡治疗策略异常表达未明相关因子

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细胞焦亡信号通路在放射损伤中的研究进展

中华放射医学与防护杂志 2022年第10期42卷 817-822页

作者：张俊张永胜曹志飞苏州大学附属第二医院病理科苏州215004

细胞焦亡是一种炎症性的程序性细胞死亡;与凋亡不同,细胞焦亡时总伴随着炎症反应。研究发现,细胞焦亡与多种疾病的发生、发展密切相关。在放射治疗引起的放射损伤中,细胞焦亡也发挥着重要作用。电离辐射使得细胞内的DNA断裂,产生氧自由... 详细信息

细胞焦亡是一种炎症性的程序性细胞死亡;与凋亡不同,细胞焦亡时总伴随着炎症反应。研究发现,细胞焦亡与多种疾病的发生、发展密切相关。在放射治疗引起的放射损伤中,细胞焦亡也发挥着重要作用。电离辐射使得细胞内的DNA断裂,产生氧自由基,而两者正是细胞焦亡良好的诱导剂。因此,本文从细胞焦亡的信号通路入手,综述了细胞焦亡在放射损伤中的研究进展,以期为减弱或阻断放射损伤提供新的思路。

关键词：细胞焦亡放射治疗放射损伤电离辐射 gasdermin家族

Changes of gut microbiome and metabolome in the AOM/DSS mouse model of colorectal cancer with FLASH radiation

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Radiation Medicine and Protection 2023年第1期4卷 1-10页

作者： Mengmeng Xu Xinyu Qiu Qiu Chen Tianyu Yang Jingze Xu Liang Chen Lixiong Shuai Zhiming Xu Xinyang Cheng Yongsheng Zhang zhifei cao Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China School of Radiation Medicine and Protection Suzhou Medical College of Soochow UniversityState Key Laboratory of Radiation Medicine and ProtectionSuzhou 215004China

Objective:To investigate the differences in small intestinal toxicity and taxonomic composition,diversity,and functional pathways of gut microbiome and metabolome after different radiotherapies in mouse colorectal cancer(CRC)***:Azoxymethane/dextran sodium sulfate(AOM/DSS)-induced mouse CRC model was treated with single pulse FLASH-RT(dose rate 100 Gy/s)or CONV-RT(dose rate 2 Gy/min)at whole *** 12 d after radiotherapy,sections of small intestinal tract tissue were dissected for hematoxylin and eosin(HE)staining and the fresh feces were collected for 16S ribosomal RNA(rRNA)microbiome sequencing and liquid chromatography and mass spectrometry(LC-MS)metabolomics sequencing to assess changes in the gut microbiota and *** high-throughput 16S rRNA data was analyzed with QIIME2 and LEfSe ***,XCMS and Ropls softwares were used for LC-MS ***:HE staining showed that FLASH-RT maintained small intestinal integrity and reduced the radiotherapyinduced *** analysis of gut fecal microbiome showed that phylum Bacteroidetes and genera Prevotella and Lactobacillus of microbial community were increased after *** sequencing analysis revealed that the metabolites after FLASH-RT were enriched in amino acid metabolism,while cholesterol metabolism was top enriched after ***:FLASH-RT significantly mitigates the small intestine tissue damage compared with *** and CONV-RT have different impact on gut microbiota and its *** results provide a theoretical basis for the early evaluation,prediction and individualized treatment of the irradiation effect after novel FLASHRT on tumors through the evaluation of intestinal microbiota and metabolites.

关键词： FLASH-RT CONV-RT Small intestinal toxicity Microbiome and metabolomics sequencing

Wu Haiyan and Her Fashion

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Women of China 1999年第11期 30-30页

作者： cao zhifei

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空间转录组学在肿瘤学研究中的应用与进展

中华病理学杂志 2023年第6期52卷 643-646页

作者：程馨阳张永胜曹志飞苏州大学附属第二医院病理科苏州215004

恶性肿瘤是全球人群发病和死亡的主要原因,其发生、发展过程中肿瘤的异质性起了关键作用,而探究肿瘤异质性成为提高恶性肿瘤诊断治疗以及预后等的关键所在,新兴崛起的空间转录组技术为此提供了可能。本文将介绍空间转录组学在肿瘤研究... 详细信息

恶性肿瘤是全球人群发病和死亡的主要原因,其发生、发展过程中肿瘤的异质性起了关键作用,而探究肿瘤异质性成为提高恶性肿瘤诊断治疗以及预后等的关键所在,新兴崛起的空间转录组技术为此提供了可能。本文将介绍空间转录组学在肿瘤研究尤其是肿瘤诊断中的应用和进展。

关键词：恶性肿瘤诊断人群发病转录组学肿瘤异质性肿瘤研究应用和进展肿瘤学研究应用与进展

长链非编码RNA在肾细胞癌发生发展中的作用研究进展

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中华病理学杂志 2022年第10期51卷 1069-1072页

作者：许竞泽曹志飞张永胜苏州大学附属第二医院病理科苏州215004

肾细胞癌是泌尿系统常见的恶性肿瘤之一,由于早期临床无症状或缺乏特异性的生物标志物,诊断时肿瘤常已发生局部侵袭或远处转移,错过最佳的治疗机会,预后较差。长链非编码RNA(lncRNA)是一类长度超过200个核苷酸的RNA分子。lncRNA可通过... 详细信息

肾细胞癌是泌尿系统常见的恶性肿瘤之一,由于早期临床无症状或缺乏特异性的生物标志物,诊断时肿瘤常已发生局部侵袭或远处转移,错过最佳的治疗机会,预后较差。长链非编码RNA(lncRNA)是一类长度超过200个核苷酸的RNA分子。lncRNA可通过表观遗传调控、转录调控、转录后调控等方面参与基因的表达调控,广泛参与肿瘤发生发展的过程,如细胞增殖、迁移、侵袭和凋亡,在肾细胞癌的早期诊断、预后评估和治疗等方面发挥重要作用。本文就lncRNA在肾细胞癌发生和发展中的作用进行综述。

关键词：肾细胞癌早期临床肿瘤发生发展无症状局部侵袭细胞增殖转录后调控泌尿系统

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肾细胞癌放疗抵抗机制的研究进展

中华放射医学与防护杂志 2024年第10期44卷 886-890页

作者：刘菁华曹志飞张永胜苏州大学附属第二医院病理科苏州215004 苏州大学苏州医学院苏州215123

放射治疗是肾细胞癌(RCC)临床治疗的有效手段。放射抗拒,即放疗过程中癌细胞对电离辐射的敏感性下降,是肿瘤放射治疗过程中的常见问题,与肿瘤转移、复发等不良结局的出现密切相关。本文以RCC放疗抵抗为切入点,从DNA损伤修复、细胞周期... 详细信息

放射治疗是肾细胞癌(RCC)临床治疗的有效手段。放射抗拒,即放疗过程中癌细胞对电离辐射的敏感性下降,是肿瘤放射治疗过程中的常见问题,与肿瘤转移、复发等不良结局的出现密切相关。本文以RCC放疗抵抗为切入点,从DNA损伤修复、细胞周期阻滞、抗凋亡途径的激活、自噬及肿瘤干细胞等方面阐述RCC细胞放射抗拒产生的机制,并对目前用于RCC放射治疗的增敏剂进行概述,以期为RCC放疗抵抗产生机制、放射治疗策略的改进以及药物的创新研发提供新的思路。

关键词：肾细胞癌放疗抵抗放射治疗放疗增敏剂