A novel role for tissue-nonspecific alkaline phosphatase at the blood-brain barrier during sepsis

作     者：Divine C.Nwafor Candice M.Brown Divine C.Nwafor;Candice M.Brown

作者机构：Department of NeuroscienceWest Virginia University Health Science CenterMorgantownWVUSA Department of MicrobiologyImmunologyand Cell BiologySchool of MedicineWest Virginia University Health Science CenterMorgantownWVUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第1期

页      面：99-100页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by the NIH T32 AG052375(to DCN),K01 NS081014(to CMB) West Virginia Clinical and Translational Science Institute(U54 GM104942) the West Virginia University Stroke Co BRE(P20 GM109098) 

主　　题：prevention diagnosis barrier 

摘      要：Sepsis and the blood-brain barrier(BBB):Sepsis is a life threatening systemic inflammatory condition involving multi-organ *** World Health Organization estimates that about 30 million people are affected by sepsis every year,and at least 6 million people die from sepsis each *** of approximately 24 million sepsis survivors,it is estimated that 70%of these individuals will experience some form of long-term neurological impairment(Iwashyna et al.,2010).Thus,when combined with prevention,diagnosis,and therapeutic management strategies,a functional understanding of the mechanisms that promote sepsis-associated neurological impairment is necessary to address the clinical challenges and economic burdens faced when treating sepsis.