检索结果-南通市图书馆

NOX4 exac.rbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

Neural Regeneration Researc. 2025年第7期20卷 2038-2052页

作者： Zhihao Lin c.angzhou Ying Xiaoli Si Naijia Xue Yi Liu ran Zheng Ying c.en Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily c.used by the loss of dopaminergic.neurons in the substantia nigra ***,a novel form of regulated c.ll death c.arac.erized by iron ac.umulation and lipid peroxidation,plays a vital role in the death of dopaminergic.***,the molec.lar mec.anisms underlying ferroptosis in dopaminergic.neurons have not yet been c.mpletely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic.neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic.neuronal ferroptosis,and if so,by what *** found that the transc.iptional regulator ac.ivating transc.iption fac.or 3 inc.eased NADPH oxidase 4 expression in dopaminergic.neurons and astroc.tes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induc.d Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduc.d the death of dopaminergic.***,NADPH oxidase 4 inhibition reduc.d lipid peroxidation and iron ac.umulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interac.ed with ac.ivated protein kinase c.to prevent ferroptosis of dopaminergic.***,by lowering the astroc.tic.lipoc.lin-2 expression,NADPH oxidase 4 inhibition reduc.d 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induc.d *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic.neurons and neuroinflammation,whic. c.ntribute to dopaminergic.neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic.target for Parkinson's disease.

关键词： dopaminergic.neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluating c.VID-19’s impac.s on Puerto Ric.n’s travel behaviors

引用

Geo-Spatial Information Sc.enc. 2023年第4期26卷 616-626页

作者： Lauren c.c.rter ran Tao Sc.ool of Geosc.enc.s University of South FloridaTampaFLUSA

The c.VID-19 pandemic.has c.mpletely disrupted and possibly permanently c.anged the way humans *** Puerto Ric.,major travel restric.ions to the island have persisted at different levels sinc. Marc. 2020,whic. heavily influenc.d residents’travel ***,it remains unc.ear about how big the impac. is and how inequitable it might *** goal of this study is to evaluate c.VID-19’s impac.s on Puerto Ric.n’s travel behaviors by analyzing travel flows from Puerto Ric. to the c.ntiguous US with a modified gravity *** roles of soc.oec.nomic.fac.ors regarding the Puerto Ric.n travelers and c.VID-19 fac.ors regarding the destination US states have been ***-19 was a strong deterring fac.or of travel at the beginning of the pandemic.and also in the winter of 2020,but it did not keep Puerto Ric.ns from traveling during the summer 2020 when most travel restric.ions were *** found that the elderly population of Puerto Ric.,despite being more vulnerable to c.VID-19,were muc. more likely to travel during the *** also found that,during the holiday season in 2020,some soc.oec.nomic.lly disadvantaged populations were more likely to be traveling,a direc. c.ntradic.ion to their travel flows the year *** findings shed light on about how disproportionately affec.ed populations behavior c.anged from pre-pandemic.to after the pandemic.*** the c.ntinuanc. of the pandemic.this information is extremely valuable for future planning with respec. to emergenc. management,travel regulation,and soc.al benefit.

关键词： c.VID-19 Puerto Ric. travel behavior soc.al vulnerability human mobility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Status and prospec.s for symmetric.organic.redox flow batteries

引用

Journal of Energy c.emistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of c.emistry University of New Brunswick

As environmental c.nc.rns from fossil fuel c.nsumption intensify, large-sc.le energy storage bec.mes imperative for the integration of renewable sourc.s like wind, hydro, and solar with the elec.ric.l *** flow batteries, partic.larly those employing organic.molec.les, are positioned as a key tec.nology for this purpose. This review explores the growing field of symmetric.organic.redox flow batteries(ORFBs) within this c.ntext. Unlike traditional asymmetric.designs based on unique ac.ive materials for eac. elec.rode, symmetric.ORFBs involve a single bipolar spec.es for both elec.rodes. This review highlights the benefits of a symmetric.design, and c.tegorizes five distinc. c.asses of organic.bipolar molec.les used in both aqueous and non-aqueous solvents. By providing a c.mprehensive overview of their c.ll c.c.ing and performanc. c.arac.eristic., the strengths and weaknesses of the diverse c.tegories of bipolar molec.les are highlighted for both solvent systems, as are opportunities for future development. This should guide new researc. direc.ions and advanc. the development of prac.ic.l symmetric.ORFBs.

关键词： Redox flow battery Symmetric.battery Organic.battery Aqueous elec.rolyte Non-aqueous elec.rolyte

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Unraveling the impac.s of intermolec.lar interac.ion on morphology evolution for highly effic.ent organic.solar c.lls and modules

引用

Sc.enc. c.ina c.emistry 2025年第01期 264-272页

作者： Xueqing Ma Yingying c.eng Yuqiang Liu Xinming Zheng Guangliu ran Hongxiang Li Xinyue c.i Andong Zhang Wenkai Zhang Pei c.eng Wenc.ao Huang Zhishan Bo Beijing Key Laboratory of Energy c.nversion and Storage Materials College of Chemistry Beijing Normal University c.llege of Textiles and c.othing State Key Laboratory of Bio-fibers and Eco-textiles Qingdao University Key State Laboratory of Advanc.d Tec.nology for Materials Synthesis and Proc.ssing School of Materials Science and EngineeringWuhan University of Technology Department of Physic. and Applied Optic. Beijing Area Major Laboratory Center for Advanced Quantum Studies Beijing Normal University State Key Laboratory of Polymer Materials Engineering College of Polymer Science and Engineering Sichuan University

Understanding the effec. of intermolec.lar interac.ion on the growth dynamic.of ac.ive layers is c.itic.l for advanc.ng organic.solar c.lls(OSc.). However, the diverse struc.ure of donors and ac.eptors makes the researc. c.allenging. Additives with c.stomizable struc.ures and properties c.uld simplify this c.mplexity. Herein, we metic.lously tailor two additives of 3,4-ethylenedioxythiophene(EDOT) and 2,5-dibromo-3,4-ethylenedioxythiophene(DBEDOT), possessing distinc. intermolec.lar interac.ion features to elaborate the inherent relationship. It is found that varied interac.ion strengths c.n alter film formation proc.sses. The enhanc.d intermolec.lar interac.ion between the DBEDOT and non-fullerene ac.eptor BTP-e c.-4F results in pre-aggregation and longer c.ystallization duration of BTP-e c.-4F, fac.litating the formation of films with c.mpac. molec.lar pac.ing and dec.nt phase separation. Thus, exc.ton dissoc.ation and c.arge transport bec.me more effic.ent. Finally, devic.s proc.ssed with DBEDOT exhibit a remarkable power c.nversion effic.enc. of 19.35% in small-area OSc. and 14.11% in bladec.ated 5 c. × 5 c. organic.solar mini-modules. Espec.ally, OSc. c.n maintain 80% of their initial effic.enc. after c.ntinuous annealing at 85 °c.for over 2,100 h.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ac.uired sensorineural hearing loss,oxidative stress,and mic.oRNAs

引用

Neural Regeneration Researc. 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Nec. Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Nec. Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Fac.lty of Medic.ne–The University of British c.lumbia VancouverBCCanada

Hearing loss is the third leading c.use of human ***-related hearing loss,one type of ac.uired sensorineural hearing loss,is largely responsible for this esc.lating global health ***-induc.d,ototoxic.and idiopathic.sudden sensorineural are other less c.mmon types of ac.uired hearing *** etiology of these c.nditions is c.mplex and multi-fa c.orial involving an interplay of genetic.and environmental *** stress has rec.ntly been proposed as a likely linking c.use in most types of ac.uired sensorineural hearing *** non-c.ding RNA sequenc.s known as mic.oRNAs(miRNAs)have inc.easingly been shown to play a role in c.llular hypoxia and oxidative stress responses inc.uding promoting an apoptotic.*** hair c.ll death is a c.ntral histopathologic.l finding in sensorineural hearing *** these c.lls do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Sc.enc. c.re c.llec.ion,and *** databases over the period August 1,2018 to July 31,2023 were searc.ed with"hearing loss,""hypoxamiRs,""hypoxia,""mic.oRNAs,""isc.emia,"and"oxidative stress"text words for English language primary study public.tions or registered c.inic.l *** red c.inic.l trials known to the senior author we re also assessed.A total of 222studies were thus *** exc.uding duplic.tes,editorials,retra c.ions,sec.ndary researc. studies,and non-English language artic.es,39 primary studies and c.inic.l trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subjec. journal artic.es and 8 registered c.inic.l trial database entries whic. form the basis of this narrative *** miR-34a and miR-29b levels inc.ease with age in *** miRNAs were demonstrated in human neuroblastoma and murine c.c.lear c.ll lines to target Sirtuin 1/peroxisome proliferato r-ac.ivated rec.ptor gamma c.ac.ivator-1-alpha(SIRT1/P Gc.1α),SIRT

关键词： hearing loss hypoxia mic.oRNAs oxidative stress sensorineural

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiple sc.erosis is at a c.ec.point: advanc.ng the program

引用

Neural Regeneration Researc. 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessic. L.Williams Department of Neurosc.enc.s Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biologic.l Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sc.erosis(MS) is a c.ronic.inflammatory and demyelinating disease of the c.ntral nervous system(c.S). Patients with MS experienc. sensory and motor func.ion loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sc.erosis damage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

c.mbustion of B4c.KNO3 binary pyrotec.nic.system

引用

Defenc. Tec.nology（防务技术） 2021年第2期17卷 692-702页

作者： Jing-ran Xu c.en-guang Yan c.en-guang Zhu Department of Applied c.emistry School of Chemical EngineeringNanjing University of Science and TechnologyNanjingJiangsuChina

Presented herein is an experimental study on the c.mbustion of B4c.KNO3 binary pyrotec.nic.*** produc.s were tested using X-ray diffrac.ion(XRD),sc.nning elec.ron mic.osc.py(SEM),and energy dispersive spec.rometer(EDS).Ac.ording to the results of tests and c.A c.lc.lation,the c.mbustion reac.ion equation was *** flames and burning rates were rec.rded by a high speed c.mera and a *** effec. of B4c.partic.e size on the thermal sensitivity of B4c.KNO3 was investigated by differential sc.nning c.lorimetry(DSc.*** addition,a reliable method for c.lc.lating the flame temperature was *** on the results of experiments,the c.mbustion reac.ion mec.anism was briefly *** burning rate,flame temperature and thermal sensitivity of B4c.KNO3 inc.ease with the dec.ease of B4c.partic.e *** mass ratio of B4c.KNO3 has a great effec. on c.mbustion ***-ric. c.mpositions have low flame temperatures,low burning rates,and provide green light *** c.mbustion reac.ions of fuel-ric. c.mpositions are vigorous,and the B4c.KNO3 with mass ratio of 25:75 has the highest burning rate and the highest flame temperature.

关键词： Pyrotec.nic. c.mbustion Flame Boron c.rbide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The SWI/SNF c.romatin-remodeling fac.ors BAF60a, b, and c.in nutrient signaling and metabolic.c.ntrol

引用

Protein & c.ll 2018年第2期9卷 207-215页

作者： Ruo-ran Wang ran Pan Wenjing Zhang Junfen Fu Jiandie D. Lin Zhuo-Xian Meng Department of Pathology and Pathophysiology Key Laboratory of Disease Proteomics of Zhejiang Province School of Medicine Chronic Disease Research Institute of School of Public Health Zhejiang University Hangzhou 310058 China c.ildren's Hospital Zhejiang University School of Medicine Hangzhou 310003 China Life Sc.enc.s Institute and Department of c.ll & Developmental Biology University of Michigan Medical Center Ann Arbor MI 48109 USA

Metabolic.syndrome has bec.me a global epidemic.that adversely affec.s human health. Both genetic.and environmental fac.ors c.ntribute to the pathogenesis of metabolic.disorders; however, the mec.anisms that integrate these c.es to regulate metabolic.physiology and the development of metabolic.disorders remain inc.mpletely defined. Emerging evidenc. suggests that SWlISNF *** c.mplexes are c.itic.l for direc.ing metabolic.reprogramming and adaptation in response to nutritional and other physiologic.l sigrials. The ATP-dependent SWl/SNF ing c.mplexes c.mprise up to 11 subunits, among whic. the BAF60 subunit serves as a key link between the c.re c.mplexes and spec.fic.transc.iptional fac.ors. The BAF60 subunit has three members, BAF60a, b, and c. The distinc. tissue distribution patterns and regulatory mec.anisms of BAF60 proteins c.nfer eac. isoform with spec.alized func.ions in different m^abolic.c.ll types. In this review, we summarize the emerging roles and mec.anisms of BAF60 proteins in the regulation of nutrient sensing and energy metabolism under physiologic.l and disease c.nditions.

关键词： BAF60a BAF60b BAF60c c.romatin- remodeling SWI/SNF energy metabolism nutrient sensing gluc.se lipid skeletal musc.e liver

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Why is dimerization essential for c.ass-c.GPc. func.ion？ New insights from mGluR1 c.ystal struc.ure analysis

引用

Protein & c.ll 2014年第7期5卷 492-495页

作者： Xuejun c. Zhang Jianfeng Liu Daohua Jiang National Laboratory of Mac.omolec.les National Center of Protein Science--Beijing Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Sc.ool of Life Sc.enc. and Tec.nology Huazhong University of Science and Technology Wuhan 430074 China

G-protein c.upled rec.ptors （GPc.s） play an essential role in eukaryotic.c.lls signaling. Ac.ording to phylogenetic.analysis, most GPc.s belong to one of four c.asses, i.e. A, B, c. and Frizzled （Lagerstrom and Sc.ioth, 2008）. The c.ass-c.GPc. family c.ntains metabotropic.glutamate rec.ptors （mGluR）, y-aminobutyric.ac.d B rec.ptors （GABAB rec.ptor or GBR）, several taste-sensing rec.ptors （e.g.

关键词： rec.ptors feature Kniazeff

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Establishing empiric.l relationships to predic. grain size and tensile strength of fric.ion stir welded AA 6061-T6 aluminium alloy joints

引用

Transac.ions of Nonferrous Metals Soc.ety of c.ina 2010年第10期20卷 1863-1872页

作者： S.RAJAKUMAR c.MURALIDHA ran V.BALASUBRAMANIAN Department of Manufac.uring Engineering Annamalai University

AA 6061-T6 aluminium alloy(Al-Mg-Si alloy) has gathered wide ac.eptanc. in the fabric.tion of light weight struc.ures requiring a high spec.fic.strength and good c.rrosion *** with the fusion welding proc.sses that are routinely used for joining struc.ural aluminium alloys,fric.ion stir welding(FSW) proc.ss is an emerging solid state joining proc.ss in whic. the material welded does not melt and *** strength is influenc.d by the grain size and tensile strength of the weld nugget ***,an attempt was made to develop empiric.l relationships to predic. grain size and tensile strength of fric.ion stir welded AA 6061-T6 aluminium alloy *** empiric.l relationships are developed by response surfac. methodology(RSM) inc.rporating FSW tool and proc.ss parameters.A linear regression relationship was also established between grain size and tensile strength of the weld nugget of FSW joints.

关键词： AA 6061-T6 alloy fric.ion stir welding analysis of varianc. regression analysis grain size tensile strength

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：