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CFTR is a negative regulator ofγδT cell IFN-γproduction and antitumor immunity

Cellular & Molecular Immunology 2021年第8期18卷 1934-1944页

作者： Yuanyuan Duan Guangqiang Li Miaomiao Xu Xiaofei Qi Mingxia Deng Xuejia Lin Zhiwei lei Yi hu Zhenghu Jia Quanli Yang Guangchao cao Zonghua Liu Qiong Wen Zhenhua Li Jie Tang Wei Kevin Zhang Pingbo huang Limin Zheng Richard A.Flavell Jianlei Hao Zhinan Yin Zhuhai Precision Medical Center Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Jinan UniversityZhuhai519000GuangdongChina The Biomedical Translational Research Institute Faculty of Medical ScienceJinan UniversityGuangzhou510632GuangdongChina department of Physiology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515GuangdongChina The First Affiliated Hospital Jinan UniversityGuangzhou510632China School of Pharmaceutical Sciences South-Central University for NationalitiesWuhan430074HubeiChina Division of Life Science Hong Kong University of Science and Technology(HKUST)Hong KongChina State Key Laboratory of Oncology in Southern china Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou510060China department of Immunobiology School of MedicineYale UniversityNew HavenCT06520USA

CFTR,a chloride channel and ion channel regulator studied mostly in epithelial cells,has been reported to participate in immune regulation and likely affect the risk of cancer ***,little is known about the effects of CFTR on the differentiation and function ofγδT *** this study,we observed that CFTR was functionally expressed on the cell surface ofγδT *** deletion and pharmacological inhibition of CFTR both increased IFN-γrelease by peripheralγδT cells and potentiated the cytolytic activity of these cells against tumor cells both in vitro and in ***,the molecular mechanisms underlying the regulation ofγδT cell IFN-γproduction by CFTR were either TCR dependent or related to Ca^(2+)*** was recruited to TCR immunological synapses and attenuated Lck-P38 MAPK-c-Jun *** addition,CFTR was found to modulate TCR-induced Ca^(2+)influx and membrane potential(Vm)-induced Ca^(2+)influx and subsequently regulate the calcineurin-NFATc1 signaling pathway inγδT ***,CFTR serves as a negative regulator of IFN-γproduction inγδT cells and the function of these cells in antitumor *** investigation suggests that modification of the CFTR activity ofγδT cells may be a potential immunotherapeutic strategy for cancer.

关键词： CFTR γδT cells TCR Membrane potential Antitumor immunity

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Risk factors for colorectal neoplasia in patients with underlying inflammatory bowel disease:a multicenter study

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Gastroenterology Report 2019年第1期7卷 67-73,I0002页

作者： Xian-Rui Wu Xiao-Bin Zheng Yan huang Qian cao Hong-Jie Zhang Ying-lei Miao Kai-Fang Zou Min Chen Fa-Ming Zhang Qiao Mei David Gonzalo Daniela Allende Pin-Jin hu Bo Shen Xiu-Li Liu Ping Lan department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina department of Pathology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina department of Gastroenterology Sir Run Run Shaw Hospital of Zhejiang University School of MedicineHangzhouChina department of Gastroenterology Jiangsu Province HospitalNanjingChina department of Gastroenterology The First Affiliated Hospital of Kunming Medical UniversityKunmingChina department of Gastroenterology Wuhan Union HospitalWuhanChina department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhanChina Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjingChina department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefeiChina department of Pathology and Laboratory Medicine University of FloridaGainesvilleFLUSA department of Anatomic Pathology The Cleveland Clinic FoundationClevelandOHUSA department of Gastroenterology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina department of Gastroenterology/Hepatology The Cleveland Clinic FoundationClevelandOHUSA

Background:This study sought to evaluate the risk factors for the development of colitis-associated neoplasia(CAN)in Chinese patients with inflammatory bowel disease(IBD).Methods:IBD patients who developed CAN between 1999 and 2016 were identified from eight medical *** addition to initial pathology evaluation,a CAN diagnosis was confirmed by two expert *** with CAN(n=29)were compared with non-CAN controls(n=87).Matching was performed for gender and IBD type with a ratio of three controls to one ***:Of the 29 patients with CAN,8(27.6%)had colorectal cancer(CRC),20(69.0%)had a final diagnosis of low-grade dysplasia and 1(3.4%)had high-grade *** analysis revealed that an older age at the time of IBD diagnosis and a longer IBD duration were independent risk factors for the development of CAN,with odds ratios of 1.09[95%confidence interval(CI):1.04–1.14,P1]and 1.14(95%CI:1.03–1.27,P=0.013),*** between IBD patients with CRC and those with dysplasia indicated that the former were older at the time of IBD diagnosis(P=0.012)and had longer IBD durations(P=0.019).Conclusions:Older age at the time of IBD diagnosis and longer IBD duration were found to be associated with the development of CAN in IBD patients.

关键词： Colorectal neoplasia inflammatory bowel disease risk factor

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采后催熟对‘台农一号’芒果理化品质及营养特性的影响

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食品工业科技 2023年第2期44卷 369-375页

作者：胡隆孝曹琳彩王凯赵雷广州市果美味食品有限公司广东广州510800 华南农业大学食品学院广东广州510642

采用外源乙烯利对‘台农一号’芒果进行催熟,乙烯利添加量0.1(w/w),温度30℃,湿度40%~50%。探讨不同催熟阶段对芒果理化指标(硬度、色泽、可滴定酸、可溶性固形物),营养成分(类胡萝卜素、维生素C、可溶性蛋白质、总糖)和香气成分的影响... 详细信息

采用外源乙烯利对‘台农一号’芒果进行催熟,乙烯利添加量0.1(w/w),温度30℃,湿度40%~50%。探讨不同催熟阶段对芒果理化指标(硬度、色泽、可滴定酸、可溶性固形物),营养成分(类胡萝卜素、维生素C、可溶性蛋白质、总糖)和香气成分的影响。结果表明,在催熟过程中果实硬度从19.76 N下降到0.99 N,可滴定酸从1.37%下降至0.27%,而可溶性固形物从12.92%上升至23.64%。当催熟时间从0 h增加至60 h,黄色指数值显著(P326.66 mg/100 g下降至180.00 mg/100 g,而总糖含量显著(P108 h,类胡萝卜素升高至10.93μg/g;维生素C、可溶性蛋白质和总糖等变化不显著。芒果果实香气物质主要是萜烯类化合物,其中异松油烯含量最高,在催熟60 h之内其含量迅速增大,外源乙烯利加快了果实中异松油烯的合成速率。综合评价催熟后果实理化及品质特性60 h后芒果色泽、香气等指标基本达到成熟。

关键词：芒果乙烯利理化指标营养特性香气成分

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Adhesive cryogel particles for bridging confined and irregular tissue defects

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Military Medical Research 2023年第6期10卷 763-777页

作者： Yao-Ting Xue Ming-Yu Chen Jia-Sheng cao lei Wang Jia-Hao hu Si-Yang Li Ji-Liang Shen Xin-Ge Li Kai-Hang Zhang Shu-Qiang Hao Sarun Juengpanich Si-Bo Cheng Tuck-Whye Wong Xu-Xu Yang Tie-Feng Li Xiu-Jun Cai Wei Yang department of Engineering Mechanics Zhejiang UniversityHang‑zhou 310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang UniversityHangzhou 310027China Center for X‑Mechanics Department of Engineering MechanicsZhejiang Univer‑sityHangzhou 310027China department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China Soft Intelligent Materials Co. LtdSuzhou 215123China School of Biomedical Engineering and Health Sciences and Advanced Membrane Technology Research Centre Universiti Teknologi Malaysia81310 SkudaiMalaysia

Background Reconstruction of damaged tissues requires both surface hemostasis and tissue *** with damage resulting from physical trauma or surgical treatments may have arbitrary surface topographies,making tissue bridging *** This study proposes a tissue adhesive in the form of adhesive cryogel particles(ACPs) made from chitosan,acrylic acid,1-ethyl-3-(3-dimethylaminopropyl) carbodiimide(EDC) and N-hydroxysuccinimide(NHS).The adhesion performance was examined by the 180-degree peel test to a collection of tissues including porcine heart,intestine,liver,muscle,and *** of ACPs was evaluated by cell proliferation of human normal liver cells(LO2)and human intestinal epithelial cells(Caco-2).The degree of inflammation and biodegradability were examined in dorsal subcutaneous rat *** ability of ACPs to bridge irregular tissue defects was assessed using porcine heart,liver,and kidney as the ex vivo ***,a model of repairing liver rupture in rats and an intestinal anastomosis in rabbits were established to verify the effectiveness,biocompatibility,and applicability in clinical *** ACPs are applicable to confined and irregular tissue defects,such as deep herringbone grooves in the parenchyma organs and annular sections in the cavernous *** formed tough adhesion between tissues[(670.9±50.1) J/m^(2) for the heart,(607.6±30.0) J/m^(2) for the intestine,(473.7±37.0) J/m^(2) for the liver,(186.1±13.3) J/m^(2) for the muscle,and(579.3±32.3) J/m^(2) for the stomach].ACPs showed considerable cytocompatibility in vitro study,with a high level of cell viability for 3 d[(98.8±1.2)%for LO2 and(98.3±1.6)%for Caco-2].It has comparable inflammation repair in a ruptured rat liver(P=0.58 compared with suture closure),the same with intestinal anastomosis in rabbits(P=0.40 compared with suture anastomosis).Additionally,ACP-based intestinal anastomosis(less than 30 s) was remarkably faster than the convention

关键词： Tissue reconstruction Wet adhesion Adhesive hydrogel Bioadhesive

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Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats

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Neuroscience Bulletin 2020年第4期36卷 333-345页

作者： Pan Gu Zi-Hao Xu Yu-Ze cao Sheng-hui Liao Qian-Fang Deng Xian-Zhen Yin Zhuo-Lu Wang Zhuo-hui Chen Xin-Hang hu hui Wang Li-Zhi Li Shi-Xin Liu hul Ding Shu-Peng Shi Hong-lei Li Ti-Qiao Xiao Bo Xiao Meng-Qi Zhang department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China School of Information Science and Engineering Central South UniversityChangsha 410008China State Key Laboratory of Drug Research CAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China department of Breast Surgery Hunan Provincial Maternal and Child Health Care HospitalChangsha 410008China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201800China

Characterizing the three-dimensional (3D) morphological alterations of microvessels under both normal and seizure conditions is crucial for a better understanding of epilepsy. However, conventional imaging techniques cannot detect microvessels on micron/sub-micron scales without angiography. In this study, synchrotron radiation(SR)-based X-ray in-line phase-contrast imaging (ILPCI)and quantitative 3D characterization were used to acquire high-resolution, high-contrast images of rat brain tissue under both normal and seizure conditions. The number of blood microvessels was markedly increased on days 1 and 14, but decreased on day 60 after seizures. The surface area, diameter distribution, mean tortuosity, and number of bifurcations and network segments also showed similar trends. These pathological changes were confirmed by histological tests. Thus, SR-based ILPCI provides systematic and detailed views of cerebrovascular anatomy at the micron level without using contrast-enhancing agents. This holds considerable promise for better diagnosis and understanding of the pathogenesis and development of epilepsy.

关键词： Epilepsy Synchrotron radiation 3D Angioarchitecture Blood vessel Remodeling

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深空合作目标高概率捕获复合扫描策略研究

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中国空间科学技术 2022年第3期42卷 58-66页

作者：扈航刘磊李聪曹桂兴西北工业大学航天学院西安710072 陕西省空天飞行器设计重点实验室西安710072 中国空间技术研究院通信与导航卫星总体部北京100094

针对深空目标长距离星间激光通信时间滞后大、光轴抖动明显、不确定区域大的问题,设计了一种基于两级执行机构的抗抖动高概率捕获复合扫描策略。将目标位置不确定区域划分为等大正方形子区域,在子区域内采用光栅扫描,通过快摆镜实现;在... 详细信息

针对深空目标长距离星间激光通信时间滞后大、光轴抖动明显、不确定区域大的问题,设计了一种基于两级执行机构的抗抖动高概率捕获复合扫描策略。将目标位置不确定区域划分为等大正方形子区域,在子区域内采用光栅扫描,通过快摆镜实现;在子区域间按照光栅螺旋扫描顺序覆盖,通过伺服转台实现子区域间的跳转。然后在考虑光轴抖动的情况下基于遗传算法对子区域大小、扫描光斑重叠大小进行了优化,得到了参数优化后的扫描方案,并通过仿真进行了验证。1 000次蒙特卡洛打靶结果表明,在目标位置不确定区域3.6 mrad、激光束散角0.1 mrad、光轴抖动标准差5μrad的情况下,优化后的扫描方案对目标的捕获概率为99.2%,对不确定区域的扫描时间为41.34 s,扫描到目标的平均扫描时间为9.62 s。

关键词：深空探测激光通信光轴抖动复合扫描高概率捕获遗传算法

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甲氯芬酯分散片和胶囊在健康人体的生物等效性

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中国新药与临床杂志 2010年第11期29卷 869-873页

作者：李健和朱运贵曹俊华刘晓磊阳巧凤曾小慧罗霞中南大学湘雅二医院药学部湖南长沙410011

目的评价甲氯芬酯分散片和胶囊在中国健康志愿者体内的生物等效性。方法 18名健康男性受试者随机分为2组,分别单剂量口服甲氯芬酯分散片(试验制剂)或甲氯芬酯胶囊(参比制剂)200 mg。7 d清洗期后再交叉给药。于服药前(0 h)和服药后0.33、... 详细信息

目的评价甲氯芬酯分散片和胶囊在中国健康志愿者体内的生物等效性。方法 18名健康男性受试者随机分为2组,分别单剂量口服甲氯芬酯分散片(试验制剂)或甲氯芬酯胶囊(参比制剂)200 mg。7 d清洗期后再交叉给药。于服药前(0 h)和服药后0.33、0.67、1、1.5、2、2.5、3、4、6、8、10、14、24 h抽取静脉血。采用高效液相色谱法测定血浆中对氯苯氧乙酸的浓度。通过DAS Ver2.0软件计算主要药动学参数,评价2种制剂的生物等效性。结果甲氯芬酯试验制剂与参比制剂的tmax分别为(1.8±s 0.3)和(2.1±0.3)h,ρmax分别为(13.9±2.6)和(12.8±2.8)mg.L-1,t1/2分别为(6.1±2.0)和(6.0±2.1)h,AUC0～t分别为(36±9)和(34±8)mg.h.L-1,AUC0～∞分别为(36±9)和(35±8)mg.h.L-1。以AUC0～t计算,试验制剂中甲氯芬酯对参比制剂的相对生物利用度为(105±10)%。结论甲氯芬酯分散片与胶囊在中国健康志愿者体内具有生物等效性。

关键词：甲氯芬酯分散片对氯苯氧乙酸色谱法高压液相生物等效性

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Diversity and independent evolutionary profiling of rodent-borne viruses in Hainan,a tropical island of china

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Virologica Sinica 2023年第5期38卷 651-662页

作者： Youyou Li Chuanning Tang Yun Zhang Zihan Li Gaoyu Wang Ruoyan Peng Yi huang Xiaoyuan hu Henan Xin Boxuan Feng Xuefang cao Yongpeng He Tonglei Guo Yijun He Haoxiang Su Xiuji Cui Lina Niu Zhiqiang Wu Jian Yang Fan Yang Gang Lu lei Gao Qi Jin Meifang Xiao Feifei Yin Jiang Du NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100005China department of Clinical Laboratory Center for Laboratory MedicineHainan Women and Children's Medical CenterHaikou571199China Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Medical UniversityHaikou571199China Hainan Medical university-The university of Hong Kong Joint Laboratory of Tropical Infectious Diseases Hainan Medical UniversityHaikou571199China department of Pathogen Biology Hainan Medical UniversityHaikou571199China

The risk of emerging infectious diseases(EID)is increasing *** than 60%of EIDs worldwide are caused by animal-borne *** study aimed to characterize the virome,analyze the phylogenetic evolution,and determine the diversity of rodent-borne viruses in Hainan Province,*** collected 682 anal and throat samples from rodents,combined them into 28 pools according to their species and location,and processed them for next-generation sequencing and bioinformatics *** diverse viral contigs closely related to mammals were assigned to 22 viral *** clues of the important rodent-borne viruses were further identified by polymerase chain reaction for phylogenetic analysis and annotation of genetic characteristics such as arenavirus,coronavirus,astrovirus,pestivirus,parvovirus,and *** identified pestivirus and bocavirus in Leopoldoms edwardsi from huangjinjiaoling,and bocavirus in Rattus andamanensis from the national nature reserves of Bangxi with low amino acid identity to known pathogens are proposed as the novel species,and their rodent hosts have not been previously reported to carry these *** results expand our knowledge of viral classification and host range and suggest that there are highly diverse,undiscovered viruses that have evolved independently in their unique wildlife hosts in inaccessible areas.

关键词： Rodents Virome Phylogenetic analysis Novel viruses Wildlife

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二氧化碳捕集、利用与封存环境风险问卷调查研究

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环境工程 2018年第2期36卷 6-9,26页

作者：曹丽斌赵学涛蔡博峰谷莹莹周颖李琦马劲风胡丽莎王永胜赵兴雷王保登环境保护部环境规划院气候变化与环境政策研究中心北京100012 北京交通大学北京100044 中国科学院武汉岩土力学研究所岩土力学与工程国家重点实验室武汉430070 西北大学地质学系二氧化碳捕集与封存技术国家地方联合工程研究中心西安710069 中国地质调查局水文地质环境地质调查中心河北保定071051 神华鄂尔多斯煤制油分公司内蒙古鄂尔多斯017209 北京低碳清洁能源研究所工艺工程研发中心北京102209

基于对从事应对气候变化的政府管理人员、科研人员和相关企业人员开展问卷调查,分析他们对CCUS技术和相关项目的环境安全性认知程度,为完善《二氧化碳捕集、利用与封存环境风险评估技术指南(试行)》(以下简称《指南》)提供重要依据。结... 详细信息

基于对从事应对气候变化的政府管理人员、科研人员和相关企业人员开展问卷调查,分析他们对CCUS技术和相关项目的环境安全性认知程度,为完善《二氧化碳捕集、利用与封存环境风险评估技术指南(试行)》(以下简称《指南》)提供重要依据。结果显示,大部分被调查对象对CCUS技术有所了解,但是对于CCUS项目的环境安全性认识还比较模糊,未来《指南》的评估范围应侧重于采用最大可信事故计算CO_2在大气、地表水、地下水等扩散来定义或者根据CO_2运移分布来定量评估。CCUS技术各环节对环境风险影响大小进行排序,捕集环节应该重点考虑捕集工艺和环境风险物质,运输环节重点考虑运输设备材质、运输方式和运输规模,利用和封存环节建议4项因素均需充分考虑。

关键词：二氧化碳利用与封存关注度环境风险技术指南

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Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis

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National Science Review 2022年第7期9卷 17-31页

作者： Yujuan Jin Qiqi Zhao Weikang Zhu Yan Feng Tian Xiao Peng Zhang Liyan Jiang Yingyong Hou Chenchen Guo Hsinyi huang Yabin Chen Xinyuan Tong Jiayu cao Fei Li Xueliang Zhu Jun Qin Dong Gao Xin-Yuan Liu hua Zhang Luonan Chen Roman K.Thomas Kwok-Kin Wong lei Zhang Yong Wang Liang hu Hongbin Ji State Key Laboratory of Cell Biology Chinese Academy of Sciences Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Center for Excellence in Mathematical Sciences National Center for Mathematics and Interdisciplinary Sciences Key Laboratory of ManagementDecision and Information SystemHua Loo-Keng Center for Mathematical Sciences Academy of Mathematics and Systems ScienceChinese Academy of Sciences Shenzhen Key Laboratory of Translational Medicine of Tumor Department of Cell Biology and Genetics Shenzhen University Health Sciences Center Shanghai Pulmonary Hospital Tongji University Shanghai Chest Hospital Shanghai Jiaotong University Zhongshan Hospital Fudan University department of Pathology School of Basic Medical Sciences Fudan University School of Life Science and Technology Shanghai Tech University CAS Key Laboratory of Tissue Microenvironment and Tumor CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Nutrition and Health SciencesChinese Academy of Sciences Laura and Isaac Perlmutter Cancer Center New York University Langone Medical Center School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences department of Translational Genomics Center of Integrated Oncology Cologne-BonnMedical FacultyUniversity of Cologne department of Pathology University Hospital Cologne

Small-cell lung cancer(SCLC) is a recalcitrant cancer characterized by high ***,the exact cell type contributing to metastasis remains *** a Rb1L/L/Trp53L/Lmouse model,we identify the NCAMhiCD44lo/-subpopulation as the SCLC metastasizing cell(SMC),which is progressively transitioned from the non-metastasizing NCAMloCD44hicell(non-SMC).Integrative chromatin accessibility and gene expression profiling studies reveal the important role of the SWI/SNF complex,and knockout of its central component,Brgl,significantly inhibits such phenotypic transition and ***,TAZ is silenced by the SWI/SNF complex during SCLC malignant progression,and its knockdown promotes SMC transition and ***,ectopic TAZ expression reversely drives SMC-to-non-SMC transition and alleviates ***-cell RNA-se quencing analyses identify SMC as the dominant subpopulation in human SCLC metastasis,and immunostaining data show a positive correlation between TAZ and patient *** data uncover high SCLC plasticity and identify TAZ as the key mole cular switch in orchestrating SCLC phenotypic transition and metastasis.

关键词： small cell lung cancer SWI/SNF complex TAZ phenotypic transition metastasis

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