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Rhodium-Catalyzed Pyridine-Assisted C-H Arylation for the Synthesis of Planar Chiral Ferrocenes

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CCS Chemistry 2020年第6期2卷 642-651页

作者： Chen-Xu Liu Zhong-jian cai Qiang Wang Zhi-Jie Wu Qing gu Shu-Li You State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032

Planar chiral ferrocenes are widely applied in organic synthesis,materials science,and medicinal chemistry,but their synthesis is not ***,a highly efficient synthesis of planar chiral ferrocene-based pyridine derivatives via Rh(I)-catalyzed direct coupling of pyridylferrocenes with aryl halides was *** yields and excellent enantioselectivity(95–>99%ee)are obtained for a wide range of *** compatibility of gram-scale synthesis and relatively low catalyst loading(down to 1 mol%based on[Rh])enhance the practicality of the current *** generated coupling products can be readily transformed into chiral *** studies suggest that the C–H bond cleavage of pyridylferrocene may be a reversible step and not the rate-determining *** nonlinear effects indicate the existence of multiple metals or ligands in the active catalyst.

关键词： asymmetric catalysis C–H arylation ferrocene planar chirality pyridine

Role of epithelial-to-mesenchymal transition in the pulmonary fi brosis induced by paraquat in rats

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World Journal of Emergency Medicine 2021年第3期12卷 214-220页

作者： jian-hua yi Zhao-cai Zhang Mei-bian Zhang Xin He Hao-ran Lin Hai-wen Huang Hai-bin Dai Yu-wen Huang Emergency Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Scientifi c Research Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 301051China Shangyu People’s Hospital Shaoxing 312300China Pharmacy Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND:This study aims to explore the characteristics of the epithelial-to-mesenchymal transition(EMT)process and its underlying molecular mechanisms in the period of paraquat(PQ)-induced pulmonary fi brosis(PF).METHODS:Picrosirius red staining and collagen volume fraction were utilized to evaluate the pathological changes of PQ-induced PF in ***,Western blot,and real-time reverse transcriptase-polymerase chain reaction(RT-PCR)were used to measure the protein and gene expression of EMT markers,EMT-associated transcription factors,and regulators of EMT-related pathways,***:The collagen deposition in the alveolar septum and increased PF markers were characteristics of pathological changes in PQ-induced PF,reached a peak on day 14 after PQ poisoning,and then decreased on day *** protein and gene expression of the fibrosis marker,EMT markers,transcription factors,and regulators of EMT-related signaling pathways signifi cantly increased at diff erent time points after PQ poisoning compared with corresponding controls(Pgulators of EMT-related signaling pathways(P0.05).CONCLUSIONS:EMT process plays a role in the PQ-induced PF,in which most PF and EMT markers have a peak phenomenon,and its underlying molecular mechanisms might be determined by further studies.

关键词： Pulmonary fibrosis Paraquat Epithelial-to-mesenchymal transition Rats

Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms

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Current Medical Science 2024年第2期44卷 391-398页

作者： Kai-kai guO Chang-ya LIU Gao-hui LI jian-ping XIANG Xiao-chang LENG yi-ke cai Xue-bin HU Department of Neurosurgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Artery Flow Technology Co. Ltd.Hangzhou 310051China

Objective:The objective of this research was to explore the difference and correlation of the morphological and hemodynamic features between sidewall and bifurcation aneurysms in anterior circulation arteries,utilizing computational fluid dynamics as a tool for ***:In line with the designated inclusion criteria,this study covered 160 aneurysms identified in 131 patients who received treatment at Union Hospital of Tongji Medical College,Huazhong University of Science and Technology,China,from January 2021 to September *** follow-up digital subtraction angiography(DSA)data,these cases were classified into two distinct groups:the sidewall aneurysm group and the bifurcation aneurysm *** and hemodynamic parameters in the immediate preoperative period were meticulously calculated and examined in both groups using a three-dimensional DSA reconstruction ***:No significant differences were found in the morphological or hemodynamic parameters of bifurcation aneurysms at varied locations within the anterior ***,pronounced differences were identified between sidewall and bifurcation aneurysms in terms of morphological parameters such as the diameter of the parent vessel(Dvessel),inflow angle(θF),and size ratio(SR),as well as the hemodynamic parameter of inflow concentration index(ICI)(P0.5,P<0.001).Conclusions:The significant differences in certain morphological and hemodynamic parameters between sidewall and bifurcation aneurysms emphasize the importance to contemplate variances in threshold values for these parameters when evaluating the risk of rupture in anterior circulation *** it is a bifurcation or sidewall aneurysm,these disparities should be *** morphological parameter SR has the potential to be a val

关键词： sidewall bifurcation unruptured aneurysms computational fluid dynamics

Invisible and semi-invisible decays of bottom baryons

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Chinese Physics C 2024年第8期48卷 127-139页

作者： Yong Zheng jian-Nan Ding Dong-Hao Li Lei-yi Li cai-Dian Lü Fu-Sheng Yu MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Center for High Energy Physics Peking UniversityBeijing 100871China Institute of High Energy Physics CASBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 101408China

The similar densities of dark matter and baryons in the universe imply that they may arise from the same ultraviolet model.B-Mesogenesis,which assumes dark matter is charged under the baryon number,attempts to simultaneously explain the origin of baryon asymmetry and dark matter in the *** particular,B-Mesogenesis may induce bottom-baryon decays into invisible or semi-invisible final states,which provide a distinctive signal for probing this *** this work,we systematically study the invisible decays of bottom baryons into dark matter and the semi-invisible decays of bottom baryons into a meson or a photon together with a dark matter *** particular,the fully invisible decay can reveal the stable particles in *** QCD-based frameworks are used to calculate the hadronic matrix elements under the B-Mesogenesis *** estimate the constraints on the Wilson coefficients or the product of some new physics couplings with the Wilson coefficients according to the semi-invisible and invisible decays of bottom baryons detectable at future colliders.

关键词： baryon asymmetry dark matter B-Mesogenesis invisible and semi-invisible decay bottom baryons

Long noncoding RNA H19 regulates degeneration and regeneration of injured peripheral nerves

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Neural Regeneration Research 2023年第8期18卷 1847-1851页

作者： Yu-Mei Feng jian Shao Min cai yi-Yue Zhou yi Yao Jia-Xi Qian Zi-Han Ding Mao-Rong jiang Deng-Bing Yao School of Life Sciences Key Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCoinnovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Nantong University Xinglin College NantongJiangsu ProvinceChina

Our previous studies have shown that long noncoding RNA(lncRNA)H19 is upregulated in injured rat sciatic nerve during the process of Wallerian degeneration,and that it promotes the migration of Schwann cells and slows down the growth of dorsal root ganglion ***,the mechanism by which lncRNA H19 regulates neural repair and regeneration after peripheral nerve injury remains *** this study,we established a Sprague-Dawley rat model of sciatic nerve transection *** performed in situ hybridization and found that at 4–7 days after sciatic nerve injury,lncRNA H19 was highly *** 14 days before injury,adeno-associated virus was intrathecally injected into the L4–L5 foramina to disrupt or overexpress lncRNA *** overexpression of lncRNA H19,the growth of newly formed axons from the sciatic nerve was inhibited,whereas myelination was ***,we performed gait analysis and thermal pain analysis to evaluate rat *** found that lncRNA H19 overexpression delayed the recovery of rat behavior function,whereas interfering with lncRNA H19 expression improved functional ***,we examined the expression of lncRNA H19 downstream target SEMA6D,and found that after lncRNA H19 overexpression,the SEMA6D protein level was *** findings suggest that lncRNA H19 regulates peripheral nerve degeneration and regeneration through activating SEMA6D in injured *** provides a new clue to understand the role of lncRNA H19 in peripheral nerve degeneration and regeneration.

关键词： adeno-associated virus dorsal root ganglion lncRNA H19 nerve degeneration nerve regeneration peripheral nerve rat sciatic nerve injury semaphorin 6D Wallerian degeneration

A Scale Invariant Interest Point Detector in Gabor Based Energy Space

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自动化学报 2014年第10期40卷 2356-2363页

作者： CAO Zheng-cai MA Feng-Lei FU yi-Li ZHANG jian College of Information Science and Technology Beijing University of Chemical Technology Beijing 100029 China State KeyLaboratory of Robotics and Systems Harbin Institute of Technology Harbin 150001 China School of Mechanical Engineering Tongji University Shanghai 200092 China

Abstract Interest point detection is a fundamental issue in many intermediate level vision problems and plays a significant role in vision systems. The previous interest point detectors are designed to detect some special image structures such as corners, junctions, line terminations and so on. These detectors based on some simplified 2D feature models will not work for image features that differ significantly from the models. In this paper, a scale invariant interest point detector, which is appropriate for most types of image features, is proposed based on an iterative method in the Gabor based energy space. It detects interest points by noting that there are some similarities in the phase domain for all types of image features, which are obtained by different detectors respectively. Firstly, this approach obtains the positions of candidate points by detecting the local maxima of a series of energy maps constructed by Gabor filter responses. Secondly, an iterative algorithm is adopted to select the corresponding characteristic scales and accurately locate the interest points simultaneously in the Gabor based energy space. Finally, in order to improve the real-time performance of the approach, a fast implementation of Gabor function is used to accelerate the process of energy space construction. Experiments show that this approach has a broader applicability than the other detectors and has a good performance under rotation and some other image changes.

关键词： Gabor滤波器空间结构能源领域检测器兴趣点 Gabor函数图像特征视觉系统

Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and Hep G2 hepatoma cells

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World Journal of Gastroenterology 2017年第34期23卷 6242-6251页

作者： cai-Jie Lu yi-Feng He Wei-Zhuang Yuan Li-Jun Xiang jian Zhang Yan-Rui Liang Juan Duan Yun-He He Ming-yi Li Laboratory of Hepatobiliary Surgery Affiliated Hospital of Guangdong Medical University the First Clinical Medical College Southern Medical University Department of Gastrointestinal Surgery. The Second Affiliated Hospital of guangzhou Medical University TCM-Integrated Hospital Southern Medical University

AIM To investigate whether Dihydromyricetin(DHM) inhibits cell proliferation and promotes apoptosis by downregulating Notch1 *** The correlation between Notch1 and Hes1(a Notch1 target molecule) expression in hepatoma samples was confirmed by q RT-PCR. In addition, MTT assays, flow cytometry and TUNEL analysis showed that DHM possessed strong anti-tumor properties, evidenced not only by reduced cell proliferation but also by enhanced apoptosis in QGY7701 and Hep G2 hepatocellular carcinoma(HCC) cells. The expressions of Notch1, Hes1, Bcl-2 and Bax were determined by Western *** Among the tested samples(n = 64), the expression levels of Notch1(75% of patients) and Hes1(79.7% of patients) m RNA in tumor tissues were higher than in the normal liver tissues. There was a negative correlation between the expression of Notch1 and the degree of differentiation and positively correlated with the Alpha Fetal Protein concentration. The viability of HCC cells treated with DHM was significantly inhibited in a dose and time-dependent manner. Apoptosis was induced in Hep G2 and QGY7701 cell lines following 24 h of DHM treatment. After treatment with DHM, the protein expression of Notch1 was downregulated, the apoptosis-related protein Bax was upregulated and Bcl2 was downregulated. Notch1 si RNA further enhanced the anti-tumor properties of DHM. CONCLUSION Notch1 is involved in the development of HCC and DHM inhibits cell proliferation and promotes apoptosis by down-regulating the expression of Notch1.

关键词： Dihydromyricetin Apoptosis Hepatocellular carcinoma Notch1

Assessment of Prognostic Factors of Racial Disparities in Testicular Germ Cell Tumor Survival in the United States(1992–2015)

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Biomedical and Environmental Sciences 2021年第2期34卷 152-162页

作者： WU Jing JI yi Bing TANG Bi Wei BROWN Matthew WANG Bao Hua DU Chen Lei DU jian Shu WANG Xue Mei cai Li Jun WU guo yi ZHOU Yan National Center for Chronic and Non-communicable Diseases Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China Inner Mongolia Medical University Hohhot 010110Inner MongoliaChina National Cancer Insitiute National Institutes of HealthBethesda 20892MarylandUnited States Shanghai Topgen Biopharm Technology Co. LtdShanghai 201203China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China State Key Laboratory of Genetic Engineering School of Life SciencesFudan UniversityShanghai 200433China Shanghai-MOST Key Laboratory of Health and Disease Genomics Chinese National Human Genome Center at ShanghaiShanghai 200000China

Objective Testicular germ cell tumors(TGCT) are the most common cancer among men aged 15 to 39 years. Previous studies have considered factors related to TGCT survival rate and race/ethnicity, but histological type of the diagnosed cancer has not yet been thoroughly *** The data came from 42,854 eligible patients from 1992 to 2015 in the Surveillance Epidemiology and End Results 18. Frequencies and column percent by seminoma and nonseminoma subtypes were determined for each covariates. We used Cox proportional hazard regression to assess the impact of multiple factors on post-diagnostic mortality of *** Black males were diagnosed at a later stage, more commonly with local or distant *** incidence of TGCT in black non-seminoma tumors increased most significantly. The difference in survival rates between different ethnic and histological subtypes, overall survival(OS) in patients with non-seminoma was significantly worse than in patients with seminoma. The most important quantitative predictor of death was the stage at the time of diagnosis, and older diagnostic age is also important factor affecting *** Histological type of testicular germ cell tumor is an important factor in determining the prognosis of testicular cancer in males of different ethnic groups.

关键词： Testicular cancer Germ cell tumor Race Survival rate Survival analysis

Update on thyroid ultrasound: a narrative review from diagnostic criteria to artificial intelligence techniques

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Chinese Medical Journal 2019年第16期132卷 1974-1982页

作者： Xiao-Wen Liang Yong-yi cai Jin-Sui Yu jian-yi Liao Zhi-yi Chen Department of Ultrasound Medicine Laboratory of Ultrasound Medicine and Artificial IntelligenceExperimental Center of Liwan HospitalThe Third Affiliated Hospital of Guangzhou Medical UniversityThe Liwan Hospital of the Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510000China.

Objective Ultrasound imaging is well known to play an important role in the detection of thyroid disease, but the management of thyroid ultrasound remains inconsistent. Both standardized diagnostic criteria and new ultrasound technologies are essential for improving the accuracy of thyroid ultrasound. This study reviewed the global guidelines of thyroid ultrasound and analyzed their common characteristics for basic clinical screening. Advances in the application of a combination of thyroid ultrasound and artificial intelligence (AI) were also presented. Data sources An extensive search of the PubMed database was undertaken, focusing on research published after 2001 with keywords including thyroid ultrasound, guideline, AI, segmentation, image classification, and deep learning. Study selection Several types of articles, including original studies and literature reviews, were identified and reviewed to summarize the importance of standardization and new technology in thyroid ultrasound diagnosis. Results Ultrasound has become an important diagnostic technique in thyroid nodules. Both standardized diagnostic criteria and new ultrasound technologies are essential for improving the accuracy of thyroid ultrasound. In the standardization, since there are no global consensus exists, common characteristics such as a multi-feature diagnosis, the performance of lymph nodes, explicit indications of fine needle aspiration, and the diagnosis of special populations should be focused on. Besides, evidence suggests that AI technique has a good effect on the unavoidable limitations of traditional ultrasound, and the combination of diagnostic criteria and AI may lead to a great promotion in thyroid diagnosis. Conclusion Standardization and development of novel techniques are key factors to improving thyroid ultrasound, and both should be considered in normal clinical use.

关键词： Thyroid Ultrasound guideline Artificial Intelligence Image Classification