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Anorectal malignant melanomas: Retrospective experience with surgical management

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World Journal of Gastroenterology 2011年第4期17卷 534-539页

作者： Xu Che Dong-Bing Zhao yong-Kai Wu Cheng-Feng Wang Jian-Qiang cai yong-Fu Shao ping Zhao Department of Abdominal Surgical Oncology Cancer Hospital Chinese Academy of Medical Sciences and Peking Union MedicalCollege Beijing 100021 China

AIM: To present the experience and outcomes of the surgical treatment for the patients with anorectal melanoma from the Cancer Hospital, Chinese Academy of Medical Sciences. METHODS: Medical records of the diagnosis, surgery, and follow-up of 56 patients with anorectal melanoma who underwent surgery between 1975 and 2008 were retrospectively reviewed. The factors predictive for the survival rate of these patients were identified using multivariate analysis. RESULTS: The 5-year survival rate of the 56 patients with anorectal melanoma was 20%, 36 patients underwent abdominoperineal resection (APR) and 20 patients underwent wide local excision (WLE). The rates of local recurrence of the APR and WLE groups were 16.13% (5/36) and 68.75% (13/20), (P = 0.001), and the median survival time was 22 mo and 21 mo, respectively (P = 0.481). Univariate survival analysis demonstrated that the number of tumor and the depth of invasion had significant effects on the survival (P < 0.05). Multivariate analysis showed that the number of tumor [P = 0.017, 95% confidence interval (CI) = 1.273-11.075] and the depth of invasion (P = 0.015, 95% CI = 1.249-7.591) were independent prognostic factors influencing the survival rate. CONCLUSION: Complete or R0 resection is the first choice of treatment for anorectal melanoma, prognosis is poor regardless of surgical approach, and early diagnosis is the key to improved survival rate for patients with anorectal melanoma.

关键词： Anorectal melanomas Prognostic factors Surgical management Survival rate

Genetic variation in LBL1 contributes to depth of leaf blades lobes between cotton subspecies, Gossypium barbadense and Gossypium hirsutum

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Journal of Integrative Agriculture 2018年第11期17卷 2394-2404页

作者： HE Dao-fang ZHAO Xiang LIANG Cheng-zhen ZHU Tao Muhammad Ali Abid cai yong-ping HE Jin-ling ZHANG Rui School of Life Science Anhui Agricultural University Biotechnology Research Institute Chinese Academy of Agricultural Sciences

Leaf is a essential part of the plants for photosynthetic activities which mainly economize the resources for boll heath. Significant variations of leaf shapes across the Gossypium sp. considerably influence the infiltration of sunlight for photosynthesis. To understand the genetic variants and molecular processes underlying for cotton leaf shape, we used F2 population derived from upland cotton genotype P30A （shallow-lobed leaf） and sea-island cotton genotype ISR （deep-lobed leaf） to map leaf deep lobed phenotype controlling genes LBL1 and LBL2. Genetic analysis and localization results have unmasked the position and interaction between both loci of LBL1 and LBL2, and revealed the co-dominance impact of the genes in regulating depth of leaf blades lobes in cotton. LBL1 had been described as a main gene and member of transcription factor family leucine zipper （HD-ZIPI） from a class I homologous domain factor ***2G244000. The qRT-PCR results elaborated the continuous change in expression level of LBL1 at different growth stages and leaf parts of cotton. Higher expression level was observed in mature large leaves followed by medium and young leaves respectively. For further confirmation, plants were tested from hormonal induction treatments, which explained that LBL 1 expression was influenced by hormonal signaling. Moreover, the highest expression level was detected in brassinolides （BR） treatment as compared to other hormones, and this hormone plays an important role in the process of leaf blade lobed formation.

关键词： leaf blades lobes HD-ZIPI LBL1 cotton Gossypium barbadense Gossypium hirsutum

Combinatorial reasoning-based abnormal sensor recognition method for subsea production control system

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Petroleum Science 2024年第4期21卷 2758-2768页

作者： Rui Zhang Bao-ping cai Chao Yang Yu-Ming Zhou yong-Hong Liu Xin-Yang Qi College of Mechanical and Electronic Engineering China University of Petroleum BGP Inc. China National Petroleum Corporation

The subsea production system is a vital equipment for offshore oil and gas production. The control system is one of the most important parts of it. Collecting and processing the signals of subsea sensors is the only way to judge whether the subsea production control system is normal. However, subsea sensors degrade rapidly due to harsh working environments and long service time. This leads to frequent false alarm incidents. A combinatorial reasoning-based abnormal sensor recognition method for subsea production control system is proposed. A combinatorial algorithm is proposed to group sensors. The long short-term memory network(LSTM) is used to establish a single inference model. A counting-based judging method is proposed to identify abnormal sensors. Field data from an offshore platform in the South China Sea is used to demonstrate the effect of the proposed method. The results show that the proposed method can identify the abnormal sensors effectively.

关键词： Abnormal sensor Combinatorial algorithm Fault identification Subsea production control system

Effect of Artificial Electric Field Surface by Wave-Driven Triboelectricity on Anti-Bioadhesion for Riser Protection

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China Ocean Engineering 2024年第3期38卷 483-490页

作者： YI Peng QIU Hong-yuan LI yong cai Bao-ping Javad MOSTAGHIMI ZHANGWen-jie XIAO Wen-sheng College of Mechanical and Electrical Engineering China University of PetroleumQingdao 266580China CNOOC EnerTech Equipment Technology Co. Ltd.Tianjin 300450China Department of Mechanical&Industrial Engineering University of TorontoToronto ONM5S3G8Canada

Biofouling has been a persistent problem in marine riser system, resulting in energy waste and equipment damage. Inthis study, a kind of water wave-driven contact-mode flexible triboelectric nanogeneration has been prepared byusing graphene-doped PDMS as dielectric friction material. When the graphene content is 2%, the average outputvoltage can reach 46 V under the contact frequency 10 Hz. The flexible triboelectric nanogeneration encapsulationmodule is impinged by water waves to generate alternating microelectric field on the riser surface and destroy theadhesion conditions of microorganisms during the biofilm stage. In the biofouling experiments at different stages, thebiofouling area of the platymonas subcordiformis has been reduced by 53%, 62% and 61%. It provides a new ideafor effective treatment of biofouling of mussels, oysters and barnacles attached to risers.

关键词： wave-drive triboelectric nanogeneration alternating microelectric field anti-biofouling

Prognostic Factors of Gastrointestinal Stromal Tumors： A Single Institutional Retrospective Experience with Surgical Management over 20 Years

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Clinical oncology and cancer researeh 2010年第3期7卷 175-180页

作者： yong-kai WU Dong-bing ZHAO Cheng-feng WANG Jian-qiang cai yong-fu SHAO ping ZHAO Department of Abdominal Surgical Oncology Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China.

OBJECTIVE To analyze the pathological features and prognosis factors of gastrointestinal stromal tumor （GIST） after primary resection. METHODS Medical records of the diagnosis, surgery, and follow-up of 327 patients with GISTs who underwent surgery between 1988 and 2007 were retrospectively reviewed. The predic-tive factors for the survival of these patients were identi. ed using multivariate analysis. RESULTS In the 327 tumors, 152 （46.5%） were located in the stomach, 89 （27.2%） in the small intestine, 33 （10.1%） in the colon and rectum, and 43 （13.1%） in other sites including the omentum and mesentery. The 3-year and 5-year overall survival rates of the 327 GIST patients were 74.4% and 62.7%, respectively, and univariate survival analysis demonstrated that factors, such as tumor size, mitotic index, NIH categories, Ki-67 index, tumor location, surgical margins, tumor bleeding, and tumor necrosis have significant effect on survival of the patients （P 〈 0.05）. Multivariate analysis demonstrated that the NIH categories, surgical margins, and Ki-67 index were independent prognostic factors for the survival rate. In the group of patients with postoperative recurrence or metastasis, the median survival time of patients who did not receive imatinib treatment was 30 months and that of patients who received imatinib treatment was 59 months. Their 5-year survival rates were 16.4% and 39.4%, respectively, and the difference was statistically significant （P = 0.017）. CONCLUSION Complete resection is the .rst choice of treat-ment for GISTs. It is reasonable to evaluate the prognosis of resect-able GISTs and guide the adjunctive therapy with NIH categories and Ki-67 index. Imatinib treatment can *** increase the survival rate of patients with recurrent and metastatic GISTs.

关键词： gastrointestinal stromal tumors prognostic factors surgical management survival adjuvant therapy

Supramolecular polymer-based gel fracturing fluid with a double network applied in ultra-deep hydraulic fracturing

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Petroleum Science 2024年第3期21卷 1875-1888页

作者： yong-ping Huang yong Hu Chang-Long Liu Yi-Ning Wu Chen-Wei Zou Li-Yuan Zhang Ming-Wei Zhao cai-Li Dai School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China Shandong Key Laboratory of Oilfield Chemistry China University of Petroleum(East China)Qingdao 266580ShandongPR China SINOPEC Petroleum Exploration and Production Research Institute Beijing102206PR China CNOOC China Co Ltd Tianjin BranchTianjin300459PR China

A gel based on polyacrylamide,exhibiting delayed crosslinking characteristics,emerges as the preferred solution for mitigating degradation under conditions of high temperature and extended shear in ultralong *** viscosity/viscoelasticity of the fracturing fluid was required to maintain excellent proppant suspension properties before *** into account both the cost and the potential damage to reservoirs,polymers with lower concentrations and molecular weights are generally *** this work,the supramolecular action was integrated into the polymer,resulting in significant increases in the viscosity and viscoelasticity of the synthesized supramolecular polymer *** double network gel,which is formed by the combination of the supramolecular polymer system and a small quantity of Zr-crosslinker,effectively resists temperature while minimizing permeability damage to the *** results indicate that the supramolecular polymer system with a molecular weight of(268—380)×10^(4)g/mol can achieve the same viscosity and viscoelasticity at 0.4 wt%due to the supramolecular interaction between polymers,compared to the 0.6 wt%traditional polymer(hydrolyzed polyacrylamide,molecular weight of 1078×10^(4)g/mol).The supramolecular polymer system possessed excellent proppant suspension properties with a 0.55 cm/min sedimentation rate at 0.4 wt%,whereas the0.6 wt%traditional polymer had a rate of 0.57 cm/*** comparison to the traditional gel with a Zrcrosslinker concentration of 0.6 wt%and an elastic modulus of 7.77 Pa,the double network gel with a higher elastic modulus(9.00 Pa)could be formed only at 0.1 wt%Zr-crosslinker,which greatly reduced the amount of residue of the fluid after *** viscosity of the double network gel was66 m Pa s after 2 h shearing,whereas the traditional gel only reached 27 m Pa s.

关键词： Ultra-deep reservoir Gel fracturing fluid Double network Supramolecular polymer system Proppant suspension property

Heterointerface Engineering-Induced Oxygen Defects for the Manganese Dissolution Inhibition in Aqueous Zinc Ion Batteries

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Energy & Environmental Materials 2024年第3期7卷 112-122页

作者： Wentao Qu yong cai Baohui Chen Ming Zhang Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics&Devices School of Physics and ElectronicsHunan UniversityChangsha 410082China Engineering Research Center of Advanced Semiconductor Technology and Application of Ministry of Education&Key Laboratory for Micro-/Nano-Optoelectronic Devices of Ministry of Education College of Semiconductors(College of Integrated Circuits)Hunan UniversityChangsha 410082China Changsha Semiconductor Technology and Application Innovation Research Institute College of Semiconductors(College of Integrated Circuits)Hunan UniversityChangsha 410082China State Key Laboratory of Disaster Prevention&Reduction for Power Grid Transmission and Distribution Equipment(Hunan Electric Power Corporation Disaster Prevention and Reduction Center) Changsha 410007China

Manganese-based material is a prospective cathode material for aqueous zinc ion batteries(ZIBs)by virtue of its high theoretical capacity,high operating voltage,and low ***,the manganese dissolution during the electrochemical reaction causes its electrochemical cycling stability to be *** this work,heterointerface engineering-induced oxygen defects are introduced into heterostructure MnO_(2)(δa-MnO_(2))by in situ electrochemical activation to inhibit manganese dissolution for aqueous zinc ion ***,the heterointerface between the disordered amorphous and the crystalline MnO_(2)ofδa-MnO_(2)is decisive for the formation of oxygen *** the experimental results indicate that the manganese dissolution ofδa-MnO_(2)is considerably inhibited during the charge/discharge *** analysis indicates that the oxygen defect regulates the electronic and band structure and the Mn-O bonding state of the electrode material,thereby promoting electron transport kinetics as well as inhibiting Mn ***,the capacity ofδa-MnO_(2)does not degrade after 100 cycles at a current density of 0.5 Ag^(-1)and also 91%capacity retention after 500cycles at 1 Ag^(-1).This study provides a promising insight into the development of high-performance manganese-based cathode materials through a facile and low-cost strategy.

关键词： electrochemical activation heterointerface manganese dissolution inhibition oxygen defects zinc ion batteries

Remaining Useful Life Prediction Method for Multi-Component System Considering Maintenance:Subsea Christmas Tree System as A Case Study

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China Ocean Engineering 2024年第2期38卷 198-209页

作者： WU Qi-bing cai Bao-ping FAN Hong-yan WANG Guan-nan RAO Xi GE Weifeng SHAO Xiao-yan LIU yong-hong CNOOC Safety Technology Services Co. Ltd.Tianjin 300456China College of Mechanical and Electronic Engineering China University of PetroleumQingdao 266580China CNOOC EnerTech Safety&Environmental Protection BranchTianjin 300456China

Maintenance is an important technical measure to maintain and restore the performance status of equipment and ensure the safety of the production process in industrial production,and is an indispensable part of prediction and health ***,most of the existing remaining useful life(RUL)prediction methods assume that there is no maintenance or only perfect maintenance during the whole life cycle;thus,the predicted RUL value of the system is obviously lower than its actual operating *** complex environment of the system further increases the difficulty of maintenance,and its maintenance nodes and maintenance degree are limited by the construction period and working conditions,which increases the difficulty of RUL *** RUL prediction method for a multi-omponent system based on the Wiener process considering maintenance is *** performance degradation model of components is established by a dynamic Bayesian network as the initial model,which solves the uncertainty of insufficient data *** on the experience of experts,the degree of degradation is divided according to Poisson process simulation random failure,and different maintenance strategies are used to estimate a variety of condition maintenance *** example of a subsea tree system is given to verify the effectiveness of the proposed method.

关键词： remaining useful life Wiener process dynamic Bayesian networks maintenance subsea Christmas tree system

Design and performance evaluation of a large field-of-view dual-particle time-encoded imager based on a depth-of-interaction detector

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Nuclear Science and Techniques 2024年第4期35卷 1-14页

作者： Dong Zhao Xu-Wen Liang ping-Kun cai Wei Cheng Wen-Bao Jia Da-Qian Hei Qing Shan yong-Sheng Ling Chao Shi Department of Nuclear Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Suzhou 215000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

Time-encoded imaging is useful for identifying potential special nuclear materials and other radioactive sources at a *** this study,a large field-of-view time-encoded imager was developed for gamma-ray and neutron source hotspot imaging based on a depth-of-interaction(DOI)*** imager primarily consists of a DOI detector system and a rotary dual-layer cylindrical coded *** EJ276 plastic scintillator coupled with two SiPMs was designed as the DOI detector to increase the field of view and improve the imager *** difference in signal time at both ends and the log of the signal amplitude ratio were used to calculate the interaction position *** position resolution of the DOI detector was calibrated using a collimated Cs-137 source,and the full width at half maximum of the reconstruction position of the Gaussian fitting curve was approximately 4.4 *** DOI detector can be arbitrarily divided into several units to independently reconstruct the source distribution *** unit length was optimized via Am-Be source-location experiments.A multidetector filtering method is proposed for image *** method can effectively reduce image noise caused by poor DOI detector position *** vertical field of view of the imager was(-55°,55°)when the detector was placed in the center of the coded mask.A DT neutron source at 20 m standoff could be located within 2400 s with an angular resolution of 3.5°.

关键词： Time-encoded imager Depth-of-interaction detector Dual-particle imaging Hotspot imaging