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Inside-out assembly of viral antigens for the enhanced vaccination

Signal Transduction and Targeted Therapy 2023年第6期8卷 3144-3157页

作者： Fengqiang cao Sha Peng Yaling An Kun Xu Tianyi Zheng Lianpan Dai Kenji Ogino To Ngai yufei Xia Guanghui Ma State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190PR China Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology2-24-16 NakachoKoganeiTokyo184-8588Japan Institute of Global Innovation Research Tokyo University of Agriculture and Technology2-24-16 NakachoKoganei-shiTokyo184-8588Japan CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101PR China Savaid Medical School University of Chinese Academy of SciencesBeijingPR China Key Laboratory of Tropical Translational Medicine of Ministry of Education School of Tropical Medicine and Laboratory MedicineThe First Affiliated HospitalHainan Medical UniversityHainan571199PR China Zhejiang University School of Medicine Hangzhou310058PR China Department of Chemistry The Chinese University of Hong KongShatinN.T.Hong Kong999077PR China University of Chinese Academy of Sciences Beijing100049PR China Innovation Academy for Green Manufacture Chinese Academy of Sciences Beijing100190PR China

Current attempts in vaccine delivery systems concentrate on replicating the natural dissemination of live pathogens,but neglect that pathogens evolve to evade the immune system rather than to provoke *** the case of enveloped RNA viruses,it is the natural dissemination of nucleocapsid protein(NP,core antigen)and surface antigen that delays NP exposure to immune ***,we report a multi-layered aluminum hydroxide-stabilized emulsion(MASE)to dictate the delivery sequence of the *** this manner,the receptor-binding domain(RBD,surface antigen)of the spike protein was trapped inside the nanocavity,while NP was absorbed on the outside of the droplets,enabling the burst release of NP before *** with the natural packaging strategy,the inside-out strategy induced potent type I interferon-mediated innate immune responses and triggered an immune-potentiated environment in advance,which subsequently boosted CD40+DC activations and the engagement of the lymph *** both H1N1 influenza and SARS-CoV-2 vaccines,rMASE significantly increased antigen-specific antibody secretion,memory T cell engagement,and Th1-biased immune response,which diminished viral loads after lethal *** simply reversing the delivery sequence of the surface antigen and core antigen,the inside-out strategy may offer major implications for enhanced vaccinations against the enveloped RNA virus.

关键词： vaccination outside evolve

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The mechanism and therapy of aortic aneurysms

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Signal Transduction and Targeted Therapy 2023年第3期8卷 963-982页

作者： Jianing Gao Huanhuan cao Gaofei Hu yufei Wu Yangkai Xu Hongtu Cui Hong S.Lu Lemin Zheng The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine School of Basic Medical SciencesKey Laboratory of Molecular Cardiovascular Science of Ministry of EducationNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijing Key Laboratory of Cardiovascular Receptors ResearchHealth Science CenterPeking University100191 BeijingChina Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchResearch Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular DiseasesChinese Academy of Medical Sciences100191 BeijingChina Department of Physiology Saha Cardiovascular Research CenterUniversity of KentuckySouth LimestoneLexingtonKY 40536-0298USA

Aortic aneurysm is a chronic aortic disease affected by many *** it is generally asymptomatic,it poses a significant threat to human life due to a high risk of *** of its strong concealment,it is difficult to diagnose the disease in the early *** present,there are no effective drugs for the treatment of *** intervention and endovascular treatment are the only *** current studies have discovered that inflammatory responses as well as the production and activation of various proteases promote aortic aneurysm,the specific mechanisms remain *** are further exploring the pathogenesis of aneurysms to find new targets for diagnosis and *** better understand aortic aneurysm,this review elaborates on the discovery history of aortic aneurysm,main classification and clinical manifestations,related molecular mechanisms,clinical cohort studies and animal models,with the ultimate goal of providing insights into the treatment of this devastating *** underlying problem with aneurysm disease is weakening of the aortic wall,leading to progressive *** not treated in time,the aortic aneurysm eventually *** aortic aneurysm is a local enlargement of an artery caused by a weakening of the aortic *** disease is usually asymptomatic but leads to high mortality due to the risk of artery rupture.

关键词： aortic diagnosis drugs treatment

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一株野禽源H4亚型禽流感病毒HA基因的序列测定及全球谱系演化分析

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中国动物检疫 2009年第4期26卷 26-28页

作者：嵇康蒋文明曹玉飞尚飞雪王洪斌黄保续陈继明东北农业大学动物医学院黑龙江哈尔滨150030 中国动物卫生与流行病学中心山东青岛266032 南京农业大学动物医学院江苏南京210095

采用RT-PCR方法扩增出一株鄱阳湖地区野禽源H4亚型AIV的血凝素基因,并进行分子克隆与测序。与GenBank上已发表的不同来源的H4亚型AIV进行同源性对比,发现该毒株与亚洲分离株核苷酸同源性较高,达96%。全球谱系分析表明,该毒株属东半球谱... 详细信息

采用RT-PCR方法扩增出一株鄱阳湖地区野禽源H4亚型AIV的血凝素基因,并进行分子克隆与测序。与GenBank上已发表的不同来源的H4亚型AIV进行同源性对比,发现该毒株与亚洲分离株核苷酸同源性较高,达96%。全球谱系分析表明,该毒株属东半球谱系的欧亚分支。研究结果对于进一步深入研究野生鸟类的禽流感传播作用具有重要参考价值。

关键词：禽流感野禽 H4亚型谱系分析

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Engineering catalytic defects via molecular imprinting for high energy Li-S pouch cells

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National Science Review 2024年第7期11卷 239-251页

作者： yufei Zhao Chuannan Geng Li Wang Yun cao Haotian Yang Linkai Peng Xin Jiang Yong Guo Xiaolin Ye Wei Lv Quan-Hong Yang Shenzhen Geim Graphene Center Engineering Laboratory for Functionalized Carbon Materials Tsinghua Shenzhen International Graduate School Tsinghua University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy StorageSchool of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin University Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University

Heterogeneous catalysis promises to accelerate sulfur-involved conversion reactions in lithium-sulfur batteries. Solid-state Li2S dissociation remains as the rate-limiting step because of the weakly matched solid-solid electrocatalysis interfaces. We propose an electrochemically molecular-imprinting strategy to have a metal sulfide（MS） catalyst with imprinted defects in positions from which the pre-implanted Li2S has been electrochemically removed. Such tailor-made defects enable the catalyst to bind exclusively to Li atoms in Li2S reactant and elongate the Li–S bond, thus decreasing the reaction energy barrier during charging. The imprinted Ni3S2catalyst shows the best activity due to the highest defect concentration among the MS catalysts examined. The Li2S oxidation potential is substantially reduced to 2.34 V from 2.96 V for the counterpart free of imprinted vacancies, and an Ah-level pouch cell is realized with excellent cycling performance. With a lean electrolyte/sulfur ratio of 1.80 μL mgS–1, the cell achieves a benchmarkedly high energy density beyond 500 Wh kg–1.

关键词： lithium-sulfur battery catalysts defects energy density metal sulfide

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避免SCR入口烟温超温的设备改造方案浅析

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锅炉制造 2018年第6期 37-39,52页

作者：刘文献焦书震刘斌杰马登卿张万德杨宝林曹宇飞金鑫国网河北电科院 050021 河北建投能源投资股份有限公司 050051 衡水恒兴发电有限责任公司 053000

多台巴威B&WB1025-18. 3/M型锅炉在高负荷运行期间发生脱硝设备入口烟温超温报警,其中2台锅炉还存在过热器减温水水量过大问题。通过将光管省煤器改造成H型省煤器,解决了高负荷期间,脱硝设备入口烟温高问题;通过一级过热器和省煤器联合... 详细信息

多台巴威B&WB1025-18. 3/M型锅炉在高负荷运行期间发生脱硝设备入口烟温超温报警,其中2台锅炉还存在过热器减温水水量过大问题。通过将光管省煤器改造成H型省煤器,解决了高负荷期间,脱硝设备入口烟温高问题;通过一级过热器和省煤器联合改造,解决了脱硝设备入口烟温高和过热器减温水水量过大问题。对两种设备改造方案的介绍和经济性分析,力求给同类型设备改造提供有益的借鉴。

关键词： SCR 超温省煤器一级过热器

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SARS-CoV-2 promote autophagy to suppress type I interferon response

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1661-1663页

作者： Xianfeng Hui Linliang Zhang Lei cao Kun Huang Ya Zhao yufei Zhang Xi Chen Xian Lin Mingzhou Chen Meilin Jin State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhanChina State Key Laboratory of Virology and Modern Virology Research Center College of Life SciencesWuhan UniversityWuhanChina CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyWuhanChina

Dear Editor,The outbreak of SARS-CoV-2 leads global epidemic with high morbidity and ***,the pathophysiology of this deadly virus is complex and largely *** is a highly conserved homeostatic process that allows cells to recycle their *** studies provided evidence that human coronavirus infections are closely related to various cellular aspects associated with autophagy.1 Autophagy may play a crucial role in the SARS-CoV-2 viral lifecycle.

关键词： mortality interferon morbidity

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Biotinylated dextran amine is an ideal anterograde tracer for the corticospinal tract in a goat model of ischemic corticospinal tract injury

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Neural Regeneration Research 2011年第25期6卷 1960-1964页

作者： Xiaoyu Yang yufei Gao Zhigang Qin Xia cao Xinquan Gu China-Japan Union Hospital Jifin University Changchun 130033 Jilin Province China School of Pharmaceutical Sciences Jilin University Changchun 130021 Jifin Province China

Existing visualized tracer studies of the corticospinal tract have been focused on rodents, which have markedly different spinal cord structures compared with humans. In this study, the segmental artery feeding the spinal cord was embolized with digital subtraction angiography to establish a goat model of ischemic spinal cord injury. Biotinylated dextran amine was injected into the motor function areas of the cortex in goats with ischemic spinal cord injury. The corticospinal tract originates from the cerebral cortex motor function area, and travels towards the lateral funiculus at the contralateral spinal dorsal horn after decussation at the pyramid. The number of corticospinal tract positive fibers was found to be gradually reduced. These findings indicate that digital subtraction angiography can be applied to a goat model of ischemic spinal cord injury. Biotinylated dextran amine visualizes the course of the goat corticospinal tract in the spinal cord, which is similar to the human spinal cord. Biotinylated dextran amine is an ideal tracer for the corticospinal tract.

关键词： corticospinal tract biotinylated dextran amine ischemic spinal cord injury digital subtraction angiography tracer neuroanatomy neural regeneration

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In-situ real-time monitoring of ultrafast laser processing using wide-field high-resolution snapshot compressive microscopy

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Light(Advanced Manufacturing) 2024年第3期5卷 52-61页

作者： Xiaodong Wang Miao cao Ziyang Chen Jiao Geng Ting Luo yufei Dou Xing Liu Liping Shi Xin Yuan Zhejiang University Hangzhou 310027China School of Engineering Westlake UniversityHangzhou 310030China School of Physics Harbin Institute of TechnologyHarbin 150001China Hangzhou Institute of Technology Xidian UniversityHangzhou 311231China Westlake Institute for Optoelectronics FuyangHangzhou 311421China Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province Westlake UniversityHangzhou 310024China

Over the last few decades,ultrafast laser processing has become a widely used tool for manufacturing microstructures and *** real-time monitoring of laser material processing provides opportunities to inspect processes and provide *** date,in-situ and real-time monitoring of laser material processing has rarely been *** this end,we propose dual-path snapshot compressive microscopy(DP-SCM)for high-speed,large field-of-view,and high-resolution imaging for in-situ and real-time ultrafast laser *** the evaluation of DP-SCM,the field of view,lateral resolution,and imaging speed were measured to be 2 mm,775 nm,and 500 fps,*** ultrafast laser processing,the laser scanning process is observed using a DP-SCM system when translating the sample stage and scanning the focused femtosecond ***,we monitored the development of a self-organized nanograting structure to validate the potential of our system for unveiling new material *** proposed method serves as an add-up(plug-and-play)module for any imaging setup and has vast potential for opening new avenues for high-throughput imaging in laser material processing.

关键词： Snapshot compressive imaging Femtosecond laser processing Laser-induced self-organization

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Crucial role of histone deacetylase SIRT1 in myeloid-derived suppressor cell-mediated reprogramming of CD4^(+) T-cell differentiation

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Cellular & Molecular Immunology 2020年第7期17卷 785-787页

作者： Lin Dong Yujing Bi Anna Jia Qing Yu Yuexin Wang yufei Wang Qiuli Yang Yejin cao Ying He Ruichen Liu Yan Li Guangwei Liu Key Laboratory of Cell Proliferation and Regulation Biology Ministry of EducationInstitute of Cell BiologyCollege of Life SciencesBeijing Normal University100875 BeijingChina State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology100071 BeijingChina

Myeloid-derived suppressor cells(MDSCs)are heterogeneous,immature myeloid cells that inhibit the immune responses of T cells.1–5 MDSCs play a crucial role in infection,6,7 transplantation,8,9 autoimmune diseases10,11,and tumors12,13 by driving the differentiation of specific T-cell subsets,but the precise regulatory mechanism is still ***,our results showed that SIRT1,a histone deacetylase,suppresses the functions of proinflammatory MDSCs and promotes tumor growth.14 However,it remains unclear whether SIRT1 regulates the MDSC-induced differentiation of T ***,we identified the regulatory effects of SIRT1 in CD11b+Gr1+MDSCs on T-cell differentiation.

关键词： SIRT1 CD11b myeloid

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盐穴地下储气库注采热工性能模拟

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天然气工业 2005年第8期25卷 103-105页

作者：曹琳谭羽非李娜哈尔滨工业大学

储气库在建造和运行时,一方面溶腔内气体通过自然对流与周围盐层进行热交换,与周围盐层壁面形成不稳态导热温度场;另一方面连续注采循环,使腔内气体压力、温度发生变化,特别是在连续采气时,降压的焦耳—汤姆逊效应极易使井口气体压力和... 详细信息

储气库在建造和运行时,一方面溶腔内气体通过自然对流与周围盐层进行热交换,与周围盐层壁面形成不稳态导热温度场;另一方面连续注采循环,使腔内气体压力、温度发生变化,特别是在连续采气时,降压的焦耳—汤姆逊效应极易使井口气体压力和温度进入生成水化物的危险范围,因此动态确定盐穴储气库注采天然气时的热工特性变化十分必要。为此,根据热力学、传热学和流体力学理论,针对注采过程天然气在井筒流动和溶腔内传热过程的特点,将井筒、溶腔和周围盐层视为一个系统,提出了描述注采动态工程相互耦合的数学模型及其求解方法,并开发了相应的数值计算软件。该软件可预测盐穴地下储气库在连续注采气过程中,溶腔内及井筒顶、底部气体的压力和温度,并判断水化物形成的危险范围等。研究成果能对盐穴地下储气库的建造和技术特性做出预测分析,对其运行工况给予指导,并对注采气地面系统的优化设计提供理论分析依据。

关键词：盐穴地下储气库注入采出参数数值模拟数学模型软件开发地下储气库

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