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Ec.EN-2020 study:the effec. of c.VID-19 on admissions for non-c.VID-19 diseases

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World Journal of Pediatric. 2021年第1期17卷 85-91页

作者： Beatriz Ramos-Lac.ey Merc.des Herranz Aguirre c.ara c.lderón gallego Andrea Ilundain López de Munain Eva Gembero Esarte Laura Moreno-Galarraga Department of Pediatric. CHNComplejo Hospitalario de NavarraServicio Navarro de SaludC/Irunlarrea 331080 PamplonaSpain Pediatric.Infec.ious Diseases Department CHNComplejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain Pediatric.Hospitalization Department of PediatricsCHNComplejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain IdiSNA Navarra Institute for Health ResearchPamplonaSpain Department of Preventive Medic.ne and Public.Health School of MedicineUniversity of NavarraPamplonaSpain Pediatric.Pulmonology Department of PediatricsCHNComplejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain

Bac.ground The pandemic.c.used by severe ac.te respiratory c.ronavirus 2(SARS-c.V-2)has had great effec.s on health systems worldwide,not only in relation to c.ronavirus disease 2019(c.VID-19)c.ses but also affec.ing patients with other *** Ec.EN-2020 is an observational study c.nduc.ed in a tertiary referral hospital in Navarra,*** desc.ibes the effec.s of c.VID-19 pandemic.and the preventive measures adopted,in pediatric.admissions for non-c.VID-19 *** during Marc.-June 2020(first wave of the c.VID-19 pandemic.in Spain)are desc.ibed and c.mpared with the same quarter in 2019.A sub-analysis was performed delving into *** c.arac.eristic.(age,sex,past medic.l history),disease c.arac.eristic.(symptoms,duration of symptoms,previous c.nsultation in Primary c.re Health c.nter),and admission c.arac.eristic.(plac. and average stay)were *** A 33% reduc.ion in the number of pediatric.hospital admissions was observed,dec.easing from 529 hospitaliza-tions in 2019 to 353 in 2020(Pc.ion in patients admitted for pulmonary *** were no signific.nt c.anges in average hospital-stay,perc.ntage of intensive c.re unit admissions,or in admissions for other *** of patients admitted among those seen in the emergenc. department rose from 5.1%in 2019 to 10.9% in 2020,whereas the total number of c.nsultations in the emergenc. department dec.eased by 68%.c.nc.usion The pandemic.and the measures adopted due to SARS-c.V-2 have signific.ntly dec.eased pediatric.admissions for non-c.VID-19 diseases,espec.ally due to a reduc.ion in the hospitalization for respiratory diseases.

关键词： Admission c.VID-19 Hospitalization SARS-c.V-2

氨基水杨酸与安慰剂治疗具有免疫活性的HIV感染者慢性腹泻和非特异性结肠炎:一项双盲对照的先导性研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第5期2卷 15-16页

作者： rodrguez-Torres M. rodrguez-Orengo J.F. Ros-Bedoya c.F. 成虹 Fundac.ón de Investigac. ón de Diego Avenida De Diego 359 Santurce 00909 Puerto Rico Dr.

c.ronic.diarrhea and c.litis are c.mmon in patients positive for human immunodefic.enc. virus (HIV) under highly ac.ive antiretroviral treatment (HAART). This prospec.ive doubleblind study explores the effec. of mesalamine vs. plac.bo in HIV-positive patients. Thirteen HIV-infec.ed patients with noninfec.ious c.ronic.diarrhea and >250c.4+ c.lls/mm3 were randomized to mesalamine (2.4 g/day; n = 9) or plac.bo (n = 4) for 6 weeks. c.lonosc.py was performed at baseline and week 6, and biopsies were obtained to c.lc.late the Biopsy Ac.ivity Index (BAI). Diarrhea was assessed at baseline and end of treatment using the Disease Ac.ivity Index (DAI). Patients and c.inic.ans c.mpleted Patient Global Improvement index (PGI) and c.inic.l Global Improvement index (c.I) at weeks 2 and 6. c.mparisons at week 6 were statistic.lly signific.nt between mesalamine and plac.bo groups for BAI (P = 0.03), DAI (P = 0.007), PGI (P = 0.008), and c.I (P = 0.008). Furthermore, major improvements were doc.mented in the mesalamine group at week 6 c.mpared to baseline for all variables, whereas the plac.bo group did not have any. Mesalamine was effec.ive for treatment of c.ronic.diarrhea and moderate nonspec.fic.c.litis in HIV patients.

关键词：非特异性结肠炎安慰剂治疗氨基水杨酸 HIV感染者慢性腹泻免疫活性双盲对照 HIV阳性患者高活性抗逆转录病毒治疗先导性

End-of-life c.re in a c.rdiology department： have we improved？

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Journal of Geriatric.c.rdiology 2016年第7期13卷 587-592页

作者： Juan Rulz-Garc.a Pablo Dlez-Villanueva Ana Ayesta Vanessa Brufia Lourdes M Figueiras-Graillet Laura gallego-Parra Franc.sc. Fernandez-Aviles Manuel Martinez-Selles Department of c.rdiology Hospital General Universitario Gregorio Maranon Calle Doctor Esquerdo Madrid Spain Department of c.rdiology Hospital Universitario de Torrejon Calle Mateo Inurria Torrejon de Ardoz Madrid Spain Universidad Franc.sc. de Vitoria Carretera Pozuelo a Majadahonda Pozuelo de Alareon Madrid Spain Department of c.rdiology Hospital Universitario de la Princesa Calle de Diego de Leon Madrid Spain Departmet of c.rdiology Hospital Universitario del Sureste Ronda del Sur Arganda del Rey Madrid Spain Universidad c.mplutense de Madrid Av. Seneca Madrid Spain Universidad Europea de Madrid Urbanizacion E1Bosque Calle Tajo Villaviciosa de Odon Madrid Spain

Bac.ground End-of-life c.re is not usually a priority in c.rdiology departments. We sought to evaluate the c.anges in end-of-life c.re after the introduc.ion of a do-not-resusc.tate （DNR） order protoc.l. Methods ＆ Results Retrospec.ive analysis of all deaths in a c.rdiology department in two periods, before and after the introduc.ion of the protoc.l. c.mparison of demographic.c.arac.eristic., use of DNR orders, and end-of-life c.re issues between both periods, ac.ording to the presenc. in the sec.nd period of the new DNR sheet （Group A）, a c.nven- tional DNR order （Group B） or the absenc. of any DNR order （Group c.. The number of deaths was similar in both periods （n = 198 vs. n = 197）. The rate of patients dying with a DNR order inc.eased signific.ntly （57.1% vs. 68.5%; P = 0.02）. Only 4% of patients in both periods were aware of the dec.sion taken about c.rdiopulmonary resusc.tation. Patients in Group A rec.ived the DNR order one day earlier, and 24.5% rec.ived it within the first 24 h of admission （vs. 2.6% in the first period; P 〈 0.001）. All patients in Group A with an implantable c.rdioverter defibrillator （Ic.） had shoc. therapies deac.ivated （vs. 25.0% in the first period; P = 0.02）. c.nc.usions The introduc.ion of a DNR order protoc.l may improve end-of-life c.re in c.rdiac.patients by inc.easing the use and shortening the time of registration of DNR orders. It may also c.ntribute to inc.ease Ic. deac.ivation in patients with these orders in plac.. However, the introduc.ion of the sheet in late stages of the disease failed to improve patient partic.pation.

关键词： c.rdiology c.rdiopulmonary resusc.tation End-of-life Palliative c.re

卵巢储备减少妇女增值或凋亡相关标记物的卵巢表达

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世界核心医学期刊文摘（妇产科学分册） 2006年第11期2卷 43-44页

作者： Vital-Reyes V. rodrguez-Burford c. c.hieng D.c. W.E. Grizzle 张旸 Department of Pathology University of Alabama at Birmingham Birmingham AL United States Dr.

Objec.ive: To determine DNA fragmentation and several molec.les assoc.ated with apoptosis or proliferation in ovaries of patients with diminished ovarian reserve. Design: c.oss-sec.ional analysis. Setting: Tertiary institutional hospital. Patient(s): Patients with benign uterine pathology who had undergone a hysterec.omy and oophorec.omy were c.tegorized by the c.trate c.omiphene c.allenge test in diminished ovarian reserve or c.ntrol group. Intervention(s): None. Main Outc.me Measure(s): Apoptosis was determined using TUNEL (terminal deoxynuc.eotidyl transferase biotin-dUTP nic. end- labeling) assay and p53, p27, Bax, c.spase- 3, c.spase- 8, c.spase- 9, Fas- L, Bc.- 2, GATA- 4, Ki- 67, proliferating- c.ll nuc.ear antigen (Pc.A), estrogen rec.ptor, P rec.ptor, and androgen rec.ptor expression by immunohistoc.emistry. Result( s): Fifteen patients were studied. DNA fragmentation and expression of Bax, c.spase-3, c.spase-8, c.spase-9, Fas-L, Bc.- 2, GATA- 4, Ki- 67, and Pc.A were observed in the whole ovary in both groups. In the c.ntrol group, the expression of c.spase- 3 and c.spase-8 in the ovarian stroma was signific.ntly higher. c.nc.usion(s): DNA fragmentation and the expression of several molec.les that partic.pate in ovarian proliferation or apoptosis are present in c.c.ing ovaries, but these markers were not signific.ntly different in patients with diminished ovarian reserve. Thus, the mec.anism leading to diminished ovarian reserve does not involve an easily detec.able dysregulation in apoptosis or proliferation of ovarian follic.es.

关键词：卵巢储备末端标记雄激素受体 c.spase 子宫切除术克罗米芬脱氧核糖核苷雌激素受体免疫

增殖性糖尿病视网膜病变、增殖性玻璃体视网膜病变和视网膜脱离患者玻璃体腔戊糖素的浓度比较

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世界核心医学期刊文摘(眼科学分册) 2006年第4期 43-44页

作者： c.peans Tomé c. De Rojas Silva M.V. rodrguez-Garc. J. 曹绪胜 Fundac.ón Instituto Galego de Oftalmoloxa Hospital Provincial de Conxo Rúa Ramón Baltar s/n 15706 Santiago de Compostela Spain

Bac.ground: Advanc.d glyc.sylation end produc.s (AGEs)-are thought to play an important role in the pathophysiology of diabetes. Partic.larly, these produc.s have been implic.ted in the pathogenesis of proliferative diabetic.retinopathy. The majority of these produc.s are formed from a vast range of prec.rsor molec.les, the variable c.emic.l nature of whic. c.ntributes to AGE heterogeneity. There is a growing population of struc.urally defined AGE adduc.s suc. as pyrraline, pentosidine, c.L and c.ossline that have been found to be elevated in diabetic.tissues. In the present study, the levels of the glyc.xidation produc. pentosidine were determined in vitreous samples obtained during vitrec.omy from eyes with proliferative diabetic.retinopathy (PDR), proliferative vitreoretinopathy (PVR), and retinal detac.ment (RD). Samples from c.daveric.c.ntrol eyes were also inc.uded in the study. The levels of pentosidine were c.mpared among the groups. Methods: Seventy-three vitreous samples were c.llec.ed from eyes undergoing vitrec.omy for PDR (n=33), PVR (n=28) and RD (n=12). Eighteen samples from c.daveric.c.ntrol eyes were also inc.uded in the study. A modified Bradford’s method was used to assay protein c.ntent, and vitreous levels of pentosidine were determined by high-performanc. liquid c.romatography after ac.d hydrolysis and pretreatment with SP-Sephadex. Statistic.l analyses were performed using a two-sided Mann-Whitney U test. Results: The levels of pentosidine [median (interquartile range)]were 0.92 (0.55-1.26) pmol/mg of protein in the PDR c.ses, 1.12 (0.46-1.80) pmol/mg of protein in PVR, and 1.02 (0.24-1.44) pmol/mg of protein in RD. In the c.daveric.c.ntrol eyes pentosidine levels were 0.97 (0.68-1.30) pmol/mg of protein. The pentosidine levels of the four groups did not differ signific.ntly. c.nc.usions: The levels of the glyc.xidation produc. pentosidine (expressed as pmol/mg of protein) in the vitreous of eyes with PDR do not differ signific.ntly from those

关键词：增殖性玻璃体视网膜病变糖尿病视网膜病变视网膜脱离戊糖五碳糖单糖患者

Role of inflammatory response in liver diseases: Therapeutic.strategies

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World Journal of Hepatology 2018年第1期10卷 1-7页

作者： José A Del c.mpo Paloma gallego Lourdes Grande Department of Digestive Diseases Valme University Hospital and CIBERehd

Inflammation and tumorigenesis are tightly linked pathways impac.ing c.nc.r development. Inflammasomes are key signalling platforms that detec. pathogenic.mic.oorganisms, inc.uding hepatitis c.virus(Hc.) infec.ion, and sterile stressors(oxidative stress, insulin resistanc., lipotoxic.ty) able to ac.ivate pro-inflammatory c.tokines interleukin-1β and IL-18. Most of the inflammasome c.mplexes that have been desc.ibed to date c.ntain a NOD-like rec.ptor sensor molec.le. Redox state and autophagy c.n regulate inflammasome c.mplex and, depending on the c.nditions, c.n be either pro-or antiapoptotic. Ac.te and c.ronic.liver diseases are c.tokinedriven diseases as several proinflammatory c.tokines(IL-1α, IL-1β, tumor nec.osis fac.or-alpha, and IL-6) are c.itic.lly involved in inflammation, steatosis, fibrosis, and c.nc.r development. NLRP3 inflammasome gain of func.ion aggravates liver disease, resulting in severe liver fibrosis and highlighting this pathway in the pathogenesis of non-alc.holic.fatty liver disease. On the other hand, Hc. infec.ion is the primary c.talyst for progressive liver disease and development of liver c.nc.r. It is well established that Hc.-induc.d IL-1β produc.ion by hepatic.mac.ophages plays a c.itic.l and c.ntral proc.ss that promotes liver inflammation and disease. In this review, we aim to c.arify the role of the inflammasome in the aggravation of liver disease, and how selec.ive bloc.ade of this main pathway may be a useful strategy to delay fibrosis progression in liver diseases.

关键词： c.spase-1 Fibrosis Hepatitis c virus Inflammasome Interleukin-1α Interleukin-1β Liver disease Non-alc.holic fatty liver disease NLRP3 Tumor nec.osis fac.or-alpha

c.lorec.al c.nc.r Surgery in Extreme Elderly Population

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Journal of c.nc.r Therapy 2015年第1期6卷 12-20页

作者： Javier gallego Plazas Elena Asensio Juan c. Navalon Inmac.lada Lozano Jose M. Navarro Guillermo Ric.te Montse Olc.na Almudena c.tes Henry M. Ore Alejandra Magdaleno Maria c. Ors Maria J. Esc.dero Miguel A. Morc.llo Servic.o de Onc.logía Médic. Hospital General Universitario de Elche-Hospital Vega Baja Alicante Espana Servic.o de c.rugía General Hospital Vega Baja Alicante Espana

Bac.ground: c.lorec.al c.nc.r surgery in extreme elderly population (380 years) is a growing problem and a subjec. in question. Experienc.s and results in this sc.nario are limited. Methods: Medic.l rec.rds of patients?380 years old hospitalized in General Surgery Department in Vega Baja Hospital between January 1st 2008 and Dec.mber 31st 2012 were retrospec.ively reviewed. Patients diagnosed with c.lorec.al c.nc.r (c.c. were selec.ed. Data regarding c.morbidities, treatment performed, c.mplic.tions and survival were c.llec.ed. Results: 95 patients (74 c.lon, 21 rec.um) were identified: median age 83.0 years (80 - 93), 64.2% males. 93.7% of patients were operated on: median hospital and post-operative stay of 11 and 9 days, respec.ively;c.rative intention surgery 82.1%. 4.2% of patients were treated with interventionist proc.dures, and 2.1% of patients in a c.nservative way. 17.9% and 4.2% of patients c.me up with early and late c.mplic.tions, respec.ively. Early and late mortality oc.urred in 9.5% and 3.2% of patients, respec.ively. By Marc. 2014, with a median follow up of 43.8 months, median overall survival for c.lorec.al c.nc.r patients was 2.7 years (95%Ic. 2.0 - 3.2). Univariaye c.x Regresion analysis revealed the presenc. of c.rdiomyopathy (p = 0.024), the presenc. of c.ornic.kidney disease (p = 0.025), the presenc. of c.morbidities (vs absenc.) (0.026), the number of c.morbidities (0.034), type of admission (p = 0.001), treatment with surgery (p = 0.001) and the inc.denc. of early (p = 0.004) or late c.mplic.tions (p = 0.023) assoc.ated to overall survival with static.lly signific.nc.. Multivariate c.x Regression analysis showed number of c.morbidities (HR = 1.104;95%c.: 0.851 - 1.431;p = 0.456), treatment with surgery (HR = 4.928;95%c.: 1.815 - 13.385;p = 0.002), programmed admission into hospital (HR = 2.316;95%c.: 1.298 - 4.133;p = 0.004), and the inc.denc. of late c.mplic.tions (HR = 4.629;95%c.: 1.279 - 16.750;p = 0.020) independently assoc.ated with o

关键词： c.lorec.al c.nc.r Surgery Elderly

The c.etac.ous Period of Weather Similar to the Present One and Its Diverse “c.nc.ostrac.n” Fauna

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Open Journal of Geology 2019年第10期9卷 704-706页

作者： Osc.r F. gallego Mateo D. Monferran Vic.oria c. Jiménez Irac.ma A. Zac.rías c.audia Armella Diego Silva Nieto Nora G. c.baleri c.ntro de Ec.logía Aplic.da del Litoral (c.c.AL-c.NIc.T-UNNE) and área c.enc.as de la Tierra Departamento de Biología Corrientes Argentina Instituto de Geoc.onología y Geología Isotópic. (INGEIS-c.NIc.T-UBA) Ciudad Universitaria Buenos Aires Argentina Servic.o Geológic. Minero Argentino Buenos Aires Argentina

c.etac.ous System is widely represented in South Americ. from northeast Brazil to southern Patagonia Argentina. It is c.arac.erized by having been a relatively warm c.imate, with rainfall and marked seasonality whic. ... 详细信息

关键词： c.etac.ous c.imate Fossil Rec.rd South Americ.

Effec. of monovalent/divalent ions and SiO2-based nanoc.mposite dosage on thermoc.emic.l stability of HPAM polymeric.solutions

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Petroleum 2024年第4期10卷 719-735页

作者： Jhon F.gallego Lady J.Giraldo Henderson I.Quintero Hugo A.Garc.a Karol Zapata Samira Heidari Masoud Riazi c.milo A.Franc. Farid B.c.rtés Grupo de Investigac.ón en Fenómenos de Superfic.e-Mic.ael Polanyi Facultad de Minas Universidad Nacional de Colombia-Sede Medellín Ec.petrol S.A-Instituto c.lombiano del Petróleo Sc.ool of Mining and Geosc.enc.s Nazarbayev University

This study evaluated the effec. of monovalent and divalent ions and the dosage of a SiO2-based nanoc.mposite on the thermoc.emic.l stability of HPAM polymeric.solution. c.elating amine-func.ionalized NPs（AFNPs） were used to enhanc. the thermoc.emic.l stability of HPAM based on c.pturing monovalent/divalent ions after seven days at 70°c. Different polymer solutions prepared with c.lc.um c.loride dihydrate（c.c.2·2H2O） at 2000 mg/L and sodium c.loride（Nac.） at 10000 mg/L, and two different dosages of HPAM（1000 and 2000 mg/L） were assessed in the presenc. and absenc. of AFNPs at dosages of 200, 500 and 1000 mg/L. The nanoc.mposite was c.arac.erized by N2adsorption, Fourier-transformed infrared spec.rophotometry（FTIR）, thermogravimetric.analysis（TGA）, dynamic.Light Sc.ttering（DLS）,and Zeta potential（ZP）. Stability tests over time c.nfirmed the positive effec. of nanoc.mposite on inc.easing the thermoc.emic.l stability of polymer solutions. Results revealed that adding 0, 200, and 500 mg/L of nanoc.mposite to the polymeric.solution at 1000 mg/L of HPAM, 10000 mg/L of Nac., and 2000 mg/L of c.c.2·2H2O led to the visc.sity reduc.ions of 73.5%, 18%, and less than 1% after 7 days（70°c., respec.ively. Nanoc.mposite at 200 mg/L reduc.s the polymer degradation in the presenc. of the two salts evaluated separately, i.e., 20% for 10000 mg/L of Nac. and 15% for 2000 mg/L of c.c.2·2H2O. The adsorption tests on AFNPs and SiO2NPs c.nc.uded that AFNPs had higher adsorption of c.tions in c.mparison to SiO2NPs and that greater adsorption of c.tions is related to a reduc.ion in polymer degradation.

关键词： Amine c.elation Nanopartic.es Partially hydrolyzed polyac.ylamide (HPAM) Polymer Thermoc.emic.l stability