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肾髓质过表达鞘氨醇1-磷酸受体1转基因可减轻醋酸脱氧皮质酮-盐诱导的高血压

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中华高血压杂志(中英文) 2024年第8期 800-800页

作者： Hu G Xie DP chen c Wang WL Li PL Ritter JK Li NJ 袁源练桂丽

前期研究表明,肾髓质鞘氨醇1-磷酸受体1(sphingosine-1-phosphate receptor 1,S1PR1)介导钠排泄,高盐摄入可增加S1PR1水平,醋酸脱氧皮质酮(deoxycorticosterone acetate,DOcA)可阻断高盐诱导的肾髓质S1PR1,在集合管中敲除S1PR1可加重DOcA盐诱导的高血压。该研究验证在肾髓质中过表达S1PR1基因是否可减轻DOcA-盐小鼠模型的钠潴留和高血压。方法:给雄性c57BL/6J小鼠肾髓质转染对照或表达S1PR1的质粒后予DOcA-盐处理。

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Decoupling path-scattering of light in a homogeneous layer and multiple bouncing at its non-Lambertian bottom

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Science china(Technological Sciences) 1996年第6期39卷 656-669页

作者：李小文倪文革胡宝新 c.Woodcock A.Strahler Institute of Remote Sensing Application chinese Academy of Sciences Beijing 100101.China Department of Geography an center for Remote Sensing Boston University 725 commonwealth Avenue.Boston.MA 02215.USA

Radiative transfer theories are usually used to calculate light transmitted and reflected on a layer of homogeneous *** if the layer has limited optical thickness and a non-Lamhertian lower bound,the multiple bouncing between the layer and the lower bound will be coupled with the multiple scattering within the layer,thus making the solution very *** atmospheric correction for FOS MODIS MISR BRDF product and modeling shortwave absorption of snow under forest canopies,it is found that two complicated and apparently different cases can he handled similarly by decoupling the problem into two simpler and more basic formulations.i.e anahtical approximations ot path scattering i.e assuming a perfect absorbing lower bound: and the multiple bouncing between the layer and ils non-Lamhertian lower bound.

关键词： remote sensing of vegetation radiative transfer multiple scattering. multiple

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Skeletal muscle mitochondrial health and spinal cord injury

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世界骨科杂志：英文版 2016年第10期7卷 628-637页

作者： Laura c O'Brien Ashraf S Gorgey Spinal cord Injury and Disorders Service Hunter Holmes McGuire VA Medical Center Department of Physiology and Biophysics Virginia Commonwealth University Department of Physical Medicine and Rehabilitation Virginia Commonwealth University

Mitochondria are the main source of cellular energy production and are dynamic organelles that undergo biogenesis, remodeling, and degradation. Mitochondrial dysfunction is observed in a number of disease states including acute and chronic central or peripheral nervous system injury by traumatic brain injury, spinal cord injury(ScI), and neurodegenerative disease as well as in metabolic disturbances such as insulin resistance, type Ⅱ diabetes and obesity. Mitochondrial dysfunction is most commonly observed in high energy requiring tissues like the brain and skeletal muscle. In persons with chronic ScI, changes to skeletal muscle may include remarkable atrophy and conversion of muscle fiber type from oxidative to fast glycolytic, combined with increased infiltration of intramuscular adipose tissue. These changes contribute to a proinflammatory environment, glucose intolerance and insulin resistance. The loss of metabolically active muscle combined with inactivity predisposes individuals with ScI to type Ⅱ diabetes and obesity. The contribution of skeletal muscle mitochondrial density and electron transport chain activity to the development of the aforementioned comorbidities following ScI is unclear. A better understanding of the mechanisms involved in skeletal muscle mitochondrial dynamics is imperative to designing and testing effective treatments for this growing population. The current editorial will review ways to study mitochondrial function and the importance of improving skeletal muscle mitochondrial health in clinical populations with a special focus on chronic ScI.

关键词： Mitochondria Spinal cord injuries Body composition Diabetes mellitus Obesity Metabolism

肠易激综合征患者与健康对照者的直肠疼痛及内源性镇痛机制激活的脑部磁共振功能成像比较

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世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 35-36页

作者： Wilder-smith c.H. Schindler D. Lovblad K. 雒向宁 Brain-Gut Research Group Bubenbergplatz 11 CH-3011 Berne SwitzerlandDr.

Background and aims: Many patients with irritable bowel syndrome (IBS) show in testinal hypersensitivity to distension and sensitisation after repeated intestinal distensions. Abnormalities in endogenous pain inhibitory mechanisms, such as diffuse noxious inhibitory controls (DNIc), may be implicated and were investig ated during brain functional magnetic resonance imaging (fMRI). Patients and methods: fMRI was performed in 10 female patients with IBS (five constipated (IBS-c) and five with diarrhoea (IBS-D)) and 10 female healthy controls during rectal balloon distension alone or during activation of DNIc by painful heterotopic stimulation of the foot with ice water. Rectal pain was scored with and without heterotopic stimulation (0 = none, 10 = maximal). Results: Heterotopic stimulation decreased median rectal pain scores significantly in healthy controls (-1.5 ( interquartile range -2 to -1); p = 0.001) but not in IBS-c (-0.7 (-1 to 0.5 )), IBS-D (-0.5 (-1.5 to 0.5)), or in all IBS patients (0 (-1.5 to 1.3)). Brain activation changes during heterotopic stimulation differed highly significan tly between IBS-c, IBS-D, and controls. The main centres affected were the amy gdala, anterior cingulate cortex, hippocampus, insula, periaqueductal gray, and prefrontal cortex, which form part of the matrix controlling emotional, autonomic, and descending modulatory responses to pain. conclusions: IBS-c and IBS-D appear to have differing abnormal endogenous pain inhibitory mechanisms, involving DNIc and other supraspinal modulatory pathways.

关键词：肠易激综合征磁共振功能成像镇痛机制内源便秘型前扣带回腹泻型弥漫性前额叶皮质调节反应

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Recent experimental progress of fractional quantum Hall effect: 5/2 illing state and graphene

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National Science Review 2014年第4期1卷 564-579页

作者： X.Lin R.R.Du X.c.Xie International center for Quantum Materials Peking University

The phenomenon of fractional quantum Hall efect(FQHE)was irst experimentally observed 33 years *** involves strong coulomb interactions and correlations among the electrons,which leads to quasiparticles with fractional elementary *** decades later,the ield of FQHE is still active with new discoveries and new technical developments.A signiicant portion of atention in FQHE has been dedicated to illing factor 5/2 state,for its unusual even denominator and possible application in topological quantum ***,FQHE has been observed in high-mobility Ga As heterostructure,but new materials such as graphene also open up a new area for *** review focuses on recent progress of FQHE at 5/2 state and FQHE in graphene.

关键词： fractional quantum Hall efect experimental progress 5/2 state graphene

Intraocular inflammation after Ultrasound cyclo Plasty for the treatment of glaucoma

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 338-341页

作者： Marco Pellegrini Stefano Sebastiani Giuseppe Giannaccare Emilio c.campos Ophthalmology Unit S.Orsola-Malpighi University Hospital DIMES University of Bologna

This is a prospective interventional clinical study evaluating intraocular inflammation developed after Ultrasound cyclo Plasty(UcP) for the treatment of glaucoma. Eighteen eyes of 18 patients were treated with UcP second-generation probes(Eye OP1). After treatment, the mean intraocular pressure(IOP) significantly decreased from 26.8±7.2 to 18.8±6.1 mm Hg at day 1 and to 14.7±3.4 mm Hg at month 6(all Pcell photometry value steeply increased after surgery from 12.1±7.5 to 64.1±53.9 ph/ms(P=0.001) at day 1, and then progressively decreased to respectively 60.6±49.7 at day 7, 43.5±38.5 at day 14 and 28.2±18.3 at month 1(all Pctively 16.7±6.2 and 12.8±10.2, both P>0.05). A significant negative correlation was found between postoperative increase of aqueous flare values and anterior chamber depth(R=-0.568, P=0.014). This timeframe may be considered reasonable for repeating UcP treatment, when required.

关键词： Ultrasound cyclo Plasty glaucoma intraocular pressure ciliary body intraocular inflammation laser flare-cell photometry

A　BRANcH-AND-PRIcE　ALGORITHM　FOR　SOLVING　THE　cUTTING　STRIPS　PROBLEM

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Applied Mathematics(A Journal of chinese Universities) 1997年第2期12卷 215-224页

作者： cHENZHIPING c.A.J.HURKENS J.L.DEJONG DepantmeatofMathematicsandcomputingSciences EindhovenUniversityofTechnologyTheNertherlands. DepartmentofMathematicsandcomputingSciences EindhovenUniversityofTechnologyTheNertherlands. DepartmeatofMathematics Xi＇anJiaotongUniversityXi＇an710049.

After giving a suitable model for the cutting strips problem, we present a branch and price algorithm for it by combining the column generation technique and the branch and bound method with LP relaxations. Some theoretical issues and implementation details about the algorithm are discussed, including the solution of the pricing subproblem, the quality of LP relaxations, the branching scheme as well as the column management. Finally, preliminary computational experience is reported.

关键词： cutting strips problem column generation branch-and-bound

A Boundary Meshless Method for Solving Heat Transfer Problems Using the Fourier Transform

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Advances in Applied Mathematics and Mechanics 2011年第5期3卷 572-585页

作者： A.Tadeu c.S.chen J.Antonio Nuno Simoes Department of civil Engineering Faculty of Sciences and TechnologyUniversity of CoimbraPolo II-Pinhal de Marrocos3030-290 CoimbraPortugal Department of Mathematics University of Southern MississippiHattiesburgMS 39406USA

Fourier transform is applied to remove the time-dependent variable in the diffusion *** non-harmonic initial conditions this gives rise to a non-homogeneous Helmholtz equation,which is solved by the method of fundamental solutions and the method of particular *** particular solution of Helmholtz equation is available as shown in[4,15].The approximate solution in frequency domain is then inverted numerically using the inverse Fourier transform *** frequencies are used in order to avoid aliasing phenomena and to allow the computation of the static *** numerical examples are given to illustrate the effectiveness of the proposed approach for solving 2-D diffusion equations.

关键词： Transient heat transfer meshless methods method of particular solutions method of fundamental solutions frequency domain Fourier transform

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Dc总线转换器提升了系统电源管理性能

今日电子 2003年第6期 43-45页

作者： carl smith 国际整流器公司

借助一种新型Dc总线转换器拓扑结构,一个优化芯片组可在效率高于96%的情况下提供150W的输出功率.针对两级分布式电源架构中的第一级,该拓扑结构将电压从48V转换为8V(标称值).

关键词： Dc总线转换器电源管理两级分布式电源架构 DPA 控制器Ic 演示板 DirectFET封装

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