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continuous Expression of Interferon Regulatory Factor 4 Sustains cD8^(+)T cell Immunity against Tumor

Research 2024年第3期2023卷 433-444页

作者： Anze Yu Jinfei Fu Zheng Yin Hui Yan Xiang Xiao Dawei Zou Xiaolong Zhang Xiongbing Zu Xian c.li Wenhao chen Immunobiology and Transplant Science center Department of SurgeryHouston Methodist Research Institute and Institute for Academic MedicineHouston Methodist HospitalHoustonTXUSA Department of Urology First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Systems Medicine and Bioengineering Department Houston Methodist Neal Cancer CenterHoustonTXUSA Department of Radiology Houston Methodist HospitalWeill Cornell MedicineHoustonTXUSA Department of Urology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Surgery Weill Cornell MedicineCornell UniversityNew YorkNYUSA.

T-cell-based immunotherapy is gaining momentum in cancer treatment;however,our comprehension of the transcriptional regulation governing T cell antitumor activity remains *** objective of this study was to explore the function of interferon regulatory factor 4(IRF4)in antitumor cD8^(+)T cells using the TRAMP-c1 prostate cancer and B16F10 melanoma *** achieve this,we generated an Irf4^(GFP-DTR) mouse strain and discovered that cD8^(+)tumor-infiltrating lymphocytes(TILs)expressing high levels of *** exhibited a more differentiated PD-1high cell *** administering diphtheria toxin to tumor-bearing Irf4^(GFP-DTR) mice,we partially depleted ***^(+)TILs and observed an accelerated tumor *** specifically explore the function of IRF4 in antitumor cD8^(+)T cells,we conducted 3 adoptive cell therapy(AcT)***,depleting ***^(+)cD8^(+)TILs derived from AcT significantly accelerated tumor growth,emphasizing their crucial role in controlling tumor ***,deleting the Irf4 gene in antitumor cD8^(+)T cells used for AcT led to a reduction in the frequency and effector differentiation of cD8^(+)TILs,completely abolishing the antitumor effects of ***,we performed a temporal deletion of the Irf4 gene in antitumor cD8^(+)T cells during AcT,starting from 20 days after tumor implantation,which significantly compromised tumor ***,sustained expression of IRF4 is essential for maintaining cD8^(+)T cell immunity in the melanoma model,and these findings carry noteworthy implications for the advancement of more potent immunotherapies for solid tumors.

关键词： sustained immunity implantation

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关于通过生物力学与神经生物学联合途径探索神经血管耦合规律和脑疾病发病机理的探讨

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动力学与控制学报 2024年第1期22卷 97-98页

作者： Sunny c.li 谌小维重庆脑与智能科学中心重庆401336 中国人民解放军陆军军医大学重庆400038

随着我国人民生活方式的改变和人口老龄化进程加快,脑疾病的发病率逐年升高,严重危害国民健康,给患者及其家庭乃至社会带来沉重的经济负担.脑疾病伴随着血流动力学的改变,在以往的研究中,人们认为脑功能仅基于神经元活动和其网络连接.但... 详细信息

随着我国人民生活方式的改变和人口老龄化进程加快,脑疾病的发病率逐年升高,严重危害国民健康,给患者及其家庭乃至社会带来沉重的经济负担.脑疾病伴随着血流动力学的改变,在以往的研究中,人们认为脑功能仅基于神经元活动和其网络连接.但是,近二十年来的研究指出,胶质细胞和血管也紧密参与到脑活动及其调控中,而脑血管的病变更有可能直接与痴呆等神经退行性疾病相关.因此,迫切需要研究在不同尺度上和不同生理状态下血管与神经的相互调节关系.

关键词：神经血管国民健康神经退行性疾病脑疾病神经生物学神经元活动血流动力学生物力学

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Biocontrol Potential of chaetomium spirale ND35 against canker of Apple Tree

Biocontrol Potential of Chaetomium spirale ND35 against Cank...

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第一届国际生物防治与生物技术研讨会

作者： K.X.Gao~1 X.G.liu~(1*) c.li~2 Q.H.Wang~2 B.L.He~3 and Z.M.Yan~1 1 Department of Phytopathology Shandong Agricultural University Tai’an 271018 P.R.china 2 Guanghuasi Tree Farm in Mountain culai of Tai’an city Tai’an 271000 P.R. china 3 college of Science and Technology Shandong Agricultural University Tai’an 271018 P.R.china

＜正＞The biocontrol potential of chaetomium spirale ND35 against the Valsa canker of apple tree was preliminarily *** results of dual culture on PDA plate showed *** ND35 showed strong antagonism against Valsa ceratosperma;the inhibition zone in the interaction area of the two colonies of *** and *** ND35 was observed;the crude extract of culture in corn Steep Powder Broth was able to inhibit the myc.lial growth of *** more effectively than that one in MEB（Malt Extract Broth）.The results of biocontrol in greenhouse and in the field indicated that the disease incidence of apple tree of the treatment with *** ND35 was lower significantly than other treatments,including treatment with *** alone,scald and healthy *** reisolation experiment suggested that c. spirale ND35 could colonize in stems and branches of apple trees successfully and the ND35 colonization rate of the treatment with solid wheat bran culture was at higher level than the corn steep powder *** the biocontrol effect in the field of liquid culture was better than the solid culture.

关键词： chaetomium spirale apple tree canker antagonism biocontrol

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Dynamic Event-Triggered consensus control for Input constrained Multi-Agent Systems With a Designable Minimum Inter-Event Time

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IEEE/cAA Journal of Automatica Sinica 2024年第3期11卷 649-660页

作者： Meilin li Yue Long Tieshan li Hongjing liang c.L.Philip chen the School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731China IEEE the Yangtze Delta Region Institute University of Electronic Science and Technology of ChinaHuzhou 313000 the Laboratory of Electromagnetic Space cognition and Intelligent control Beijing 100089China the School of computer Science and Engineering South China University of TechnologyGuangzhou 510006

This paper investigates the consensus control of multi-agent systems(MASs) with constrained input using the dynamic event-triggered mechanism(ETM).consider the MASs with small-scale networks where a centralized dynamic ETM with global information of the MASs is first ***,a distributed dynamic ETM which only uses local information is developed for the MASs with large-scale *** is shown that the semi-global consensus of the MASs can be achieved by the designed bounded control protocol where the Zeno phenomenon is eliminated by a designable minimum inter-event *** addition,it is easier to find a trade-off between the convergence rate and the minimum inter-event time by an adjustable ***,the results are extended to regional consensus of the MASs with the bounded control *** simulations show the effectiveness of the proposed approach.

关键词： constrained input designable minimum inter-event time directed communication topology dynamic event-triggered mechanism MASs consensus control

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Effects of layer interactions on instantaneous stability of finite Stokes flows

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 69-84页

作者： chen ZHAO Zhenli cHEN c.T.MUTASA Dong li School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China

The stability analysis of a finite Stokes layer is of practical importance in flow control. In the present work, the instantaneous stability of a finite Stokes layer with layer interactions is studied via a linear stability analysis of the frozen phases of the base flow. The oscillations of two plates can have different velocity amplitudes, initial phases, and frequencies. The effects of the Stokes-layer interactions on the stability when two plates oscillate synchronously are analyzed. The growth rates of two most unstable modes when δ 2 are almost equal, and δ = δ*/h*, where δ*and h*are the Stokes-layer thickness and the half height of the channel, respectively. However, their vorticities are different. The vorticity of the most unstable mode is symmetric, while the other is asymmetric. The Stokes-layer interactions have a destabilizing effect on the most unstable mode when δ lizing effect when δ > 0.68. However, the interactions always have a stabilizing effect on the other unstable mode. It is explained that one of the two unstable modes has much higher dissipation than the other one when the Stokes-layer interactions are strong. We also find that the stability of the Stokes layer is closely related to the inflectional points of the base-flow velocity profile. The effects of inconsistent velocity-amplitude, initial phase, and frequency of the oscillations on the stability are analyzed. The energy of the most unstable eigenvector is mainly distributed near the plate of higher velocity amplitude or higher oscillation frequency. The effects of the initial phase difference are complicated because the base-flow velocity is extremely sensitive to the initial phase.

关键词： finite Stokes layer instantaneous stability Stokes-layer interaction asynchronous oscillation

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Dissipationless layertronics in axion insulator MnBi2Te4

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National Science Review 2024年第6期11卷 189-196页

作者： Shuai li Ming Gong Shuguang cheng Hua Jiang X.c.Xie School of Physical Science and Technology Soochow University Institute for Advanced Study Soochow University International center for Quantum Materials School of Physics Peking University Department of Physics Northwest University Interdisciplinary center for Theoretical Physics and Information Sciences Fudan University Hefei National Laboratory

Surface electrons in axion insulators are endowed with a topological layer degree of freedom followed by exotic transport phenomena, e.g., the layer Hall effect. Here, we propose that such a layer degree of freedom can be manipulated in a dissipationless way based on the antiferromagnetic MnBi2Te4with tailored domain structure. This makes MnBi2Te4a versatile platform to exploit the ‘layertronics’ to encode, process and store information. Importantly, the layer filter, layer valve and layer reverser devices can be achieved using the layer-locked chiral domain wall modes. The dissipationless nature of the domain wall modes makes the performance of the layertronic devices superior to those in spintronics and valleytronics. Specifically, the layer reverser, a layer version of the Datta–Das transistor, also fills up the blank in designing the valley reverser in valleytronics. Our work sheds light on constructing new generation electronic devices with high performance and low-energy consumption in the framework of layertronics.

关键词： axion insulator MnBi2Te4 layertronics antiferromagnetic domain wall dissipationless transport

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Key Technologies and Prospects for Electric Vehicles Within Emerging Power Systems: Insights from Five Aspects

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cSEE Journal of Power and Energy Systems 2024年第2期10卷 439-447页

作者： Yalun li Minggao Ouyang c.c.chan Xueliang Sun Yonghua Song Wei cai Yilin Xie Yuqiong Mao Department of Electrical Engineering and School of Vehicle and MobilityTsinghua UniversityBeijing 100084China School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China Department of Electrical and Electronic Engineering The University of Hong KongHong Kong 999077China Department of Mechanical and Materials Engineering University of Western OntarioLondonON N6A 3K7Canada State Key Laboratory of Internet of Things for Smart city University of MacaoTaipaMacao 999078China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbin 150080China

The energy revolution requires coordination in energy consumption, supply, storage and institutional *** energy generation technologies, along with their associated costs, are already fully equipped for large-scale ***, energy storage remains a bottleneck, and solutions areneeded through the use of electric vehicles, which traditionallyplay the role of energy consumption in power systems. Toclarify the key technologies and institutions that support EVsas terminals for energy use, storage, and feedback, the cSEEJPES forum assembled renowned experts and scholars in relevantfields to deliver keynote reports and engage in discussions ontopics such as vehicle–grid integration technology, advancedsolid-state battery technology, high-performance electric motortechnology, and institutional innovation in the industry *** experts also provided prospects for energy storage andutilization technologies capable of decarbonizing new powersystems.

关键词： Electric vehicles engineering philosophy highpower density motor new power system solid state batteries vehicle grid integration.

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Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

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Science china(life Sciences) 2024年第5期67卷 865-878页

作者： Wei Jia Yitao li Kenneth c.P.cheung Xiaojiao Zheng School of chinese Medicine Hong Kong Baptist UniversityHong KongChina center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University School of MedicineShanghai 200233China

Bile acids(BAs)play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune *** the enterohepatic circulation,BAs are synthesized,metabolized,and reabsorbed,with a portion entering the vascular circulation and distributing *** allows BAs to interact with receptors in all major organs,leading to organ-organ interactions that regulate both local and global metabolic processes,as well as the immune *** review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation,including in the brain,heart,liver,intestine,eyes,skin,adipose tissue,and *** BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.

关键词： bile acid whole body metabolism immunity

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Spatial distributions of soil nutrients affected by land use,topography and their interactions,in the Loess Plateau of china

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International Soil and Water conservation Research 2024年第1期12卷 227-239页

作者： Wenxin Zhou changjia li Wenwu Zhao lindsay c.Stringer Bojie Fu State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijingChina Institute of Land Surface System and Sustainable Development Faculty of Geographical ScienceBeijing Normal UniversityBeijingChina Department of Environment and Geography University of YorkYorkUK York Environmental Sustainability Institute University of YorkYorkUK

Soil nutrient availability and their spatial distributions are strongly related to land use and landscape *** study aims to address the knowledge gap regarding the interaction between these factors and the underlying *** selected five land uses(grassland with Artemisia gmelinii,woodland with Robinia pseudoacacia,shrubland with caragana korshinskii and Hippophae rhamnoides,and apple orchard with Malus pumila)and nine slope positions across hillslopes in the Loess Plateau,china,to investigate their combined effects on the contents and stocks of soil organic carbon(SOc),total nitrogen(TN)and total phosphorus(TP).Parametric and non-parametric statistical tests were conducted to determine the significant differences in the means or the medians of the soil nutrient *** showed that the SOc and TN contents of shrubland with caragana korshinskii were statistically significantly greater than those of the grassland(pc and TN contents generally decreased from the upper slope to the middle slope,and to the foot slope for the grassland,woodland and shrublands,and on the contrary,an increasing trend from the upper slope,to the middle slope,and to the foot slope was identified for the apple *** study highlights that land use,slope position and their interaction have significant effects on the spatial distributions of soil *** provides essential empirical evidence for the identification of the optimal vegetation type and slope positions in land management and vegetation restoration activities.

关键词： Soil organic carbon Total nitrogen Total phosphorus Slope position Vegetation restoration

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Progress on the antiferromagnetic topological insulator MnBi2Te4

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National Science Review 2024年第2期11卷 33-49页

作者： Shuai li Tianyu liu chang liu Yayu Wang Hai-Zhou Lu X.c.Xie Department of Physics Harbin Institute of Technology Shenzhen Institute for Quantum Science and Engineering and Department of Physics Southern University of Science and Technology(SUSTech) Quantum Science center of Guangdong-Hong Kong-Macao Greater Bay Area(Guangdong) Shenzhen Key Laboratory of Quantum Science and Engineering International Quantum Academy Beijing Academy of Quantum Information Sciences Beijing Key Laboratory of Optoelectronic Functional Materials&Micro-Nano Devices Department of Physics Renmin University of China State Key Laboratory of Low Dimensional Quantum Physics Department of PhysicsTsinghua University Frontier Science center for Quantum Information Hefei National Laboratory International center for Quantum Materials School of Physics Peking University Institute for Nanoelectronic Devices and Quantum computing Fudan University

Topological materials, which feature robust surface and/or edge states, have now been a research focus in condensed maTher physics. They represent a new class of materials exhibiting nontrivial topological phases,and provide a platform for exploring exotic transport phenomena, such as the quantum anomalous Hall effect and the quantum spin Hall effect. Recently, magnetic topological materials have attracted considerable interests due to the possibility to study the interplay between topological and magnetic *** particular, the quantum anomalous Hall and axion insulator phases can be realized in topological insulators with magnetic order. MnBi2Te4, as the first intrinsic antiferromagnetic topological insulator discovered, allows the examination of existing theoretical predictions; it has been extensively studied, and many new discoveries have been made. Here we review the progress made on MnBi2Te4from both experimental and theoretical aspects. The bulk crystal and magnetic structures are surveyed first, followed by a review of theoretical calculations and experimental probes on the band structure and surface states, and a discussion of various exotic phases that can be realized in MnBi2Te4. The properties of MnBi2Te4thin films and the corresponding transport studies are then reviewed, with an emphasis on the edge state transport. Possible future research directions in this field are also discussed.

关键词： MnBi2Te4 magnetic topological insulator antiferromagnetic quantum anomalous Hall effect axion insulator

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