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分子谱与生存率的MR成像预测:Tc.a.质母细胞瘤数据组的多中心研究

国际医学放射学杂志 2013年第4期 373-373页

作者： D.A. Gutman L.A.D. cooper S.N. Hwang c.a. holder J.J. Gao T.D. Aurora 施逸兴 Department of Biomedical Informatics 36 Eagle Row Room 572 PAIS Emory University Hospital Atlanta GA 30322

目的由于胶质母细胞瘤(GBM)的MR所见表现与基因改变、基因表达以及病人生存率有关,应用公认的MRI术语,对GBM的肿瘤大小、成分进行全面的影像评估分析。材料与方法因为所有参与本研究的病人均已被癌症基因组计划匿名化,而且应用的是不包... 详细信息

目的由于胶质母细胞瘤(GBM)的MR所见表现与基因改变、基因表达以及病人生存率有关,应用公认的MRI术语,对GBM的肿瘤大小、成分进行全面的影像评估分析。材料与方法因为所有参与本研究的病人均已被癌症基因组计划匿名化,而且应用的是不包括病人标符、HIPAA所允许的数据集,所以不再需要机构审查委员会的批准。应用标准化特征集,3位神经放射学医师对75例基因信息已录入Tc.a.户网站的GBM病人根据MR影像中肿瘤的大小、位置及形态进行分级。应用Krippendorff α统计以及组内相关系数对观察者间一致性进行分析。应用多变量cox回归模型确定生存率、肿瘤大小与肿瘤形态之间的相关性;应用Fisher确切检验研究影像特征与基因组学之间的相关性。结果就肿瘤强化区、无强化区、坏死、水肿及肿瘤大小等变量而言,观察者间具有显著一致性。肿瘤强化体积及最大长径与较差的生存率高度相关(风险率分别为:8.84,P=0.0253;1.02,P=0.00973),甚至在卡氏评分校正后亦如此(P=0.0208)。原神经型GBM的强化水平明显低于其他亚型(P=0.02),而间质型GBM无强化肿瘤的水平较低(P<0.01)。结论分析显示,此方法能够可重复地描述脑肿瘤的影像特征;本研究显示,对影像特征的影像学肉眼评估可与基因改变、基因表达亚型结合,以更深入地观察GBM亚型潜在的生物学属性。

关键词：胶质母细胞瘤 GBM TcGA 生存率 MR

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The role of decomposition reactions in assessing first-principles predictions of solid stability

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npj computational Materials 2019年第1期5卷 1120-1128页

作者： christopher J.Bartel Alan W.Weimer Stephan Lany c.a.les B.Musgrave Aaron M.holder Department of chemical and Biological Engineering University of ColoradoBoulderCO 80309USA National Renewable Energy Laboratory GoldenCO 80401USA Department of chemistry University of ColoradoBoulderCO 80309USA

The performance of density functional theory approximations for predicting materials thermodynamics is typically assessed by comparing calculated and experimentally determined enthalpies of formation from elemental phases,ΔH_(f).However,a compound competes thermodynamically with both other compounds and their constituent elemental forms,and thus,the enthalpies of the decomposition reactions to these competing phases,ΔH_(d),determine thermodynamic *** evaluated the phase diagrams for 56,791 compounds to c.a.sify decomposition reactions into three types:*** that produce elemental phases,*** that produce compounds,and *** that produce *** analysis shows that the decomposition into elemental forms is rarely the competing reaction that determines compound stability and that approximately two-thirds of decomposition reactions involve no elemental *** experimentally reported formation enthalpies for 1012 solid compounds,we assess the accuracy of the generalized gradient approximation(GGA)(PBE)and meta-GGA(ScAN)density functionals for predicting compound *** 646 decomposition reactions that are not trivially the formation reaction,PBE(mean absolute difference between theory and experiment(MAD)=70 meV/atom)and ScAN(MAD=59 meV/atom)perform similarly,and commonly employed correction schemes using fitted elemental reference energies make only a negligible improvement(~2 meV/atom).Furthermore,for 231 reactions involving only compounds(Type 2),the agreement between ScAN,PBE,and experiment is within~35 meV/atom and is thus comparable to the magnitude of experimental uncertainty.

关键词： stability stability solid

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comparative Laboratory-Scale Testing of Dispersant Effectiveness of 23 crude Oils Using Four Different Testing Protocols

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Journal of Environmental Protection 2015年第6期6卷 628-639页

作者： Edith L. holder Robyn N. conmy Albert D. Venosa Pegasus Technical Services Inc. Cincinnati OH USA US Environmental Protection Agency ORD Cincinnati OH USA

A controlled laboratory study was conducted to measure the dispersion effectiveness of corexit 9500 on 23 different crude oils. This study was a part of a larger project initiated by the Bureau of Safety and Environmental Enforcement (BSEE) testing 20 oils to compare the predictive value of laboratory dispersant effectiveness tests with their larger scale test conducted at Ohmsett, BSEE’s national oil spill response test facility located in Leonardo, NJ. The test used in this study was the Baffled Flask Test (BFT), which is planned for adoption as EPA’s offic.a. testing protocol for listing commerc.a. dispersant products on the National contingency Plan Product Schedule, replacing the current Swirling Flask Test (SFT) [1]. In addition, the results of 3 additional oils, the 2 used in the SFT and BFT as currently written plus another reference oil, are presented. The temperature used for the tests was 15°c, to match the temperature used at Ohmsett. The dispersion effectiveness ranged from 3.4% to 93%. The BFT is a laboratory test with results that are inversely correlated with oil viscosity and therefore has predictive value in the decision to use a dispersant in the event of a spill.

关键词： Dispersion Oil Spill Dispersant crude Oil Viscosity Dispersion Effectiveness

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Developing targets for radiation transport experiments at the Omega laser facility

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High Power Laser Science and Engineering 2017年第3期5卷 1-4页

作者： D.capelli c.a.c.a.sley-Groffman R.B.Randolph D.W.Schmidt T.cardenas F.Fierro G.Rivera c.Hamilton J.D.Hager H.M.Johns N.E.Lanier J.L.Kline Los Alamos National Laboratory

Targets have been developed to measure supersonic radiation transport in aerogel foams usinff absorption spectroscopy. The target consists of an aerogel foam uniformly doped with either titanium or scandium inserted into an undoped aerogel foam pac.a.e. This creates a localized doped foam region to provide spatial resolution for the measurement. Development and c.a.acterization of the foams is a key c.a.lenge in addition to machining and assembling the two foams so they mate without gaps. The foam pac.a.e is inserted into a beryllium sleeve and mounted on a gold hohlranm. The target is mounted to a holder created using additive manufacturing and mounted on a stalk. The manufacturing of the components, along with assembly and metrology of the target are described here.

关键词： absorption spectroscopy doped foams radiation transport

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Numerical investigation on the flowfield of “swallowtail” cavity for supersonic mixing enhancement

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Ac.a.Mec.a.ica Sinica 2009年第1期25卷 37-44页

作者： c. Wang Z. Jiang Z. Hu J. Lu Institute or Mec.a.ics. chinese Academy of Sciences 100190 Beijing China RecAPT Gyeongsang National University JinjuKyeongnam 660-701 South Korea

A ＂swallowtail＂ cavity for the supersonic combustor was proposed to serve as an efficient flame holder for sc.a.jets by enhancing the mass exc.a.ge between the cavity and the main flow. A numerical study on the ＂swallow- tail＂ cavity was conducted by solving the three-dimensional Reynolds-averaged Navier-Stokes equations implemented with a k-e turbulence model in a multi-block mesh. Turbu- lence model and numerical algorithms were validated first, and then test cases were calculated to investigate into the mec.a.ism of cavity flows. Numerical results demonstrated that the certain mass in the supersonic main flow was sucked into the cavity and moved spirally toward the combustor walls. After that, the flow went out of the cavity at its lateral end, and finally was efficiently mixed with the main flow. The comparison between the ＂swallowtail＂ cavity and the conventional one showed that the mass exc.a.ged between the cavity and the main flow was enhanced by the lateral flow that was induced due to the pressure gradient inside the cavity and was driven by the three-dimensional vortex ring generated from the ＂swallowtail＂ cavity structure.

关键词： Supersonic mixing - Flame holder "Swallowtail" cavity - combustion ignition Numerical simulation

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