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江苏经贸职业技术学院学报 2024年第1期 41-44页

作者：蔡巧燕浙江经贸职业技术学院工商管理学院浙江杭州310018

中国特色学徒制是一种独特而有效的职业教育模式,是工匠精神传承的重要载体,为知识的传递与转化架起了一座“桥梁”,旨在通过师傅与学徒之间的互动和传承,实现隐性知识与显性知识的传递与转化。

关键词：中国特色学徒制隐性知识显性知识知识传递与转化

Chemical Composition,Anticancer,Anti-neuroinflammatory,and Antioxidant Activities of the Essential Oil of Patrinia scabiosaefolia

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Chinese Journal of Integrative Medicine 2018年第3期24卷 207-212页

作者： LIN Jing cai qiao-yan XU Wen LIN Jiu-mao PENG Jun Academy of Integrative Medicine Biomedical Research Center Fujian University of Traditional Chinese Medicine Fujian Key Laboratory of Integrative Medicine on Geriatrics Fujian University of Traditional Chinese Medicine Department of Pharmacology Fujian University of Traditional Chinese Medicine

Objective：To study the chemical composition,anticancer,anti-neuroinflammatory,and antioxidant activities of the essential oil of Patrinia scabiosaefolia（EO-PS）.Methods：Patrinia scabiosaefolia was analyzed by gas chromatography-mass *** human carcinoma cell lines,including SGC-7901,AGS,Hep G2,HT-29,HCT-8,5-FU/HCT-8,He La,and MDA-MB-231,were assessed by methylthiazolyldiphenyltetrazolium bromide（MTT） ***-neuroinflammatory activity was assessed by production of interleukin（IL）-1β and IL-6 induced by lipopolysaccharide in BV-2 cells（microglia from mice）.The antioxidant activity was evaluated with a 2,2-diphenyl-1-picrylhydrazyl（DPPH） scavenging ***：Forty-four components,representing 83.919% of the total oil,were identified in the *** major constituents were caryophyllene oxide（12.802%）,caryophyllene（6.909%）,α-caryophyllene（2.927%）,β-damascenone（3.435%）,calarene（5.621%）,and phenol（3.044%）.The MTT assay showed that the EO-PS exhibited significant dose-dependent growth inhibition in the 50–200 μg/m L dilution *** EO-PS exhibited a dose-dependent scavenging activity against the DPPH radical,with an half of maximal inhibitory concentration 1.455 mg/m ***：The EO-PS possesses a wide range of antitumor,anti-neuroinflammatory and antioxidant activities,suggesting that it may be a good candidate for further investigations of new bioactive substances.

关键词： Patrinia scabiosaefolia essential oil anti-neuroinflammatory anticancer antioxidant caryophyllene oxide

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基于贝叶斯正则化神经网络的裂纹扩展预测

航空计算技术 2024年第4期54卷 71-75页

作者：李配缘蔡巧言胡雨传王飞张涛北京宇航系统工程研究所北京100000 中国运载火箭技术研究院北京100000

针对运载器结构合金材料的断裂行为仿真的快速性需求,提出了一种基于贝叶斯正则化的神经网络模型的裂纹生长行为快速预测方法。构建裂纹生长预测神经网络模型,提高神经网络模型任务适应能力,采用贝叶斯正则化方法训练模型获得网络权重,... 详细信息

针对运载器结构合金材料的断裂行为仿真的快速性需求,提出了一种基于贝叶斯正则化的神经网络模型的裂纹生长行为快速预测方法。构建裂纹生长预测神经网络模型,提高神经网络模型任务适应能力,采用贝叶斯正则化方法训练模型获得网络权重,并对比多种神经网络训练方法的预测准确率。基于扩展有限元法及经典理论,对有限元仿真中的材料参数进行推算,并对中心预置裂纹的7050铝合金板件的静载拉断进行有限元仿真批量计算,观察不同加载水平下,不同长度及角度的预置裂纹损伤扩展特性。仿真结果表明,方法计算速度快且具有良好的预测准确率,能够满足在飞行器结构中对裂纹扩展特性进行快速评估。

关键词：断裂有限元法贝叶斯网络神经网络

Superatom-assembled boranes,carboranes,and low-dimensional boron nanomaterials based on aromatic icosahedral B_(12)and C_(2)B_(10)

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Nano Research 2024年第7期17卷 6734-6740页

作者： qiao-qiao yan yan-Fang Wei Qiang Chen Yue-Wen Mu Si-Dian Li Institute of Molecular Science Shanxi UniversityTaiyuan 030006China

Using the experimentally known aromatic icosahedral superatoms I_(h)B_(12)H_(12)2−and D_(5d)1,12-C_(2)B_(10)H_(12)as building blocks and based on extensive density functional theory calculations,we predict herein a series of core–shell superpolyhedral boranes and carboranes in a bottom-up approach,including the high-symmetry Th B_(12)@B_(152)H_(72)2−(2),C2h C_(2)B_(10)@B_(152)H_(72)(3),D_(3d)B_(12)@B_(144)H_(66)(4),I_(h)B_(12)@C_(24)B_(12)0H_(72)2−(6),and D_(5d)C_(2)B_(10)@C_(24)B_(12)0H_(72)(7).More interestingly,the superatom-assembled linear D2h B_(36)H_(32)^(2−)(8),close-packed planar D_(3d)B_(84)H_(60)^(2−)(10),and nearly close-packed core−shell D_(3d)B_(12)@B144H_(6)6(4)can be extended periodically to form the one-dimensional(1D)α-rhombohedral borane nanowire B_(12)H_(10)(Pmmm)(9),two-dimensional(2D)α-rhombohedral monolayer borophane B_(12)H_(6)(P m1)(11),and the experimentally known three-dimensional(3D)α-rhombohedral boron(R m)(12)which can be viewed as an assembly of the monolayer B_(12)H_(6)(11)staggered in vertical direction,setting up a bottom-up strategy to form low-dimensional boron-based nanomaterials from their borane“seeds”via partial or complete *** bonding analyses indicate that the high stability of these nanostructures originates from the spherical aromaticity of their icosahedral B_(12)or C_(2)B_(10)structural units which possess the universal skeleton electronic configuration of 1S21P61D101F8 following the Wade’s n+1 *** infrared(IR)and Raman spectra of the most-concerned neutral B_(12)@B144H_(6)6(4)and C_(2)B_(10)@C_(24)B_(12)0H_(72)(7)are computationally simulated to facilitate their experimental characterizations.

关键词： superatom-assembling bottom-up approach density functional theory superpolyhedral boranes superpolyhedral carboranes borophanes

Therapeutic Effects of Different Animal Bile Powders on Lipid Metabolism Disorders and Their Composition Analysis

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Chinese Journal of Integrative Medicine 2022年第10期28卷 918-923页

作者： CHEN Da-xin CHU Jian-feng LIN Shan ZHANG Ling CHEN Hong-wei SUN Zhi-wei XU Jian-feng cai qiao-yan WANG Li-li PENG Jun Academy of Integrative Medicine Cardiovascular Research Institute Fuzhou(350122)China Fujian Key Laboratory of Integrative Medicine on Geriatric Fujian University of Traditional Chinese MedicineFuzhou(350122)China Chen Ke-ji Academic Thought Heritage Studio Fuzhou(350122)China Fujian Guizhentang Pharmaceutical Co. Ltd.HuianFujian Province(362142)China

Objective: To compare the therapeutic effect of different animal bile powders on lipid metabolism disorders induced by high-fat diet in rats, and analyze the bioactive components of each animal bile powder. Methods: Sixty Sprague-Dawley rats were randomly divided into 6 groups(n=10): normal diet control group, high-fat diet model group, high-fat diet groups orally treated with bear, pig, cow and chicken bile powders, respectively. Serum biochemical markers from the abdominal aorta in each group were analyzed. Changes in the body weight and liver weight were recorded. Pathohistological changes in the livers were examined. High performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry was used to determine the composition of bioactive components in each animal bile powder. Results: Treatment with different types of animal bile powders had different inhibitory effects on high-fat diet-induced increase of body weight and/or liver weight in rats, most notably in bear and pig bile powders(P<0.05). High-fat diet induced lipid metabolism disorder in rats, which could be reversed by treatment with all kinds of bile powders. Bear bile and chicken bile showed the most potent therapeutic effect against lipid metabolism disorder. Cow and bear bile effectively alleviated high-fat diet induced liver enlargement and discoloration, hepatocyte swelling, infiltration of inflammatory cells and formation of lipid vacuoles. Bioactive component analysis revealed that there were significant differences in the relative content of taurocholic acid, taurodeoxycholic acid and ursodeoxycholic acid among different types of animal bile. Interestingly, a unique component with molecular weight of 496.2738 Da, whose function has not yet been reported, was identified only in bear bile powder. Conclusions: Different animal bile powders had varying therapeutic effect against lipid metabolism disorders induced by high-fat diet, and bear bile powder demonstrated th

关键词： bile powders lipid metabolism active ingredient liver

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网格计算技术在大规模CFD计算上的应用

空气动力学学报 2009年第6期27卷 696-700页

作者：蔡巧言杜涛西北工业大学航空学院西安710072 中国运载火箭技术研究院研究发展中心北京100076

针对大规模数值计算规模化管理的难题,采用网格计算技术将网络环境下分散的计算资源组建了CFD网格计算环境。采用主动接入方式,以中心服务器为核心的网格计算管理和服务模式,构建CFD网格计算环境,实现了CFD计算在网格环境内的自动化计... 详细信息

针对大规模数值计算规模化管理的难题,采用网格计算技术将网络环境下分散的计算资源组建了CFD网格计算环境。采用主动接入方式,以中心服务器为核心的网格计算管理和服务模式,构建CFD网格计算环境,实现了CFD计算在网格环境内的自动化计算管理,提高了计算资源的利用效率,降低了设计人员的劳动强度。

关键词：网格计算 CFD 大规模计算

Mutational landscape of TP53 and CDH1 in gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 276-283页

作者： Hong-qiao cai Li-Yue Zhang Li-Ming Fu Bin Xu yan Jiao Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Critical Care Medicine The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Traditional Chinese Medicine The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

In this editorial we comment on an article published in a recent issue of the World J Gastrointest Surg.A common gene mutation in gastric cancer(GC)is the TP53 *** a tumor suppressor gene,TP53 is implicated in more than half of all tumor ***53 gene mutations in GC tissue may be related with clinical pathological *** TP53 mutation arose late in the progression of GC and aided in the final switch to ***1 encodes E-cadherin,which is involved in cell-to-cell adhesion,epithelial structure maintenance,cell polarity,differentiation,and intracellular signaling pathway ***1 mutations and functional loss can result in diffuse GC,and CDH1 mutations can serve as independent prognostic indicators for poor *** patients can benefit from genetic counseling and testing for CDH1 *** therapy may assist to postpone the onset and progression of *** investigation of TP53 and CDH1 gene mutations in GC allows for the investigation of the relationship between these two gene mutations,as well as providing some basis for evaluating the prognosis of GC patients.

关键词： TP53 CDH1 Gastric cancer Gene mutation Methylation

Cervical cancer prevention in China: where are we now, and what's next?

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Cancer Biology & Medicine 2024年第3期21卷 213-217页

作者： Huijiao yan Qiankun Wang Youlin qiao School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100730China Department of Cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100021China

Cervical cancer(CC) epidemiology CC, the fourth most frequently diagnosed malignancy in women worldwide, is a major global health challenge, particularly in low-resource regions. Approximately 88.1% of the 604,000 CC new cases occurred in low-and middle-income countries in 2020, and more than 90% of the 342,000 CC deaths occurred in low-and middle-income countries in 2020~1.

关键词： prevention Cervical epidemiology

Reveal the lost entanglement for accelerated atoms in the high-dimensional spacetime

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 48-57页

作者： Jiatong yan Baocheng Zhang Qingyu cai School of Mathematics and Physics China University of GeosciencesWuhan 430074China Physics Department Brown UniversityProvidenceRhode Island 02912USA Center for Theoretical Physics Hainan UniversityHaikou 570228China School of Information and Communication Engineering Hainan UniversityHaikou 570228China Peng Huanwu Center for Fundamental Theory Hefei 230026China

When atoms are accelerated in the vacuum,entanglement among atoms will degrade compared with the initial situation before the *** this study,we propose a novel and interesting view that the lost entanglement can be recovered completely when the high-dimensional spacetime is exploited,in the case that the acceleration is not too large,since the entanglement loss rate caused by the large acceleration is faster than the recovery *** also calculate the entanglement change caused by the anti-Unruh effect and found that the lost entanglement could just be recovered part by the anti-Unruh effect,and the anti-Unruh effect could only appear for a finite range of acceleration when the interaction time scale is approximately shorter than the reciprocal of the energy gap in two dimensional *** limit case of zero acceleration is also investigated,which gives an analytical interpretation for the increase or recovery of entanglement.

关键词： entanglement acceleration high-dimensional spacetime

Is there a place for endoscopic management in postcholecystectomy iatrogenic bile duct injuries?

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1218-1222页

作者： Hong-qiao cai Guo-Qiang Pan Shou-Jing Luan Jing Wang yan Jiao Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of General Surgery Qilu HospitalShandong UniversityJinan 250000Shandong ProvinceChina Department of Endocrinology and Metabolism Weifang People’s HospitalWeifang 261041Shandong ProvinceChina Shandong Medical College Jinan 250000Shandong ProvinceChina

In this editorial we comment on the article by Emara et al published in the recent issue of the World Journal of Gastrointestinal ***,surgery was the primary treatment for bile duct injuries(BDI).The treatment of BDI has advanced due to technological breakthroughs and minimally invasive *** and percutaneous treatments have largely supplanted surgery as the primary treatment for most instances in recent *** management,including the specific technique,is typically impacted by local knowledge and the kind and severity of the *** therapy is a highly successful treatment for postoperative benign bile duct stenosis and offers superior long-term outcomes compared to surgical *** on the damage features of BDI,therapeutic options include endoscopic duodenal papillary sphincterotomy,endoscopic nasobiliary drainage,and endoscopic biliary stent implantation.

关键词： Post-cholecystectomy Iatrogenic Bile duct injuries Endoscopic management Benign bile duct stenosis