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A bipolar verdazyl radical for a symmetric all-organic redox flow-type battery

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Journal of Energy chemistry 2019年第7期28卷 52-56页

作者： Grant D.charlton Stephanie M.Barbon Joe B.Gilroy c.adam Dyker Department of chemistry University of New BrunswickFredericton E3B 5A3New BrunswickCanada Department of chemistry and the centre for Advanced Materials and Biomaterials Research(cAMBR) The University of Western OntarioLondon N6A 5B7OntarioCanada

A symmetric all-organic non-aqueous redox flow-type battery was investigated employing the neutral small molecule radical 3-phenyl-1,5-di-p-tolylverdazyl,which can be reversibly oxidized and reduced in one-electron processes,as the sole charge storage *** voltammetry of the verdazyl radical in 0.5 M tetrabutylammonium hexa fluoro phosphate(TBAPF6)in acetonitrile revealed redox couples at-0.17 V and-1.15 V ***+/Ag,leading to a theoretical cell voltage of 0.98 *** the dependence of peak currents on the square root of the scan rate,diffusion coefficients on the order of 4 x 10 6 cm2 s-1 were *** performance was assessed in a static cell employing a Tokoyuma AHA anion exchange membrane,with 0.04 M verdazyl as catholyte and anolyte in 0.5 M TBAPF6 in acetonitrile at a current density of 0.12 mA *** coulombic efficiencies were good(94%-97%)throughout the experiment,the capacity faded gradually from high initial values of 93%of the theoretical discharge capacity to 35%by the 50th *** and energy efficiencies were 68%and 65%,*** analysis by cyclic voltammetry revealed that decomposition of the active material with cycling is a leading cause of cell degradation.

关键词： All-organic redox flow battery Energy storage Verdazyl radicals Organic radical coin cell

Multinuclear MR and MRI study of lithium-ion cells using a variable field magnet and a fixed frequency RF probe

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Magnetic Resonance Letters 2024年第1期4卷 10-20页

作者： Andrés Ramírez Aguilera Florin Marica Kevin J.Sanders Md Al Raihan c.adam Dyker Gillian R.Goward Bruce *** UNB MRI centre Department of PhysicsUniversity of New BrunswickFrederictonNew BrunswickE3B 5A3Canada Department of chemistry McMaster UniversityHamiltonOntarioL8S 4L8Canada Department of chemistry University of New BrunswickFrederictonNew BrunswickE3B 5A3Canada

An exploratory multinuclear magnetic resonance(MR)and magnetic resonance imaging(MRI)study was performed on lithium-ion battery cells with ^(7)Li,^(19)F,and ^(1)H measurements.A variable field superconducting magnet with a fixed frequency parallel-plate radiofrequency(RF)probe was employed in the *** magnetic field was changed to set the resonance frequency of each nucleus to the fixed RF probe frequency of 33.7 *** cartridge-like lithium-ion cells,with graphite anodes and LiNi_(0.5)Mn_(0.3)co_(0.2)O_(2)(NMc)cathodes,were *** cell was pristine,and one was charged to a cell voltage of 4.2 *** results presented demonstrate the great potential of the variable field magnet approach in multinuclear measurement of lithium-ion *** methods open the door for developing faster and simpler methods for detecting,quantifying,and interpreting MR and MRI data from lithium-ion and other batteries.

关键词： Multinuclear MR/MRI Variable field magnet Lithium-ion battery Parallel-plate rf probe

深度学习在膝关节MRI前交叉韧带撕裂检测中的价值:多中心验证研究

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国际医学放射学杂志 2023年第1期46卷 122-122页

作者： A.Tran L.Lassalle P.Zille R.Guillin E.Pluot c.adam 沈晶

摘要目的开发一种用于前交叉韧带(AcL)撕裂检测的深度学习算法,并采用2个外部数据集验证其准确性。方法收集来自不同厂家和不同场强的19 765例膝关节MRI

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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel adam Felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany center for Molecular Medicine cologne(cMMc) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： chao Weng adam M.R.Groh Moein Yaqubi Qiao-Ling cui Jo Anne Stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Interventions and targets aimed at improving quality in inflammatory bowel disease ambulatory care

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World Journal of Gastroenterology 2013年第38期19卷 6375-6382页

作者： adam V Weizman Geoffrey c Nguyen Division of Gastroenterology Women’s College HospitalUniversity of TorontoTorontoON M5S 1B2Canada Mount Sinai Hospital centre for Inflammatory Bowel Disease University of TorontoTorontoON M5G 1X5Canada Division of Gastroenterology and Hepatology Johns Hopkins School of MedicineBaltimoreMD 21205United States

Over the past decade,there has been increasing focus on improving the quality of healthcare delivered to patients with chronic diseases,including inflammatory bowel *** bowel disease is a complex,chronic condition with associated morbidity,health care costs,and reductions in quality of *** condition is managed primarily in the outpatient *** delivery of high quality of care is suboptimal in several ambulatory inflammatory bowel disease domains including objective assessments of disease activity,the use of steroid-sparing agents,screening prior to anti-tumor necrosis factor therapy,and monitoring thiopurine *** review outlines these gaps in performance and provides potential initiatives aimed at improvement including reimbursement programs,quality improvement frameworks,collaborative efforts in quality improvement,and the use of healthcare information technology.

关键词： Ambulatory care crohn’s disease Inflammatory bowel disease Quality improvement Ulcerative colitis

Quality of care delivered to hospitalized inflammatory bowel disease patients

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World Journal of Gastroenterology 2013年第38期19卷 6360-6366页

作者： adam V Weizman Geoffrey c Nguyen Division of Gastroenterology Women’s College HospitalUniversity of TorontoTorontoM5S 1B2OntarioCanada Mount Sinai Hospital centre for Inflammatory Bowel Disease University of TorontoTorontoM5G 1X5OntarioCanada Division of Gastroenterology and Hepatology Johns Hopkins School of MedicineBaltimoreMD 21201United States

Hospitalized patients with inflammatory bowel disease(IBD)are at high risk for morbidity,mortality,and health care utilization *** the literature on trends in hospitalization rates for this disease is conflicting,there does appear to be significant variation in the delivery of care to this complex group,which may be a marker of suboptimal quality of *** is a need for improvement in identifying patients at risk for hospitalization in an effort to reduce ***,appropriate screening for a number of hospital acquired complications such as venous thromboembolism and clostridium difficile infection is *** review discusses areas of inpatient care for IBD patients that are in need of improvement and outlines a number of potential quality improvement initiatives such as payfor-performance models,quality improvement frameworks,and healthcare information technology.

关键词： crohn’s disease Hospitalization Inflammatory bowel disease Quality improvement Ulcerative colitis

Special issue on “Fluorescent probes”

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Frontiers of chemical Science and Engineering 2020年第1期14卷 1-3页

作者： adam c.Sedgwick Tony D.James Department of chemistry University of Texas at AustinAustinTX 78712-1224USA Department of chemistry University of BathBathBA27AYUK

Fluorescent probes are intelligently designed molecules that transform the act of binding/reacting with a target analyte into an optical signal[1,2].Their high sensitivity and specificity coupled with high spatial and temporal resolution offers a non-invasive approach to observe a specific analyte within complex biological environments in real time with high precision[3].These"molecular tools"have the capability to interrogate the role of specific biomarkers that are associated with a particular disease state or can be used to improve our understanding of the role or certain species in a biological pathway[4,5].

关键词： Fluorescent specific reacting