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动脉壁功能与结构的遗传度:Erasmus Rucphen家族(ERF)研究的结果

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世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 46-47页

作者： Sayed-Tabatabaei F.A. van Rijn m.J.E. Schut A.F.c. c.m. van duijn 高宗恩 Department of Epidemiology and Biostatistics Erasmus Medical Centre Postbus 1738 3000 DR Rotterdam Netherlands

Background and Purpose -Using 930 individuals connected in a single pedigree from an isolated population, participants of the Erasmus Rucphen Family (ERF) study, we investigated the heritability of carotid-femoral pulse wave velocity (PWV), carotid intima media thickness (ImT), and carotid plaque score. methods -PWV was measured between the carotid and femoral arteries as an indicator of aortic stiffness. c.m.on carotid ImT and plaque score, quantifying alterations in arterial wall structure, were measured by ultrasonography. Results -All 3 traits were significantly associated with classic cardiovascular risk factors. Age-and gender-adjusted heritability estimates were 0.36 for PWV, 0.41 for carotid ImT, and 0.28 for plaque score. After adjustment for appropriate risk factors, the heritabilities were 0.26, 0.35, and 0.21 for PWV, ImT, and plaque score, respectively. All heritability estimates were statistically significant (P ccount different proportions of variance associated with covariates for each trait, genetic factors explained ≈12%of the total variability for each of the pheno types. conclusions -To our knowledge, this is the first report on the heritabi lity of PWV. The heritability estimates of ImT and plaque score were similar to those in previous reports. We conclude that genetic factors significantly contri bute to arterial structure and function in this isolated population, presenting the opportunity to locate susceptibility genes related to cardiovascular disorde rs.

关键词：动脉壁 ERF 遗传度脉搏波速度内膜中层厚度颈总动脉动脉硬度协变量血管危险因素易感基因

朊病毒蛋白基因中缩胆囊素反复序列的插入与早发型痴呆的相关性研究

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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 19-20页

作者： croes E.A. Theuns J. Houwing-Duistermaat J.J. c.m. van duijn 罗勇 Dept. of Epidemiol. and Biostatist. Erasmus MC PO Box 1738 3000 DR Rotterdam Netherlands

Objectives: The most c.m.on familial early onset dementia mutations are found in the genes involved in Alzheimer’ s disease; the amyloid precursor protein (APP) and the presenilin 1 and 2 (PSEN1 and 2) genes; the prion protein gene (PRNP) may be involved. methods: Following identification of a two octapeptide repeat insertion in PRNP, we conducted a meta analysis to investigate the relation of number of PRNP octapeptide repeats with age at disease onset and duration of illness; identifying 55 patients with PRNP octapeptide repeat insertions. We used a linear mixed effects model to assess the relation of number of repeats with age at disease onset, and studied the effect of the number of inserted octapeptide repeats on disease duration with a cox proportional hazards regression analysis. Results: We found an increasing number of repeats associated with younger age at onset (p creased significantly with the length of the octapeptide repeat (p conclusions: Our findings showsignificant inverse associations of the length of the PRNP octapeptide repeat with age at disease onset and disease duration in the spongiform encephalopathies.

关键词：朊病毒蛋白缩胆囊素早发型复序列基因突变淀粉样前体蛋白入次数发病年龄混合效应模型回归模型分析

consumer transparency in the production chain for plant varieties produced using new genomic techniques

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aBIOTEcH 2024年第2期5卷 239-246页

作者： J.m.Lukasiewicz c.c.m.van de Wiel L.A.P.Lotz m.J.m.Smulders Wageningen University&Research P.O.Box 386NL-6700 AJ WageningenThe Netherlands

Plants edited with new genomic techniques(NGTs)currently fall under the Genetically modified Organisms Directive(2001/18/Ec)in the European *** the proposal of the European c.m.ission,NGT plants are partially exempted from the regulations of this *** proposal makes a distinction between two categories of NGT plants:NGT-1 and ***-1 category plants are considered equal to plants obtained through conventional breeding *** plants will not be labelled for the consumer,although they will be labelled as ***-2 category plants may be labelled with additional information as a positive *** of seeds of varieties made with gene editing,but not the products,would mean that most steps in the production chain are transparent,but not the last step towards ***“right to know”and increasing knowledge of gene-edited food is a c.m.on theme in food labelling towards ***,we describe current labelling regimes and registers and how these may be applied to provide transparency on gene-edited products to ***,we also look into consumer studies,which indicate a greater acceptance of gene-edited food among consumers,especially when additional benefits such as sustainability are mentioned.

关键词： Labelling New genomic techniques consumer transparency Plant products

multichannel coupling induced topological insulating phases with full multimerization

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Photonics Research 2024年第3期12卷 491-498页

作者： JUN LI YAPING YANG c.m.HU mOE Key Laboratory of Advanced micro-Structured materials School of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Physics and Astronomy University of ManitobaWinnipegManitoba R3T 2N2Canada

We propose and experimentally realize a class of quasi-one-dimensional topological lattices whose unit cells are constructed by coupled multiple identical resonators,with uniform hopping and inversion *** the presence of coupling-path-induced effective zero hopping within the unit cells,the systems are characterized by c.m.lete multimerization with degenerate-1 energy edge states for open boundary condition.

关键词： symmetry topological coupling

Enabling low-cost decentralized power reserves adopting carbon dioxide for green methane exchange in stabilized clathrate adsorbent

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Journal of Energy chemistry 2024年第10期97卷 438-443页

作者： Lucas Hanssens maarten Houlleberghs c.Vinod chandran Geert Watson Sambhu Radhakrishnan Pascal van Der Voort Joeri F.m.Denayer christine E.A.Kirschhock Johan A.martens Eric Breynaert centre for Surface chemistry and catalysis-characterization and Application Team (cOK-KAT) NmR/X-Ray Platform for convergence Research (NmRcoRe) centre for Ordered materials Organometallics and Catalysis (COMOC) Department of Chemistry Ghent University Department of chemical Engineering Vrije Universiteit Brussel

*** circular methane energy systems In recent decades,methane-based energy systems have rapidly gained traction across the globe because of the increasing availability of low-cost methane production ***,fossil methane... 详细信息

关键词： Long duration energy storage Green methane carbon neutrality confined clathrate hydrates cH4 /cO2 exchange Direct gas exchange ENERGY-STORAGE cONFINED NANOSPAcE TO-mETHANE GAS mEcHANISmS ADSORPTION HYDROGEN

Supramolecular Polymerization of Hydrogen-Bonded Trimers in Bulk and Aqueous medium

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ccS chemistry 2024年第6期6卷 1458-1465页

作者： Freek V.de Graaf Stef A.H.Jansen Sandra m.c.Schoenmakers Bas van Genabeek marle E.J.Vleugels Bart W.L.van den Bersselaar E.W.meijer Ghislaine vantomme Institute for c.m.lex molecular Systems Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven School of chemistry and RNA Institute University of New South WalesSydneyNew South Wales 2052

Synthetic.m.lecules that form functional noncovalent assemblies in water have received much attention for their potential applications as *** this work,we introduce a novel water-c.m.atible monomer based on the phthalhydrazide moiety that assembles into hydrogen-bonded trimeric *** bulk,the material exhibits a cylindrical nanostructure in the liquid-crystalline phase at elevated temperatures,morphologically distinct from the crystalline lamellar *** water,these molecules effectively form cylinders in a one-dimensional fashion,yielding fibrous *** formation of these supramolecular polymers follows a cooperative mechanism,as evidenced by denaturation *** trimerized pattern represents a new category of aqueous su pramolecular polymers with future prospects for functional c.m.lex molecular systems.

关键词： noncovalent chemistry supramolecular polymers hydrogen bonding cooperativity nanostructure

clinical-based phenotypes in children with pediatric post-cOVID-19 condition

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World Journal of Pediatrics 2024年第7期20卷 682-691页

作者： Lieke c.E.Noij Jelle m.Blankestijn coen R.Lap marlies A.van Houten Giske Biesbroek Anke-Hilse maitland-van der Zee mahmoud I.Abdel-Aziz Johannes B.van Goudoever mattijs W.Alsem caroline L.H.Brackel Kim J.Oostrom Simone Hashimoto Suzanne W.J.Terheggen-Lagro Department of Pediatric Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary medicine Amsterdam UMCAmsterdamThe Netherlands Department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of child and Adolescent Psychiatry and Psychosocial care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(cOVID-19)condition(PPcc)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPcc,to better characterize and treat this *** Participants were children with physician-diagnosed PPcc,referred to the academic hospital Amsterdam Umc in the Netherlands between November 2021 and march *** factors and information on post-cOVID symptoms,c.m.rbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms c.m.ared to 8 and 10 for clusters 1 and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPcc phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-cOVID symptoms in children.

关键词： Adolescents clusters Long cOVID Pediatric Phenotypes Post-cOVID syndrome

Performance of evolutionary optimized machine learning for modeling total organic carbon in core samples of shale gas fields

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Petroleum 2024年第1期10卷 150-164页

作者： Leonardo Goliatt c.m.Saporetti L.c.Oliveira E.Pereira Department of c.m.utational and Applied mechanics Federal University of Juiz de Fora Department of c.m.utational modeling Polytechnic Institute Rio de Janeiro State University Petrobras Department of Stratigraphy and Paleontology Rio de Janeiro State University

Rock samples' TOc content is the best indicator of the organic.m.tter in source rocks. The origin rock samples' analysis is used to calculate it manually by specialists. This method requires time and resources because it relies on samples from many well intervals in source rocks. Therefore, research has been done to aid this effort. machine learning algorithms can estimate total organic carbon instead of well logs and stratigraphic studies. In light of these efforts, the current work present a study on automating the total organic carbon estimation using machine learning approaches improved by an evolutionary methodology to give the model flexibility and precision. Genetic algorithms, differential evolution, particle swarm optimization, grey wolf optimization, artificial bee colony, and evolution strategies were used to improve machine learning models to predict TOc. The six metaheuristics were integrated into four machine learning methods: extreme learning machine, elastic net linear model, linear support vector regression, and multivariate adaptive regression splines. core samples from the YuDong-Nan shale gas field, located in the Sichuan basin, were used to evaluate the hybrid strategy. The findings show that c.m.ining machine learning models with an evolutionary algorithms in a hybrid fashion produce flexible models that accurately predict TOc. The results show that, independent of the metaheuristic used to guide the model selection, optimized extreme learning machines attained the best performance scores according to six metrics. Such hybrid models can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic carbon Hybrid models Automated machine learning Evolutionary algorithms Geology

An improved pulse coupled neural networks model for semantic IoT

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Digital c.m.unications and Networks 2024年第3期10卷 557-567页

作者： Rong ma Zhen Zhang Yide ma Xiping Hu Edith c.H.Ngai Victor c.m.Leung School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China School of medical Technology Beijing Institute of TechnologyBeijing100081China Department of Electrical and Electronic Engineer The University of Hong KongHong Kong 999077China college of c.m.uter Science and Software Engineering Shenzhen UniversityShenzhen 518060China Department of Electrical and c.m.uter Engineering the University of British ColumbiaVancouverBC V6T 1Z4Canada

In recent years,the Internet of Things(IoT)has gradually developed applications such as collecting sensory data and building intelligent services,which has led to an explosion in mobile data ***,with the rapid development of artificial intelligence,semantic c.m.unication has attracted great attention as a new c.m.unication ***,for IoT devices,however,processing image information efficiently in real time is an essential task for the rapid transmission of semantic *** the increase of model parameters in deep learning methods,the model inference time in sensor devices continues to *** contrast,the Pulse coupled Neural Network(PcNN)has fewer parameters,making it more suitable for processing real-time scene tasks such as image segmentation,which lays the foundation for real-time,effective,and accurate image ***,the parameters of PcNN are determined by trial and error,which limits its *** overc.m. this limitation,an Improved Pulse coupled Neural Networks(IPcNN)model is proposed in this *** IPcNN constructs the connection between the static properties of the input image and the dynamic properties of the neurons,and all its parameters are set adaptively,which avoids the inconvenience of manual setting in traditional methods and improves the adaptability of parameters to different types of *** segmentation results demonstrate the validity and efficiency of the proposed self-adaptive parameter setting method of IPcNN on the gray images and natural images from the matlab and Berkeley Segmentation *** IPcNN method achieves a better segmentation result without training,providing a new solution for the real-time transmission of image semantic information.

关键词： Internet of things(IoT) Semantic information Real-time application Improved pulse coupled neural network Image segmentation