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FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer

World Journal of Clinical Oncology 2018年第5期9卷 110-118页

作者： candice carola Fran?ois Ghiringhelli Stefano Kim Thierry ANDré Juliette Barlet Le?la Bengrine-Lefevre Hélène Marijon Marie-Line Garcia-Larnicol Christophe Borg Linda Dainese Nils Steuer Hubert Richa Magdalena Benetkiewicz Annette K Larsen Aimery de Gramont Benoist Chibaudel Department of Medical Oncology Franco-British Institute Department of Medical Oncology Centre George Fran?ois Leclerc Department of Medical Oncology CHU Besan?on Department of Medical Oncology Saint-Antoine Hospital and Sorbonne Universités UMPC Department of Anatomy-Pathology Paris Pathology Institute Department of Gastrointestinal Surgery Franco-British Institute Fondation ARCAD Cancer Biology and Therapeutics Centre de Recherche Saint-Antoine INSERM U938 Faculté de Médecine Sorbonne Université

AIM To evaluate the efficacy and safety of the modified FOLFIRI3-aflibercept as second-line therapy in patients with metastatic colorectal *** This is a retrospective multicenter cohort, evaluating the efficacy and safety of the association of aflibercept with FOLFIRI3(day 1: aflibercept 4 mg/kg, folinic acid 400 mg/m^2, irinotecan 90 mg/m^2, 5-fluorouracil infusion 2400 mg/m^2 per 46 h; day 3: irinotecan 90 mg/m^2) in patients with previously treated metastatic colorectal cancer. The primary endpoint was overall response rate(ORR). Secondary endpoints were disease control rate(DCR), progression-free survival(PFS), overall survival(OS), and *** Among 74 patients treated in four French centers, nine were excluded due to prior use of aflibercept(n = 3), more than one prior treatment line in irinotecanna?ve patients(n = 3), and inadequate liver function(n = 3). In the "irinotecan-na?ve" patients(n = 30), ORR was 43.3% and DCR was 76.7%. Median PFS and OS were 11.3 mo(95%CI: 6.1-29.0) and 17.0 mo(95%CI: 13.0-17.3), respectively. The most common(> 5%) grade 3-4 adverse events were diarrhea(37.9%), neutropenia(14.3%), stomatitis and anemia(10.4%), and hypertension(6.7%). In the "pre-exposed irinotecan" patients(n = 35), 20(57.1%) received ≥ 2 prior lines of treatment. ORR was 34.3% and DCR was 60.0%. Median PFS and OS were 5.7 mo(95%CI: 3.9-10.4) and 14.3 mo(95%CI: 12.8-19.5), *** Minimally modified FOLFIRI has improvement dramatically the FOLFIRI3-aflibercept efficacy, whatever prior use of irinotecan. A prospective randomized trial is warranted to compare FOLFIRI-aflibercept to FOLFIRI3-aflibercept.

关键词： Chemotherapy Irinotecan Aflibercept Second-line Colorectal cancer

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A novel role for tissue-nonspecific alkaline phosphatase at the blood-brain barrier during sepsis

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Neural Regeneration Research 2021年第1期16卷 99-100页

作者： Divine C.Nwafor candice M.Brown Department of Neuroscience West Virginia University Health Science CenterMorgantownWVUSA Department of Microbiology Immunologyand Cell BiologySchool of MedicineWest Virginia University Health Science CenterMorgantownWVUSA

Sepsis and the blood-brain barrier(BBB):Sepsis is a life threatening systemic inflammatory condition involving multi-organ *** World Health Organization estimates that about 30 million people are affected by sepsis every year,and at least 6 million people die from sepsis each *** of approximately 24 million sepsis survivors,it is estimated that 70%of these individuals will experience some form of long-term neurological impairment(Iwashyna et al.,2010).Thus,when combined with prevention,diagnosis,and therapeutic management strategies,a functional understanding of the mechanisms that promote sepsis-associated neurological impairment is necessary to address the clinical challenges and economic burdens faced when treating sepsis.

关键词： prevention diagnosis barrier

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Alpha-adrenoceptor antagonism by Crassostrea gigas oyster extract inhibits noradrenalineinduced vascular contraction in Wistar rats

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Journal of Integrative Medicine 2015年第3期13卷 194-200页

作者： Kylie Connolly Douglas Jackson candice Pullen Andrew Fenning School of Medical and Applied Sciences CQUniversity Australia

OBJECTIVE： Crassostrea gigas oyster extract has been reported to have antioxidant, antihypertensive and lipid-lowering properties that may be useful for treating cardiovascular diseases. This study aimed to evaluate the effect of C. gigas oyster extract on cardiovascular function in tissues from healthy rats. METHODS： Single-cell microelectrode and isolated thoracic aortic organ bath studies were performed on tissues from 8-week-old healthy Wistar rats, using varying concentrations of C. gigas oyster extract. To elucidate a mechanism of action for the oyster’s vasoactive properties, concentration response curves were carried out in the presence of a calcium channel inhibitior（verapamil）, a nitric oxide synthase inhibitor（N G-nitro-L-arginine methyl ester）, a potassium channel inhibitor（4-aminopyridine）, in addition to the α-adrenoceptor inhibitor prazosin. RESULTS： Oyster solution at 7 500 mg/m L inhibited noradrenaline-induced contraction in isolated aortic rings. Cardiac electrophysiology results showed that neither concentration of oyster solution was able to significantly reduce action potential duration at all phases of repolarisation in left ventricular papillary muscles from healthy animals. CONCLUSION： When administered to healthy vascular tissue, C. gigas oyster extract inhibits contraction induced by noradrenaline. This effect is likely to be mediated through α-adrenoceptor inhibition, and to a lesser extent, calcium modulating activity.

关键词： Crassostrea hypertension calcium channels receptors,adrenergic rats

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Chest complications in autologous breast reconstruction

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Plastic and Aesthetic Research 2023年第1期10卷 205-215页

作者： candice M.Leach Meredith S.Collins Department of Plastic and Reconstructive Surgery University of Kansas Medical CenterKansas CityKS 66160USA

Complications from autologous free flap reconstruction of the breast can present with both common surgical complications and unique complications at the chest recipient *** review covers complications at the chest recipient site,including chest wall deformity,chronic pain,mastectomy skin flap necrosis,infection,pyoderma gangrenosum,bleeding complications,pneumothorax,chyle leak,and positive internal mammary lymph node metastasis.

关键词： Autologous breast reconstruction complications chest wall deformity pneumothorax mastectomy skin flap necrosis chyle leak internal mammary node metastasis

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Dynamic Patterns of Gene Expression Additivity and Regulatory Variation throughout Maize Development

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Molecular Plant 2019年第3期12卷 410-425页

作者： Peng Zhou candice N.Hirsch Steven P.Briggs Nathan M.Springer Department of Plant and Microbial Biology University of MinnesotaSaint PaulMN 55108USA Department of Agronomy and Plant Genetics University of MinnesotaSaint PaulMN 55108USA Division of Biological Sciences University of CaliforniaSanDiegoLaJollaCA92093USA

Gene expression variation is a key component underlying phenotypic variation and heterosis. Transcriptome profiling was performed on 23 different tissues or developmental stages of two maize inbreds, B73 and Mo17, as well as their hybrid. The obtained large-scale datasets provided opportunities to monitor the developmental dynamics of differential expression, additivity for gene expression, and regulatory variation. The transcriptome can be divided into .30 000 genes that are expressed in at least one tissue of one in bred and an additional ~10 000 “silent” genes that are not expressed in any tissue of any genotype, 90% of which are non-syntenic relative to other grasses. Many (.74%) of the expressed genes exhibit differential expression in at least one tissue. However, the majority of genes with differential expression do not exhibit consistent differential expression in different tissues. These genes often exhibit tissue-specific differential expression with equivalent expression in other tissues, and in many cases they switch the directionality of differential expression in different tissues. This suggests widespread variation for tissue-specific regulation of gene expression between the two maize inbreds B73 and Mo17. Nearly 5000 genes are expressed in only one parent in at least one tissue (single parent expression) and 97% of these genes are expressed at mid-parent levels or higher in the hybrid, providing extensive opportunities for hybrid complementation in heterosis. In general, additive expression patterns are much more common than non-additive patterns, and this trend is more pronounced for genes with strong differential expression or single pare nt expressi on. There is relatively little evidence for non-additive expression patterns that are maintained in multiple tissues. The analysis of allele-specific expression allowed classification of cis. and trans-regulatory variation. Genes with c/s-regulatory variation often exhibit additive expression and tend

关键词： maize gene expression heterosis differential expression non-additive expression allele-specific expression

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The role of radiation therapy in the management of primary thymic epithelial neoplasms

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 160-173页

作者： candice Johnstone Charles B.Simone 2nd Department of Radiation Oncology Medical College of WisconsinMilwaukeeWI 53211USA Department of Radiation Oncology New York Proton CenterNew YorkNY 10035USA

Therapeutic radiation plays an important role in the management of thymoma and thymic *** two tumor types differ substantially in their aggressiveness and *** most pressing issue in radiotherapy is which thymoma and thymic carcinoma patients need *** that these are rare cancers,few randomized trials have been *** remains regarding which patients benefit from adjuvant radiation *** literature spans patients treated over nearly 50 years,during which time radiation therapy has evolved from rudimentary 2-dimensional based planning to conformal 3-dimensional planning to yet more conformal dose painting techniques such as intensity-modulated radiation therapy and proton *** the effect of radiation is small and the natural history of a disease long,as is the case for stage I favorable histology thymoma,then differences in techniques and toxicities may have as much of an impact as whether radiation was given or not.

关键词： Thymoma thymic carcinoma post-operative radiation therapy

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The Legends of Four Seasons

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新高考（高一语文、数学、英语） 2010年第2期 45-46页

作者： candice

春天，万物复苏，微风拂面；夏季，绿树成荫，阳光灿烂；秋天，北雁南飞，落叶蹁跹；冬日，银装素裹，苍茫纯洁。四个季节，四种心情。我们享受春目的喜悦，感受夏日的激情，分享秋季的收获，体验冬季的高远。

关键词：高中英语课外阅读阅读材料

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The Legends of Four Seasons

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新高考(语文备考) 2010年第2期 45-46页

作者： candice

春天,万物复苏,微风拂面;夏季,绿树成荫,阳光灿烂;秋天,北雁南飞,落叶蹁跹;冬日,银装素裹,苍茫纯洁。四个季节,四种心情。我们享受春日的喜悦,感受夏日的激情,分享秋季的收获,体验冬季的高远。四季,总是被赋予着浪漫的气息。现在,就让... 详细信息

春天,万物复苏,微风拂面;夏季,绿树成荫,阳光灿烂;秋天,北雁南飞,落叶蹁跹;冬日,银装素裹,苍茫纯洁。四个季节,四种心情。我们享受春日的喜悦,感受夏日的激情,分享秋季的收获,体验冬季的高远。四季,总是被赋予着浪漫的气息。现在,就让我们一同去看看东西方文化都有哪些关于四季不同的传奇故事吧!

关键词：情态动词 The Legends of Four Seasons

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Lactate reloaded–reevaluation of the importance of lactate monitoring in the management of adult sepsis in the emergency department

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BIOCELL 2021年第3期45卷 445-449页

作者： GABOR XANTUS BALINT KISS GYULA MOLNAR candice MATHESON V.A NNA GYARMATHY PETER L.KANIZSAI Cardiff University CardiffCF103ATUK Semmelweis University Budapest1085Hungary Dalhuis University Halifax HalifaxNS B3H 4R2Canada EpiConsult Biomedical Consulting and Medical Communications Agency DoverDE 19901USA Pecs University Clinical CentrePecs7626Hungary

For about a quarter of a century,monitoring lactate levels and/or lactate clearance has been an unquestionable cornerstone in sepsis *** elevated lactate level appeared to be an independent predictor of mortality,and the consequent metabolic acidosis was thought to explain a number of pathophysiological changes seen in septic *** physiological and clinical findings seem to challenge the adverse role of lactic acidosis in *** suggests that lactate levels are not necessarily directly proportional to either tissue or cellular hypoxia,and conversely,despite high lactate levels,increased peripheral tissue oxygen pressure can be measured in adult patients with septic *** to the most recent understanding of in vitro and in vivo evidence,the elevated lactate level in sepsis might be a normal reaction due to adrenergic stress with potential beneficial/protective physiological effects,as *** the one hand,burning lactic may help fuel the body during critical illness,but on the other hand,with a slight drop in pH,the body may counteract certain deleterious changes during the dysregulated host response;reduce the chances of reperfusion myocardial injury,and improve tissue oxygenation by shifting the haemoglobin dissociation curve to the *** the pathophysiological process in sepsis resulting in elevated lactate levels may aid management in an emergency,medicine,and intensive care *** more in-depth physiological knowledge,physicians may inevitably surpass normalisation heuristics and deliver personalized rather than protocolised sepsis resuscitation.

关键词： Reevaluation Lactate Sepsis Resuscitation

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Immanant positivity for Catalan-Stieltjes matrices

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Frontiers of Mathematics in China 2022年第5期17卷 887-903页

作者： Ethan Y.H.LI Grace M.X.LI Arthur L.B.YANG candice X.T.ZHANG Center for Combinatorics LPMCNankai UniversityTianjin 300071China

We give some sufficient conditions for the nonnegativity of immanants of square submatrices of Catalan-Stieltjes matrices and their corresponding Hankel *** obtain these sufficient conditions,we construct new planar networks with a recursive nature for Catalan-Stieltjes *** applications,we provide a unified way to produce inequalities for many combinatorial polynomials,such as the Eulerian polynomials,Schröder polynomials,and Narayana polynomials.

关键词： Immanant character Catalan-Stieltjes matrices Hankel matrices planar network

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