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LASIK术后1个月的反应性淋巴增生

世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 45-45页

作者： reddy S. Finger P.T. chynn E.W. Iacob c.E. 王静波 The New York Eye cancer center 115 East 61st Street New York NY 10021 United States

Purpose: This study was conducted to investigate a case of reactive lymphoid hyperplasia following laser assisted in situ keratomileusis (LASIK). Methods: A 31- year-old man who underwent LASIK presented 1 month later with a fleshy conjunctival (plical) tumor in the left eye. An excision biopsy of the tumor was performed. Results: Histopathology of the excised tumor revealed reactive lymphoid hyperplasia. Discussion: conjunctival lymphomas can masquerade as chronic conjunctivitis and can be preceded by reactive lymphoid hyperplasia. It is important to identify and differentiate these tumors. This report describes the unusual occurrence of a lymphoid conjunctival tumor after LASIK eye surgery.

关键词： LASIK术慢性结膜炎淋巴瘤组织病理学后反应能因

Enantioseparation of Palonosetron Hydrochloride and Its Related Enantiomeric Impurities by computer Simulation and Validation

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American Journal of Analytical chemistry 2011年第4期2卷 437-446页

作者： M.Vishnu Murthy c.Krishnaiah Kodithyala Jyothirmayi Katkam Srinivas K.Mukkanti Ramesh Kumar Gautam Samanta Analytical Research and Development Integrated Product Development OperationsDr.Reddy’s Laboratories Ltd.BachupallyQutubullapurAndhra PradeshIndia Department of chemistry Jawaharlal Nehru Technological UniversityHyderabadIndia

A rapid, simple and single stereo selective high-performance liquid chromatographic (HPLc) method was developed and validated for enantiomers of palonosetron hydrochloride (PALO) and its process related chiral impurities. A computer simulating software was used for the development of chiral method. The developed method was able to separate not only the enantiomers of palonosetron hydrochloride but also its process related chiral impurities within 12 min. The chromatographic separation was carried out by normal phase chromatography using a 3 μm column of cellulose based chiral stationary phase (chiralcel-OD 250mm × 4.6mm) with a mobile phase comprised of n-hexane: ethanol: methanol: heptafluoro butyric acid: diethyl amine (70:15:15:0.05:0.1, v/v) at a flow rate of 1.0 mL/min. The effects of additive concentration as well as nature of polar organic modifier, flow rate, and temperature on enantioselectivity were investigated. The limit of detection (LOD) and limit of quantification (LOQ) of the palonosetron isomers and its related chiral impurities were found to be in the range 0.06-0.10 μg/mL and 0.14 - 0.24 μg/mL respectively. The method showed excellent linearity (R2 > 0.998) over a range of 0.14 to 1.125 μg/mL. The percentage recovery of the isomers in bulk drug samples ranged from 87.0 to 116.0.

关键词： High Performance Liquid chromatography Palonosetron Hydrochloride chiral Impurities Drylab^(█) Software Method Development Method Validation

Hepatic Histology in Patients with chronic Hepatitis c and End Stage Renal Disease

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胃肠病学 2000年第B8期5卷 123-123页

作者： S.M.W.Jafri R.Khan K.R.reddy D.Roth L.Jeffers E.R.Schiff AgaKhanUniversityHospitalKarachi Pakistan＆DivisionofHepatologyUniversityofMiamiSchoolofMedicine.MiamiFloridaUSA

Hepatitis c is being reported with increasing frequency in the hemodialysis units. The role of blood transfusion, the duration of hemodialysis treatment and the nosocomial transmission have been suggested as possible the modes of transmission. Some of these patients may be considered for renal transplantation. Aims: To assess the severity of chronic hepatitis c in patients with End Stage Renal Disease (ESRD) who are being considered for renal transplantation.

关键词：肝组织学慢性乙型肝炎肾脏疾病消化系统

Relationship of High Sensitivity c-Reactive Protein with cardiovascular,Diabetic, and Hepatic Biomarkers

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酒精的使用、种族和病毒的交叉感染对美国退伍军人HcV自然清除的影响

International Journal of clinical Medicine（临床医学国际期刊） 2023年第9期

作者： Hari Krishnan Krishnamurthy Swarnkumar reddy Vasanth Jayaraman Karthik Krishna Qi Song Karenah E.Rajasekaran Tianhao Wang Kang Bei John J.Rajasekaran

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 51-51页

作者： Piasecki B.A. Lewis J.D. reddy K.R. 沈才飞 Penn Medicine Radnor GastroenterologyClinic 250 King of Prussia Road Radnor PA 19087 Unite d StatesDr.

Hepatitis c virus (HcV) is spontaneously cleared in 15%to 45%of individuals during primary infection. To define the role of alcohol, race, and HBV or HIV co infections in natural HcV clearance, we examined these parameters in 203 spontan eously HcV-recovered subjects (HcV Ab+/RNA-subjects without prior antiviral t herapy) and 293 chronically HcV-infected patients (HcV Ab+/RNA+). Subjects we re identified from 1,454 HcV antibody-seropositive US veterans tested for HcV R NA between January 2000 and July 2002 at the Philadelphia Veterans Affairs Medic al center. In univariate analysis, alcohol use disorder (odds ratio > 0.52; 9 5%cI, 0.31-0.85; P = .006) and black race (OR 0.65;95%cI, 0.44-0.96;P = .024 ) were both associated with decreased likelihood of spontaneous HcV clearance. I n multivariate analyses adjusting for race, HIV infection, age, and alcohol use disorder, alcohol remained strongly associatedwith reduced HcV clearance (OR0.49 ;95%cI, 0.30-0.81; P = .005). In contrast, the association between black race and viral clearance was no longer statistically significant (adjusted OR 0.72; 9 5%cI, 0.48-1.09; P = .125). HIV coinfection was negatively associated with HcV clearance (OR 0.37; 95%cI, 0.16-0.83; P = .016), while HBV coinfection was po sitively associated with HcV clearance (unadjusted OR 5.0; 95%cI, 1.26-28.6; P = .008). In conclusion, the likelihood of spontaneous clearance of HcV may be i nfluenced by alcohol and viral coinfections.

关键词： HcV 黑色人种 RNA 单变量分析负相关多变量分析

2个患严重颗粒状角膜营养不良的印度家系中基因-表型间的关系

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 28-29页

作者： Kannabiran c Sridhar M.S chakravarthi S.K 韩静 Kallam Anji reddy Molecular Genetics Laboratory Professor Brien Holden Eye Research Centre L. V. Prasad Eye Institute L. V. Prasad Marg Banjara Hills Hyderabad 500 034 India.Dr

Objectives: To determine genotypes in 2 Indian families with severe granular corneal dystrophy, to document clinical and histopathologic features, and to attempt a genotype-phenotype correlation. Methods: Mutation analysis of exon 12 of the TGFBI gene was carried out in 9 individuals from 2 families. Results: A c→ T mutation at residue 1710 of TGFBI complementary DNA, corresponding to an Arg555Trp mutation in keratoepithelin, was found in affected members of both families. In 5 patients, this mutation was homozygous, and it was heterozygous in the other 4. clinical examination revealed a severe form of granular corneal dystrophy with early onset and superficial lesions in the homozygous individuals and a milder phenotype in the heterozygous individuals. Histopathologic evaluation of corneal specimens from 2 homozygous patients confirmed the presence of superficial granular deposits. conclusions: To our knowledge, this is the first molecular and clinical characterization of severe granular corneal dystrophy in India. Genotype-phenotype correlation and comparison with earlier reports on this entity highlight the uniform expressivity of the Arg555Trp allele in homozygous individuals. clinical Relevance: Homozygous granular corneal dystrophy has a severe phenotype and can be recognized based on clinical and histopathologic features, especially in association with consanguinity or inbreeding.

关键词：角膜上皮颗粒状纯合子严重型沉着物组织病理学突变分析分子学杂合子病理学检查

A Validated Model for the Imaging Diagnosis of cystic Lung Disease

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