Crucial role of histone deacetylase SIRT1 in myeloid-derived suppressor cell-mediated reprogramming of CD4^(+) T-cell differentiation

作     者：Lin Dong Yujing Bi Anna Jia Qing Yu Yuexin Wang Yufei Wang Qiuli Yang Yejin Cao Ying He Ruichen Liu Yan Li Guangwei Liu Lin Dong;Yujing Bi;Anna Jia;Qing Yu;Yuexin Wang;Yufei Wang;Qiuli Yang;Yejin Cao;Ying He;Ruichen Liu;Yan Li;Guangwei Liu

作者机构：Key Laboratory of Cell Proliferation and Regulation BiologyMinistry of EducationInstitute of Cell BiologyCollege of Life SciencesBeijing Normal University100875 BeijingChina State Key Laboratory of Pathogen and BiosecurityBeijing Institute of Microbiology and Epidemiology100071 BeijingChina 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2020年第17卷第7期

页      面：785-787页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：The authors’research is supported by grants from the National Natural Science Foundation for Key Programs of China(31730024,G.L.) the National Natural Science Foundation for General Programs of China(31671524,G.L.) 

主　　题：SIRT1 CD11b myeloid 

摘      要：Myeloid-derived suppressor cells(MDSCs)are heterogeneous,immature myeloid cells that inhibit the immune responses of T cells.1–5 MDSCs play a crucial role in infection,6,7 transplantation,8,9 autoimmune diseases10,11,and tumors12,13 by driving the differentiation of specific T-cell subsets,but the precise regulatory mechanism is still ***,our results showed that SIRT1,a histone deacetylase,suppresses the functions of proinflammatory MDSCs and promotes tumor growth.14 However,it remains unclear whether SIRT1 regulates the MDSC-induced differentiation of T ***,we identified the regulatory effects of SIRT1 in CD11b+Gr1+MDSCs on T-cell differentiation.