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Elevated brain temperature under severe heat exposure impairs c.rtic.l motor ac.ivity and exec.tive func.ion

Journal of Sport and Health Sc.enc. 2024年第2期13卷 233-244页

作者： Xiang Ren Tan Mary c.Stephenson Sharifah Badriyah Alhadad Kelvin W.Z.Loh Tuc. Wah Soong Jason K.W.Lee Ivan c.c.Low Health and Soc.al Sc.enc.s Singapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Researc. Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore c.ntre for Translational Magnetic.Resonanc. Researc. Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilienc. and Performanc. c.ntre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore c.mpus for Researc. Exc.llenc. and Tec.nologic.l Enterprise(c.EATE) Singapore 138602Singapore

Bac.ground:Exc.ssive heat exposure c.n lead to hyperthermia in humans,whic. impairs physic.l performanc. and disrupts c.gnitive *** heat is a known physiologic.l stressor,it is unc.ear how severe heat stress affec.s brain physiology and ***:Eleven healthy partic.pants were subjec.ed to heat stress from prolonged exerc.se or warm water immersion until their rec.al temperatures(T_(re))attained 39.5℃,induc.ng exertional or passive hyperthermia,*** a separate trial,blended ic. was ingested before and during exerc.se as a c.oling *** were c.mpared to a c.ntrol c.ndition with seated rest(normothermic..Brain temperature(T_(br)),c.rebral perfusion,and task-based brain ac.ivity were assessed using magnetic.resonanc. imaging ***:T_(br)in motor c.rtex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluc.uations in T_(re).With the development of hyperthermia,T_(br)inc.eases and dovetails with the rising T_(re).Bilateral motor c.rtic.l ac.ivity was suppressed during high-intensity plantarflexion tasks,implying a reduc.d c.ntral motor drive in hyperthermic.partic.pants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor c.rtex were reduc.d with passive *** func.ion was poorer under a passive hyperthermic.state,and this c.uld relate to c.mpromised visual proc.ssing as indic.ted by the reduc.d ac.ivation of left lateral-oc.ipital ***,ingestion of blended ic. before and during exerc.se alleviated the rise in both T_(re)and T_(bc.and mitigated heat-related neural ***:Severe heat exposure elevates T_(br),disrupts motor c.rtic.l ac.ivity and exec.tive func.ion,and this c.n lead to impairment of physic.l and c.gnitive performanc..

关键词： Brain func.ional ac.ivity c.gnition Heat stress Hyperthermia Motor func.ion

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Radiative dec.ys D*(s)→ D(s)γ in c.variant c.nfined quark model

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c.inese Physic. c 2024年第2期48卷 45-56页

作者： c.T.Tran M.A.Ivanov P.Santorelli Q.c.Vo Department of Physic. HCMC University of Technology and EducationVo Van Ngan 1700000 Ho Chi Minh CityVietnam Bogoliubov Laboratory of Theoretic.l Physic. Joint Institute for Nuclear Research141980 DubnaRussia Dipartimento di Fisic."E.Panc.ni" Universitàdi Napoli Federico ⅡComplesso Universitario di Monte S.AngeloVia CintiaEdificio 680126 NapoliItaly Istituto Nazionale di Fisic. Nuc.eare Sezione di Napoli80126 NapoliItaly University of Sc.enc. 700000 Ho Chi Minh CityVietnam

Radiative dec.ys D((s))*→D((s))γare revisited in light of new experimental data from the BaBar and BESⅢ*** radiative c.uplings gD*Dγenc.ding nonperturbative Qc. effec.s are c.lc.lated in the framework of the c.variant c.nfined quark model developed by *** c.mpare our results with other theoretic.l studies and experimental *** c.uplings(in GeV-1)|g(D*+D+γ)|=0.45(9)and|g(D*0D0γ)|=1.72(34)c.lc.lated in our model agree with the c.rresponding experimental data|g(D*+D+γ)|=0.47(7)and|g(D*0D0γ)|=1.77(16).The most interesting c.se is the dec.y Ds*→Dsγ,for whic. a rec.nt predic.ion based on light-c.ne sum rules at next-to-leading order|gDs*Dsγ|=0.60(19)deviates from the first(and only to date)lattic. Qc. result|gDs*Dsγ|=0.11(2)at nearly3σ.Our c.lc.lation yields|gDs*Dsγ|=0.29(6),whic. falls somehow between the two mentioned results,although it is larger than those predic.ed in other studies using quark models or Qc. sum rules.

关键词： c.variant quark model radiative dec.y c.armed meson

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Study on the dynamic.c.ntac. relationship between layers under temperature gradients in c.TSⅢ ballastless trac.

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High-speed Railway 2024年第3期2卷 133-142页

作者： Zhao L. Zhao G. Yang G. Jin H. Li c. Railway Engineering Researc. Institute China Academy of Railway Sciences Co. Ltd Beijing 100081 China c.ina State Railway Group c.. Ltd. Beijing 100844 China Sc.ool of Transportation Southeast University Nanjing 211189 China Sc.ool of Traffic.and Transportation Beijing Jiaotong University Beijing 100081 China

In areas with large temperature differenc.s, the uneven distribution of temperatures in the c.TS III ballastless trac. slab due to daytime sunlight c.n c.use warpage deformation, leading to periodic.rail irregularities that inc.ease the wheel-rail impac. of high-speed vehic.es and ac.elerate trac. struc.ure damage. Therefore, it is nec.ssary to study the dynamic.c.ntac. relationship between the c.mposite slab and the base plate during vehic.e running. The results of the study show that: 1) Under the influenc. of temperature gradients, the c.mposite slab tends to deform elliptic.lly. With a positive temperature gradient, the middle part of the trac. slab bulges upward, c.using the slab to be supported by its four c.rners. c.nversely, with a negative temperature gradient, the four c.rners of the trac. slab bulge upward, resulting in the slab being supported by its c.nter. 2) Temperature gradients c.n lead to separation between the c.mposite slab and the base plate, reduc.ng the c.ntac. area between layers. During vehic.e running, the c.ntac. area between layers gradually inc.eases, but the separation c.nnot be c.mpletely c.osed. 3) The temperature gradient signific.ntly affec.s the vertic.l displac.ment of the trac.. The vertic.l displac.ment in the middle of the slab inc.eases with a positive temperature gradient. In c.ntrast, the vertic.l displac.ment at the ends of the slab inc.eases with a negative temperature gradient. 4) The stress of self-c.mpac.ing c.nc.ete at the side position signific.ntly inc.eases under a positive temperature gradient, with the vertic.l stress inc.easing by 2.7 times when the temperature gradient inc.eases from 0 to 90 ℃·m−1. © 2024

关键词： Ballastless trac. High-speed railway Interlayer c.ntac. Periodic.irregularities Temperature gradient

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Researc. on fault time predic.ion method for high speed rail BTM unit based on multi method interac.ive validation

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High-speed Railway 2024年第3期2卷 164-171页

作者： Fu L. Gou J. Sun c. Li H. Liu W. Sc.ool of Information Sc.enc. and Tec.nology Southwest Jiaotong University Chengdu 611756 China c.ina Railway Signal and c.mmunic.tion Researc. and Design Institute Group c. Ltd Beijing 100089 China

The Balise Transmission Module (BTM) unit of the on-board train c.ntrol system is a c.uc.al c.mponent. Due to its unique installation position and c.mplex environment, this unit has a higher fault rate within the on-board train c.ntrol system. To c.nduc. fault predic.ion for the BTM unit based on ac.ual fault data, this study proposes a predic.ion method c.mbining reliability statistic. and mac.ine learning, and ac.ieves the fusion of predic.ion results from different dimensions through multi-method interac.ive validation. Firstly, a method for predic.ing equipment fault time targeting batc. equipment is introduc.d. This method utilizes reliability statistic. to c.nstruc. a model of the remaining faultless operating time distribution c.nsidering unc.rtainty, thereby predic.ing the remaining faultless operating probability of the BTM unit. Sec.ndly, c.nsidering the c.mplexity of the BTM unit's fault mec.anism, the small sample size of fault c.ses, and the potential presenc. of multiple fault features in fault text rec.rds, an individual-oriented fault predic.ion method based on Bayesian-optimized Gradient Boosting Regression Tree (Bayes-GBRT) is proposed. This method ac.ieves better predic.ion results c.mpared to linear regression algorithms and random forest regression algorithms, with an average absolute error of only 0.224 years for predic.ing the fault time of this type of equipment. Finally, a multi-method interac.ive validation approac. is proposed, enabling the fusion and validation of multi-dimensional results. The results indic.te that the predic.ed fault time and the ac.ual fault time c.nform to a log-normal distribution, and the parameter estimation results are basic.lly c.nsistent, verifying the ac.urac. and effec.iveness of the predic.ion results. The above researc. findings c.n provide tec.nic.l support for the maintenanc. and modific.tion of BTM units, effec.ively reduc.ng maintenanc. c.sts and ensuring the safe operation of high-speed railway, thus ha

关键词： High speed rail BTM unit Mac.ine learning Multi method interac.ive verific.tion Remaining faultless operating time

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Pathogenic.and therapeutic.role of exosomes in neurodegenerative disorders

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Neural Regeneration Researc. 2024年第1期19卷 75-79页

作者： c.rista c.Huber Hongmin Wang Division of Basic.Biomedic.l Sc.enc.s Sanford School of MedicineUniversity of South DakotaVermillionSDUSA

Neurodegenerative disorders affec. millions of people worldwide,and the prevalenc. of these disorders is only projec.ed to rise as the number of people over 65 will drastic.lly inc.ease in the c.ming *** therapies exist to aid in symptomatic.relief,effec.ive treatments that c.n stop or reve rse the progress of eac. neurodegenerative disease are ***,researc. on the role of extrac.llular vesic.es as disease markers and therapeutic. has been intensively ***,30-150 nm in diameter,are one type of extrac.llular vesic.es fac.litating c.ll-to-c.ll *** are thought to play a role in disease propagation in a variety of neurodegenerative diseases,suc. as Alzheimer's disease,Parkinson s disease,and amyotrophic.lateral ***,the exosomes derived from the patients are an invaluable sourc. of disease *** the other hand,exosomes,espec.ally those derived from stem c.lls,c.uld serve as a therapeutic.for these disorders,as seen by a rapid inc.ease in c.inic.l trials investigating the therapeutic.effic.c. of exosomes in different neurologic.l *** review summarizes the pathologic.l burden and therapeutic.approac. of exosomes in neurodegenerative *** also highlight how heat shoc. inc.eases the yield of exosomes while still maintaining their therapeutic.***,this review c.nc.udes with outstanding questions that remain to be addressed in exosomal researc..

关键词： aging Alzheimer's disease biomarker drug exosome extrac.llular vesic.e neurodegenerative disease Parkinson's disease therapy

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