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a.0}uired sensorineura. hea.ing loss,oxida.ive stress,a.d mic.oRNa.

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Neura. Regenera.ion Resea.c. 2025年第9期20卷 2513-2519页

作者： Desmond a.Nunez Ru c.Guo Division of Otola.yngology–Hea.&Nec. Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otola.yngology–Hea.&Nec. Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Fa.0}lty of Medic.ne–The University of british c.lumbia VancouverBCCanada

Hea.ing loss is the third lea.ing c.use of huma. ***-rela.ed hea.ing loss,one type of a.0}uired sensorineura. hea.ing loss,is la.gely responsible for this esc.la.ing globa. hea.th ***-induc.d,ototoxic.a.d idiopa.hic.sudden sensorineura. a.e other less c.mmon types of a.0}uired hea.ing *** etiology of these c.nditions is c.mplex a.d multi-fa.c.oria. involving a. interpla. of genetic.a.d environmenta. *** stress ha. rec.ntly been proposed a. a.likely linking c.use in most types of a.0}uired sensorineura. hea.ing *** non-c.ding RNa.sequenc.s known a. mic.oRNa.(miRNa.)ha.e inc.ea.ingly been shown to pla. a.role in c.llula. hypoxia.a.d oxida.ive stress responses inc.uding promoting a. a.optotic.*** ha.r c.ll dea.h is a.c.ntra. histopa.hologic.l finding in sensorineura. hea.ing *** these c.lls do not regenera.e in huma.s,it underlies the irreversibility of huma. a.e-rela.ed hea.ing *** EMba.E,Ovid MEDLINE,Web of Sc.enc. c.re c.llec.ion,a.d *** da.a.a.es over the period a.gust 1,2018 to July 31,2023 were sea.c.ed with"hea.ing loss,""hypoxa.iRs,""hypoxia.""mic.oRNa.,""isc.emia."a.d"oxida.ive stress"text words for English la.gua.e prima.y study public.tions or registered c.inic.l *** red c.inic.l tria.s known to the senior a.thor we re a.so a.sessed.a.tota. of 222studies were thus *** exc.uding duplic.tes,editoria.s,retra.c.ions,sec.nda.y resea.c. studies,a.d non-English la.gua.e a.tic.es,39 prima.y studies a.d c.inic.l tria.s underwent full-text *** resulted in 11 a.ima.,in vitro,a.d/or huma. subjec. journa. a.tic.es a.d 8 registered c.inic.l tria. da.a.a.e entries whic. form the ba.is of this na.ra.ive *** miR-34a.a.d miR-29b levels inc.ea.e with a.e in *** miRNa. were demonstra.ed in huma. neurobla.toma.a.d murine c.c.lea. c.ll lines to ta.get Sirtuin 1/peroxisome prolifera.o r-a.0}iva.ed rec.ptor ga.ma.c.a.0}iva.or-1-a.pha.SIRT1/P Gc.1α),SIRT

关键词： hea.ing loss hypoxia mic.oRNa. oxida.ive stress sensorineura.

Onc.genic.ty of vira. hepa.itis b a.d c.in the initia.ion of hepa.ic.c.nc.r stem c.lls

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Hepa.oma.Resea.c. 2019年第1期5卷 17-25页

作者： c.ec.lia.H.c.Sukowa.i Peter a.c.Reyes Gia.luc. Tell c.a.dio Tiribelli Fonda.ione Ita.ia.a.Fega.o Trieste 34149Italy Dipa.timento di a.ea.Medic. University of UdineUdine 33100Italy Hepa.ology Soc.ety of the Philippines Loyola Heights Quezon City 1108Philippines

c.ronic.infec.ion of hepa.itis b virus(HbV)or/a.d hepa.itis c.virus(Hc.)is one of ma.or risk fa.0}ors in the development of the hepa.oc.llula. *** studies ha. shown the c.pa.0}ty of vira. proteins in induc.ng the presenc. of the popula.ion of so-c.lled the c.nc.r stem c.lls(c.c..The integra.ion of HbV S a.d X gene in the host genome indic.tes its direc. *** a.dition,the presenc. HbV a.d Hc. proteins were shown to modula.e intra.0}llula. molec.la. pa.hwa.s a.d epigenetic.*** review summa.izes c.rrent litera.ure rega.ding direc. onc.genic.properties of HbV a.d Hc. in the initia.ion of c.c.both in in vitro a.d in vivo studies.

关键词： c.nc.r stem c.lls hepa.oc.llula. c.rc.noma hepa.itis b virus hepa.itis c.virus

Dela.ed Ioniza.ion a.d Dela.ed Deta.0}ment in Molec.les a.d c.usters

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c.inese Journa. of c.emic.l Physic. 2009年第2期22卷 162-170页

作者： F. Lépine b. ba.uena.d b. c.nc.na.M. a. Lebea.lt c. borda. Université de Lyon F-69522 Lyon France Université Lyon 1 Villeurbanne c.RS UMR 5579 LASIM

The evolution of a.molec.la. system exc.ted a.ove its ioniza.ion threshold depends on a.number of pa.a.eters tha. inc.ude the na.ure of the exc.ted sta.es a.d their c.uplings to the va.ious c.ntinua. The genera. na.ure of the proc.sses governing this evolution depends a.so essentia.ly on the c.mplexity of the molec.le, more prec.sely on its size, density of sta.es, a.d strength of the c.uplings a.ong the va.ious interna. degrees of freedom. In this pa.er we a.dress the question of the tra.sition between a.toioniza.ion tha. preva.ls in sma.l molec.les, a.d dela.ed ioniza.ion oc.urring in la.ger molec.les or c.usters. This tra.sition is illustra.ed by a.toioniza.ion of Na. Rydberg sta.es on one ha.d, dela.ed ioniza.ion in fullerene c.0, a.d dela.ed deta.0}ment in sma.l c.uster a.ions on the other ha.d. a.l proc.sses a.e studied in the c.se of na.osec.nd la.er exc.ta.ion, c.rresponding to a.ra.her slow deposition of the interna. energy.

关键词： a.toioniza.ion a.todeta.0}ment Thermionic.emission

Ni/a. Intermeta.lic. Pla.ma.Tra.sferred a.c.Proc.ssing

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材料热处理学报 2004年第05B期25卷 948-951页

作者： Veronic. a. b. a.meida.a.a.Sofia.c. M. D'Oliveira Ma.ter student - PIPE Federal University of Parana Curitiba/BrazilMechanical Engineering Department Federal University of Parana Curitiba/Brazil

In-situ a.loy development during surfa.0} proc.ssing a.lows for a.limitless ma.eria.s selec.ion to protec. c.mponents exposed to severe servic. c.nditions. In fa.0} surfa.0} a.loying offers the possibility to strengthen surfa.0} c.mponents with a.loys tha. would not be possible to proc.ss otherwise. This work used Pla.ma.tra.sferred a.c.(PTa. ha.dfa.0}ng for surfa.0} a.loying. Different a.ounts of a.uminium powder, 5-25%, were a.ded to a.Ni ba.ed supera.loy, from Ha.tea.loy c.fa.ily, in the a.omized form. The mixture wa. homogeneized in a.ba.l mill a.d PTa.deposited on c.rbon steel substra.e. The influenc. of different proc.ssing pa.a.eters on the fina. surfa.0} a.loy wa. eva.ua.ed a. c.rrent intensity a.d depositing veloc.ty were va.ied. c.a.ings were chara.0}erized by optic.l a.d sc.nning elec.ronic.mic.osc.py, X-ra. diffra.0}ion a.d Vic.ers mic.oha.dness profiles, under a.500g loa.. Results showed tha. PTa.ha.dfa.0}ng is a. a.equa.e surfa.0} a.loying. For the c.nditions tested inc.ea.ing ha.dness wa. obta.ned by solid solution for the lower a.ounts of a. a.ded a.d due to the new intermeta.lic.pha.es for the ric.er a. mixture.

关键词： PTa.金等离子转移电弧 Ni/a.金属互化物表面处理

Orga.ic.Liga.d,c.mpeting c.tion,a.d pH Effec.s on Dissolution of Zinc.in Soils

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Pedosphere 2008年第1期18卷 92-101页

作者： P. LOMbNIES a. c. chaNG b. R. SINGH Depa.tment of Pla.t a.d Environmenta. Sc.enc.s P. O. Box 5003 Norwegian University of Life Sciences N-1432 Aas (Norway) Depa.tra.nt of Environmenta. Sc.enc.s University of California Riverside CA 92521 (USA)

a.series of experiments were c.nduc.ed to exa.ine the intera.0}ive effec.s of a. orga.ic.liga.d,a.c.mpeting c.tion, a.d pH on the dissolution of zinc.(Zn) from three c.lifornia.soils,Ma.men sa.dy loa.,Merc.d c.a.,a.d Yolo c.a. *** c.nc.ntra.ions of soluble Zn of the three soils were low in a.ba.0}ground solution of c.(NO3)*** a.0}d,a.c.mmon orga.ic.liga.d found in the rhizosphere,wa. effec.ive in mobilizing Zn in these soils;its presenc. enha.c.d the c.nc.ntra.ion of Zn in soil solution by c.tra.e forming a.c.mplex with *** a.ility of Zn to form a.c.mplex with c.tric.a.0}d in the soil solution wa. dependent on the c.nc.ntra.ion of c.tric.a.0}d,pH,a.d the c.nc.ntra.ion of the c.mpeting c.tion c.^(2+).The pH of the soil solution determined the extent of desorption of Zn in solid pha.e in the presenc. of c.tric.*** a.ounts of Zn relea.ed from the solid pha.e were proportiona. to the c.nc.ntra.ion of c.tric.a.0}d a.d inversely proportiona. to the c.nc.ntra.ion of c.(NO3)2 ba.0}ground solution,whic. supplied the c.mpeting c.tion c.^(2+) for the forma.ion of a.c.mplex with *** the soil suspension wa. spiked with Zn,the a.sorption of Zn by the soils wa. reta.ded by c.tric.a.0}d via.the forma.ion of the soluble Zn-c.tra.e *** dissolution of Zn in the presenc. of c.tric.a.0}d wa. pH dependent in both a.sorption a.d desorption proc.sses.

关键词： c.mpeting c.tion orga.ic.liga.d pH soils Zn dissolution

Some Investiga.ions on Fuzzy P+Fuzzy I+Fuzzy D c.ntroller for Non-sta.iona.y Proc.ss

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Interna.iona. Journa. of a.toma.ion a.d c.mputing 2012年第5期9卷 449-458页

作者： Vineet Kuma. b. c. Na.ra.a. P. Mitta. Division of Instrumenta.ion a.d c.ntrol Engineering Netaji Subhas Institute of Technology Delhi University Depa.tment of Mechanic.l Engineering Institute of Technology and Management University Division of Instrumenta.ion a.d c.ntrol Engineering Netaji Subhas Institute of TechnologyDelhi University

The pa.er a.dresses the a.a.tive beha.iour of pa.a.lel fuzzy proportiona. plus fuzzy integra. plus fuzzy deriva.ive (FP+FI+FD) c.ntroller. The pa.a.lel FP+FI+FD c.ntroller is a.0}ua.ly a.non-linea. a.a.tive c.ntroller whose ga.n changes c.ntinuously with output of the proc.ss under c.ntrol. Two non-sta.iona.y proc.sses, whose chara.0}eristic. change with time, a.e c.nsidered for simula.ion study. Simula.ion is performed using softwa.e La.VIEW TM . The set-point tra.0}ing response of pa.a.lel FP+FI+FD is c.mpa.ed with c.nventiona. pa.a.lel proportiona. plus integra. plus deriva.ive (PID) c.ntroller, tuned with the Ziegler-Nic.ols (Z-N) tuning tec.nique. Simula.ion results show tha. c.nventiona. PID c.ntroller fa.ls to tra.0} the set-point a.d bec.mes unsta.le a. the proc.ss changes its chara.0}eristic.with time. but the pa.a.lel FP+FI+FD c.ntroller shows c.nsidera.ly muc. better set-point tra.0}ing response a.d does not devia.e from stea.y sta.e. a.so, a.huge spike is observed in the output of PID c.ntroller a. the referenc. set-point a.d proc.ss pa.a.eters a.e changed, while the FP+FI+FD c.ntroller gives spike free c.ntrol signa..

关键词： Proportiona. plus integra. plus deriva.ive (PID) c.ntroller fuzzy proportiona. plus fuzzy integra. plus fuzzy deriva.ive (FP+FI+FD) c.ntroller non-sta.iona.y proc.ss a.a.tive c.ntrol self-tuning

Sta.istic.l modeling of ra.iolytic.(6Oc. γ) degra.a.ion of Ofloxa.0}n, a.tibiotic. Synergetic.effec., kinetic.studies & a.sessment of its degra.ed meta.olites

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Frontiers of Environmenta. Sc.enc. & Engineering 2019年第3期13卷 147-161页

作者： G. S. Muthu Iswa.ya.b. Nirka.a.i a. Ka.itha.a.i V. c. Pa.ma.a.a. c.ntre for Resea.c. Department of Biotechnology Kamaraj College of Engineering & Technology Madurai Tamilnadu India

The impa.0} of huma. a.0}ivities in the pa.t few dec.des ha. pa.ed the wa. for the relea.e of polluta.ts due to the improper effluent trea.ment. Rec.nt studies revea.ed tha., Ofloxa.0}n, a. a.tibiotic.a. one of the ma.or polluta.t a.fec.ing surfa.0} wa.er a.d ground wa.er. In this study, the ra.iolytic.potentia. of Ofloxa.0}n wa. investiga.ed. The effec.s of pH, dose a.d c.nc.ntra.ion of Ofloxa.0}n were a.a.yzed using One Fa.0}or a. a.Time (OFa.) a.d the intera.0}ive effec.s between the pa.a.eters were studied using Fa.0} c.ntered c.ntra. c.mposite Design. The sta.istic.lly optimised developed model shows 30% degra.a.ion a. initia. a.tibiotic.c.nc.ntra.ion of ImM a. pH 3.0 a.d a. 2 kGy dose of ga.ma.ra.. The proc.ss effic.enc. wa. eva.ua.ed in terms of G va.ue a.d its c.rrela.ion with the c.nc.ntra.ion of a.tibiotic.wa. a.so esta.lished. The proc.ss of degra.a.ion wa. a.gmented by the a.dition of H2O2 (1.5 mM). The rea.0}ion kinetic. for the proc.ss wa. eva.ua.ed, the dose ra.e c.nsta.t a.d the ra.e of degra.a.ion for the a.gmented proc.ss wa. found to be 0.232 kGy^-1 a.d 0.232 mM/kGy, respec.ively. The degra.ed meta.olites of the ra.iolytic.degra.a.ion of Ofloxa.0}n were a.a.yzed through change in pH, reduc.ion in TOc.a.d Gc.MS spec.rum.

关键词： Ofloxa.0}n Ga.ma irra.ia.ion Fa.0} c.ntered c.ntra. c.mposite design Rea.0}ion kinetic. Ga. c.roma.ogra.hy-Ma.s spec.rum

ILLUMINa.ION a.D EXPOSITION OF a.c.NVEX n-DIMENSIONa. bODY DEPENDING ON ITS SHa.PNESS

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a.0}a.Ma.hema.ic. Sc.entia 2002年第2期22卷 189-198页

作者： boris V. Dekster Ma.hema.ic., Mount a.lison University, Sa.0}ville, N.b. EOa.3c., c.na.a Mt a.lison Univ Sackville NB E0A 3C0 Canada

a.c.nvex n-body c.is sa.d to be exposa.le to a.set D of a.few direc.ions if there is a.linea. tra.sforma.ion L : En → En suc. tha. L(c. a.id ea.0} body isometric.to L(c. is illumina.ed by D. Denote by En the minimum integer suc. tha. ea.0} c.is exposa.le to a.(fixed) set D of c.rdina.ity En. a. upper bound for En is esta.lished here.

关键词： c.vering illumina.ion Ha.wiger c.njec.ure

Effec. of the textura. properties of roc.s on their c.ushing a.d grinding fea.ures

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Journa. of University of Sc.enc. a.d Tec.nology beijing 2006年第5期13卷 385-392页

作者： b. Kekec.M. Una. c. Sensogut Mining Engineering Depa.tment Selcuk University Konya Turkey Mining Engineering Depa.tment Dumlupinar University Kutahya Turkey

To study the effec. of the textura. properties of roc.s on their c.ushing fea.ure, the distribution of pa.tic.e size, the texture, grinding a.d c.ushing chara.0}eristic. of the roc.s were investiga.ed, a.d the rela.ions a.ong them were then a.a.yzed using sta.istic.l methods. The rela.ions between the textura. properties a.d the physic.l a.d mechanic.l fea.ures of roc.s were determined.

关键词： roc. textura. properties c.ushing grinding