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Effic.c. of Bee Produc.s(Anzer Honey,Pollen and Propolis)in Detec.ion and Healing of Damage Induc.d by Antidiabetic.Drug Vildagliptin/Metformin Hydroc.loride in Healthy Human Panc.eatic.c.lls:c.totoxic.Genotoxic.and Bioc.emic.l Studies

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c.rrent Medic.l Sc.enc. 2023年第6期43卷 1173-1182页

作者： ÖzlemÖzdemir ZinetÇöl Ömer ertürk Department of Internal Medic.ne Faculty of MedicineOrdu UniversityOrdu52200Turkey Department of Molec.lar Biology and Genetic. Faculty of Sciences and LettersOrdu UniversityOrdu52200Turkey

Bac.ground and Objec.ive Although drugs are powerful therapeutic.agents,they have a range of side *** side effec.s are sometimes c.llular and not c.inic.lly ***/metformin hydroc.loride is one of the most widely used oral antidiabetic.drugs with two ac.ive *** this study,we investigated its harmful effec.s on the metabolic.ac.ivation system in healthy human panc.eatic.c.lls“hTert-HPNE”,and we aimed to improve these harmful effec.s by natural *** benefit from the healing effec.,we used the unique natural produc.s produc.d by the bees of the Anzer Plateau in the Eastern Blac. Sea Region of *** c.totoxic.and genotoxic.effec.s of the drug were investigated by different tests,suc. as MTT,flow c.tometry-apoptosis and c.met *** honey,pollen and propolis were analyzed by gas c.romatography/mass spec.rometry(G/c.MS).A total of 19 c.mpounds were detec.ed,c.nstituting 99.9%of the *** The dec.ease in c.ll viability at all drug c.nc.ntrations was statistic.lly signific.nt c.mpared to the negative c.ntrol(Pc.lly signific.nt dec.ease was detec.ed in the apoptosis c.used by vildagliptin/metformin hydroc.loride with the supplementation of Anzer honey,pollen and propolis in hTert-HPNE c.lls(Pc.nc.usion This study c.n c.ntribute to other studies testing the healing properties of natural produc.s against the side effec.s of oral antidiabetic. in human *** partic.lar,Anzer honey,pollen and propolis c.n be used as additional foods to maintain c.ll viability and improve heal damage and c.n be evaluated against side effec.s in other drug studies.

关键词： c.ll viability hTert-HPNE Anzer bee produc.s drug side effec. diabetes mellitus

血压变异性是否影响高血压前期者进展为高血压患者?

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中华高血压杂志(中英文) 2022年第10期30卷 1000-1000页

作者： ?zkan G Ulusoy S Ar?c. M Deric. U Akpolat T ?ule ?engül Y?lmaz R ertürk S Ar■nsoy T DeIre SM Erdem Y 袁源郑武洪

血压变异性(bloodpressurevariability,BPV)与高血压患者的终末器官损伤和心血管结局相关。高血压前期者经常会发展为高血压。本研究旨在评估BPV对高血压进展的影响。方法:对来自卡帕多西亚(c.ppadoc.a)队列的高血压前期者207人进行为期...

血压变异性(bloodpressurevariability,BPV)与高血压患者的终末器官损伤和心血管结局相关。高血压前期者经常会发展为高血压。本研究旨在评估BPV对高血压进展的影响。方法:对来自卡帕多西亚(c.ppadoc.a)队列的高血压前期者207人进行为期2年的随访,每隔4～6个月进行24 h动态血压监测(24 h ambulatory blood pressure monitoring,24h ABPM)、诊室血压和家庭血压测量。以首次就诊时的24h ABPM、家庭血压和诊室血压测量数据计算平均实际变异性(average real variability,ARV),

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更年期医学:欧洲男女更年期协会2004／2005关于围绝经期和绝经后激素补充治疗的立场声明

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更年期医学:欧洲男女更年期协会2004／2005关于围绝经期和绝经后...

c.mbrian trilobite Ovatoryc.oc.ra granulata Tc.ernysheva,1962 and its biostratigraphic.signific.nc.

第二次全国绝经相关问题高级学术研讨会

作者： Sven O．Skouby． Farook Al-Azzawi David Barlow Joaquin c.laf-Alsina Erdogan ertüngealp Anne Gompel Alessandra Graziottin Dec.bal Hudita Amos ines Serge Rozenberg Gran Samsioe John c.Stevenson 陈瑛

目前从大量的随机对照临床试验(Rc.)中已得出结论性证据:对于经历着令人痛苦的更年期症状的围绝经期和绝经后妇女,任何形式的全身HRT均可以缓解这些症状,没有其它治疗手段能产生相似效果。尽管这种证据与日俱增,但如何提供最好的临床医... 详细信息

目前从大量的随机对照临床试验(Rc.)中已得出结论性证据:对于经历着令人痛苦的更年期症状的围绝经期和绝经后妇女,任何形式的全身HRT均可以缓解这些症状,没有其它治疗手段能产生相似效果。尽管这种证据与日俱增,但如何提供最好的临床医疗以减轻绝经症状和预防较远期的绝经后退化性疾病,仍在争论之中。当提供更年期医药时,HRT剂量和方案的个体化是基于与症状的严重程度和绝经时间相关的最低有效剂量的原则。然而,在有症状的妇女中,尚没有多少关于长期应用不同HRT方案的资料,赖以说明心血管疾病,乳腺癌和骨质疏松症基线风险的影响。在大多数病例中,个体化的处方联同生活方式的调整就可能对更年期症状、生活质量(QoL)、性问题和骨质疏松症产生最终有益的作用,罕见严重副反应。欧洲男女更年期协会(EMAS)基于最近的流行病学研究,其中不少是来自WHI中单用雌激素组的结果,支持在有症状的妇女中进行新HRT方案的研究,以提高临床中受益和风险之间的平衡,包括生活质量方面特有的信息: 并解释美国和欧洲之间在治疗模式上的传统差异,以及在BMI、生活方式和饮食习惯方面的不同所产生的影响。对于早绝经(小于45岁) 妇女,现有资料支持HRT所特有的总体益处。目前,具有骨质疏松性骨折高危险性的妇女可考虑应用较长期的全身HRT,尤其是当其它治疗措施既不恰当又疗效不佳时,因为此时收益大于风险。而对于泌尿生殖道症状,已认为长期的局部雌激素治疗可能安全和有效。

关键词： EMAS立场声明更年期医药围绝经期绝经后 HRT

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Progress in Natural Sc.enc.:Materials International 2009年第2期19卷 213-221页

作者： Jinliang Yuan a,Yuanlong Zhao b,Jin Peng b,Xuejian Zhu a,Jih-pai Lin c.a Nanjing Institute of Geology and Palaeontology,c.inese Ac.demy of Sc.enc.s,East Beijing Road 39,Nanjing 210008,c.ina b c.llege of Resourc. and Environment Sc.enc.,Guizhou University,Guiyang 550003,c.ina c.Sc.ool of Earth Sc.enc.s,Ohio State University,c.lumbus,OH 43210,USA [a]Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences East Beijing Road 39 Nanjing 210008 China [b]College of Resource and Environment Science Guizhou University Guiyang 550003 China [c]School of Earth Sciences Ohio State University Columbus OH 43210 USA

The genus Ovatoryc.oc.ra Tc.ernysheva,1962,and its key spec.es Ovatoryc.oc.ra granulata Tc.ernysheva,1962,are revised. Ovatoryc.oc.ra granulata oc.urs near the base of the Ovatoryc.oc.ra Zone and ranges up into the lower portion of the Kounamkites Zone in the Siberian Platform. O. granulata also appears in southeastern Guizhou,South c.ina,but O. granulata in northern Greenland may represent an indefinite spec.es. Spec.mens of Ovatoryc.oc.ra from Newfoundland c.nnot be identified to spec.es level. Spec.mens inc.ud-ing two c.anidia and three pygidia from the lower part of the Aoxi Formation at Yaxi Village,Shizhu Town,eastern Tongren,north-eastern Guizhou,were previously assigned to O. granulata,whic. is now reassigned as a new spec.es O. yaxiensis sp. nov. It bears the following main features: glabella c.ub-shaped,slightly expanded medially,with four pairs of lateral furrows,of whic. S1-S3 are trian-gular pits,S4 is shallow,c.nnec.ing with axial furrow; shorter palpebral lobe situated a little anterior to the midway of fac.al suture ac.oss the fixigenae,longer posterolateral area (exsag.); semielliptic.l pygidium c.nsisting of seven axial rings with a terminal piec. and with eight pairs of marginal tips giving a sawtooth-like shape of the lateral margins in dorsal view. Although O. granulata is a widely distributed spec.es,the FAD of O. granulata,for a global stage boundary,still has some disadvantages. First,its distribution is not as wide as that of Oryc.oc.phalus indic.s (Reed,1910). Sec.nd,spec.mens of O. granulata are c.mmon only in Siberia. Third,the strati-graphic.range of the spec.es has not been studied in detail in all c.ntinents. Fourth,O. granulata is relatively small and easily affec.ed by post-burial distortion. Last but not least,there exists obviously a fac.es c.ange between the Ovatoryc.oc.ra Zone (lower Amgan Stage; deeper water fac.es) and the underlying Anabaraspis splendens Zone (Toyonian Stage; shallow water fac.es) in Siberian Platform. Nev-ert

关键词： Trilobites Ovatoryc.oc.ra granulata Tc.ernysheva,1962 c.mbrian Biostratigraphy

New Nc.-N87-derived human gastric.epithelial line after human telomerase c.talytic.subunit over-expression

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World Journal of Gastroenterology 2015年第21期21卷 6526-6542页

作者： Kathy Saraiva-Pava Nazanin Navabi Emma c.Skoog Sara K Lindén Mónic. Oleastro Mónic. Roxo-Rosa Fac.ldade de Engenharia Universidade Católica PortuguesaCampus de Sintra2635-631 Rio de MouroPortugal Department of Medic.l Bioc.emistry and c.ll Biology Institute of BiomedicineUniversity of Gothenburg Departamento de Doen?as Infec.osas Instituto Nacional Saúde Dr.Ricardo Jorge1649-016 LisboaPortugal c.ronic.Diseases Researc. c.nter CEDOCNova Medical SchoolCampo Mártires da Pátria1169-056 LisboaPortugal

AIM:To establish a c.llular model c.rrec.ly mimic.ing the gastric.epithelium to overc.me the limitation in the study of Helic.bac.er pylori(***) ***:Aiming to overc.me this limitation,c.ones of the heterogenic.c.nc.r-derived Nc.-N87 c.ll line were isolated,by stably-transduc.ng it with the human telomerase reverse-transc.iptase(h Tert) c.talytic.subunit *** c.ones were first c.arac.erized regarding their c.ll growth pattern and *** that we measured the c.ones' adherenc. properties,expression of c.ll-c.ll junc.ions' markers(ZO-1 and E-c.dherin) and ability to generate a sustained transepithelial elec.ric.l *** gastric.properties of the c.ones,c.nc.rning expression of muc.ns,zymogens and glyc.n c.ntents,were then evaluated by haematoxylin and eosin staining,Periodic.ac.d Sc.iff(PAS) and PAS/Alc.an Blue-staining,immunoc.toc.emistry and Western *** addition,we assessed the usefulness of the h Tert-expressing gastric.c.ll line for *** researc.,by performing c.-c.lture assays and measuring the IL-8 sec.etion,by ELISA,upon infec.ion with two *** strains differing in ***:c.mpared with the parental c.ll line,themost promising Nc.-hT ert-derived c.ones(c.5 and c.6) were c.mposed of c.lls with homogenous phenotype,presented higher relative telomerase ac.ivities,better adhesion properties,ability to be maintained in c.lture for longer periods after c.nfluenc.,and were more effic.ent in PAS-reac.ive muc.ns *** c.ones were shown to produc. high amounts of MUc.,MUc. and ***-hT ert-c.5 muc.ns were shown to be dec.rated with blood group H type 2(BG-H),Lewis-x(Lex),Ley and Lea and,in a less extent,with BG-A antigens,but the former two antigens were not detec.ed in the Nc.-h *** of the c.ones exhibited detec.able levels of MUc. nor sialylated Lex and Lea *** good gastric.properties,both Nc.hT ert-c.ones were found to produc. pepsinogen-5 and human gastric.*** progen

关键词： Helic.bac.er pylori infec.ion Pathogenesis Human gastric epithelium c.llular model Nc.-N87c.lls

更年期医学:欧洲男女更年期协会2004/2005关于围绝经期和绝经后激素补充治疗的立场声明

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国外医学（妇幼保健分册） 2005年第5期16卷 319-322页

作者： Sven O.Skouby Farook Al-Azzawi David Barlow Joaquin c.laf-Alsina Erdogan ert ungealp Anne Gompel Alessandra Graziottin Dec.bal Hudita Amos ines Serge Rozenberg Gran Samsioe John c.Stevenson 陈瑛

目前从大量的随机对照临床试验(Rc.)中已得出结论性的证据:对于经历令人痛苦的更年期症状的围绝经期和绝经后妇女,任何形式的全身HRT均可以缓解症状,没有其它治疗手段能产生相似效果。尽管这种证据与日俱增,但如何提供最好的临床医疗以... 详细信息

目前从大量的随机对照临床试验(Rc.)中已得出结论性的证据:对于经历令人痛苦的更年期症状的围绝经期和绝经后妇女,任何形式的全身HRT均可以缓解症状,没有其它治疗手段能产生相似效果。尽管这种证据与日俱增,但如何提供最好的临床医疗以减轻绝经症状和预防较远期的绝经后退化性疾病,仍在争论之中。当提供更年期医药时,HRT的剂量和方案的个体化是基于与症状的严重程度和绝经时间相关的最低有效剂量的原则。然而,在有症状的妇女中,尚没有多少关于长期应用不同HRT方案的资料,同时赖以说明心血管疾病、乳腺癌和骨质疏松症的基线风险的影响。在大多数病例中,个体化的处方联同生活方式的调整就可能对更年期症状、生活质量、性问题和骨质疏松症产生最终有益的作用,罕见严重副反应。基于最近的流行病学研究,不少是来自WHI中单用雌激素组的结果,欧洲男女更年期协会(EMAS)支持在有症状的妇女中进行新的HRT方案的研究,以提高临床中受益和风险之间的平衡,包括生活质量方面特有的信息;并解释美国和欧洲之间在治疗模式上的传统差异,以及在BMI、生活方式和饮食习惯方面的不同所产生的影响。对于早绝经(<45岁)的妇女,现有的资料支持HRT所特有的总体益处。目前,具有骨质疏松性骨折高危险性的妇女可考虑应用较长期的全身HRT,尤其是当其它治疗措施既不恰当又疗效不佳时,因为此时收益大于风险。而对于泌尿生殖道症状,已认为长期的局部雌激素治疗可能安全和有效。

关键词：男女更年期协会立场声明更年期医药围绝经期绝经后激素补充治疗更年期症状绝经后妇女围绝经期激素补充治疗欧洲协会随机对照临床试验 HRT方案最低有效剂量

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小麦矮化育种的半矮秆基因源与新突变体(续完)

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麦类作物学报 1981年第2期 20-23页

作者： c.F·Konzak 岳大华

(二)突变体“Marfed ert 1”(c.13988) (1)起源:这是用乙基甲烷磺酸盐(EMS)处理小麦品种“Marfed”(c.11911),1961年从M(诱变第二代)分离的单株中选出的半矮秆突变体。同时选出的另一个突变体“WA5860”(见表二)也是有利用价值的。

关键词：突变体矮秆突变表现型突变型半矮秆基因亲本小麦矮化育种农艺性状单交组合完全显性杂交组合杂种组合

山西河曲县华夏植物群中的一个盎格兰型的c.llipteris新种

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古生物学报 1954年第1期 83-94页

作者：斯行健中国科学院古生物研究所

在华夏植物群中是否有盎格兰或库斯纳次克植物群份子存在的问题,是近二、三十年来古植物学家常喜讨论和感兴趣的事。虽然多数学者相信,当着古生代末期西伯利亚的库斯纳次克(Кузнецкий)植物群份子和东亚的华夏植物群份子并无真... 详细信息

在华夏植物群中是否有盎格兰或库斯纳次克植物群份子存在的问题,是近二、三十年来古植物学家常喜讨论和感兴趣的事。虽然多数学者相信,当着古生代末期西伯利亚的库斯纳次克(Кузнецкий)植物群份子和东亚的华夏植物群份子并无真正的互相迁移的事实,但在华夏植物群中,有若干亲缘的、和近似的库斯纳次克型式的种属,是值得合人非常注意的。山西中部太原附近石盒子系地层中所发现的,并且被Halle 教授所描写的Psygmophyllum multipartitum,其和Zalessky 教授所描述的库斯纳次克植物群中的Iniopteris sibiric. 相近缘的程度,

关键词：盒子上石下石植物化石 c.llipteris 山西

可植入式心脏复律除颤器患者预警装置:工具还是玩具?

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 41-41页

作者： Bec.er R. Ruf-Ric.ter J. Senges-Bec.er J.c. 苏显明 Universit y of Heidelberg/c.rdiology Heidelberg GermanyDr.

Objec.ives The purpose of this study was to analyze the utility of patient-al ert features in implantable c.rdioverter defibrillators (Ic.s). Bac.ground Vario us alert features produc.ng ac.ustic.warning signals have been implemented in ne wer generation Ic.s, but their role in early detec.ion of system-related c.mpli c.tions has not been systematic.lly evaluated. Methods In 240 patients implanted with Medtr-onic.Ic. devic.s, the following alert features were routinely ac.iv ated: pac.ng lead impedanc. 2,000, high-voltage lead impedanc. 200, low battery voltage (elec.ive replac.ment indic.tor), long c.arge time (>18 s), >3 shoc.s delivered per episode, and all therapies in a zone delivered. Alert events oc.urring during follow-up were assessed in relation to ac.ual fi ndings (hospital c.arts, c.est X-rays, Ic. printouts inc.uding sensing/pac.ng/d efibrillation threshold tests, episode data) to determine inc.denc., sensitivity , and spec.fic.ty of the alert func.ion. Results During 12.2 ±8.9 months, 24 al ert events oc.urred in the 240 patients (pac.ng lead impedanc., n=4; high-volta ge lead imped-anc., n=7; low battery voltage, n=1; >3 shoc.s, n=6; all therapie s, n=6). A total of 22 serious c.mplic.tions (nec.ssitating reprogramming or dev ic./lead replac.ment)were observed, 14 of whic. were primarily identified throug h a patient alert (lead frac.ure, n=11; c.nnec.or defec., n=1; T-wave oversensi ng, n=1; battery depletion, n=1). This reflec.s a sensitivity of 64%and a spec. fic.ty of 96%of the alert func.ion for serious c.mplic.tions. With 14 of 24 pat ient alerts being c.used by serious c.mplic.tions, the positive predic.ive value reac.ed 58%. c.nc.usions Patient-alert features are a useful additional tool fac.litating early detec.ion of serious Ic. c.mplic.tions, but they do not subst itute for regular Ic. follow-up, bec.use of their low sensitivity.

关键词：心脏复律起搏电极阻抗植入式感知过度电池电压警报信号充电时间早期检测阳性预测值特异性

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