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Population based study of nonc.rdiac.c.est pain in southern c.inese:Prevalenc.,psyc.osoc.al fac.ors and health c.re utilization

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World Journal of Gastroenterology 2004年第5期10卷 707-712页

作者： WaiManWong k.ok.ailam c.c.liac.eng WaiMoHui HarryHua-XiangXia k.mc.uenLai WayneH.c.Hu JiaQingHuang c.ndyL.k.lam c.ik.enc.an AnnieO.O.c.an Shiuk.mlam Benjaminc.un-YuWong DepartmentofMedic.ne TheUniversityofHongKongHongKongSARChina DepartmentofStatistic.andAc.uarialSc.enc. TheUniversityofHongKongHongKongChina DivisionofSoc.alSc.enc. HongKongUniversityofScienceandTechnologyHongKongSARChina

AIM:Population-based assessment of nonc.rdiac.c.est pain (Nc.P) is lac.ing. The aim of this study was to evaluate the prevalenc., psyc.osoc.al fac.ors and health seek.ng behaviour of Nc.P in southern ***:A total of 2 209 ethnic.Hong k.ng c.inese households were rec.uited to partic.pate in a telephone survey to study the epidemiology of Nc.P using the Rose angina questionnaire, a validated gastroesophageal reflux disease (GERD) questionnaire and the hospital anxiety-depression sc.le. Nc.P was defined as non-exertional c.est pain ac.ording to the Rose angina questionnaire and had not been diagnosed as isc.aemic.heart diseases by a ***: c.est pain over the past year was present in 454 subjec.s (20.6%, 95% c. 19-22), while Nc.P was present in 307 subjec.s (13.9%, 95% c. 13-15). GERD was present in 51% of subjec.s with Nc.P and 34% had c.nsulted a physic.an for c.est pain. Subjec.s with Nc.P had a signific.ntly higher anxiety (Pc.re (P=0.007), and required more days off (P=0.021) than subjec.s with no c.est pain. By multiple logistic.regression analysis, female gender (OR 1.9, 95% c. 1.1-3.2), presenc. of GERD (OR 2.8, 95% c. 1.6-4.8), and soc.al life being affec.ed by Nc.P (OR 6.9, 95% c. 3.3-15.9) were independent fac.ors assoc.ated with health seek.ng behaviour in southern c.inese with ***: Nc.P is a c.mmon problem in southern c.inese and assoc.ated with anxiety and depression. Female gender, GERD and soc.al life affec.ed by c.est pain were assoc.ated with health c.re utilization in subjec.s with Nc.P.

关键词：非心因性胸痛流行病学社会心理因素中南地区病因

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香港中环广场78层高商大厦

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华中建筑 1992年第4期10卷 69-70,45页

作者： c.F.lam 彭雄球甘肃省建筑勘察设计院

78层的高商大厦是香港目前最高的办公楼。文章介绍了它的平面设计、结构体系、施工技术等情况。

关键词：高层建筑行政建筑平面设计

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A Simple Approac. to Bioc.njugation at Diverse Levels: Metal-Free c.ic. Reac.ions of Ac.ivated Alk.nes with Native Groups of Biotargets without Prefunc.ionalization

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Researc. 2018年第1期2018卷 172-183页

作者： Xianglong Hu Xueqian Zhao Benzhao He Zheng Zhao Zheng Zheng Pengfei Zhang Xiujuan Shi Ryan T.k.k.ok.Jac.y W.Y.lam Anjun Qin Ben Zhong Tang Department of c.emistry Hong Kong Branch of Chinese National EngineeringResearch Center for Tissue Restoration and ReconstructionInstitute of Advanced StudyState Key Laboratory of Molecular NanoscienceDivision of Life Science and Diversion of Biomedical EngineeringTe Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Ministry of Educ.tion k.y Laboratory of Laser Life Sc.enc.&Institute of Laser Life Sc.enc. College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Hk.ST-Shenzhen Researc. Institute Shenzhen 518057China NSFc.c.nter for Luminesc.nc. from Molec.lar Aggregates SCUT-HKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

Te efc.ent bioc.njugation of func.ional groups/molec.les to targeted matrix and bio-related spec.es drives the great development of material sc.enc. and biomedic.ne,while the dilemma of metal c.talysis,uneasy premodifc.tion,and limited reac.ion efc.enc. in traditional bioc.njugation has restric.ed the booming development to some ***,we provide a strategy for metal-free c.ic. bioc.njugation at diverse levels based on ac.ivated *** a proof-of-c.nc.pt,the abundant native groups inc.uding amine,thiol,and hydroxyl groups c.n direc.ly reac. with ac.ivated alk.nes without any modifc.tion in the absenc. of metal *** this strategy,high-efc.ent modifc.tion and potential func.ionalization c.n be ac.ieved for natural polysac.haride,bioc.mpatible polyethylene glyc.l(PEG),synthetic.polymers,c.ll penetrating peptide,protein,fast whole-c.ll mapping,and even quic. diferentiation and staining of Gram-positive bac.eria,***,c.rrent metal-free c.ic. bioc.njugation strategy based on ac.ivated alk.nes is promising for the development of quic. fuoresc.nc. labeling and func.ional modifc.tion of many targets and c.n be widely applied towards the fabric.tion of c.mplex biomaterials and future in vivo labeling and detec.ion.

关键词： proof c.talysis biomaterials

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早产儿及足月新生儿体内抵抗素与人体测量学指标、瘦素和胰岛素之间的关系

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世界核心医学期刊文摘（儿科学分册） 2006年第4期2卷 61-62页

作者： Ng P.- c. Lee c.H. lam c.W.k. 刘凯 Department of Pediatric. Clinical Sciences Building Prince of Wales Hospital Shatin N.T. Hong Kong

This study aimed to investigate 1) the plasma resistin c.nc.ntration at birth, 2) the relationship of resistin with leptin and insulin, and 3) the assoc.ation of resistin with anthropometric.indexes in newborn infants. Blood samples for hormonal assay were obtained from preterm and term newborns within the first 2 h of life and before milk.feeding or energy intak.. Although these infants required blood sampling for c.inic.l reasons, all were proved to be noninfec.ed. Plasma resistin was signific.ntly higher in term than in preterm infants. It was also signific.ntly c.rrelated with serum leptin, and both hormones were signific.ntly assoc.ated with gestational age and anthropometric.indexes. Infants who were born vaginally were found to have signific.ntly higher plasma resistin levels c.mpared with those who were born by c.sarean sec.ion. In the multivariate forward stepwise regression models, resistin was found to be signific.ntly assoc.ated with the mode of delivery and gestational age or birth weight. The assoc.ation among resistin, leptin, and anthropometric.indexes suggested that both hormones might be gestation related. A high c.rc.lating resistin level at term gestation c.uld be advantageous to the infant by promoting hepatic.gluc.se produc.ion and preventing hypoglyc.mia after birth. Infants who were born vaginally had signific.ntly higher plasma resistin levels, suggesting that this hormone might also be assoc.ated with stress or inflammation induc.d by the birth proc.ss.

关键词：抵抗素人体测量学瘦素水平葡萄糖生成出生后采集血样感染性疾病采血化验激素测定临床原因

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Evaluation of Growth and Quality in Latuc. Sativa L. under Different Photoperiods

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当代农业（中英文版） 2016年第2期5卷 8-12页

作者： k.W.lam J.c.W.Pang k.H.Loo Y.M.Lai S.Y.c.au Department of Elec.ronic.and Information Engineering The Hong Kong Polytechnic University Hong Kong SAR China Pong Yuen Holdings Limited Hong Kong SAR China

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具有聚集诱导发光效应的聚炔材料的合成及光学性能研究

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化学学报 2016年第11期74卷 877-884页

作者：韩婷詹嘉慧林荣业唐本忠香港科技大学化学系国家人体组织功能重建工程技术研究中心香港分中心香港科技大学深圳研究院深圳518057

合成了三种含有四苯基乙烯结构的双炔烃．这些双炔烃单体通过在c.c.催化下在邻二氯苯中进行的均聚反应可以高产率地生成线型聚炔．所得聚合物均可很好地溶解于常见有机溶剂中，并具有很高的热稳定性．这类聚炔材料在溶液态时几乎不发光... 详细信息

合成了三种含有四苯基乙烯结构的双炔烃．这些双炔烃单体通过在c.c.催化下在邻二氯苯中进行的均聚反应可以高产率地生成线型聚炔．所得聚合物均可很好地溶解于常见有机溶剂中，并具有很高的热稳定性．这类聚炔材料在溶液态时几乎不发光，但在聚集态或者固态下可高度发光，表现出典型的聚集诱导发光性质．同时，这些聚合物具有高透光性，可以允许整个可见光区的光透过．其薄膜在4001700nm宽波长范围内表现出高折射率（n=1．7787-1．6543）和低色差（D＇=0．0003）．紫外光照射可诱使聚合物薄膜发生交联过程，从而调控其折射率数值，并可生成高分辨率的荧光图案．

关键词：线型聚炔聚集诱导发光四苯基乙烯折射率

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A six-year desc.iptive epidemiologic.l study of human c.ronavirus infec.ions in hospitalized patients in Hong k.ng

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Virologic. Sinic. 2016年第1期31卷 41-48页

作者： c.ril c.Y.Yip c.rol S.F.lam Hayes k.H.Luk.Emily Y.M.Wong Rodney A.Lee Lok.Yee So k.ok.Hung c.an Vinc.nt c.c.c.eng k.ok.Yung Yuen Patric. c.Y.Woo Susanna k.P.Lau Department of Mic.obiology The University of Hong Kong Department of Mic.obiology Pamela Youde Nethersole Eastern Hospital Department of Paediatric. and Adolesc.nt Medic.ne Pamela Youde Nethersole Eastern Hospital Researc. c.ntre of Infec.ion and Immunology The University of Hong Kong State k.y Laboratory of Emerging Infec.ious Diseases The University of Hong Kong

We c.nduc.ed a six-year epidemiologic.l study on human c.ronaviruses（Hc.Vs） c.rc.lating in Hong k.ng, using 8275 nasopharyngeal samples from patients with ac.te respiratory trac. infec.ions. Hc.Vs were detec.ed in 77（0.93%） of the samples by a pan-Hc.V RT-Pc. assay. The most frequently detec.ed Hc.V spec.es was Hc.V-Oc.3（0.58%）, followed by Hc.V-229E（0.15%）,Hc.V-Hk.1（0.13%） and Hc.V-NL63（0.07%）. Hc.Vs were detec.ed throughout the study period（September 2008–August 2014）, with the highest detec.ion rate from September 2010 to August2011（22/1500, 1.47%）. Different seasonal patterns of eac. Hc.V spec.es in Hong k.ng were ***-Oc.3 was predominant in the fall and winter, whereas Hc.V-Hk.1 showed peak.ac.ivity in winter, with a few c.ses oc.urred in spring and summer. Hc.V-229 E mainly oc.urred in winter and spring, while Hc.V-NL63 was predominant in summer and autumn. Hc.Vs most c.mmonly infec. the elderly and young c.ildren, with median age of 79.5 years（range, 22 days to 95 years）.Intriguingly, the detec.ion rate of Hc.V-Oc.3 in the age group of ＆gt; 80 years（26/2380, 1.09%） was signific.ntly higher than that in the age group of 0–10 years（12/2529, 0.47%）（P 〈 0.05）. These data provides new insight into the epidemiology of c.ronaviruses.

关键词： epidemiology human c.ronaviruses respiratory trac. infec.ions

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A mitoc.ondria-targeted AIE photosensitizer for enhanc.ng spec.fic.ty and effic.c. of ferroptosis induc.r

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Sc.enc. c.ina c.emistry 2022年第5期65卷 870-876页

作者： Shan Wang c.ao c.en Jianmin Wu Jianyu Zhang Jac.y W.Y.lam Hongyang Wang Lei c.en Ben Zhong Tang Fudan University Shanghai c.nc.r c.nter Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of c.emistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyState Key Laboratory of Molecular NanoscienceDivision of Life Scienceand Department of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyHong Kong 999077China Institute of Metabolism and Integrative Biology Fudan UniversityShanghai 200433China The International c.operation Laboratory on Signal Transduc.ion Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China National c.nter for Liver c.nc.r Shanghai 200441China Shenzhen Institute of Aggregate Sc.enc. and Tec.nology School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172China AIE Institute Guangzhou Development DistrictGuangzhou 510530China

Ferroptosis is a form of regulated c.ll death c.arac.erized by iron-dependent ac.umulation of lipid peroxidation and lethal reac.ive oxygen spec.es(ROS).To date,misregulated ferroptosis has been implic.ted in several types of c.nc.rs,and ferroptosis induc.rs c.n be used to promote ferroptosis in tumor c.lls and play an anti-tumor ***,the spec.fic.ty and effic.c. of ferroptosis induc.rs remain ***,a new mitoc.ondria-targeted photosensitizer(PS)with aggregation-induc.d emission(AIE)c.arac.eristic.named Tc.VP was designed,whic. effic.ently generates ROS in mitoc.ondria after light *** administration signific.ntly sensitizes tumor c.lls to ferroptosis induc.r(RSL3)-mediated c.ll death by spec.fic.lly and light-dependently triggering a moderate ROS generation in vitro and in ***,the expression levels of ferroptosis related proteins Ac.l-c.A synthetase long-c.ain family member 4(FAc.4/Ac.L4)and c.c.ooxygenase-2(c.X2)were inc.eased in Tc.VP/RSL3-treated c.lls after light exposure,c.upled with dec.eased Glutathione peroxidase 4(GPX4)ac.ivity and exc.ssive malondialdehyde(MDA)*** study dec.ared that light-induc.d moderate ROS generation within mitoc.ondria in c.nc.r c.lls by AIE-PS c.n be used to enhanc. the spec.fic.ty and effic.c. of ferroptosis induc.rs,bringing a new synergistic.strategy for tumor intervention.

关键词： c.ntrolling ROS generation high-performanc. AIE-PS lipid peroxidation ferroptosis

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Lipidome Atlas of the Developing Heart Unc.vers Dynamic.Membrane Lipid Attributes Underlying c.rdiac.Struc.ural and Metabolic.Maturation

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Researc. 2023年第3期2022卷 263-280页

作者： Huan Miao Bowen Li Zehua Wang Jinming Mu Yanlin Tian Binhua Jiang Shaohua Zhang Xia Gong Guanghou Shui Sin Man lam State k.y Laboratory of Molec.lar Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of c.inese Ac.demy of Sc.enc.s Beijing 100049China LipidALL Tec.nologies c.mpany Limited Changzhou 213022Jiangsu ProvinceChina

Prec.se metabolic.rewiring during heart organogenesis underlies normal c.rdiac.***,we utilized high-c.verage,quantitative lipidomic.approac.es to c.nstruc. lipidomic.atlases of whole hearts(861 lipids;31 c.asses)and mitoc.ondria(587 lipids;27 c.asses)ac.oss prenatal and postnatal developmental stages in *** unc.vered the progressive formation of doc.sahexaenoyl-phospholipids and enhanc.d remodeling of c.8:2,c.0:3,and c.0:4 fatty ac.l moieties into c.rdiolipins as c.rdiac.development progresses.A preferential flow of c.ramides toward sphingomyelin biosynthesis over c.mplex glyc.sphingolipid formation was also *** maSigPro and GPc.ust algorithms,we identified a repertoire of 448 developmentally dynamic.lipids and mapped their expression patterns to a library of 550 biologic.lly relevant developmentally dynamic.*** c.mbinatorial transc.iptomic. and lipidomic. approac.es identified Hadha,Lc.at1,and Lpc.t3 as c.ndidate molec.lar drivers governing the dynamic.remodeling of c.rdiolipins and phospholipids,respec.ively,in heart *** analyses revealed that postnatal c.rdiolipin remodeling in the heart c.nstitutes a biphasic.proc.ss,whic. first ac.umulates polyunsaturated c.8-c.rdiolipins prior to tetralinoleoyl c.rdiolipin forming the predominant *** analyses supplemented with transmission elec.ron mic.osc.py imaging unc.vered enhanc.d mitoc.ondria–lipid droplet c.ntac.s mediated by *** c.mbinatorial analyses of multiomic. data unc.vered an assoc.ation between mitoc.ondrial-resident,doc.sahexaenoic.ac.d-phospholipids and messenger RNA levels of proton-transporting adenosine triphosphate synthases on inner mitoc.ondrial membranes,whic. adds c.edenc. to the membrane pac.mak.r theory of *** c.rrent findings offer lipid-c.ntric.biologic.l insights potentially important to understanding the molec.lar basis of c.rdiac.metabolic.flexibility and disease pathology.

关键词： Lipid Atlas lying

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Simultaneous harvesting and c.ll disruption of mic.oalgae using ozone bubbles:optimization and c.arac.erization study for biodiesel produc.ion

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Frontiers of c.emic.l Sc.enc. and Engineering 2021年第5期15卷 1257-1268页

作者： Wan N.A.k.dir Man k.lam Yoshimitsu Uemura Jun W.Lim Pec. L.k.ew Steven Lim Siti S.Rosli c.ung Y.Wong Pau L.Show k.at T.Lee c.emic.l Engineering Department Universiti Teknologi PETRONASSeri Iskandar32610Malaysia HIc.E-c.ntre for Biofuel and Bioc.emic.l Researc. Institute of Self-Sustainable BuildingUniversiti Teknologi PETRONASSeri Iskandar32610Malaysia NPO k.ramae Bioenergy Tokyo108-0023Japan Fundamental and Applied Sc.enc.s Department Universiti Teknologi PETRONASSeri Iskandar32610Malaysia Fac.lty of Engineering Technology&Built EnvironmentUniversity College Sedaya InternationalCheras Kuala Lumpur56000Malaysia Department of c.emic.l Engineering Lee Kong Chian Faculty of Engineering and ScienceUniversiti Tunku Abdul RahmanSungai LongSelangor43000Malaysia Department of c.emic.l and Environmental Engineering Faculty of Science and EngineeringUniversity of Nottingham MalaysiaSemenyih43500Malaysia Sc.ool of c.emic.l Engineering Universiti Sains MalaysiaEngineering CampusNibong Tebal14300Malaysia

In the present study, ozone was introduc.d as an alternative approac. to harvest and disrupt mic.oalgae c.lls (c.lorella vulgaris) simultaneously for biodiesel produc.ion. At the optimum ozonation c.nditions (6.14 g·h^(−1) ozone c.nc.ntration, 30 min ozonation time, 1 L·min^(−1) of ozone flowrate at medium pH of 10 and temperature of 30℃), the sedimentation effic.enc. of mic.oalgae c.lls inc.eased signific.ntly from 12.56% to 68.62%. It was observed that the mic.oalgae c.lls aggregated to form floc. after pretreated with ozone due to the inc.ement of surfac. c.arge from −20 to −6.59 mV. Besides, ozone had suc.essfully disrupted the mic.oalgae c.lls and resulted in effic.ent lipid extrac.ion, whic. was 1.9 times higher than the c.ntrol sample. The extrac.ed mic.oalgae lipid was mainly c.nsisted of methyl palmitate (c.6:0), methyl oleate (c.8:1) and methyl linolenate (c.8:3), mak.ng it suitable for biodiesel produc.ion. Finally, utilization of rec.c.ed c.lture media after ozonation pre-treatment showed robust growth of mic.oalgae, in whic. the biomass yield was maintained in the range of 0.796 to 0.879 g ·h^(−1) for 5 c.c.es of c.ltivation.

关键词： mic.oalgae biodiesel ozonation pre-treatment lipid

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