Oncogenicity of viral hepatitis B and C in the initiation of hepatic cancer stem cells

作     者：Caecilia H.C.Sukowati Peter A.C.Reyes Gianluca Tell Claudio Tiribelli Caecilia H. C. Sukowati;Peter A. C. Reyes;Gianluca Tell;Claudio Tiribelli

作者机构：Fondazione Italiana FegatoTrieste 34149Italy Dipartimento di Area MedicaUniversity of UdineUdine 33100Italy Hepatology Society of the PhilippinesLoyola Heights Quezon City 1108Philippines 

出 版 物：《Hepatoma Research》 (肝癌研究（英文版）)

年 卷 期：2019年第5卷第1期

页      面：17-25页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Sukowati CHC was supported by a Research Grant of Associazione Italiana per la Ricerca sul Cancro(AIRC-#IG19862 to Tell G)and Reyes PAC by Philippine Council for Health Research and Development(PCHRD)and the Hepatology Society of the Philippines(HSP) 

主　　题：Cancer stem cells hepatocellular carcinoma hepatitis B virus hepatitis C virus 

摘      要：Chronic infection of hepatitis B virus(HBV)or/and hepatitis C virus(HCV)is one of major risk factors in the development of the hepatocellular *** studies had shown the capacity of viral proteins in inducing the presence of the population of so-called the cancer stem cells(CSC).The integration of HBV S and X gene in the host genome indicates its direct *** addition,the presence HBV and HCV proteins were shown to modulate intracellular molecular pathways and epigenetic *** review summarizes current literature regarding direct oncogenic properties of HBV and HCV in the initiation of CSC both in in vitro and in vivo studies.