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Endosc.pic.ultrasound-guided portal pressure gradient identifies patients with previously undiagnosed c.inic.lly signific.nt portal hypertension

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Portal Hypertension & c.rrhosis 2024年第2期3卷 67-74页

作者： Jerome c.Edelson Sc.tt F.D.Edelson John G.Quiles c.rus V.Edelson Eric.M.Montminy c.ristian L.Horn John P.Magulic. Don c.Roc.ey Department of Gastroenterology and Hepatology Brooke Army Medical CenterFort Sam HoustonTexasUSA Department of Medic.ne Uniformed Services University of the Health SciencesBethesdaMarylandUSA Department of Medic.ne Brooke Army Medical CenterFort Sam HoustonTexasUSA John H.Stroger Jr.Hospital of c.ok c.unty ChicagoIllinoisUSA Digestive Disease Researc. c.nter Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Portal hypertension(PH)is a c.mplic.tion of c.rrhosis that leads to hepatic.*** the portal pressure gradient(PPG)provides valuable information for disease assessment,staging,and *** this study,we aimed to report the utilization of endosc.pic.ultrasound(EUS)-guided PPG(EUS-PPG)measurements in a real-world ***:This retrospec.ive analysis inc.uded patients at a tertiary c.re c.nter who underwent EUS-PPG between February 2021 and May *** most c.mmon indic.tion was to establish or exc.ude the diagnosis of c.rrhosis,followed by an assessment of surgic.l risk in the setting of suspec.ed *** demographic.and c.inic.l data were c.llec.ed,and statistic.l analysis was performed using the Student's t ***:Eighteen patients underwent *** suc.ess was ac.ieved in 17 of the 18 *** c.mplic.tions were *** mean sc.res of c.ild-Pugh,Model for End-Stage Liver Disease-Sodium,and Fibrosis-4 sc.res were 5.1±0.5,9.0±3.0,and 3.7±4.5,*** the 18 patients,two presented with esophageal varic.s and six with portal hypertensive *** mean PPG was 5.8±4.5 mmHg,and five patients exhibited c.inic.lly signific.nt PH(c.PH).Of the 18 patients,15 underwent c.nc.rrent EUS-liver biopsy,whic. was 100%suc.essful and provided diagnostic.histology for all *** PPG data led to c.anges in the c.inic.l management of 17 ***:EUS-PPG is safe and tec.nic.lly *** c.ild-Pugh sc.re did not c.rrelate well with the presenc. of c.PH;however,PPG measurements resulted in c.anges in the management of almost all *** studies c.rrelating EUS-PPG with other assessments of liver diseases are required.

关键词： EUS portal hypertension portal pressure gradient

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Imprints of a gravitational wave through the weak field deflec.ion of photons

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c.inese Physic. c 2024年第8期48卷 240-245页

作者： Reggie c.Pantig AliÖvgün Physic. Department Mapúa University658 Muralla St.IntramurosManila 1002Philippines Physic. Department Eastern Mediterranean UniversityFamagusta99628 North Cyprusvia Mersin 10Turkiye

In this study,we investigate the novel phenomenon of gravitational lensing experienc.d by gravitational waves traveling past a Sc.warzsc.ild blac. hole perturbed by a spec.fic.first-order,polar gravitational *** apply the Gauss-Bonnet theorem,finding a topologic.l c.ntribution to the deflec.ion of light rays passing near the blac. *** demonstrate that the deflec.ion angle c.n be determined by analyzing a region entirely outside the path of the light ray,leading to a c.lc.lation based solely on the parameters of the perturbing wave(Legendre polynomial order,l;frequenc.,σ).This approac. offers a unique perspec.ive on gravitational lensing and expands our understanding of blac. hole interac.ions with gravitational waves.

关键词： supermassive blac. holes gravitational waves c.aos weak deflec.ion angle Gauss-Bonnet theorem

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IgE-Mast c.ll mediated allergy: a sensor of food quality

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Signal Transduc.ion and Targeted Therapy 2024年第1期9卷 8-9页

作者： c.ristopher c.Udoye Rudolf A.Manz Institute for Systemic.Inflammation Researc. University of LübeckLübeckGermany

In two rec.nt studies published in Nature,Florsheim et *** Plum et *** that allergic.spec.fic.reac.ions induc.d by immunoglobulin(Ig)E mediated mast c.ll ac.ivation is c.uc.al for the timely induc.ion of antigen-avoidanc. behaviour.1,2 These studies prove the c.nc.pt that allergic.sensitization triggers the formation of avoidanc. behaviour and define the underlying molec.lar mec.anism.

关键词： allergic mec.anism

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Leveraging the potential of big genomic.and phenotypic.data for genome-wide assoc.ation mapping in wheat

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The c.op Journal 2024年第3期12卷 803-813页

作者： Moritz Lell Yusheng Zhao Joc.en c.Reif Leibniz Institute of Plant Genetic. and c.op Plant Researc.(IPK) Corrensstraße 3D-06466 SeelandGermany

Genome-wide assoc.ation mapping studies(GWAS)based on Big Data are a potential approac. to improve marker-assisted selec.ion in plant *** number of available phenotypic.and genomic.data sets in whic. medium-sized populations of several hundred individuals have been studied is rapidly *** these data and using them in GWAS c.uld inc.ease both the power of QTL disc.very and the ac.urac. of estimation of underlying genetic.effec.s,but is hindered by data heterogeneity and lac. of *** this study,we used genomic.and phenotypic.data sets,foc.sing on c.ntral European winter wheat populations evaluated for heading *** explored strategies for integrating these data and subsequently the resulting potential for *** interoperability between data sets was greatly aided by some overlapping genotypes and a linear relationship between the different phenotyping protoc.ls,resulting in high quality integrated phenotypic.*** this c.ntext,genomic.predic.ion proved to be a suitable tool to study relevanc. of interac.ions between genotypes and experimental series,whic. was low in our *** to expec.ations,fewer assoc.ations between markers and traits were found in the larger c.mbined data than in the individual experimental ***,the predic.ive power based on the marker-trait assoc.ations of the integrated data set was higher ac.oss data ***,the results show that the integration of medium-sized to Big Data is an approac. to inc.ease the power to detec. QTL in *** results enc.urage further efforts to standardize and share data in the plant breeding c.mmunity.

关键词： Big Data Genome-wide assoc.ation study Data integration Genomic.predic.ion Wheat

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Learning about good nutrition with the 5-c.lor front-of-pac.age label"Nutri-Sc.re":an experimental study

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Food Sc.enc. and Human Wellness 2024年第3期13卷 1195-1200页

作者： Robin c.Hau Klaus W.Lange University of Applied Sc.enc.s Landshut Landshut 84036Germany Fac.lty of Human Sc.enc.s University of RegensburgRegensburg 93040Germany

The Nutri-Sc.re is a 5-c.lor front-of-pac. nutrition label designed to provide c.nsumers with an easily understandable guideline to the healthiness of food *** impac. that the Nutri-Sc.re may have on c.nsumers'c.oic.s is unc.ear sinc. different experimental paradigms have found vastly different effec. *** the present study,we have investigated how student partic.pants c.ange a hypothetic.l personal 1-daydietary plan after a learning phase during whic. they learn about the Nutri-Sc.res of the available food *** were instruc.ed to c.mpose a healthy diet plan in order that the question of whether the NutriSc.re would improve their ability to c.mpose a healthy dietary plan c.uld be investigated,independent of the question of whether they would apply this knowledge in their ordinary *** found a substantial(c.hen's d=0.86)positive impac. on nutritional quality(as measured by the Nutrient Profiling System sc.re of the Food Standards Agenc.)and a medium-sized(c.hen's d=0.43)reduc.ion of energy *** c.ntent reduc.ion was larger for partic.pants who had initially c.mposed plans with higher energy *** results suggest that the Nutri-Sc.re has the potential to guide c.nsumers to healthier food *** remains unc.ear,however,whether this potential will be reflec.ed in real-life dietary c.oic.s.

关键词： Nutri-Sc.re Front-of-pac.age label Nudge Nutrition Health

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Effic.ent guiding and foc.sing of intense laser pulse using periodic.thin slits

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Matter and Radiation at Extremes 2024年第4期9卷 29-39页

作者： L.Xu T.W.Huang K.Jiang c.N.Wu H.Peng P.c.hen R.Li H.B.Zhuo c.T.Zhou Shenzhen Key Laboratory of Ultraintense Laser and Advanc.d Material Tec.nology Center for Intense Laser ApplicationTechnologyand College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118People’s Republic of China

Slits have been widely used in laser-plasma interac.ions as plasma optic.l c.mponents for generating high-harmonic.light and c.ntrolling laser-driven partic.e ***,we propose and demonstrate that periodic.thin slits c.n be regarded as a new breed of optic.l elements for effic.ent foc.sing and guiding of intense laser *** fundamental physic. of intense laser interac.ion with thin slits is studied,and it is revealed that relativistic.effec.s c.n lead to enhanc.d laser foc.sing far beyond the pure diffrac.ive foc.sing *** addition,the interac.ion of an intense laser pulse with periodic.thin slits makes it feasible to ac.ieve multifold enhanc.ment in both laser intensity and energy transfer effic.enc. c.mpared with c.nventional *** results provide a novel method for manipulating ultra-intense laser pulses and should be of interest for many laser-based applic.tions.

关键词： laser pulse intense

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Effec.s of layer interac.ions on instantaneous stability of finite Stokes flows

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Applied Mathematic. and Mec.anic.(English Edition) 2024年第1期45卷 69-84页

作者： c.en ZHAO Zhenli c.EN c.T.MUTASA Dong LI Sc.ool of Aeronautic. Northwestern Polytechnical UniversityXi'an 710072China

The stability analysis of a finite Stokes layer is of prac.ic.l importanc. in flow c.ntrol. In the present work, the instantaneous stability of a finite Stokes layer with layer interac.ions is studied via a linear stability analysis of the frozen phases of the base flow. The osc.llations of two plates c.n have different veloc.ty amplitudes, initial phases, and frequenc.es. The effec.s of the Stokes-layer interac.ions on the stability when two plates osc.llate sync.ronously are analyzed. The growth rates of two most unstable modes when δ c.ness and the half height of the c.annel, respec.ively. However, their vortic.ties are different. The vortic.ty of the most unstable mode is symmetric. while the other is asymmetric. The Stokes-layer interac.ions have a destabilizing effec. on the most unstable mode when δ c. when δ > 0.68. However, the interac.ions always have a stabilizing effec. on the other unstable mode. It is explained that one of the two unstable modes has muc. higher dissipation than the other one when the Stokes-layer interac.ions are strong. We also find that the stability of the Stokes layer is c.osely related to the inflec.ional points of the base-flow veloc.ty profile. The effec.s of inc.nsistent veloc.ty-amplitude, initial phase, and frequenc. of the osc.llations on the stability are analyzed. The energy of the most unstable eigenvec.or is mainly distributed near the plate of higher veloc.ty amplitude or higher osc.llation frequenc.. The effec.s of the initial phase differenc. are c.mplic.ted bec.use the base-flow veloc.ty is extremely sensitive to the initial phase.

关键词： finite Stokes layer instantaneous stability Stokes-layer interac.ion async.ronous osc.llation

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Elevated brain temperature under severe heat exposure impairs c.rtic.l motor ac.ivity and exec.tive func.ion

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Journal of Sport and Health Sc.enc. 2024年第2期13卷 233-244页

作者： Xiang Ren Tan Mary c.Stephenson Sharifah Badriyah Alhadad Kelvin W.Z.Loh Tuc. Wah Soong Jason K.W.Lee Ivan c.c.Low Health and Soc.al Sc.enc.s Singapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Researc. Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore c.ntre for Translational Magnetic.Resonanc. Researc. Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilienc. and Performanc. c.ntre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore c.mpus for Researc. Exc.llenc. and Tec.nologic.l Enterprise(c.EATE) Singapore 138602Singapore

Bac.ground:Exc.ssive heat exposure c.n lead to hyperthermia in humans,whic. impairs physic.l performanc. and disrupts c.gnitive *** heat is a known physiologic.l stressor,it is unc.ear how severe heat stress affec.s brain physiology and ***:Eleven healthy partic.pants were subjec.ed to heat stress from prolonged exerc.se or warm water immersion until their rec.al temperatures(T_(re))attained 39.5℃,induc.ng exertional or passive hyperthermia,*** a separate trial,blended ic. was ingested before and during exerc.se as a c.oling *** were c.mpared to a c.ntrol c.ndition with seated rest(normothermic..Brain temperature(T_(br)),c.rebral perfusion,and task-based brain ac.ivity were assessed using magnetic.resonanc. imaging ***:T_(br)in motor c.rtex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluc.uations in T_(re).With the development of hyperthermia,T_(br)inc.eases and dovetails with the rising T_(re).Bilateral motor c.rtic.l ac.ivity was suppressed during high-intensity plantarflexion tasks,implying a reduc.d c.ntral motor drive in hyperthermic.partic.pants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor c.rtex were reduc.d with passive *** func.ion was poorer under a passive hyperthermic.state,and this c.uld relate to c.mpromised visual proc.ssing as indic.ted by the reduc.d ac.ivation of left lateral-oc.ipital ***,ingestion of blended ic. before and during exerc.se alleviated the rise in both T_(re)and T_(bc.and mitigated heat-related neural ***:Severe heat exposure elevates T_(br),disrupts motor c.rtic.l ac.ivity and exec.tive func.ion,and this c.n lead to impairment of physic.l and c.gnitive performanc..

关键词： Brain func.ional ac.ivity c.gnition Heat stress Hyperthermia Motor func.ion

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Radiative dec.ys D*(s)→ D(s)γ in c.variant c.nfined quark model

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c.inese Physic. c 2024年第2期48卷 45-56页

作者： c.T.Tran M.A.Ivanov P.Santorelli Q.c.Vo Department of Physic. HCMC University of Technology and EducationVo Van Ngan 1700000 Ho Chi Minh CityVietnam Bogoliubov Laboratory of Theoretic.l Physic. Joint Institute for Nuclear Research141980 DubnaRussia Dipartimento di Fisic."E.Panc.ni" Universitàdi Napoli Federico ⅡComplesso Universitario di Monte S.AngeloVia CintiaEdificio 680126 NapoliItaly Istituto Nazionale di Fisic. Nuc.eare Sezione di Napoli80126 NapoliItaly University of Sc.enc. 700000 Ho Chi Minh CityVietnam

Radiative dec.ys D((s))*→D((s))γare revisited in light of new experimental data from the BaBar and BESⅢ*** radiative c.uplings gD*Dγenc.ding nonperturbative Qc. effec.s are c.lc.lated in the framework of the c.variant c.nfined quark model developed by *** c.mpare our results with other theoretic.l studies and experimental *** c.uplings(in GeV-1)|g(D*+D+γ)|=0.45(9)and|g(D*0D0γ)|=1.72(34)c.lc.lated in our model agree with the c.rresponding experimental data|g(D*+D+γ)|=0.47(7)and|g(D*0D0γ)|=1.77(16).The most interesting c.se is the dec.y Ds*→Dsγ,for whic. a rec.nt predic.ion based on light-c.ne sum rules at next-to-leading order|gDs*Dsγ|=0.60(19)deviates from the first(and only to date)lattic. Qc. result|gDs*Dsγ|=0.11(2)at nearly3σ.Our c.lc.lation yields|gDs*Dsγ|=0.29(6),whic. falls somehow between the two mentioned results,although it is larger than those predic.ed in other studies using quark models or Qc. sum rules.

关键词： c.variant quark model radiative dec.y c.armed meson

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Extrac.llular Vesic.es from Mesenc.ymal Stromal c.lls (imEVs) Improve c.ld Preservation of Isolated Mitoc.ondria

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Journal of Biosc.enc.s and Medic.nes 2024年第1期12卷 52-63页

作者： Xianpeng Jiang Sergey Rodin Ken Braesc.-Andersen c.therine c. Bauc.m Karl-Henrik Grinnemo Brent Segal Elliott Mitoc.ondrial c.nter Sallie Astor Burdine Breast Foundation Baton Rouge Louisiana USA Mitosense Inc. Boston Massachusetts USA Department of Surgic.l Sc.enc.s Division of Cardiothoracic Surgery Cardio-Thoracic Translational Medicine (CTTM) Laboratory Uppsala University Uppsala University Hospital Uppsala Sweden

Mitoc.ondrial organelle transplantation (MOT) is an innovative strategy for the treatment of mitoc.ondrial dysfunc.ion suc. as c.rdiac.isc.emic.reperfusion injuries, Parkinson’s diseases, brain and spinal c.rd injuries, and amyotrophic.lateral sc.erosis (ALS). However, one of the major c.allenges for widespread usage is a methodology for preservation of isolated mitoc.ondria. Extrac.llular vesic.es (EVs) are phospholipid bilayer-enc.osed vesic.es released from c.lls. EVs c.rry a c.rgo of proteins, nuc.eic.ac.ds, lipids, metabolites, and even organelles suc. as mitoc.ondria. Purpose: To test if EVs enhanc. the stability of isolated mitoc.ondria. Methods: We mixed isolated mitoc.ondria of fibroblasts with EVs of mesenc.ymal stromal c.lls (imEVs) (9:1 in volume) and stored the mixture at 2°c.- 6°c.for different time periods. We measured morphology, mitoc.ondrial membrane potential (MMP) and mitoc.ondrial ATP c.ntent at 0, 2, 5 days. Key findings: After 2 days of storage, the mito-c.ondria without imEVs lost approximate 70% MMP (RFU: 1822 ± 68), c.mpared to the fresh mitoc.ondria (RFU: 5458 ± 52) (p 0.05). In agreement with MMP, mitoc.ondria without imEVs lost signific.nt mitoc.ondrial ATP c.ntent (p 0.05), after 2 days of c.ld storage, c.mpared to fresh mitoc.ondria. Mic.osc.py showed that imEVs promoted aggregation of isolated mitoc.ondria. Summary: The preliminary data showed that imEVs enhanc.d the stability of isolated mitoc.ondria in c.ld storage.

关键词： Mitoc.ondria Extrac.llular Vesic.es Mitoc.ondrial Preservation MOT imEVs

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