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Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第23期13卷 3221-3227页

作者： FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F fresno-Forcelledo MD corte L Rodrigo Unidad de Investigación. Fundación Hospital de Jove. Gijón Spain Gastroenterology Service. Hospital Universitario central de Asturias. Oviedo Spain Instituto Universitario de Oncología del Principado de Asturias. Oviedo Spain Pathology Service. Hospital Universitario central de Asturias. Oviedo Spain

AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (Hcc) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 Hcc patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HcV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. cONcLUSION: Our results indicate a moderate clinical value of the steroid receptor status in Hcc, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies.

关键词： Androgen Estrogen Progesterone and Apolipoprotein D receptors Hepatocellular carcinoma Tissue micro-arrays

Response to chemoradiotherapy and lymph node involvement in locally advanced rectal cancer

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World Journal of Gastrointestinal Surgery 2015年第9期7卷 196-202页

作者： Luis J García-Flórez Guillermo Gómez-álvarez Ana M Frunza Luis Barneo-Serra Manuel F fresno-Forcelledo General and Digestive Surgery Service Hospital San Agustín Department of Surgery University of Oviedo coloproctology Section General SurgeryHospital Universitario Central de Asturias Pathology Hospital Universitario Central de Asturias

AIM: To establish the association between lymph node involvement and the response to neoadjuvant therapy in locally advanced rectal ***: Data of 130 patients with mid and low locally advanced rectal adenocarcinoma treated with neoadjuvant chemoradiation followed by radical surgery over a 5-year period were reviewed. Tumor staging was done by endorectal ultrasound and/or magnetic resonance imaging. Tumor response to neoadjuvant therapy was determined by T-downstaging and tumor regression grading(TRG). Pathologic complete response(p cR) is defined as the absence of tumor cells in the surgical specimen(yp T0N0). The varying degrees TRG were classified according to Mandard's scoring system. The evaluation of the response is based on the comparison between previous clinico-radiological staging and the results of pathological evaluation. χ2 and Spearman's correlation tests were used for the comparison of variables. RESULTS: Pathologic complete response(p cR, yp T0N0, TRG1) was observed in 19 cases(14.6%), and other 18(13.8%) had only very few residual malignant cells in the rectal wall(TRG2). T-downstaging was found in 63(48.5%). Mean lymph node retrieval was 9.4(range0-38). In 37 cases(28.5%) more than 12 nodes were identified in the surgical specimen. Preoperative lymph node involvement was seen in 77 patients(59.2%), 71 N1 and 6 N2. Postoperative lymph node involvement was observed in 41 patients(31.5%), 29 N1 and 12 N2, while the remaining 89 were N0(68.5%). In relation to yp T stage, we found nodal involvement of 9.4% in yp T0-1, 22.2% in yp T2 and 43.7% in yp T3-4. Of the 37 patients considered "responders" to neoadjuvant therapy(TRG1 and 2), there were only 4 N+(10.8%) and the remainder N0(89.2%). In the "non responders" group(TRG 3, 4 and 5), 37 cases were N+(39.8%) and 56(60.2%) were N0(P cONcLUSION: Response to neoadjuvant chemoradiation in rectal cancer is associated with lymph node involvement.

关键词： Response to treatment Neoadjuvant therapy Rectal c

UNIQUE ASPEcTS OF MOdelING IRRIGATION-INDUcED SOIL EROSION

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International Journal of Sediment Research 2000年第2期 245-252页

作者： D.L. Bjorneberg D.c. Kincaid R.D. Lentz R.E. Sojka (USDA-ARS, Northwest Irrigation and Soils Research Lab, Kimberly, ID) T.J. Trout (USDA-ARS, Water Management Research Lab, fresno, cA)

The mechanics of soil erosion from irrigated and rainfed lands are similar. Soil particles are detached,transported and deposited. However, there are some systematic differences between irrigation and rainfallerosion. Electrolyte concentrations in irrigation water, for example, are almost always greater than in rainwater. Differences between rainfall and irrigation are more prominent for surface irrigation than forsprinkler irrigation. For instance, rainfall wets the soil before runoff begins, but water initially flows ontodry soil in irrigation furrows. Furthermore, furrow flow rate decreases with distance and increases withtime, while the opposite tends to occur with rainfall. For sprinkler systems, travel direction and slopeaspect interact, so runoff can flow within the irrigated area or from the irrigated area onto dry or wet ***, a sprinkler-irrigation erosion model must consider both the rainfall-runoff situation and the furrowflow situation. These differences in soil and water interactions must be considered before computermodels can accurately simulate irrigation-induced soil erosion.

关键词： Soil erosion Irrigation Electrolyte concentration Furrow flow Runoff Modeling

comparison of four scanning mobility particle sizers at the fresno Supersite

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Particuology 2011年第3期9卷 204-209页

作者： John G. Watson Judith c. chow David A. Sodeman Douglas H. Lowenthal M.-c. Oliver chang Kihong Park Xiaoliang Wang Desert Research Institute 2215 Raggio Parkway Reno NV 89512 USA Institute of Earth Environment Chinese Academy of Sciences 10 Fenghui South Road Xi'an High Tech Zone Xi'an 710075 China San Diego Air Pollution control District San Diego CA USA. california Air Resources Board El Monte CA USA. Gwangju Institute of Science and Technology Gwangju Korea.

Size distributions of ambient aerosols at the fresno Supersite were measured with four commercially available scanning mobility particle sizers （SMPS）. TSI nano, TSI standard, Grimm, and MSP instruments were collocated at the fresno Supersite and particle size distributions were measured continuously from August 18 through September 18, 2005. For particles with diameters between 10 and 200 nm, differences among hourly-average ambient particle concentrations ranged from 0% between the TSI nano and Grimm in the 30-50 nm size range to 39% between the Grimm and MSP in the 10-30 nm size range. MSP concentrations were 10-33% lower than those measured with the TSI standard for particles smaller than 200 nm. The TSI nano and TSI standard agreed to within 5% in their overlapping size range （10-84 nm）. The TSI nano and Grimm agreed to within 40% for 5-10 nm particles.

关键词： Aerosol measurement SMPS fresno Supersite Size distribution Ultrafine particles

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心脏MRI与FDG PET对心脏结节病诊断准确性的比较：系统综述与Meta分析

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国际医学放射学杂志 2022年第6期45卷 729-729页

作者： M.Aitken M.V.chan c.U.fresno A.Farrell N.Islam M.D.F.McInnes 王姝文

摘要心脏 MRI 相对于 FDG PET 对心脏结节病的诊断效能的共识有限。目的通过系统评价和 Meta 分析比较心脏MRI 和 FDG PET 在心脏结节病诊断中的准确性。资料与方

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A Bar code and Radio-Frequency Identification System for Transfusion Safety

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中国输血杂志 2006年第Z1期19卷 5-7页

作者： Sandler SG DiBandi L Langeberg A Gibble J Wilson c Feldman cF Georgetown University Hospital Washington DC American Red Cross Baltimore and Precision Dynamics corporation Fresno CA USA 　　　　

This presentation will describe a pilot study of radio-frequency (RF) identification tags ("chips") that was conducted in parallel with standard procedures for the collection and testing of Red Blood cells (Greater chesapeake and Potomac Region, American Red cross Biomedical Services, Baltimore, MD) and transfusion (Georgetown University Hospital, Washington, Dc). The purpose of the study was to evaluate whether multi-write RF chips could be attached to blood bags, programmed, and used to facilitate the collection of information from (1) a blood bag manufacturer to (2) a blood collection center and, subsequently, to (3) a hospital transfusion service.

关键词： Identification System pilot study Blood cells

Radiation Use Efficiency of cotton in contrasting Environments

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American Journal of Plant Sciences 2012年第5期3卷 649-654页

作者： Evangelos D. Gonias Derrick M. Oosterhuis Androniki c. Bibi Bruce A. Roberts Department of crop Soil and Environmental Sciences University of Arkansas Fayetteville USA Plant Science Department California State University Fresno USA

crop growth and yield varies among locations due to differences in environmental parameters, such as temperature, relative humidity, solar radiation and vapor pressure deficit. Previous research has shown that increasing vapor pressure deficit has a negative effect on radiation use efficiency of many crops. In this study, the radiation use efficiency of cot-ton (Gossypium hirsutum L.) grown in two contrasting production environments, Arkansas and california, was evaluated for two years, in 2006 and 2007. Temperature, relative humidity, vapor pressure deficit and photosyntheti-cally active radiation were recorded at both locations. Although the crop in california accumulated more dry matter during the period of the study, the radiation use efficiency was found to be lower compared to Arkansas. Radiation use efficiency for the Arkansas and california locations was estimated at 2.060 and 1.518 g?MJ–1 of intercepted photosynthetically active radiation, respectively. The higher productivity observed in california can be attributed to larger amounts of incident and intercepted radiation in this location. Radiation use efficiency of cotton was estimated to decrease with increasing vapor pressure deficit by a slope of –0.47 g?MJ–1?kPa–1.

关键词： Dry Matter Environment Gossypium hirsutum L. Light Interception Radiation Use Efficiency Vapor Pressure Deficit

A Bar code and Radio-Frequency Identification System for Transfusion Safety

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A Bar Code and Radio-Frequency Identification System for Tra...

家庭中杀虫剂浓度的时间变异性和对流行病学研究中衰减偏倚的启示

中国输血协会第四届输血大会

作者： Sandler SG DiBandi L Langeberg A Gibble J Wilson c Feldman cF Georgetown University Hospital WashingtonDC American Red cross BaltimoreMD and Precision Dynamics corporation FresnoCAUSA

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环境与职业医学 2013年第8期30卷 647-647页

作者： Nicole c.Deziel Mary H.Ward Erin M.Bell Todd P.Whitehead Robert B.Gunier Melissa c.Friesen John R.Nuckols

[背景]已证实住宅杀虫剂暴露与成人和儿童的不良健康结局相关。高质量的暴露评估是确认这些关联的关键。以往的流行病学研究采用一次测量地毯灰尘中杀虫剂浓度来描述个体长期暴露的平均值。如果浓度随着时间的推移而变化，那么这种方法... 详细信息

[背景]已证实住宅杀虫剂暴露与成人和儿童的不良健康结局相关。高质量的暴露评估是确认这些关联的关键。以往的流行病学研究采用一次测量地毯灰尘中杀虫剂浓度来描述个体长期暴露的平均值。如果浓度随着时间的推移而变化，那么这种方法会导致对暴露明显的错误分类，削弱对风险的估计。[目的]评估地毯灰尘样本中杀虫剂浓度的可重复性和流行病学研究中依赖于一个样本的潜在衰减偏倚。[方法]在2003-2005年期间，从加州fresno县的21个家庭中，重复收集地毯灰尘样本（中位数=3，范围1～7）。使用气相色谱-质谱法分析灰尘中的13种杀虫剂；采用混合效应模型估计家庭之间和家庭内的方差。计算每一种杀虫剂的组内相关系数（Icc），并估计收集单次灰尘样品的假设病例对照研究衰减回归系数。[结果]Icc的中位数为0．73（范围0．37—0．95），表明大多数杀虫剂家庭之间的变异性高于家庭内部的变异性。对于13种化合物中进行评估的7种，与使用单一灰尘样本相关的预期衰减偏倚估计为≤30％。[结论]对于研究的几种杀虫剂，使用一个灰尘样本代表约为2年的暴露期，其比值比不会大幅衰减。还需要进一步研究，以确定上述研究结果是否可以代表更长的暴露时间并且适用于其他杀虫剂。

关键词：灰尘环境暴露杀虫剂信度

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