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Evaluation of the Antibacterial and Antifungal capacity of Nanoemulsions Loaded with Synthetic chalcone Derivatives Di-Benzyl cinnamaldehyde and Benzyl 4-Aminochalcone

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Journal of Renewable Materials 2024年第2期12卷 285-304页

作者： Flavia Oliveira Monteiro da Silva Abreu Taysse holanda Joice Farias do Nascimento henety Nascimento Pinheiro Rachel Menezes castelo hélcio Silva dos Santos Thais Benincá Patrícia da Silva Malheiros Júlio césar Sousa Prado Raquel de Oliveira Fontenelle Maria Madalena de camargo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product chemistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food hygiene and Microbiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antimicrobial resistance,it has become necessary to explore alternative approaches for combating and preventing ***-cinnamaldehyde(cNM)and Benzyl4-amino(B4AM)are bioactive compounds derived from chalcones but with restricted solubility in aqueous *** can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials,with reduced side effects and prolonged *** objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages,to propose a stable formulation with antimicrobial *** showed that nanoemulsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm,indicating that emulsification was a suitable method for nanoemulsion *** with higher dosages exhibited significant antimicrobial effects when compared to free chalcones and positive ***,B4AM nanoemulsions at higher dosages showed expressive activity against Salmonella minnesota,with a 420%greater inhibitory response compared to the free form and showing equivalence to the positive *** nanoemulsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against *** and Staphylococcus *** greater number of conjugated bonds in cNM increased the antimicrobial activity in comparison with B4AM,and the formation of nanometric domains enhanced the bioavailability,being a promising alternative for antimicrobial applications.

关键词： Polysaccharide nanoemulsions S.aureus S.minnesota chalcones alginate

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carbon coated LaFe_(0.92)Pd_(0.08)O_(3) composites for catalytic transfer hydrogenation:Balance in the ability of substrates adsorption and conversion

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Nano Research 2024年第5期17卷 3724-3732页

作者： Bowen Wang Nan Zhang Ping Xiao Jian Zhang Sónia A.c.carabineiro Junjiang Zhu hubei Key Laboratory of Biomass Fibers and Eco-dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile UniversityWuhan 430200China college of chemistry and Materials Engineering Wenzhou UniversityWenzhou 325035China LAQV-REQUIMTE Department of ChemistryNOVA School of Science and TechnologyUniversidade NOVA de LisboaLargo da Torre2829-516 CaparicaPortugal

catalytic transfer hydrogenation(cTh)is a green and efficient pathway for selective hydrogenation of unsaturated aldehydes and ***,managing the abilities of solid catalysts to adsorb substrates and to convert them into desired products is a challenging ***,we report the synthesis of carbon coated LaFe_(0.92)Pd_(0.08)O_(3) composites(LFPO-8@c)for cTh of benzaldehyde(Bzh)into benzyl alcohol(BzOh),using isopropanol(IPA)as hydrogen *** coating with carbon improves the ability to adsorb/transfer reactants from solution to active sites,and the doping of Pd2+at Fe3+site strengthens the ability of LaFeO_(3) to convert Bzh into BzOh.A balanced point between them(i.e.,abilities to adsorb Bzh and to convert Bzh into BzOh)is obtained at LFPO-8@c,which exhibits a BzOh formation rate of 3.88 mmol·gcat^(-1)·h^(-1) at 180℃ for 3 h,which is 1.50 and 2.72 times faster than those of LFPO-8 and LaFeO_(3)@c.A reaction mechanism is proposed,in which the acidic sites(e.g.,Fe^(4+),oxygen vacancy)are used for the activation of c=O bond of Bzh and O-h bond of IPA,and the basic sites(e.g.,lattice oxygen)for the activation ofα-h(O-h)bond of IPA.

关键词： LaFe_(0.92)Pd_(0.08)O_(3) porous carbon catalytic transfer hydrogenation isopropanol reaction mechanism

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Seasonal changes in hermit Thrush (catharus guttatus) song syntax

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Avian Research 2024年第2期15卷 172-179页

作者： Sean P.Roach Luke c.McLean Jeff W.MacLeod Leslie S.Phillmore Psychology Department University of New Brunswick Saint John100 Tucker Park RoadSaint JohnNBCanada Department of Psychology and Neuroscience Dalhousie University1355 Oxford StHalifaxNSB3H 4J1Canada

In many songbird species,birdsong features phonological syntax,meaning that the units within their vocal se-quences are ordered in a non-random way that adheres to a *** such syntactical patterns have been richly described in many species,comparatively little is known about how those patterns contribute to song achieving its important *** each of song’s main functions,territorial defense and mate attraction,evidence of a role for syntax is *** species for which syntax has been thoroughly described is the hermit Thrush(catharus guttatus),which presents song types from their repertoires in a semi-predictable order and,in doing so,rapidly cycle up and down the frequency *** objective of the present study was to explore the importance of song syntax in the hermit Thrush through a within-subject examination of how measures of syntax,such as the predictability of song type order within song sequences,shift over the breeding *** hypothesized that,if such syntactical characteristics are important to breeding behaviour,they would be most prominent at the start of the breeding season when activity associated with territory establishment and mate attraction is most *** revealed that,as predicted,the rigidness of song type ordering within se-quences was highest at the start of the season and declined *** song type sequences were most predictable at the vitally important early part of the breeding season fit our hypothesis that this aspect of song syntax is important to song’s functions related to territory establishment and/or mate *** work will clarify whether that role relates to one of song’s two main functions or serves song transmission in some broader way.

关键词： Birdsong hermit Thrush Seasonal change Stereotypy Syntax

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Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression

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World Journal of clinical Oncology 2024年第2期15卷 195-207页

作者： Angeles c Tecalco-cruz Karen h Medina-Abreu Enrique Oropeza-Martínez Jesus Zepeda-cervantes AleidaVázquez-Macías Marina Macías-Silva Posgrado en ciencias Genómicas Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico colegio de ciencias y humanidades Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Instituo de Fisiología celular Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico

Interferon-gamma(IFN-γ)plays a dual role in cancer;it is both a pro-and an antitumorigenic cytokine,depending on the type of *** deregulation of the IFN-γcanonic pathway is associated with several disorders,including vulner-ability to viral infections,inflammation,and cancer *** particular,the interplay between lung adenocarcinoma(LUAD)and viral infections appears to exist in association with the deregulation of IFN-γ*** this mini-review,we investigated the status of the IFN-γsignaling pathway and the expression level of its components in ***,a reduction in IFNGR1 expression seems to be associated with LUAD progression,affecting defenses against viruses such as severe acute respiratory syndrome coronavirus *** addition,alterations in the expression of IFNGR1 may inhibit the antiproliferative action of IFN-γsignaling in LUAD.

关键词： Interferon-gamma IFNGR1 JAK1 Antiviral Anti-tumor Lung adenocarcinoma

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Fully integrated and broadband Si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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Photonics Research 2024年第3期12卷 I0001-I0010页

作者： VALERIO VITALI ThALÍA DOMÍNGUEZ BUcIO hAO LIU JOSÉMANUEL LUQUE GONZÁLEZ FRANcIScO JURADO-ROMERO ALEJANDRO ORTEGA-MOÑUX GLENN chURchILL JAMES c.GATES JAMES hILLIER NIKOLAOS KALFAGIANNIS DANIELE MELATI JENS h.SchMID ILARIA cRISTIANI PAVEL chEBEN J.GONZALO WANGÜEMERT-PÉREZ ÑIGO MOLINA-FERNÁNDEZ FREDERIc GARDES cOSIMO LAcAVA PERIKLIS PETROPOULOS Optoelectronics Research centre University of SouthamptonSouthampton SO171BJUK Electrical Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy Telecommunication Research Institute(TELMA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain School of Science and Technology Nottingham Trent UniversityNottingham NG118NSUK Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece centre de Nanosciences et de Nanotechnologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanced Electronics and Photonics Research center National Research Council CanadaOttawaOntario K1A 0R6Canada

Intermodal four-wave mixing(FWM)processes have recently attracted significant interest for all-optical signal processing applications thanks to the possibility to control the propagation properties of waves exciting distinct spatial modes of the same *** allows,in principle,to place signals in different spectral regions and satisfy the phase matching condition over considerably larger bandwidths compared to intramodal ***,the demonstrations reported so far have shown a limited bandwidth and suffered from the lack of on-chip components designed for broadband manipulation of different *** demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWM,which integrates mode conversion,multiplexing and de-multiplexing functionalities *** system enables wavelength conversion between pump waves and a signal located in different telecommunication bands(separated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which represents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWM-based system.

关键词： scattering pump modal

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Distinct Electrical and Mechanical Responses of a cu-10Fe composite Prepared by hot-Pressed Sintering and Post Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 255-265页

作者： X.Y.Yue S.Y.Peng X.Zhang c.N.he Y.Z.Tian Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China School of Materials Science and Engineering and Tianjin Key Laboratory of composite and Functional Materials Tianjin UniversityTianjin300350China Research centre for Metallic Wires Northeastern UniversityShenyang110819China

A cu-10wt%Fe composite was prepared through hot-pressed sintering,and the material was subsequently solution *** hot-pressed sintered and solution treated materials were rolled and *** precipitation behavior and performance changes were systematically studied by using scanning electron microscopy and transmission electron *** contrast to the hot-pressed sintered specimen,the solution treatment significantly affects the thermal stability and properties of the cu-10wt%Fe *** cu-10wt%Fe composite was prepared after solid solution,cold rolling and aging at 773 K for 1 h,and it obtained excellent tensile strength of 494 MPa,uniform elongation of 16.3%,electrical conductivity of 51.1%IAcS and softening temperature of 838 *** for the distinct difference in thermal stability and properties between hot-pressed sintered and solution treated specimens were *** findings provide a theoretical basis for designing high-performance cu-based in-situ composites by post treatment.

关键词： cu-Fe composite hot-pressed sintering Thermal stability Strength Electrical conductivity

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DPY19L3 promotes vasculogenicmimicry by its c-mannosyltransferase activity

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Oncology Research 2024年第4期32卷 607-614页

作者： hASSAN BAYDOUN YUJI KATO hIROKI KAMO ANNA hÜSch hAYATO MIZUTA RYOTA KAWAhARA SIRO SIMIZU Department of Applied chemistry Faculty of Science and TechnologyKeio UniversityYokohama223-8522Japan Department of Pharmacy and Biochemistry Faculty of ScienceUniversity of TübingenTübingen72074Germany

c-mannosylation is a post-translational modification that occurs intracellularly in the endoplasmic *** humans,biosynthesis of c-mannosylation in proteins containing thrombospondin type 1 repeat is catalyzed by the DPY19 family;nonetheless,biological functions of protein c-mannosylation are not yet fully understood,especially in tumor *** mimicry(VM)is the formation of fluid-conducting channels by highly invasive and genetically deregulated tumor cells,enabling the tumors to form matrix-embedded vasculogenic structures,containing plasma and blood cells to meet the metabolic demands of rapidly growing *** this study,we focused on DPY19L3,a c-mannosyltransferase,and aimed to unravel its role in *** of DPY19L3 inhibited the formation of VM in hT1080 human fibrosarcoma ***-expression of wild-type DPY19L3 recovered VM formation;however,DPY19L3 isoform2,an enzymatic activity-defect mutant,did not restore it,suggesting that the c-mannosyltransferase activity of DPY19L3 is crucial to its ***,the knockdown of DPY19L3 in MDA-MB-231 breast cancer cells hindered its network formation ***,our findings suggest that DPY19L3 is required for VM formation and stipulate the relevance of c-mannosylation in oncogenesis.

关键词： c-mannosylation Vasculogenic mimicry DPY19L3

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Microscopic shell-model description of irrotational-flow dynamics in^(102)Pd

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chinese Physics c 2024年第1期48卷 82-93页

作者： h.G.Ganev Joint Institute for Nuclear Research DubnaRussia Institute of Mechanics Bulgarian Academy of SciencesSofiaBulgaria

The structure of the low-lying collective excitations in 102Pd is examined within the recently proposed microscopic shell-model version of the Bohr-Mottelson(BM)collective model.A good description of the excitation energies of the lowest ground,γ,andβbands,as well as the staggering function between the collective states of theγband and some other energy-dependent quantities,is *** low-energy intraband and interband quadrupole dynamics is reasonably well described within the present proton-neutron sympletic based shell-model approach without the use of an effective charge and compared with the predictions of nuclear structure *** obtained results of the present study shed light on the question of the existence of irrotational-flow type quadrupole dynamics,which lies on the ground of the original BM model of quantized vibrations and surface-wave rotations in atomic nuclei.

关键词： shell-model version of the Bohr-Mottelson model irrotational-flow dynamics proton-neutron symplectic model Sp(12,R)dynamical algebra

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hematological Malignancies in Sickle cell Disease Patients: Report of Four cases in Togo and Literature Review

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Open Journal of Blood Diseases 2024年第1期14卷 31-41页

作者： Padaro Essohana Guedenon M. Koffi Magnang hèzouwè Womey M. c. Kodzovi Layibo Yao Kalaissi Mandjamana Agate R. Pikiliwè Department of hematology Campus Teaching Hospital University of Lomé Lomé Togo Department of Pediatrics Sylvanus Olympio Teaching Hospital University of Lomé Lomé Togo National center of Research and Treatement of Sickle cell Disease Patients (cNRSD) Lomé Togo Department of hematology Sylvanus Olympio Teaching Hospital University of Lomé Lomé Togo

Background: hemopathies were rarely observed in major sickle cell disease patients some thirty years ago, probably due to the high mortality rate among the latter as a result of progressive complications. Thanks to advances in the management of sickle cell disease, patients' life expectancy has increased considerably, exposing them more frequently to neoplasia, including hematological malignancies. The increased risk of leukemogenesis is multifactorial and linked to the pathophysiological mechanisms of the clinical manifestations of sickle cell disease. Study Setting: The clinical haematology department of campus teaching hospital and the paediatric onco-haematology unit of Sylvanus Olympio teaching hospital in Lomé were used as study settings. Observations: Four hematologic malignancies were collected in a cohort of 5847 major sickle cell syndromes. The median age of the patients was 31.25 years (extremes: 14 and 58 years) and they were predominantly female (sex ratio M/F = 0.25). Two were on background therapy with hydroxyurea. Among the four patients, there were two cases of acute lymphocytic leukemia, including ALL3 in a 58-year-old SS woman and T-ALL2 in a 12-year-old Sc. Then, a case of lymphocytic lymphoma in a 20-year-old SS man was reported and finally a case of chronic myelocytic leukemia in a 33-year-old woman of Sβ+ thalassaemia phenotype. conclusion: To further report this coexistence, it is therefore essential to systematically consider hematological malignancies during major sickle cell syndromes even if there are similarities in the symptomatology of these two serious pathological situations.

关键词： hematological Malignancies Sickle cell Disease Lomé-Togo

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Phytoconstituents Profiling of Indigenous herbal Drugs and Its in vitro Microbial,in Silico Biological Examination against Severe Acute Respiratory Syndrome coronavirus 2

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World Journal of Traditional chinese Medicine 2024年第1期10卷 121-136页

作者： T.h.Mohamed Ahadu Shareef MMohamed Divan Masood Irfan Navabshan MSaiyad Musthafa Department of chemistry The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia School of computer Applications B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia crescent School of Pharmacy B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia Department of Zoology The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia

Background:habb-E-Shifa,hamdard Sualin,and hamdard Joshanda traditional herbal medicines may promote host resistance against infection by bacteria,viruses,and fungi which are easily accessible at inexpensive with no *** herbal medicines are used to cure sore throat,cough,fever,lung cancer,and asthma patients in developing South Asian *** traditional herbal medicines acted a crucial role in the prevention and control of coronavirus disease 2019(cOVID-19).Aims and Objectives:This research article aimed at conducting phytochemistry,antimicrobial activity,cOVID-19 docking and some spectroscopic(Infrared,Ultraviolet,13c-Nuclear Magnetic Resonance(13c-NMR),1h-NMR,and Mass Spectra)characterizations of the polyherbal drugs were carried ***,In-vitro and In-silico analyses were performed to measure activity against *** Performance-Liquid chromatography(hPLc),Gas chromatography-Mass Spectrometry(Gc-MS),antimicrobial,and docking studies were carried *** preliminary phytochemical assay and bioactive compounds were screened using hPLc and *** study is an attempt to assess the promising effects of selected polyherbal indigenous drugs such as habb-E-Shifa,hamdard Sualin,and hamdard Joshanda phytoconstituents against the severe acute respiratory syndrome coronavirus-2(SARS-co V-2).Materials and Methods:The extract of the selected polyherbal formulations showed high-to-moderate preventive effects on the growth inhibition in the pathogenic bacterium,namely Streptococcus oralis,Staphylococcus aureus,Propionibacterium acnes,Pseudomonas aeruginosa,Escherichia coli,and Proteus vulgaris,and three fungal candida albicans,Aspergillus fumigatus,and Aspergillus *** docking study evaluates the pharmacological activity of bioactive chemical compounds with SARS-co V-2 NSP5(PDB ID:7nxh)and SARS-co V-2 Omicron spike protein with human angiotensin-converting enzyme 2(AcE-2)(PDB ID:7wk6).Results:In this study,for the first time,we at

关键词： Antimicrobial herbal drug Omicron and coronavirus disease 2019 phytochemicals spectroscopic

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