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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan cao Younghye Moon chen chen Nai-Kui Liu Xiao-ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

Analysis of Interaction Factors Between Two Piles

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Journal of Shanghai Jiaotong university(Science) 2008年第2期13卷 171-176页

作者：曹明陈龙珠 Department of Civil Engineering Shanghai Jiaotong University

A rigorous analytical method is presented for calculating the interaction factor between two identical piles subjected to vertical loads. Following the technique proposed by Muki and Sternberg, the problem is decomposed into an extended soil mass and two fictitious piles characterized respectively by Young＇s modulus of the soil and that of the difference between the pile and soil. The unknown axial forces along fictitious piles are determined by solving a Fredholm integral equation of the second kind, which imposes the compatibility condition that the axial strains of the fictitious piles are equal to those corresponding to the centroidal axes of the extended soil. The real pile forces and displacements can subequally be calculated based on the determined fictitious pile forces, and finally, the validity of the proposed approach and desired pile interaction factors may be obtained. Results confirm the portray the influence of the governing parameters on the pile interaction.

关键词： fictitious pile vertical load interaction factor analytical solution

媒体视野中的宁粤对峙与和解——以1931年《大公报》报道与评论为中心的讨论

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四川师范大学学报（社会科学版） 2013年第2期40卷 121-128页

作者：曹明臣浙江大学人文学院杭州310012

1931年,《大公报》对宁粤对峙与和解作了大量的报道与评论,其反对军事冲突、坚持和平解决政争的立场,从一个侧面反映了当时媒体的基本倾向,而这种倾向对宁粤双方均产生了影响。期间,宁粤双方均极为重视处理同媒体的关系,利用媒体为自身... 详细信息

1931年,《大公报》对宁粤对峙与和解作了大量的报道与评论,其反对军事冲突、坚持和平解决政争的立场,从一个侧面反映了当时媒体的基本倾向,而这种倾向对宁粤双方均产生了影响。期间,宁粤双方均极为重视处理同媒体的关系,利用媒体为自身服务。

关键词：媒体宁粤对峙和解《大公报》

Myocardial injury resulting from radiofrequency catheter ablation： comparison of circumferential pulmonary vein isolation and complex fractionated atrial electrograms ablation

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Chinese Medical Journal 2011年第17期124卷 2674-2677页

作者： ZHANG Feng-xiang YANG Bing chen Hong-wu JU Wei-zhu cao Ke-jiang chen ming-long Department of Cardiology First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China

Background Radiofrequency catheter ablation （RFCA） necessarily produces an area of myocardial necrosis. However, the difference of the extent of myocardial injury between circumferential pulmonary vein isolation （CPVI） and complex fractionated atrial electrograms （CFAE） ablation in patients with atrial fibrillation （AF） has not been investigated before. Methods Twenty-nine consecutive male patients （n=29） with either paroxysmal or persistent AF were selected for CPVI or CFAE ablation. The CPVI or CFAE ablation was performed with a three-dimensional electroanatomical mapping system （CARTO）. Serum cardiac biomarkers, for example, cardiac troponin T （cTnT）, aspartate transaminase （AST）, lactate dehydrogenase （LDH）, creatine kinase （CK）, and creatine kinase myocardial bound （CKMB） were determined by the Elecsys STATE immunoassay. Cardiac structure and function were measured with echocardiography. Results Echocardiography showed that there was no significant difference of atrioventricular structure or function parameters between the CPVI group and the CFAE ablation group. Serum cTnT showed a significant increase in the CFAE ablation group over the CPVI group at 12 and 24 hours after the procedure （P〈0.05, respectively）, and then it was reduced to a normal level after 48 hours. Serum AST showed a significant increase in the CFAE ablation group over the CPVI group at post-procedure, 4 and 12 hours after the procedure （P 〈0.05, respectively）, and then it reached to a normal level after 24 hours. There was no significant difference in LDH, CK, or CKMB levels between the CFAE ablation group and the CPVI group at any time point （P〉0.05）. Conclusions cTnT and AST other than LDH, total CK or CKMB activity significantly increased more in the CFAE ablation group than the CPVI group. However, the difference of the serum levels of cTnT, AST between two groups was temporary.

关键词： atrial fibrillation catheter ablation myocardial injury

Determination of platelet-activating factor by reverse phase high-performance liquid chromatography and its application in viral hepatitis

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World Journal of Gastroenterology 2005年第46期11卷 7364-7367页

作者： Hong-Cui cao, Xiao-ming chen, Wei Xu, Department of Infectious Diseases, First Affiliated Hospital, Medical School of Zhejiang University Key Laboratory of Infectious Diseases of Ministry of Public Health, Hangzhou 310003, Zhejiang Province, China Department of Infectious Disease First Affiliated Hospital Medical School of Zhejiang University Zhejiang Province China.

AIM： To detect the plateletoactivating factor （PAF） and the plasma or serum levels of tumor necrosis factoroa （TNF-α） malondialdehyde （MDA）, endotoxin （ET） and to discuss their significance in various types of viral hepatitis. METHODS： PAF, TNF-α, MDA, and ET levels in 60 controls, 16 cases of acute viral hepatitis, 71 cases of chronic viral hepatitis, 19 cases of severe viral hepatitis were detected by reverse phase high-performance liquid chromatography （rHPLC）, bio-assay, ELISA, thiobarbituric acid （TBA）, and limulus lysate test （LLT）, respectively. RESULTS： The rHPLC was more sensitive and specific than bio-assay （r = 0.912, P〈0.01）. The plasma levels of PAF, TNF-α, MDA, and ET in patients with viral hepatitis were higher than those in controls （P〈0.01）. CONCLUSION： rHPLC is more reliable and accurate for the detection of PAF.

关键词： Platelet-activating factor Malondialdehyde Endotoxin rHPLC Viral hepatitis

Si-C Foam Porous-Medium Combustion Power-Generation System for Low-Calorific-Value Biomass Syngas

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Journal of Thermal Science 2025年第1期34卷 206-222页

作者： YANG Jianwen chen Wei cao Bingwei LIU Xinhui LI Hang College of Mechanical and Aerospace Engineering Jilin University School of Mechanical and Vehicle Engineering Changchun University

Syngas produced from the gasification of organic feedstocks from biomass is one of the clean and sustainable sources of *** advantages of simple access and renewability of biomass energy can meet the energy needs of temporary power *** study presents a biomass power-generation system for vehicular *** biomass and a free-piston Stirling engine generator（FPSEG） as the primary material and prime mover,respectively,biomass energy is converted into electricity by combusting the syngas to heat the *** and key parameter design for biomass gasification and thermoelectric conversion systems within a power generation system were performed.A porous medium area was constructed using Si-C foam ceramics to obtain an energy-conversion experimental *** effects of bed height,porosity,porous-region diameter,and air-intake conditions on the power-generation performance were investigated,and optimisations were performed for the thermoelectric conversion *** rate of increase during FPSEG power generation first increased and then decreased with increasing bed height,peaking at a bed height of 40 *** increasing porous-region diameter accelerated FPSEG power generation,whereas porosity changes in the porous media did not significantly affect the rate of change during FPSEG power *** increasing air intake,the rate of increase during power generation first increased and then *** maximum change rate and the highest thermoelectric conversion efficiency of the power-generation system occurred at 9.5 m3/h and 6.5 m3/h（～45.1%）air intakes,*** the thermal inertia and combustion structure of the thermoelectric conversion system significantly increased the power-generation rate of the system,with 1.8 W/s being observed at a 9.7 m3/h air intake.

关键词： biomass combined heat and power (CHP) gasification porous media combustion power generation

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煤炭漏电保护装置安装和动作原因分析

中国安全科学学报 2007年第7期17卷 120-125页

作者：曹晨明山西潞安集团公司

论述煤矿井下漏电保护装置的工作原理及动作值的确定;提出漏电保护装置正确安装的5原则;从安全性和可靠性角度,分析漏电保护装置的接线问题并提出安装建议。详细分析在生产实际中可能造成漏电保护装置误动作、拒动作的各类原因,并总结... 详细信息

论述煤矿井下漏电保护装置的工作原理及动作值的确定;提出漏电保护装置正确安装的5原则;从安全性和可靠性角度,分析漏电保护装置的接线问题并提出安装建议。详细分析在生产实际中可能造成漏电保护装置误动作、拒动作的各类原因,并总结了针对性的预防措施。根据现场运行经验及《剩余电流保护器的运行规程》,提出了煤炭漏电保护装置在运行管理上应遵循的原则。

关键词：漏电保护动作值误动作拒动作保护线

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联合加固技术在破碎软岩中的应用

煤炭工程 2008年第10期40卷 30-32页

作者：曹晨明潞安矿业集团公司山西长治046204

针对潞安矿业集团屯留煤矿副井井底车场破碎软岩的复杂地质条件,在分析支护存在问题及围岩破坏机理的基础上,提出了联合加固技术,并对加固材料和技术参数进行合理选取。通过联合加固技术,使副井井底车场周围常期处于蠕变状态的破碎软岩... 详细信息

针对潞安矿业集团屯留煤矿副井井底车场破碎软岩的复杂地质条件,在分析支护存在问题及围岩破坏机理的基础上,提出了联合加固技术,并对加固材料和技术参数进行合理选取。通过联合加固技术,使副井井底车场周围常期处于蠕变状态的破碎软岩得到很好的加固,增强了围岩的抗扰动能力,消除了安全隐患,提高了矿井的整体安全性,确保了安全生产。

关键词：联合加固技术破碎软岩破坏机理

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-cheng Tang Ding-Kang chen ming-ming cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids