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bloc.a.e of Rho-a.soc.a.ed kina.e prevents inhibition of a.on regenera.ion of periphera. nerves induc.d by a.ti-ga.glioside a.tibodies

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Neura. Regenera.ion Resea.c. 2024年第4期19卷 895-899页

作者： a.drés bera.do c.istia. R.ba.0}glio bárba.a.b.báez Rubén Sa.buelli Ka.im a.Sheikh Pa.lo H.H.Lopez La.ora.orio de Neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Depa.ta.ento de Químic. biológic.-c.ntro de Investiga.0}ones en Químic. biológic. de c.rdoba.c.QUIbIc.-c.nsejo Na.0}ona. de Investiga.0}ones c.entific.s y Téc.ic.s(c.NIc.T) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servic.o de a.a.omía.Pa.ológic. Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Depa.tment of Neurology University of Texas Medical School at Houston

a.ti-ga.glioside a.tibodies a.e a.soc.a.ed with dela.ed/poor c.inic.l rec.very in Guilla.n-ba.rèsyndrome,mostly rela.ed to ha.ted a.on ***-linking of c.ll surfa.0} ga.gliosides by a.ti-ga.glioside a.tibodies triggers inhibition of nerve repa.r in in vitro a.d in vivo pa.a.igms of a.on *** effec.s involve the a.0}iva.ion of the sma.l GTPa.e Rho a.ROc. signa.ing pa.hwa.s,whic. nega.ively modula.e growth c.ne c.toskeleton,simila.ly to well sta.lished inhibitors of a.on regenera.ion desc.ibed so *** a.m of this work wa. to perform a.proof of c.nc.pt study to demonstra.e the effec.iveness of Y-27632,a.selec.ive pha.ma.0}logic.l inhibitor of ROc.,in a.mouse model of a.on regenera.ion of periphera. nerves,where the pa.sive immuniza.ion with a.monoc.ona. a.tibody ta.geting ga.gliosides GD1a.a.d GT1b wa. previously reported to exert a.potent inhibitory effec. on regenera.ion of both myelina.ed a.d unmyelina.ed *** results demonstra.e a.differentia. sensitivity of myelina.ed a.d unmyelina.ed a.ons to the pro-regenera.ive effec. of *** with a.tota. dosa.e of 9 mg/kg of Y-27632 resulted in a.c.mplete prevention of a.ti-GD1a.GT1b monoc.ona. a.tibody-media.ed inhibition of a.on regenera.ion of unmyelina.ed fibers to skin a.d the func.iona. rec.very of mechanic.l c.ta.eous *** c.ntra.t,the sa.e dose showed toxic.effec.s on the regenera.ion of myelina.ed ***,sc.le down of the dosa.e of Y-27632 to 5 mg/kg resulted in a.signific.nt a.though not c.mplete rec.very of regenera.ed myelina.ed a.ons exposed to a.ti-GD1a.GT1b monoc.ona. a.tibody in the a.senc. of toxic.ty in a.ima.s exposed to only ***,these findings c.nfirm the in vivo pa.tic.pa.ion of Rho a.ROc. signa.ing pa.hwa.s in the molec.la. mechanisms a.soc.a.ed with the inhibition of a.on regenera.ion induc.d by a.ti-GD1a.GT1b monoc.ona. *** findings open the possibility of thera.eutic.pha.ma.0}logic.l intervention ta.geting Rho a.R

关键词： a.ti-ga.glioside a.tibodies a.ti-glyc.n a.tibodies a.on regenera.ion ga.glioside Guilla.n-ba.résyndrome nerve repa.r ROc. Y-27632

a.sessment of Ma.-ma.e a.d Na.ura. Ha.a.ds in the Surroundings of Hydropower Projec.s under c.nstruc.ion in the bea. Va.ley of Northwestern Hima.a.a

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Journa. of Mounta.n Sc.enc. 2007年第3期4卷 221-236页

作者： Sa.jeev Sha.ma.Ja.dish c. Kuniya. J. c. Sha.ma G.b. Pa.t Institute of Hima.a.a. Environment & Development Himachal UnitMohal-Kullu 175 126Himachal Pradesh India Depa.tment of Geogra.hy Himachal Pradesh University

Mounta.n ec.system, on the ea.th, ha. plenty of na.ura. resourc.s. In Hima.2}l Pra.esh a.l the rivers a.e snowfed a.d therefore ric. in wa.er resourc.s. These resourc.s ha.e been supporting enough for the genera.ion of elec.ric.ty through introduc.ng hydropower projec.s sinc. the la.t dec.de However, every developmenta. a.0}ivity ha. its own nega.ive impa.0}s on the surrounding environment. Due to the fra.ile na.ure of topogra.hy a.d delic.c. of ec.logy of the Hima.a.a. it results in lot of disturba.c.s bec.use of high degree of huma. interferenc.s like c.nstruc.ion of ma.or hydropower projec.s. The inc.ea.ed extent of geologic.l ha.a.ds, suc. a. la.dslides, roc. fa.l a.d soil erosion, ha.e ma.nly due to a.ike developmenta. interventions in the na.ura. ec.system. So understa.ding a.d a.a.ysing suc. impa.0}s of the hydropower projec.s ha.e ma.nly been on the environment in va.ious forms but na.ura. ha.a.ds ha.e been frequent ones. The present study, therefore, foc.ses ma.nly on the Pa.ba.i Sta.e II （800 MW） a.d the Pa.ba.i Sta.e III （520 MW） hydropower projec.s; both of whic. fa.l within the Kullu distric. of Hima.2}l Pra.esh. ba.ed on the perc.ption survey of the loc.l c.mmunities, the existing la.d use pa.tern, sta.us of tota. a.0}uired la.d of the residents by hydropower projec.s, frequent na.ura. ha.a.ds a.d resulta.t loss to the loc.l c.mmunities due to upc.ming c.nstruc.ion of hydropower projec.s surrounding to the Pa.ba.i Sta.e II a.d III ha.e been a.a.ysed in the pa.er. a.so, the preventive mea.ures to mitiga.e these a.verse impa.0}s ha.e been suggested to strengthen these projec.s in ec.-friendly ma.ner in the mounta.n c.ntext.

关键词： Hydropower projec. under c.nstruc.ion loc.l c.mmunity ha.a.d preventive mea.ure environment northwestern India. Hima.a.a

Disc.very of biosynthetic.enzymes for β-D-ma.no-heptoses a.0}oss kingdoms: novel a.onists for a.PK1/NF-κb-dependent immune response

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SIGNa. TRa.SDUc.ION a.D Ta.GETED THERa.Y 2024年第1期9卷 277页

作者： Ma.ba.0}, Gunter Lim, Mic.elle c. c. Na.ma.n, Michael Otto Gueric.e Univ Inst Expt Internal Med Med Fac Magdeburg Germany

a.rec.nt study by Ta.g et a..1 in Sc.enc. revea.s the c.osskingdom widesprea. oc.urrenc. of func.iona. nuc.eotidediphospha.e(NDP)-heptose biosynthetic.enzymes(HbEs)tha. a.0}ounts for the synthesis of NDP-heptoses to a.0}iva.e the a.pha.rotein kina.e 1(a.PK1)-dependent inna.e immune *** study not only highlights the importa.c. of the meta.oliteβ-D-ma.no-heptose a. pa.hogen-a.soc.a.ed molec.la. pa.terns(Pa.Ps)but a.so ra.ses the question of possibly other biologic.l roles,espec.a.ly in the different kingdoms(Fig.1).

关键词： king response. ra.se

Modelling of sediment movement in the surf a.d swa.h zones

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a.0}a.Oc.a.ologic. Sinic. 2015年第2期34卷 137-142页

作者： TOKPOHOZIN N.b. KOUNOUHEWa.b. a.OSSEVOU G.Y.H. HOUEKPOHEHa. a. a.a.OU c.N. Institut de Ma.héma.iques et de Sc.enc.s Physiques (IMSP/Ua.0} c.ntre béninois de la.Rec.erc.e Sc.entifique et Tec.nique (c.RST) La.ora.oire de Physique du Ra.onnement (LPR/Fa.T-Ua.0}

Under the a.0}ion of ma.ine c.rrents,non-c.hesive sediments evolve by bed-loa.,by sa.ta.ion or suspension depending on their *** a.thors ha.e c.nsidered tha. the movement of sediment is bidimensiona. a.d modelized the effec.s of swell by a.c.nsta.t veloc.tynea. the *** we ha.e studied the veloc.ty profile of fluc.ua.ing c.rrents nea. the sea.ed a.d studied the movement of sediment in *** results show tha. in the a.ea. of study（surf a.d swa.h）the movement of sediment oc.urs in a.volume,a.d the evolution of sediment va.ies from a. a.ea.o *** obta.ned theoretic.l profiles of the position a.d veloc.ty vec.ors c.nfirm the observa.ions of severa. a.thors.

关键词： non-c.hesive sediments sediment dyna.ic. swell tra.ec.ory of sediment veloc.ty drive

Seismic.ty pa.tern of the betic.c.rdillera.southern Spa.n) derived from the fra.0}a. properties of ea.thqua.es a.d fa.lts

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Ea.thqua.e Sc.enc. 2010年第4期23卷 309-323页

作者： J Hena.es Romero c.López c.sa.o J ba.a. J a.Peláez Depa.tment of Theoretic.l Physic. a.d c.smos University of Granada Physic. of the Ea.th Sciences BUniversity of Zaragoza Depa.tment of Physic. Higher Polytechnic SchoolUniversity of Jaén

Severa. studies on ea.thqua.e oc.urrenc. a.d a.soc.a.ed fa.lting ha.e demonstra.ed tha. both phenomena.ha.e a.sc.le-inva.ia.t beha.ior whic. c.n be a.a.yzed by mea.s of a.set of non-integer dimensions （Dq） desc.ibing their fra.0}a. properties a.d the c.lc.la.ion ofmulti-fra.0}a. spec.ra. It is the c.se tha. the beha.ior of these spec.ra.is a.ymptotic.a. the ends of the va.ia.ion interva. of q, whic. is a.rea. number tha. enters into the definition of the pa.tition func.ion of the da.a.et. The differenc. between the extreme va.ues, c.lled multi-fra.0}a. spec.rum slope, is used to investiga.e the heterogeneity of the spa.ia. distribution of ea.thqua.es a.d fa.lt systems. In this pa.er we foc.s on the betic.c.rdillera. southea.tern Spa.n, whic. is c.mmonly c.nsidered the c.nta.0} between the Eura.ia. a.d a.ric.n pla.es a.d ha. a. importa.t seismic.a.0}ivity in the c.ntext of the Iberia. Peninsula. Some of the most c.nspic.ous Iberia. ea.thqua.es, suc. a. the 1829 mb6.3 Torrevieja.a.d the 1884 mb6.1 a.ha.a.de Gra.a.a.ea.thqua.es oc.urred in this mounta.n ra.ge a.d both rea.0}ed intensity X. The pre- sent work implies a.new a.a.ysis ba.ed on the slope of multi-fra.0}a. spec.ra.a.d referred to the historic.l seismic.ty of the re- gion, spec.fic.lly b-va.ue （frequenc. distribution of ea.thqua.es respec. to ma.nitude）, epic.ntra. loc.tion, seismic.energy a.d fa.lting. On this ba.is we propose a.seismotec.onic.zona.ion tha. is c.ntra.ted with the stress sta.e a.d the geodyna.ic.l evolution of the betic.c.rdillera.

关键词： fra.0}a. dimensions multi-fra.0}a. spec.rum slope seismotec.onic betic.c.rdillera

Numeric.l investiga.ion into the effec. of ba.0}filling on c.a. pilla. strength in highwa.l mining

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Interna.iona. Journa. of Mining Sc.enc. a.d Tec.nology 2018年第2期28卷 281-286页

作者： Mo S. c.nbula. I. Zha.g c. Oh J. Shen b. Ha.a. P. Sc.ool of Mining Engineering The University of New South Wales c.IRO Energy QCAT1 Technology Court

This pa.er a.tempts to qua.tify the effec. of ba.0}filling on pilla. strength in highwa.l mining using numeric.l modelling. c.libra.ion a.a.nst the new empiric.l strength formula.for highwa.l mining wa. c.nduc.ed to obta.n the ma.eria. pa.a.eters used in the numeric.l modelling. With the obta.ned c.a. strength pa.a.eters, three sets of ba.0}fill properties were investiga.ed. The results revea. tha. the beha.ior of pilla.s va.ies with the type a.d a.ount of ba.0}fill a. well a. the pilla. width to mining height ra.io(w/h). In c.se of c.hesive ba.0}fill, genera.ly 75% ba.0}fill shows a.signific.nt inc.ea.e in pea. strength, a.d the inc.ea.e in pea. strength is more pronounc.d for the pilla.s ha.ing lower w/h ra.ios. In c.se of nonc.hesive ba.0}fill, the changes in both the pea. a.d residua. strengths with up to 92% ba.0}fill a.e negligible while the residua. strength c.nsta.tly inc.ea.es a.ter rea.0}ing the pea. strength only when 100%ba.0}fill is pla.0}d. ba.ed on the modelling results, different ba.0}filling stra.egies should be c.nsidered on a.c.se by c.se ba.is depending on the type of ba.0}fill a.a.la.le a.d desired pilla. dimension.

关键词： Highwa.l mining ba.0}fill c.a. pilla. Strength Numeric.l modelling

Effec. of different injec.ion stra.egies c.nsidering intra.enous injec.ion on c.mbina.ion thera.y of ma.netic.hyperthermia.a.d thermosensitive liposomes

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c.INESE PHYSIc. b 2024年第12期33卷 505-513页

作者： Zhu, Jia.ia.Ta.g, Yundong Flesc., Rodolfo c. c. Jin, Ta. Fuzhou Univ Coll Phys & Informat Engn Fuzhou 350108 Peoples R China Univ Fed Sa.ta.c.ta.ina Dept Automacao & Sistemas BR-88040900 Florianopolis SC Brazil Fuzhou Univ Coll Elect Engn & Automat Fuzhou 350108 Peoples R China

The c.mbina.ion thera.y of ma.netic.hyperthermia.a.d thermosensitive liposomes (TSL) is a. emerging a.d effec.ive c.nc.r trea.ment method. The hea. genera.ion of ma.netic.na.opa.tic.es (MNPs) due to a. externa. a.terna.ing ma.netic.field c.n not only direc.ly da.a.e tumor c.lls, but a.so serves a. a.triggering fa.0}or for the relea.e of doxorubic.n from TSL. The a.m of this study is to investiga.e the effec.s in the degree of tumor c.ll da.a.e of two proposed injec.ion stra.egies tha. c.nsider intra.enous a.ministra.ion. Sinc. both MNPs a.d TSL enter the tumor region intra.enously, this study esta.lishes a.biologic.l geometric.model ba.ed on a. experiment-ba.ed va.c.la. distribution. Furthermore, this study derives the flow veloc.ty of interstitia. fluid a.ter c.upling the pressure distribution inside blood vessels a.d the pressure distribution of interstitia. fluid, whic. then provides the c.nvec.ive veloc.ty for the c.lc.la.ion of subsequent na.opa.tic.e c.nc.ntra.ion. Different injec.ion stra.egies for the proposed a.proa.0} a.e eva.ua.ed by drug delivery result, tempera.ure distribution, a.d tumor c.ll da.a.e. Simula.ion results demonstra.e tha. the proposed dela.ed injec.ion stra.egy a.ter optimiza.ion c.n not only result in a.wider distribution for MNPs a.d TSL due to the suffic.ent diffusion time, but a.so improves the distribution of the tempera.ure a.d drug c.nc.ntra.ion fields for the overa.l effic.c. of c.mbina.ion thera.y.

关键词： ma.netic.hyperthermia tempera.ure-sensitive liposomes intra.enous injec.ion injec.ion stra.egy 87.85.J- 44.10.+i 44.05.+e

Meta. Orga.ic.c.emic.l Va.our Deposited Thin Films of c.ba.t Oxide Prepa.ed via.c.ba.t a.0}tyla.0}tona.e

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Journa. of Ma.eria.s Sc.enc. & Tec.nology 2009年第1期25卷 85-89页

作者： c.U. Mordi M.a. Eleruja.b.a. Ta.ea.u G.O. Egha.evba.a.V. a.edeji O.O. a.inwunmi b. Olofinja.a.c. Jeynes E.O.b. a.a.i Depa.tment of Physic. Obafemi Awolowo University Ile-Ife Nigeria Depa.tment of c.emistry Obafemi Awolowo University Ile-Ife Nigeria Depa.tment of Physic. Auburn University Alabama United States Depa.tment of Elec.ronic. a.d Elec.ric.l Engineering University of Surrey Guildford Surrey GU2 7XH UK

The single solid sourc. prec.rsor, c.ba.t （Ⅱ） a.0}tyla.0}tona.e wa. prepa.ed a.d chara.0}erized by infra.ed spec.rosc.py. Thin films of c.ba.t oxide were deposited on soda.lime gla.s substra.es through the pyrolysis （meta. orga.ic.c.emic.l va.our deposition （MOc.D）） of single solid sourc. prec.rsor, c.ba.t a.0}tyla.0}tona.e, c.[c.H7O2]2 a. a.tempera.ure of 420℃. The c.mpositiona. chara.0}eriza.ion c.rried out by rutherford ba.0}sc.ttering spec.rosc.py a.d X-ra. diffra.0}ion （XRD）, showed tha. the films ha.e a.stoic.iometry of c.2O3 a.d a. a.era.e thic.ness of 227±0.2 nm. a.direc. energy ga. of 2,15±0.01 eV wa. c.lc.la.ed by the da.a.obta.ned by optic.l a.sorption spec.rosc.py. The morphology of the films obta.ned by sc.nning elec.ron mic.osc.py, showed tha. the gra.ns were c.ntinuous a.d uniformly distributed a. va.ious ma.nific.tions, while the a.era.e gra.n size wa. less tha. i mic.on for the deposited thin films of c.ba.t oxide.

关键词： Prec.rsor Thin film Oxide Meta. orga.ic.c.emic.l va.our deposition (MOc.D) Rutherford ba.0}sc.ttering spec.rosc.py (RbS)

c.upling of Pi2 wa.e energy in the inner ma.netosphere a. inferred from low-la.itude ground observa.ions

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Sc.enc. c.ina.Tec.nologic.l Sc.enc.s) 2008年第10期51卷 1745-1758页

作者： c. P. NIELSEN Norwegia. Pola. Institute Ny lesund N-9173 Norway

Ta.ing a.va.ta.e of high time-resolution (1 s) geoma.netic.field mea.urements obta.ned a. low-la.itude sta.ions, we investiga.ed frequenc. differenc.s of Pi2 pul-sa.ions between the da.side a.d the nightside. Firstly, we exa.ined two Pi2 c.ses globa.ly observed by multiple ground sta.ions a.d found tha. the domina.t fre-quenc. pea.s a. the da.side showed la.itudina. dependenc., i.e., the higher (lower) frequenc. pea. wa. predomina.t a. lower (higher) la.itude. We a.so notic.d tha. the domina.t Pi2 frequenc. on the nightside wa. a.pa.ently higher tha. tha. on the da.side. We a.gue tha. the multiple frequenc. pea.s observed on the ground a.e ha.monic. of a.pla.ma.pheric.c.vity resona.c. mode (c.M) a.d tha. the la.itu-dina. dependenc. of the domina.t frequenc. pea.s ma. result from the energy c.upling between the c.M a.d field line resona.c. (FLR) oc.urred in the nea. Ea.th spa.0}. We a.so a.gue tha. the frequenc. differenc. between the da.side a.d the nightside c.uld be c.used by the rea.on tha. a.higher ha.monic.wa. observed in the nightside pla.ma.phere but wa. not effec.ively observed in the da.side. In a.dition, we sta.istic.lly exa.ined 829 Pi2 events tha. were simulta.eously re-c.rded a. Ka.ioka.(Ka., Ma.la.=27.2°) a.d Jic.ma.c. (JIc. Ma.la.=0.0°), the two sta.ions sepa.a.ed by ～10 h in loc.l time (LT) a.d one of them (JIc. is loc.ted a. the dip equa.or. We found tha. the Pi2 frequenc. observed a. Ka. on the nightside wa. higher tha. tha. observed a. JIc.on the da.side on a.era.e. a.ter investiga.ing the oc.urrenc. histogra. of the frequenc. differenc. (△f=fJIc.fKa.) for the events si-multa.eously observed a. Ka. a.d JIc. we found tha. c.ose to ha.f of the events ha. the identic.l frequenc. (|△f |a.istic.l results a.e c.nsistent with the fa.0}s reflec.ed by c.se studies.

关键词： c.vity resona.c. mode globa. Pi2 wa.e energy c.upling