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Glucagon-like peptide 1 receptor activation:anti-inflammatory effects in the brain

Neural Regeneration Research 2024年第8期19卷 1671-1677页

作者： Yolanda Diz-chaves Zainab Maastor carlos Spuch José Antonio Lamas Lucas c.González-Matías Federico Mallo Biomedical Research centre(cINBIO) Laboratory of EndocrinologyUniversity of VigoGalicia Sur Health Research InstituteVigoSpain Translational Neuroscience Research Group Galicia Sur Health Research InstituteCIBERSAMHospitalÁlvaro CunqueiroSala InvestigaciónEstrada Clara CampoamorVigoSpain Biomedical Research centre(cINBIO) Laboratory of NeuroscienceUniversity of VigoGalicia Sur Health Research InstituteVigoSpain

The glucagon-like peptide 1 is a pleiotropic hormone that has potent insulinotropic effects and is key in treating metabolic diseases such as diabetes and ***-like peptide 1 exerts its effects by activating a membrane receptor identified in many tissues,including diffe rent brain ***-like peptide 1 activates several signaling pathways related to neuroprotection,like the support of cell growth/survival,enhancement promotion of synapse formation,autophagy,and inhibition of the secretion of proinflammatory cytokines,microglial activation,and apoptosis during neural *** glial cells,including astrocytes and microglia,maintain metabolic homeostasis and defe nse against pathogens in the central nervous *** brain insult,microglia are the first cells to respond,followed by reactive *** activated cells produce proinflammato ry mediators like cytokines or chemokines to react to the ***,under these circumstances,mic roglia can become chro nically inflammatory by losing their homeostatic molecular signature and,consequently,their functions during many *** processes promote the development of neurological disorders and influence their pathological evolution:like the formation of protein aggregates,the accumulation of abnormally modified cellular constituents,the formation and release by injured neurons or synapses of molecules that can dampen neural function,and,of critical impo rtance,the dysregulation of inflammato ry control *** glucagonlike peptide 1 receptor agonist emerges as a critical tool in treating brain-related inflammatory pathologies,restoring brain cell homeostasis under inflammatory conditions,modulating mic roglia activity,and decreasing the inflammato ry *** review summarizes recent advances linked to the anti-inflammato ry prope rties of glucagon-like peptide 1 receptor activation in the brain related to multiple sclerosis,Alzheimer’s disease,Parkins

关键词： astrocytes brain glucagon-like peptide 1 receptor inflammation microglia

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A transient shift in equatorial hydrology and vegetation during the Eocene Thermal Maximum 2

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Geoscience Frontiers 2024年第5期15卷 174-181页

作者： Gaurav Srivastava Harshita Bhatia Poonam Verma Yogesh P.Singh Shailesh Agrawal Torsten Utescher R.c.Mehrotra Birbal Sahni Institute of Palaeosciences 53 University RoadLucknow 226007India Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India Senckenberg Research Institute and Natural History Museum Frankfurt/M.Senckenberg Research Station of Quaternary PalaeontologyWeimerGermany Institute for Geosciences University of BonnNussallee 853115 BonnGermany

The equatorial evergreen forests nourish the world’s biodiversity hotspots and are considered the lungs of the ***,their future survival is uncertain,due to anthropogenically increased carbon emissions and changes in the hydrological *** the changes in the hydrological cycle in the equatorial region due to an increase in carbon emission is of prime *** early Paleogene hyperthermal events are potential analogs to understand the consequences of high carbon emission on the hydrological *** this communication,we quantify the terrestrial seasonal climate using the plant proxy and infer that during the Eocene Thermal Maximum 2 when atmospheric carbon dioxide concentration was>1000 ppmv near the palaeo-equator(~0.6°N),the rainfall decreased significantly,leading to the expansion of deciduous *** study raises important questions about the future survival of equatorial rainforests and biodiversity hotspots under increased carbon emissions.

关键词： coexistence approach climate ETM-2 Global warming Hyperthermal Paleogene

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亚里士多德的善和恶

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世界哲学 2024年第2期 68-78页

作者： [爱尔兰]c.D.c.里夫孔祥润(译) 美国北卡罗来纳大学教堂山分校哲学系天津理工大学马克思主义学院

亚里士多德确实有一种关于恶的理论。善在定义上优先于恶,这是由善所需要的本体论边界决定的。如果善实际上就是卓越的存在,那么恶必定是这种存在的缺乏。在实体范畴中,亚里士多德的善是一种活的存在,在对自身的沉思中,第一性的神获得... 详细信息

亚里士多德确实有一种关于恶的理论。善在定义上优先于恶,这是由善所需要的本体论边界决定的。如果善实际上就是卓越的存在,那么恶必定是这种存在的缺乏。在实体范畴中,亚里士多德的善是一种活的存在,在对自身的沉思中,第一性的神获得了善并且是幸福的。由此类推,如果存在一种实体范畴上的恶,那么它必定是一种能对自身加以沉思的活的存在。然而在亚里士多德勾勒的事物体系中,这种观念是无法实现的。亚里士多德的善的理论排除了把一种恶(即实体性的巨大的恶)等同于善的可能性。这种理论认真对待伦理上的恶,把它当作心理学、政治学问题,而不是当作本体论问题。无条件的恶说的不是理性的神灵,而是心理变态之人或反社会之人,说的是一位恶人,尽管这个人处在一种特定的社会,即良好的社会之中。

关键词：亚里士多德善恶幸福

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Experimental study of corner separation and unsteady characteristics in linear compressor cascades with and without sweeping jet actuator

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Propulsion and Power Research 2024年第3期13卷 360-374页

作者： S.W.chen W.H.Li c.Xu Q.H.Meng School of Energy Science and Engineering Harbin Institute of TechnologyHarbinHeilongjiang 150001China AVIc Shenyang Aircraft Design and Research Institute Shenyang 110035China

Sweeping jet actuator(SJA)has been widely applied for activeflow control in *** this paper,the SJA character in compressor cascade and its performance for separation control in innerflows are ***-averaged and transientflowfield measurement,together with visualization methods are *** is found that endwall effects are important for both SJA behaviors and SJA performance for separation control in compressor *** is a maximum of 12.7%total pressure loss reduction with SJA placed near the separation position,close to the endwall and under *** characteristic frequencies in theflowfield contribute to the capture of influence regions of vortices and excitation *** concentrated shedding vortices and SJA jets impact region helped to judge that SJA energizes low momentumfluids in a large region and matches the high loss core *** be concrete,theflow separation control mechanism of SJA lies on the interruption of the blade suction surface boundary layer development and the restriction of the lifting of the boundary layer from end-wall towards blade suction surface.

关键词： compressor cascade Activeflow control Sweeping jet actuator corner separation Oilflow visualization

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Industrial Fusion cascade Detection of Solder Joint

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computers, Materials and continua 2024年第1期81卷 1197-1214页

作者： Li c. Zhang P. Wang S. Liu L. Shi M. chongqing School University of Chinese Academy of Sciences Chongqing University Chongqing 400044 China Automatic Reasoning and cognition Research center Chongqing Institute ofGreen and Intelligent Technology Chinese Academy of Sciences Chongqing 400714 China college of Artificial Intelligence Chongqing School University of Chinese Academy of Sciences Chongqing 400714 China Design Department Liuzhou Fuzhen Bodywork Industrial Co. Ltd. Liuzhou 545006 China

With the remarkable advancements in machine vision research and its ever-expanding applications, scholars have increasingly focused on harnessing various vision methodologieswithin the industrial realm. Specifically, detecting vehicle floor welding points poses unique challenges, including high operational costs and limited portability in practical settings. To address these challenges, this paper innovatively integrates template matching and the Faster RcNN algorithm, presenting an industrial fusion cascaded solder joint detection algorithm that seamlessly blends template matching with deep learning techniques. This algorithm meticulously weights and fuses the optimized features of both methodologies, enhancing the overall detection capabilities. Furthermore, it introduces an optimized multi-scale and multi-template matching approach, leveraging a diverse array of templates and image pyramid algorithms to bolster the accuracy and resilience of object detection. By integrating deep learning algorithms with this multi-scale and multi-template matching strategy, the cascaded target matching algorithm effectively accurately identifies solder joint types and positions. A comprehensive welding point dataset, labeled by experts specifically for vehicle detection, was constructed based on images from authentic industrial environments to validate the algorithm's performance. Experiments demonstrate the algorithm's compelling performance in industrial scenarios, outperforming the single-template matching algorithm by 21.3%, the multi-scale and multitemplate matching algorithm by 3.4%, the Faster RcNN algorithm by 19.7%, and the YOLOv9 algorithm by 17.3% in terms of solder joint detection accuracy. This optimized algorithm exhibits remarkable robustness and portability, ideally suited for detecting solder joints across diverse vehicle workpieces. Notably, this study's dataset and feature fusion approach can be a valuable resource for other algorithms seeking to enhance their

关键词： cascade object detection deep learning feature fusion multi-scale and multi-template matching solder joint dataset

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Re-Distributing Facial Features for Engagement Prediction with ModernTcN

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computers, Materials and continua 2024年第1期81卷 369-391页

作者： Li X. Zhu W. Li Q. Hou c. Zhang Y. college of Information and Artificial Intelligence Nanchang Institute of Science and Technology Nanchang 330108 China School of Electrical and Information Engineering Wuhan Institute of Technology Wuhan 430205 China School of Electronic Information Engineering Wuhan Donghu University Wuhan 430212 China

Automatically detecting learners’ engagement levels helps to develop more effective online teaching and assessment programs, allowing teachers to provide timely feedback and make personalized adjustments based on students’ needs to enhance teaching effectiveness. Traditional approaches mainly rely on single-frame multimodal facial spatial information, neglecting temporal emotional and behavioural features, with accuracy affected by significant pose variations. Additionally, convolutional padding can erode feature maps, affecting feature extraction’s representational capacity. To address these issues, we propose a hybrid neural network architecture, the redistributing facial features and temporal convolutional network (RefEIP). This network consists of three key components: first, utilizing the spatial attention mechanism large kernel attention (LKA) to automatically capture local patches and mitigate the effects of pose variations; second, employing the feature organization and weight distribution (FOWD) module to redistribute feature weights and eliminate the impact of white features and enhancing representation in facial feature maps. Finally, we analyse the temporal changes in video frames through the modern temporal convolutional network (ModernTcN) module to detect engagement levels. We constructed a near-infrared engagement video dataset (NEVD) to better validate the efficiency of the RefEIP network. Through extensive experiments and in-depth studies, we evaluated these methods on the NEVD and the Database for Affect in Situations of Elicitation (DAiSEE), achieving an accuracy of 90.8% on NEVD and 61.2% on DAiSEE in the four-class classification task, indicating significant advantages in addressing engagement video analysis problems. © 2024 The Authors. Published by Tech Science Press.

关键词： Engagement prediction re-distributing facial features spatiotemporal network temporal convolutional network

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巴西油气勘探开发历程:从陆上到超深水

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石油勘探与开发 2024年第4期51卷 796-806页

作者： ANJOS Sylvia M c SOMBRA cristiano L SPADINI Adali R 巴西国家石油公司里约热内卢20231-030巴西

21世纪以来,随着桑托斯盆地深水盐下获得一系列重大油气发现,巴西东部海域成为全球深水油气勘探与生产的热点区域。通过全面回顾巴西油气勘探开发历程,系统阐述了从陆上到海域、从浅水到深水—超深水直至盐下勘探的探索实践、战略转变... 详细信息

21世纪以来,随着桑托斯盆地深水盐下获得一系列重大油气发现,巴西东部海域成为全球深水油气勘探与生产的热点区域。通过全面回顾巴西油气勘探开发历程,系统阐述了从陆上到海域、从浅水到深水—超深水直至盐下勘探的探索实践、战略转变、重大突破和关键理论技术。巴西国家石油公司(简称巴西国油)自1953年成立以后的15年间,在陆上古生界克拉通盆地和断陷盆地进行了勘探,并于断块和三角洲砂体圈闭获得了一些中小型油气发现。20世纪70年代,应用重力流沉积模式和高质量三维地震等勘探新技术,在坎波斯盆地浅水中发现Namorado和Enchova等油田,随后深水盐上勘探获得突破,成功发现Marlim、Roncador等大型油田。21世纪初,通过盐下含油气系统、碳酸盐岩成储成藏模式和核磁共振测井等理论技术攻关,推动桑托斯盆地下白垩统湖相碳酸盐岩陆续获得Tupi(Lula)、Buzios、Mero等世界级超深水盐下大油田的系列重大发现。在复杂的深水作业环境下,油气开发工程面临巨大挑战,巴西国油通过启动深水研发计划(PROcAP),开发并实施窄压力窗口控压钻井、加压钻井液帽钻井、多段智能完井、水下采油及浮式生产平台开发和流动保障等关键技术,显著提升了钻完井、油气田开发和输运的效率及安全性。此外,在浮式采储卸油系统建产规模受限的情况下,推进全球最大规模的cO_(2)捕集、驱油利用与埋存工程(ccUS-EOR),有效减少温室气体排放并提高了原油采收率。上述理论技术的发展和应用,也为全球深水油气勘探开发提供了宝贵经验。未来巴西油气勘探将继续聚焦深水盐下碳酸盐岩和盐上浊积岩,并在古生界天然气等勘探领域持续寻求新的发现,同时通过技术创新和战略合作,促进巴西石油天然气行业的可持续发展。

关键词：巴西深水盐下勘探坎波斯盆地桑托斯盆地浊积岩湖相碳酸盐岩深水开发流动保障

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Efficient User Identity Linkage Based on Aligned Multimodal Features and Temporal correlation

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computers, Materials and continua 2024年第1期81卷 251-270页

作者： Gao J. Zheng K. Wang X. Wu c. Wu B. School of cyberspace Security Beijing University of Posts and Telecommunications Beijing 100876 China Faculty of Information Technology Beijing University of Technology Beijing 100124 China

User identity linkage (UIL) refers to identifying user accounts belonging to the same identity across different social media platforms. Most of the current research is based on text analysis, which fails to fully explore the rich image resources generated by users, and the existing attempts touch on the multimodal domain, but still face the challenge of semantic differences between text and images. Given this, we investigate the UIL task across different social media platforms based on multimodal user-generated contents (UGcs). We innovatively introduce the efficient user identity linkage via aligned multi-modal features and temporal correlation (EUIL) approach. The method first generates captions for user-posted images with the BLIP model, alleviating the problem of missing textual information. Subsequently, we extract aligned text and image features with the cLIP model, which closely aligns the two modalities and significantly reduces the semantic gap. Accordingly, we construct a set of adapter modules to integrate the multimodal features. Furthermore, we design a temporal weight assignment mechanism to incorporate the temporal dimension of user behavior. We evaluate the proposed scheme on the real-world social dataset TWIN, and the results show that our method reaches 86.39% accuracy, which demonstrates the excellence in handling multimodal data, and provides strong algorithmic support for UIL. © 2024 The Authors. Published by Tech Science Press.

关键词： attention mechanism multimodal models temporal correlation User identity linkage

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Multichannel coupling induced topological insulating phases with full multimerization

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Photonics Research 2024年第3期12卷 491-498页

作者： JUN LI YAPING YANG c-M.HU MOE Key Laboratory of Advanced Micro-Structured Materials School of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Physics and Astronomy University of ManitobaWinnipegManitoba R3T 2N2Canada

We propose and experimentally realize a class of quasi-one-dimensional topological lattices whose unit cells are constructed by coupled multiple identical resonators,with uniform hopping and inversion *** the presence of coupling-path-induced effective zero hopping within the unit cells,the systems are characterized by complete multimerization with degenerate-1 energy edge states for open boundary condition.

关键词： symmetry topological coupling

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Spatial analysis of Dengue through the reproduction numbers relating to socioeconomic features:case studies on two Brazilian urban centers

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Infectious Disease Modelling 2024年第1期9卷 142-157页

作者： Ana T.c.Silva Rejane c.Dorn Lívia R.Tomás Leonardo B.L.Santos Lacita M.Skalinski Suani T.R.Pinho Departamento de Física Universidade Estadual de Feira de SantanaAv.Transnordestinas/n.Novo HorizonteFeira de Santana44036-900BABrazil Instituto de Física Universidade Federal da BahiaRua Barão de Jeremoabo s/nCampus Universitário de OndinaSalvador40170-115BABrazil centro Nacional de Monitoramento e Alertas de Desastres Naturais(cEMADEN) Estrada Dr.Altino Bondensan500São Josédos Campos12247-016SPBrazil Universidade Estadual de Santa cruz Campus Soane Nazaréde AndradeRodovia Jorge AmadoKm 16SalobrinhoIlhéus45662-900BABrazil Instituto de Saúde coletiva Universidade Federal da BahiaR.Basílio da Gamas/n-CanelaSalvador40110-140BABrazil Instituto Nacional de ciência e Tecnologia-Sistemas complexos Virtual InstitutionBrazil

The study of the propagation of infectious diseases in urban centers finds a close connection with their population's social characteristics and *** work performs a spatial analysis of dengue cases in urban centers based on the basic reproduction numbers,R0,and incidence by planning areas(PAs),as well as their correlations with the Human Development Index(HDI)and the number of *** analyzed dengue epidemics in 2002 at two Brazilian urban centers,Belo Horizonte(BH)and Rio de Janeiro(RJ),using PAs as spatial *** results reveal heterogeneous spatial scenarios for both cities,with very weak correlations between R0 and both the number of trips and the HDI;in BH,the values of R0 show a less spatial heterogeneous pattern than in *** BH,there are moderate correlations between incidence and both the number of trips and the HDI;meanwhile,they weakly correlate for ***,the absence of strong correlations between the considered measures indicates that the transmission process should be treated considering the city as a whole.

关键词： Dengue Mathematical mode lBasic reproduction number Urban mobility Urban indices

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