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Genes & Diseases 2024年第2期11卷 589-592页

作者： Maria Papatsirou Andreas Scorilas Diamantis c.Sideris christos K.Kontos Department of Biochemistry and Molecular Biology National and Kapodistrian University of AthensPanepistimiopolisAthens GR 15701Greece

Long-read sequencing with nanopore technology has been widely utilized for the identification of the full-length sequence of RNA molecules."It is especially suitable for the identification of circular RNAs(circRNAs),which are regulatory molecules that are regarded as promising non-invasive biomarkers for various human malignancies,including breast cancer.2 The impact of circRNAs derived from the protein arginine methyltransferase 1(PRMT1)gene has not been clarified yet,even though the effect of PRMT1-mediated methylation on breast cancer cell characteristics has been well established.

关键词： PRMT1 breast cancer

Hydrocarbon indication in Rio Bonito Formation sandstone:Implication for cO_(2)storage in São Paulo,Brazil

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Energy Geoscience 2024年第1期5卷 331-341页

作者： Richardson M.Abraham-A haline V.Rocha Saulo B.de Oliveira colombo c.G.Tassinarri Orlando c.da Silva Institute of Energy and Environment University of São PauloSão PauloBrazil Research centre for Greenhouse Gas Innovation University of São PauloSão PauloBrazil

São Paulo State has witnessed cO_(2)storage-based investigations considering the availability of suitable geologic structures and proximity to primary cO_(2)source sinks related to bioenergy and carbon capture and storage(BEccS)*** current study presents the hydrocarbon viability evaluations and cO_(2)storage prospects,focusing on the sandstone units of the Rio Bonito *** objective is to apply petrophysical evaluations with geochemical inputs in predicting future hydrocarbon(gas)production to boost cO_(2)storage within the study *** study used data from eleven wells with associated wireline logs(gamma ray,resistivity,density,neutron,and sonic)to predict potential hydrocarbon accumulation and fluid mobility in the investigated *** samples(shale and carbonate)obtained from depths>200 m within the study location have shown bitumen *** geochemistry data of the Rio Bonito Formation shale beds suggest they are potential hydrocarbon source rocks and could have contributed to the gas accumulations within the sandstone *** drilled well data,e.g.,cB-1-SP and TI-1-SP,show hydrocarbon(gas)presence based on the typical resistivity and the combined neutron-density responses at depths up to 3400 m,indicating the possibility of other hydrocarbon members apart from the heavy oil(bitumen)observed from the near-surface rocks *** the three-dimensional(3-D)model,the free fluid indicator(FFI)is more significant towards the southwest and southeast of the area with deeper depths of occurrence,indicating portions with reasonable hydrocarbon recovery rates and good prospects for cO_(2)injection,circulation and permanent ***,future studies based on contemporary datasets are required to establish the hydrocarbon viability further,foster gas production events,and enhance cO_(2)storage possibilities within the region.

关键词： ParanáBasin Hydrocarbon indication Sandstone reservoirs Rio Bonito Formation cO_(2)storage Hydrocarbon recovery factor Fluid injection rate

Antigen-specific mRNA lipid nanoparticle platforms for the prevention and treatment of allergy and autoimmune diseases

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BMEMat(BioMedical Engineering Materials) 2024年第2期2卷 61-68页

作者： Emma Y.Yim Amanda c.Zhou Yvonne c.Yim Xiang Wang Tian Xia Department of Molecular Cell and Developmental BiologyUniversity of CaliforniaLos AngelesUSA Department of Bioengineering University of CaliforniaLos AngelesUSA Department of chemistry and Biochemistry University of CaliforniaLos AngelesUSA Division of NanoMedicine Department of MedicineCenter for Environmental Implications of Nanotechnology(UC CEIN)California NanoSystems InstituteUniversity of CaliforniaLos AngelesUSA

While most nanomedicines primarily aim to stimulate the immune system against infections or tumors,there is a growing demand for inducing immune tolerance under certain conditions,such as allergic and autoimmune *** have explored nanotechnology-based strategies to induce immune tolerance in a targeted and specific *** approach involves the use of nanoparticles(NPs)to encapsulate immunosuppressive drugs and/or antigens to educate naïve T cells and promote the generation of antigen-specific regulatory T cells that inhibit immune ***,this approach has certain *** hydrophobicity of proteins or peptides restricts the degree to which they can be encapsulated in NPs,which in turn,affects their loading efficiency and treatment *** the emergence of mRNA lipid nanoparticle(LNP)platforms,there is the possibility of overcoming the limitations of protein and peptide *** date,mRNA LNP systems have been shown to provide organ,cellular,and subcellular targeting for the induction of immune *** method of drug delivery is flexible and scalable that can be customized for a specific patient,resulting in an effective means of administering relevant proteins or epitopes to induce antigen-specific immune *** continued research and development,this technology could offer a safer and more effective alternative to current therapies,ultimately improving the quality of life of patients worldwide.

关键词： allergy autoimmune diseases immune tolerance mRNA lipid nanoparticle nanomedicine

characterization of Arroyo Verde Epithermal Deposit:Paragenesis,Mineral Geochemistry,Geochronology and Fluid Inclusions in Lower chon Aike Volcanism,Argentina

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Journal of Earth Science 2024年第1期35卷 62-84页

作者： cecilia Pavón Pivetta Leonardo Benedini Paulo Marcos Ma.Agustina cócola Mercedes Virginia Barros Daniel Gregori Leonardo Strazzere Anderson costa dos Santos Mauro c.Geraldes Instituto Geologico del Sur(INGEOSUR) Universidad Nacional del Sur(UNS)-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)Bahia Blanca 8000Argentina Dpto.de Geologia Universidad Nacional del Sur(UNS)Bahia Blanca 8000Argentina Universidad Nacional de Rio Negro Instituto de Investigacion en Paleobiologia y GeologiaGeneral Roca 8332Argentina Universidade do Estado do Rio de Janeiro Faculdade de GeologiaDepartamento de Mineralogia e Petrologia igneaRiodeJaneiro20559-900Brazil Geobiotec Departamento de GeocienciasUniversidade de AveiroAveiro 3800-002Portuga

Arroyo Verde epithermal deposit,in the North Patagonia region of Argentina,is located within the Lower chon Aike volcanism and is developed between 192.6±2.5 Ma(mineralization host rock)and 189.5±2.6 Ma(overlying lava).Marifil volcanic complex is the host rock for these veins,veinlets and *** particular small deposit has developed low to intermediate sulphidation characteristics,with gangue mineral textures associated with several ore *** probe microanalysis determines electrum,silver minerals such as acanthite,and tetrahedrite,related Ag-cu minerals like jalpaite,mckinstryite,stromeyerite,and base metals like chalcopyrite,sphalerite,galena and *** inclusions in quartz of two out of five events indicate that these Low Jurassic veins were formed due to subtle boiling and dilution mechanisms and by low-salinity(3.4 wt.%to 6.7 wt.%Nacl Eq)magmatic-hydrothermal fluid at 225 to 310℃.The fluid inclusion measurements that indicate boiling(Event 3)were plotted,and based on this data,we interpret that the Arroyo Verde deposit has been eroded between 550 and 700 *** particular character has not been previously recorded for other sectors of the eastern north Patagonian region.

关键词： epithermal deposit Ag minerals mineral geochemistry fluid inclusions chon Aike geochronology

Decision and coordination of an E-commerce Supply chain considering Returns and Network Externalities

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Journal of Systems Science and Systems Engineering 2024年第5期33卷 552-575页

作者： Liang Shen Fei Lin Yuyan Wang Luping Ding T.c.E.cheng Dexia Wang School of Public Finance and Taxation Shandong University of Finance and Economicsjinan 250014China bschool of Management Science and Engineering Shandong University of Finance and EconomicsJinan 250014China PolyU Business School The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077China

considering the large number of returns in online sales and the network externalities of e-platforms,we develop a decentralized model and a centralized model to explore the impacts of returns and network externalities on e-commerce supply chain(EcSc)*** show that in the decentralized model,the service level,price,market demand,and EcSc members’profits increase with the network externality ***,the service level and price increase,while the market demand and EcSc members’profits decrease with the product return *** centralized model is the optimal operating mode when it is properly *** design the“commission and return cost-sharing”contract to optimize EcSc,in which the proportion of the e-platform’s sharing of the return handling cost is exactly equal to the proportion of the system profit after *** on the decentralized model,we develop two extended models in which we endogenize the impacts of the service level and return rate on the network externality *** comparisons between the extended and decentralized models,we show that high-quality service can improve EcSc’s profitability,while a high return rate hurts its economic performance.

关键词： E-commerce supply chain coordination mechanism network externalities return products

carbon coated LaFe_(0.92)Pd_(0.08)O_(3) composites for catalytic transfer hydrogenation:Balance in the ability of substrates adsorption and conversion

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Nano Research 2024年第5期17卷 3724-3732页

作者： Bowen Wang Nan Zhang Ping Xiao Jian Zhang Sónia A.c.carabineiro Junjiang Zhu Hubei Key Laboratory of Biomass Fibers and Eco-dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile UniversityWuhan 430200China college of chemistry and Materials Engineering Wenzhou UniversityWenzhou 325035China LAQV-REQUIMTE Department of ChemistryNOVA School of Science and TechnologyUniversidade NOVA de LisboaLargo da Torre2829-516 CaparicaPortugal

catalytic transfer hydrogenation(cTH)is a green and efficient pathway for selective hydrogenation of unsaturated aldehydes and ***,managing the abilities of solid catalysts to adsorb substrates and to convert them into desired products is a challenging ***,we report the synthesis of carbon coated LaFe_(0.92)Pd_(0.08)O_(3) composites(LFPO-8@c)for cTH of benzaldehyde(BzH)into benzyl alcohol(BzOH),using isopropanol(IPA)as hydrogen *** coating with carbon improves the ability to adsorb/transfer reactants from solution to active sites,and the doping of Pd2+at Fe3+site strengthens the ability of LaFeO_(3) to convert BzH into BzOH.A balanced point between them(i.e.,abilities to adsorb BzH and to convert BzH into BzOH)is obtained at LFPO-8@c,which exhibits a BzOH formation rate of 3.88 mmol·gcat^(-1)·h^(-1) at 180℃ for 3 h,which is 1.50 and 2.72 times faster than those of LFPO-8 and LaFeO_(3)@c.A reaction mechanism is proposed,in which the acidic sites(e.g.,Fe^(4+),oxygen vacancy)are used for the activation of c=O bond of BzH and O-H bond of IPA,and the basic sites(e.g.,lattice oxygen)for the activation ofα-H(O-H)bond of IPA.

关键词： LaFe_(0.92)Pd_(0.08)O_(3) porous carbon catalytic transfer hydrogenation isopropanol reaction mechanism

Impact of cOVID-19 pandemic on cardiovascular health in sedentary and athletes:consensus,uncertainties,and ways for mitigation

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Sports Medicine and Health Science 2024年第3期6卷 205-208页

作者： John c.Quindry Lei Xi School of Integrative Physiology and Athletic Training University of MontanaMissoulaMT59812USA Pauley Heart center Department of Internal MedicineSchool of MedicineVirginia Commonwealth UniversityRichmondVA23298-0204USA

More than 4 years has elapsed since the World Health Organization(WHO)ofﬁcially announced the coronavirus disease 2019(cOVID-19)as a pandemic outbreak in March 11,*** the ongoing investigations and political debates upon the origin,exacerbation,resurgence,andﬁnal control of cOVID-19,medical and scientiﬁc consensus indicates that the now endemic cOVID-19 virus is one of the worst public health crises in our *** every person on earth has been directly or indirectly impacted by the adverse effects of the highly contagious viral pathogen-SARS-coV-2(severe acute respiratory syndrome coronavirus 2).Indeed,the population reach of the cOVID-19 infection includes governmental response measures(e.g.,lockdowns and social distancing,mandates for masks and face coverings,vaccines,etc.)that have restricted entrenched societal routines,personal mobility,and ***,the host of health problems linked to this viral infection linger to this day,with selective groups of people experiencing a higher risk for untoward medical outcomes and/or elevated levels of vulnerability to the post-acute sequelae of cOVID-19(***-cOVID).For example,a 2021 study by Logue et *** initial evidence that 10%–30%of individuals in United States may experience prolonged symptoms following SARS-coV-2 infection,including cardiovascular abnormalities.1 Similarly,a 2021 retrospective cohort study in England suggest that the incidence of major adverse cardiovascular events(*** failure,myocardial infarction,ischemic stroke.

关键词： cardiovascular routine Impact

Mineral-mediated stability of organic carbon in soil and relevant interaction mechanisms

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Eco-Environment & Health 2024年第1期3卷 59-76页

作者： Zibo Xu Daniel c.W.Tsang Department of civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongChina

Soil,the largest terrestrial carbon reservoir,is central to climate change and relevant feedback to environmental *** are the essential components that contribute to over 60%of soil carbon ***,how the interactions between minerals and organic carbon shape the carbon transformation and stability remains poorly ***,we critically review the primary interactions between organic carbon and soil minerals and the relevant mechanisms,including sorption,redox reaction,co-precipitation,dissolution,polymerization,and catalytic *** interactions,highly complex with the combination of multiple processes,greatly affect the stability of organic carbon through the following processes:(1)formation or deconstruction of the mineral–organic carbon association;(2)oxidative transformation of the organic carbon with minerals;(3)catalytic polymerization of organic carbon with minerals;and(4)varying association stability of organic carbon according to the mineral *** pieces of evidence related to the carbon turnover and stability during the interaction with soil minerals in the real eco-environment are then *** also highlight the current research gaps and outline research priorities,which may map future directions for a deeper mechanismsbased understanding of the soil carbon storage capacity considering its interactions with minerals.

关键词： carbon stability Mineral transformation carbon sequestration Bio-geochemistry Soil carbon management Sustainable waste management

Mathematical modeling and simulations of stress mitigation by coating polycrystalline particles in lithium-ion batteries

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 947-962页

作者： N.IQBAL J.cHOI S.F.SHAH c.LEE S.LEE Department of Mechanical Roboticsand Energy EngineeringDongguk University-SeoulSeoul 04620Republic of Korea

A chemo-mechanical model is developed to investigate the effects on the stress development of the coating of polycrystalline Ni-rich LiNixMnyco_(z)O_(2)(x≥0.8)(NMc)particles with poly(3,4-ethylenedioxythiophene)(PEDOT).The simulation results show that the coating of primary NMc particles significantly reduces the stress generation by efficiently accommodating the volume change associated with the lithium diffusion,and the coating layer plays roles both as a cushion against the volume change and a channel for the lithium transport,promoting the lithium distribution across the secondary particles more ***,the lower stiffness,higher ionic conductivity,and larger thickness of the coating layer improve the stress *** paper provides a mathematical framework for calculating the chemo-mechanical responses of anisotropic electrode materials and fundamental insights into how the coating of NMc active particles mitigates stress levels.

关键词： lithium-ion battery(LIB) polycrystalline particle coating finite element simulation Ni-rich LiNixMnyco_(z)O_(2)(x>0.8)(NMc)

Effect of trigger system on experimental dispersion characteristics of active surface wave testing

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 311-318页

作者： Lin Shibin Jeramy c.Ashlock Zhu Liming Qin Zexiang Li Bo Zhu Xingji Zhai changhai State Key Laboratory of Precision Blasting Jianghan UniversityWuhan 430056China Hubei Key Laboratory of Blasting Engineering Jianghan UniversityWuhan 430056China Department of civil Construction&Environmental EngineeringIowa State UniversityAmesIA 50010USA Wuhan Airport Road Development co. Ltd.Wuhan 430065China School of civil and Environmental Engineering Harbin Institute of TechnologyShenzhen 518055China Key Lab of Structures Dynamic Behavior and control of the Ministry of Education Harbin Institute of TechnologyHarbin 150090China Key Lab of Smart Prevention and Mitigation of civil Engineering Disaster of the Ministry of Industry and Information Technology Harbin Institute of TechnologyHarbin 150090China

A trigger system is typically employed in active seismic testing to trigger and synchronize multichannel surface wave data *** effect of the trigger system on the dispersion image of surface waves is empirically known to be negligible,however,theoretical explanation regarding the effect of the trigger system is *** study systematically examines the theory for surface wave dispersion analysis and proves that the effect of the trigger system on a dispersion image is negligible via a solid theoretical ***,based on the new theoretical explanation,an alternative method that uses only the relative phase difference between sensors to extract dispersion characteristics with better conceptual clarity is *** active surface wave testing cases are considered to validate the theory and *** results indicate that(1)an accurate trigger system is not necessary for surface wave data acquisition,and(2)it is unnecessary to assume that the impact point is the generation point of the surface waves for the experimental dispersion analysis.

关键词： site investigation surface waves data acquisition dispersion