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A comparative study of machine learning in predicting the mechanical properties of the deposited AA6061 alloys via additive friction stir deposition

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Materials Genome Engineering Advances 2024年第1期2卷 134-147页

作者： Qian Qiao Quan Liu Jiong Pu Haixia Shi Wenxiao Li Zhixiong Zhu Dawei Guo Hongchang Qian Dawei Zhang Xiaogang Li c.t.kwok L.M.tam Department of Electromechanical Engineering University of MacaoMacaoChina Institute for the Development and Quality MacaoChina IDQ Science and technology Development(Hengqin Guangdong)Co.LtdHengqinGuangdongChina Aerospace Engineering Equipment(Suzhou)co.Ltd SuzhouChina National Materials corrosion and Protection Data center Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijingChina

Additive friction stir deposition(AFSD)provides strong flexibility and better performance in component design,which is controlled by the process *** is an essential and difficult task to tune those *** recent exploration of machine learning(ML)exhibits great potential to obtain a suitable balance between productivity and set *** this study,ML techniques,including support vector machine(SVM),random forest(RF)and artificial neural network(ANN),are applied to predict the mechanical properties of the AFSD-based AA6061 *** for the stable parameters(temperature,force and torque)in situ monitored by the self-developed process-aware kit during the AFSD process and the other factors(rotation speed,traverse speed,feed rate and layer thickness)are also set as input *** output variables are microhardness and ultimate tensile strength(UtS).Prediction results show that the ANN model performs the best prediction accuracy with the highest R2(0.9998)and the lowest mean absolute error(MAE,0.0050)and root mean square error(RMSE,0.0063).Furthermore,analysis suggests that the feed rate(24.8%/24.1%)and layer thickness(25.6%/26.6%)indicate a higher contribution that affects the mechanical properties.

关键词： additive friction stir deposition in-situ monitored machine learning mechanical properties prediction

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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of cNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina china Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of cNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina co-innovation center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

the presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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Letter from the Editor-in-chief

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Neural Regeneration Research 2025年第1期20卷 5-5页

作者： kwok-Fai So Neural Regeneration Research

Greetings esteemed readers,As we embark on a new year filled with promise and innovation,it is my pleasure to reflect on the remarkable achievements and advancements in the journal Neural Regeneration Research(NRR)showcased throughout ***,the 2024 International Neural Regeneration Symposium(INRS2024)and the 15^(th) Asia Pacific Symposium on Neural Regeneration(APSNR),held from April 12^(th) to 14^(th) in Guangzhou,china,stand as shining examples of collaboration,knowledge exchange,and scientific excellence.

关键词： Regeneration filled journal

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commentary on:“Human neural stem cell-derived artificial organelles to improve oxidative phosphorylation”

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Neural Regeneration Research 2025年第10期20卷 3040-3040页

作者： kwok-Fai So Key Laboratory of cNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina State Key Laboratory of Brain and cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Mitochondrial function is fundamental to neuroregeneration,particularly in neurons,where high energy demands are essential for repair and recovery(Patrón and Zinsmaier,2016;Beckervordersandforth et al.,2017;Iwata et al.,2023).Mitochondrial dysfunction,characterized by an imbalance in AtP levels and excessive production of mitochondrial reactive oxygen species,is a key factor that impedes neural regeneration in neurodegenerative diseases and after neuronal injury(Han et al.,2016,2020;Zheng et al.,2016;Zong et al.,2024).

关键词： neural Becker Human

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. this review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. this review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. this should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Strategies in boosting photosensitization for biomedical applications

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Science china chemistry 2022年第4期65卷 647-649页

作者： Ming chen Ryan t.K.kwok Youhong tang Dan Ding college of chemistry and Materials Science Jinan UniversityGuangzhou 510632China Frontiers Science center for cell Responses State Key Laboratory of Medicinal Chemical BiologyKey Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China Department of Nephrology Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second HospitalHuai’an 223002China Department of chemistry The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyDepartment of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyHong KongChina Australia-china Joint centre for Personal Health technologies Medical Device Research InstituteCollege of Science and EngineeringFlinders UniversitySouth Australia 5042Australia Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates South China University of TechnologyGuangzhou 510640China

Photodynamic therapy(PDt)has emerged as an effective treatment method for its few adverse effects,little invasiveness,short treatment time and low cost[1,2].the rapid development of PDt has dramatically boosted its mu... 详细信息

关键词： treatment boosting immunotherapy

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cFD-based analysis of urban haze-fog dispersion—A preliminary study

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Building Simulation 2021年第2期14卷 365-375页

作者： Yu Zhang Yong Yu K.c.S.kwok Feng Yan School of Medicine Tsinghua UniversityBeijingChina School of Aerospace Engineering Beijing Institute of TechnologyBeijingChina Faculty of Engineering School of Civil EngineeringThe University of SydneySydneyNew South WalesAustralia First Hospital of tsinghua University BeijingChina

this paper proposes a computational fluid dynamics(cFD)model,along with dimensionless quantitative assessment standard—air pollution residual time(APRt)for the evaluation of local haze-fog(HF)dispersion in a built environment.A low APRt value ensures good ventilation.A building group model that comprises high-rise business building,mid-rise office buildings,low-mid-rise residential buildings(at the center of the building group),a mid-rise recreational center,and a local road(open terrain),was scaled down(1:100)to simulate the HF dispersion *** orientation of the building group was numerically modified to generate a wind incidence normal to the high-rise building,mid-rise buildings,recreational center,and *** results showed that the orientation of the building group largely determines the *** most favorable orientation can reduce APRt by more than 50%.Our results strongly suggested that in order to reduce the consequential negative effect of air pollution,future urban designs should undergo a comprehensive ventilation assessment to ensure a low APRt value.

关键词： air pollution residual time urban environment high-rise building wind direction computational fluid dynamics

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Organics in the solar system

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Research in Astronomy and Astrophysics 2019年第4期19卷 1-6页

作者： Sun kwok Laboratory for Space Research The University of Hong Kong Department of Earth Oceanand Atmospheric SciencesUniversity of British ColumbiaVancouver

complex organics are now commonly found in meteorites, comets, asteroids, planetary satellites and interplanetary dust particles. the chemical composition and possible origin of these organics are presented. Specifically, we discuss the possible link between Solar System organics and the complex organics synthesized during the late stages of stellar evolution. Implications of extraterrestrial organics on the origin of life on Earth and the possibility of existence of primordial organics on Earth are also discussed.

关键词： meteorites organics stellar evolution origin of life

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A GENERALIZAtION OF BOYD’S INtERPOLAtION tHEOREM

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Acta Mathematica Scientia 2021年第4期41卷 1263-1274页

作者： kwok-Pun HO Department of Mathematics and Information technology the Education University of Hong KongHong KongChina

Boyd^interpolation theorem for quasilinear operators is generalized in this paper,which gives a generalization for both the Marcinkiewicz interpolation theorem and Boyd^interpolation *** using this new interpolation theorem,we study the spherical fractional maximal functions and the fractional maximal commutators on rearrangement-invariant quasi-Banach function *** particular,we obtain the mapping properties of the spherical fractional maximal functions and the fractional maximal commutators on generalized Lorentz spaces.

关键词： Interpolation of operator quasilinear operator rearrangement-invariant function space spherical fractional maximal function fractional maximal commutator generalized Lorentz space

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