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Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 117-134页

作者： Mahavir singh suresh c Tyagi Eye and Vision science Laboratory Department of Physiology University of Louisville School of Medicine

Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our eyes. Based on these findings, it is becoming clear that an early diagnosis employing genetic testing can help evaluate patients＇ conditions for instituting treatment plan（s） and follow-up care to avoid vision complications later. For example, knowing family history becomes crucial for inherited eye diseases as it can benefit members in family who may have similar eye diseases or predispositions. Therefore, gathering information from an elaborate examination along with complete assessment of past medical illness by ophthalmologists followed by consultation with geneticists can help create a roadmap for making diagnosis and treatment precise and beneficial. In this review, we present an update on ocular genomic medicine that we believe has tremendous potential towards unraveling genetic implications in ocular diseases and patients＇ susceptibilities. We also discuss translational aspects of genetic ophthalmology and genome engineering that may help advance molecular diagnostics and therapeutics.

关键词： cRIsPR/cas9 precision medicine genetic ophthalmology genome engineering inflammation single nucleotide polymorphism

Is the type of insufflation a key issue in gastro-intestinal endoscopy?

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World Journal of Gastroenterology 2014年第9期20卷 2193-2199页

作者： Amy c Lord stefan Riss Department of General surgery Basingstoke and North Hampshire Hospital Basingstoke Hampshire RG24 9NA United Kingdom Department of General surgery Medical University of Vienna A-1090 Vienna Austria

Endoscopic procedures continue to play an emerging role in diagnosing and treating upper and lower gastrointestinal (GI) disorders. In particular, the introduction of colonoscopy in bowel cancer screening has underlined its promising role in decreasing the incidence of colorectal cancer and reducing tumour related mortality. To achieve these goals patients need to contemplate endoscopic examinations as painless and fearless procedures. The use of carbon dioxide (cOsub>2sub>) as an alternative insufflation gas in comparison to air has been considered as an essential key to improving patients’ acceptance in undergoing endoscopic procedures. cOsub>2sub> is absorbed quickly through the bowel mucosa causing less luminal distension and potentially less abdominal pain. However, its exact role has not been defined completely. In particular, the beneficial use of cOsub>2sub> in upper GI endoscopy and in sedated patients is still conflicting. In the present review, we aimed to assess the current evidence for using cOsub>2sub> in endoscopy and to evaluate its potential role in the future.

关键词： Gastrointestinal endoscopy colonoscopy Endoscopic retrograde cholangiopancreatography Insufflation gas carbon dioxide

Motor speed estimation and failure detection of a small UAV using density of maxima

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Frontiers of Information Technology & Electronic Engineering 2021年第7期22卷 1002-1009页

作者： Jefferson s.sOUZA Moises c.BEZERRIL Mateus A.sILVA Frank c.VERAs Abel LIMA-FILHO Jorge Gabriel RAMOs Alisson V.BRITO Laboratory of system Engineering and Robotics Federal University of ParaibaJoao PessoaBrazil Department of Information systems Federal University of PiauiPicosBrazil Department of Mechanical Engineering Federal University of ParaibaJoao PessoaBrazil Department of Physics Federal University of ParaibaJoao PessoaBrazil

This work presents the application of the technique named signal analysis based on chaos using density of maxima to analyze brushless direct current *** uses a correlation coefficient estimated from the density of maxima of the current *** study demonstrates in experiments the speed estimation of a brushless motor on a testbench and failure detection in a small flying *** experimental results demonstrate that it is possible to estimate the speed in 97.8%of the cases and to detect failure in 82.75%of the analyzed cases.

关键词： Unmanned aerial vehicle(UAV) speed identification Failure detection chaos

sOME NEW cLAssEs OF ALMOsT PERIODIc FUNcTIONs

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chinese Annals of Mathematics,series B 1989年第2期10卷 200-213页

作者： c.J.F.UPTON University of Melbourne Parkville Victoria 3052 Australia

In this paper classes of almost periodic functions are formed whlch lie between those established by W. stepanoff and by H. Burkill.

关键词： cLAssEs everywhere adding proof whenever 妇功 false apply Lebesgue 即夕

The evolution of plant reproductive ecology in china

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Journal of Plant Ecology 2015年第2期8卷 101-108页

作者： spencer c.H.Barrett Department of Ecology and Evolutionary Biology University of TorontoTorontoOntario M5S 3B2Canada

scientific interest in plant reproduction has a long and venerable history going back to early European naturalists including carl Linnaeus,christian Konrad sprengel,Joseph Kölreuter,Fritz and Hermann Müller,George Henslow and of course,charles *** can be considered the founder of modern plant reproductive *** three books(Darwin 1862,1876,1877)laid the conceptual foundation for the field,and many of the ideas they contain are still topics of active research(reviewed in Barrett 2010).The turn of the 20th century saw the rediscovery of Mendel’s Laws and breeding experiments on flowering plants played an important role in establishing many key elements of modern *** the 1940s,Fisher had developed the population genetic principles for theoretical analysis of the evolution of plant mating systems(Fisher 1941)。

关键词： reproductive plant evolution

A review of friction stir welding of steels： Tool, material flow, microstructure, and properties

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Journal of Materials science & Technology 2018年第1期34卷 39-57页

作者： F.c. Liu Y. Hovanski M.P. Miles c.D. sorensen T.W. Nelson Department of Mechanical Engineering Brigham Young University Provo UT 84602. USA Manufacturing Engineering Technology Brigham Young University Provo UT 84602 USA

considerable progress has been achieved in friction stir welding （FsW） of steels in every aspect of tool fab- rication, microstructure control and properties evaluation in the past two decades. With the development of reliable welding tools and precise control systems, FsW of steels has reached a new level of technical maturity. High-quality, long welds can be produced in many engineering steels. compared to traditional fusion welding, FsW exhibits unique advantages producing joints with better properties. As a result of active control of the welding temperature and/or cooling rate, FsW has the capability of fabricating steel joints with excellent toughness and strength. For example, unfavorable phase transformations that usu- ally occur during traditional welding can be avoided and favorable phase fractions in advanced steels can be maintained in the weld zone thus avoiding the typical property degradations associated with fusion welding. If phase transformations do occur during FsW of thick steels, optimization of microstructure and properties can be attained by controlling the heat input and post-weld cooling rate.

关键词： Joining stainless steels carbon steels High strength low alloy (HsLA) steels Advanced high strength steels (AHss) Oxide dispersion strengthened (ODs) steels

Metalloproteinases as mediators of inflammation and the eyes： molecular genetic underpinnings governing ocular pathophysiology

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1308-1318页

作者： Mahavir singh suresh c Tyagi Eye and Vision science Laboratory Department of Physiology University of Louisville School of Medicine Louisville KY 40202 USA

There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases （MMPs）; the Zn （2＋）-dependent endoproteases in eye health along with pathogenesis of prominent ocular diseases such as macular degeneration, diabetic retinopathy, and glaucoma via understanding MMPs regulation in affected patients, interactions of MMPs with their substrate molecules, and key regulatory functions of tissue inhibitor of metalloproteinases （TIMPs） towards maintaining overall homeostasis.

关键词： age-related macular degeneration choroidal neovascularization diabetes glaucoma metalloproteinases tissue inhibitors of metalloproteinases

Prosthetic and orthotic options for lower extremity amputation and reconstruction

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Plastic and Aesthetic Research 2019年第2期6卷 8-22页

作者： christopher s.crowe Kate A.Impastato Alex c.Donaghy caryn Earl Janna L.Friedly Kari A.Keys Division of Plastic and Reconstructive surgery Department of SurgeryUniversity of Washington School of MedicineSeattleWA 98104USA Department of Rehabilitation Medicine University of Washington School of MedicineSeattleWA 98104USA Prosthetics and Orthotics clinic Harborview Medical CenterSeattleWA 98109USA

Lower extremity injury and deformity can result from a number of etiologies. Regardless of the underlying cause, the decision to pursue amputation or reconstruction of a lower limb is challenging for both patients and *** decision is largely dependent on the patient's premorbid health and function, functional goals and preferences,and characteristics and viability of the affected limb. The role of adaptive devices following surgery should never be underestimated. Advances in prostheses and orthoses have provided patients with a wider range of options to consider when deciding between limb reconstruction and amputation. The primary goals of any adaptive device are to improve function, prevent recurrence or ulceration of the defect, and allow for use of conventional footwear and/or *** a lower extremity amputation is indicated, selection of the correct level is of critical importance in order to optimize healing potential and function. Each distinct level has certain inherent prosthetic and orthotic considerations. Likewise,the application of an adaptive device following reconstruction of the lower extremity also has demonstrable benefits and must be tailored to the specific defect and procedure performed. Knowledge of available prosthetic and orthotic options is of considerable importance for the reconstructive surgeon tasked with limb salvage or resurfacing an amputated extremity. This article reviews considerations of various types of lower extremity amputation and reconstruction, and provides a framework for the role of adaptive devices following surgery.

关键词： Prosthesis orthosis amputation reconstruction rehabilitation lower extremity

spray granulation of Fe and c nanoparticles and their impedance match for microwave absorption

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Journal of Materials science & Technology 2018年第3期34卷 496-502页

作者： H.Huang Y.Gao c.F.Fang A.M.Wu X.L.Dong B.s.Kim J.H.Byun G.F.Zhang D.Y.Zhou Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian116024China composites Research Division Korea Institute of Materials Science797 Changwon-daeroSeongsan-guChangwonGyeongnam642-831Republic of Korea

The microwave absorbents of Fe and c nanoparticles as magnetic loss and dielectric loss material respectively were composited with the polyvinyl alcohol （PVA） as binder by spray granulation method, The electromagnetic parameters of Fe and c composite particles were analyzed by vector network. The complex permittivity and magnetic permeability of Fe and c composite particles matched well with increasing c nanoparticle content, and then the microwave loss property was improved. A minimum reflection loss （RL） of -42.7 dB at 3.68 GHz for a composite with 4.6 mm in thickness can be obtained when the content ratio of the c nanoparticles, the modified Fe nanoparticles and the PVA is 21：49：30 （sample 3）.

关键词： Dielectric loss Magnetic loss spray granulation method Impedance match