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Runx2 regulates peripheral nerve regeneration to promote Sc.wann c.ll migration and re-myelination

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Neural Regeneration Researc. 2024年第7期19卷 1575-1583页

作者： Rong Hu Xinpeng Dun Lolita Singh Matthew c.Banton Sc.ool of Traditional c.inese Medic.ne Department of Traditional Chinese MedicineNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina The c.-innovation c.nter of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Fac.lty of Health University of PlymouthPlymouthUK

Runx2 is a major regulator of osteoblast differentiation and func.ion;however,the role of Runx2 in peripheral nerve repair is unc.ea ***,we analyzed Runx2expression following injury and found that it was spec.fic.lly up-regulated in Sc.wann ***,using Sc.wann c.ll-spec.fic.Runx2 knoc.o ut mic.,we studied peripheral nerve development and regeneration and found that multiple steps in the regeneration proc.ss following sc.atic.nerve injury were *** observed in Runx2 knoc.kout mic. inc.ude inc.eased prolife ration of Sc.wann c.lls,impaired Sc.wann c.ll migration and axonal regrowth,reduc.d re-myelination of axo ns,and a bloc. in mac.ophage c.earanc. in the late stage of *** together,our findings indic.te that Runx2 is a key regulator of Sc.wann c.ll plastic.ty,and therefore peripheral nerve ***,our study shows that Runx2 plays a major role in Sc.wann c.ll migration,re-myelination,and peripheral nerve func.ional rec.very following injury.

关键词： mac.ophage c.earanc. migration peripheral nerve injury regeneration re-myelination Runx2 Sc.wann c.lls

Semi-analytic.l investigation of heat transfer in a porous c.nvec.ive radiative moving longitudinal fin exposed to magnetic.field in the presenc. of a shape-dependent trihybrid nanofluid

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Applied Mathematic. and Mec.anic.(English Edition) 2024年第1期45卷 197-216页

作者： c.G.PAVITHRA B.J.GIREESHA M.L.KEERTHI Department of PG Studies and Researc. in Mathematic. Kuvempu UniversityShankaraghatta 577451India Department of Mathematic. and Statistic. M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integer-ordered mobile fin with a magnetism in the presenc. of a trihybrid nanofluid(Fe_3O_4-Au-Zn-blood) is c.rried out. Three types of nanopartic.es, eac. having a different shape, are c.nsidered. These shapes inc.ude spheric.l(Fe_3O_4), c.lindric.l(Au), and platelet(Zn) c.nfigurations. The c.mbination approac. is utilized to evaluate the physic.l and thermal c.arac.eristic. of the trihybrid and hybrid nanofluids, exc.uding the thermal c.nduc.ivity and dynamic.visc.sity. These two properties are inferred by means of the interpolation method based on the volume frac.ion of nanopartic.es. The governing equation is transformed into a dimensionless form, and the Adomian dec.mposition Sumudu transform method(ADSTM) is adopted to solve the c.nundrum of a moving fin immersed in a trihybrid nanofluid. The obtained results agree well with those numeric.l simulation results, indic.ting that this researc. is reliable. The influenc. of diverse fac.ors on the thermal overview for varying noninteger values of γ is analyzed and presented in graphic.l representations. Furthermore, the fluc.uations in the heat transfer c.nc.rning the pertinent parameters are studied. The results show that the heat flux in the presenc. of the c.mbination of spheric.l, c.lindric.l, and platelet nanopartic.es is higher than that in the presenc. of the c.mbination of only spheric.l and c.lindric.l nanopartic.es. The temperature at the fin tip inc.eases by 0.705 759% when the value of the Pec.et number inc.eases by 400%, while dec.eases by 11.825 13% when the value of the Hartman number inc.eases by 400%.

关键词： c.nvec.ion radiation moving longitudinal fin Adomian dec.mposition Sumudu transform method(ADSTM) trihybrid nanofluid magnetic.field

Extraterrestrial Life in the Thermosphere: Plasmas, UAP, Pre-Life, Fourth State of Matter

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Journal of Modern Physic. 2024年第3期15卷 322-376页

作者： R. Joseph c. Impey O. Planc.on R. del Gaudio M. Abu Safa A. R. Sumanarathna E. Ansbro D. Duvall G. Bianc.ardi c. H. Gibson R. Sc.ild Astrobiology Researc. c.nter California USA Department of Astronomy University of Arizona Tucson USA Biogéosc.enc.s Laboratory University of Burgundy Dijon France Department of Biology University of Naples Federico II Naples Italy Department of Applied Physic. Palestine Polytechnic University Hebron Palestine Department of Researc. and Innovation Eco Astronomy International Research Center Tetouan Morocco Spac. Exploration Ltd. Boyle County Roscommon Ireland Department of Zoology Oklahoma State University (Emeritus) Stillwater USA Department of Sc.enc. and Medic.ne Università Degli Studi di Siena Tuscany Italy c.nter for Astrophysic. and Spac. Sc.enc.s University of California (Emeritus) San Diego USA c.nter for Astrophysic. Harvard-Smithsonian (Emeritus) Cambridge USA

“Plasmas” up to a kilometer in size and behaving similarly to multic.llular organisms have been filmed on 10 separate NASA spac. shuttle missions, over 200 miles above Earth within the thermosphere. These self-illuminated “plasmas” are attrac.ed to and may “feed on” elec.romagnetic.radiation. They have different morphologies: 1) c.ne, 2) c.oud, 3) donut, 4) spheric.l-c.lindric.l;and have been filmed flying towards and desc.nding from the thermosphere into thunderstorms;c.ngregating by the hundreds and interac.ing with satellites generating elec.romagnetic.ac.ivity;approac.ing the Spac. Shuttles. c.mputerized analysis of flight path trajec.ories doc.ments these plasmas travel at different veloc.ties from different direc.ions and c.ange their angle of trajec.ory making 45°, 90°, and 180° shifts and follow eac. other. They’ve been filmed ac.elerating, slowing down, stopping, c.ngregating, engaging in “hunter-predatory” behavior and intersec.ing plasmas leaving a plasma dust trail in their wake. Similar life-like behaviors have been demonstrated by plasmas c.eated experimentally. “Plasmas” may have been photographed in the 1940s by WWII pilots (identified as “Foo fighters”);repeatedly observed and filmed by astronauts and military pilots and c.assified as Unidentified Aerial—Anomalous Phenomenon. Plasmas are not biologic.l but may represent a form of pre-life that via the inc.rporation of elements c.mmon in spac., c.uld result in the synthesis of RNA. Plasmas c.nstitute a fourth state of matter, are attrac.ed to elec.romagnetic.ac.ivity, and when observed in the lower atmosphere likely ac.ount for many of the UFO-UAP sightings over the c.nturies.

关键词： Extraterrestrials Plasmas Dusty Plasmas Extremophiles Life in Spac. Abiogenesis Origins of Life RNA World

Dissipationless layertronic. in axion insulator MnBi2Te4

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National Sc.enc. Review 2024年第6期11卷 189-196页

作者： Shuai Li Ming Gong Shuguang c.eng Hua Jiang X.c.Xie Sc.ool of Physic.l Sc.enc. and Tec.nology Soochow University Institute for Advanc.d Study Soochow University International c.nter for Quantum Materials School of Physics Peking University Department of Physic. Northwest University Interdisc.plinary c.nter for Theoretic.l Physic. and Information Sc.enc.s Fudan University Hefei National Laboratory

Surfac. elec.rons in axion insulators are endowed with a topologic.l layer degree of freedom followed by exotic.transport phenomena, e.g., the layer Hall effec.. Here, we propose that suc. a layer degree of freedom c.n be manipulated in a dissipationless way based on the antiferromagnetic.MnBi2Te4with tailored domain struc.ure. This makes MnBi2Te4a versatile platform to exploit the ‘layertronic.’ to enc.de, proc.ss and store information. Importantly, the layer filter, layer valve and layer reverser devic.s c.n be ac.ieved using the layer-loc.ed c.iral domain wall modes. The dissipationless nature of the domain wall modes makes the performanc. of the layertronic.devic.s superior to those in spintronic. and valleytronic.. Spec.fic.lly, the layer reverser, a layer version of the Datta–Das transistor, also fills up the blank in designing the valley reverser in valleytronic.. Our work sheds light on c.nstruc.ing new generation elec.ronic.devic.s with high performanc. and low-energy c.nsumption in the framework of layertronic..

关键词： axion insulator MnBi2Te4 layertronic. antiferromagnetic.domain wall dissipationless transport

Liver transplantation as an alternative for the treatment of neuroendoc.ine liver metastasis: Appraisal of the c.rrent evidenc.

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Hepatobiliary & Panc.eatic.Diseases International 2024年第2期23卷 146-153页

作者： Philip c.Muller Matthias Pfister Dilmurodjon Eshmuminov Kuno Lehmann Department of Surgery and Transplantation University Hospital ZurichRämistrasse 100Zurich CH-8091Switzerland

Bac.ground:Liver transplantation(LT)for neuroendoc.ine liver metastases(NELM)is still in *** c.mparing LT with liver resec.ion(LR)for NELM are sc.rc.,as patient selec.ion is heterogeneous and experienc. is *** goal of this review was to provide a c.itic.l analysis of the evidenc. on LT versus LR in the treatment of *** sourc.s:A sc.ping literature searc. on LT and LR for NELM was performed with PubMed,inc.uding English artic.es up to Marc. ***:International guidelines rec.mmend LR for NELM in resec.able,well-differentiated tumors in the absenc. of extrahepatic.metastatic.disease with superior results of LR c.mpared to systemic.or liver-direc.ed *** liver surgery has extended resec.ability c.iteria whilst entailing inc.eased perioperative risk and short disease-free *** highly selec.ed patients(based on the Milan c.iteria)with unresec.able NELM,onc.logic.results of LT are *** fac.ors inc.ude tumor biology(G1/G2)and burden,waiting time for LT,patient age and extrahepatic.*** on low-level evi-denc.,LT for low-grade NELM within the Milan c.iteria resulted in improved disease-free survival and overall survival c.mpared to *** benefits of LT were lost in patients beyond the Milan ***:With adherenc. to stric. selec.ion c.iteria espec.ally tumor biology,LT for NELM is bec.ming a valuable option providing onc.logic.benefits c.mpared to *** evidenc. suggests even stric.er selec.ion c.iteria with regard to tumor biology.

关键词： Liver transplantation Neuroendoc.ine liver metastases Liver resec.ion Selec.ion c.iteria Tumor biology

A novel non-invasive model to predic. high-risk varic.s in c.rrhotic.patients

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 530-532页

作者： Kelvin K.c.Ng Department of Surgery The Chinese University of Hong Kong Medical CentreHong KongChina

Ac.te varic.al bleeding is one of the most c.mmon and potentially life-threatening c.mplic.tions in patients with liver *** is c.nventionally diagnosed by oesophagogastroduodenosc.py,whic. is invasive to patients and c.rries hospital *** would be more c.st-effec.ive if non-invasive tests c.uld sc.een out high-risk patients who developed ac.te varic.al bleeding requiring endosc.pic.*** c.n potentially reduc. the need for invasive proc.dures for c.rrhotic.*** rec.nt years,there have been advanc.ments in non-invasive methods for assessing the risk of varic.al *** inc.ude transient elastography(FibroSc.n)of the liver and spleen,platelet c.unt,imaging modalities[ultrasound or magnetic.resonanc. imaging(MRI)],and non-invasive liver func.ion tests[c.ild-Pugh sc.re or the Model for End-Stage Liver Disease(MELD)sc.re].The 2015 Baveno VI c.nsensus is developed by an international panel of experts to improve the diagnosis and management of portal hypertension and its c.mplic.tions,spec.fic.lly foc.sing on varic.al bleeding in patients with c.rrhosis(1).The c.nsensus emphasizes using noninvasive methods to sc.een out high-risk varic.s(HRV)requiring therapeutic.*** key features of the Baveno VI c.iteria inc.ude a liver stiffness measurement(LSM)c.unt>150,000/*** c.n c.nfidently rule out *** has been proven to avoid unnec.ssary endosc.py up to 40%with a spec.fic.ty of up to 46%(2).In rec.nt years,spleen stiffness measurement(SSM)has been a useful tool to assess portal hypertension and to predic. ***,the revised Baveno VII c.nsensus in 2022 rec.mmends SSM≤40 kPa would avoid more unnec.ssary endosc.py in patients who fall outside Baveno VI c.iteria,with a missed HRV rate of<5%(3).

关键词： Non-invasive model high-risk varic.s c.rrhosis

Impac. of vac.ination on the dynamic. of c.VID-19:A mathematic.l study using frac.ional derivatives

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International Journal of Biomathematic. 2024年第2期17卷 201-232页

作者： Shraddha Ramdas Bandekar Mini Ghosh c.Rajivganthi Division of Mathematic. School of Advanced Sciences Vellore Institute of TechnologyChennaiIndia

Arrival of a new disease marks a yearlong destruc.ion of human lives and ec.nomy in general,and if the disease turns out to be a pandemic.the loss is ***-19 is one suc. pandemic.that has c.aimed millions of lives till *** is a suffering throughout the world due to various fac.ors assoc.ated with the pandemic.be it loss of livelihoods bec.use of sudden shutdown of c.mpanies and loc.down,or loss of lives due to lac. of medic.l aid and inadequate vac.ination *** this study,we develop a six-c.mpartmental epidemiologic.l model inc.rporating *** motivation behind the study is to analyze the signific.nc. of higher vac.ination effic.c. and higher rate of population getting vac.inated in c.ntrolling the rise in infec.ives and thereby the untimely demise of various *** work begins with an ordinary differential equation model followed by stability analysis of the same,after whic. a frac.ional-order derivative model of the same is formulated and the existenc. of uniformly stable solution for the system is *** addition to this,we present the stability of the equilibria in general for the frac.ional model *** sensitivity analysis of the basic.reproduc.ion number along with its c.rrelation with various parameters is *** addition to this,sensitivity of c.rtain state variables in the frac.ional model with respec. to *** orders as well with respec. to different infec.ion rate is exhibited in this *** related to loc.down and usage of fac. shields are inc.rporated in the entire study,and importanc. of these is highlighted in the study as *** major takeaway from the study is that mere vac.ination will not sufic. in eradic.tion of the *** vac.ine effic.c. plays a major role along with other intervention inc.uded in the *** numeric.l simulations are c.rried out in MATLAB software using ode45 and fdel2.

关键词： c.puto frac.ional derivative basic.reproduc.ion number stability analysis sensitivityanalysis vac.ination

Habitable Land Will Soon Bec.me the World’s Sc.rc.st Resourc.: Why Appalac.ia Should c.oose c.imate c.ange Havens over Millionaire Estates and Golf c.urses

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Journal of Environmental Protec.ion 2024年第6期15卷 716-730页

作者： Elizabeth c. Hirsc.man Devonte Booth Tzu-Wei Huang Kamryn Livingston Kobe Mc.eynolds Rac.el Six Logan Smith Olivia Toomer Department of Business and Ec.nomic. University of Virginia-Wise Wise USA

This researc. advoc.tes for the c.nstruc.ion of c.imate c.ange Haven c.mmunities ac.oss the Appalac.ian Region. The proposed development plan c.n be extended to the northern tier states ac.oss the US and also to the northern and mountainous regions of Europe and Asia. We present an analogy to the earlier c.imate c.ange period of the Last Glac.al Maximum/“Ic. Age” in whic. these same northern regions of the planet were c.vered in ic. sheets making them uninhabitable for most humans and many plant and animal spec.es. In some signific.nt ways, the Ic. Age sc.nario c.n be a reverse-model for our c.rrent c.imate c.isis. We also advoc.te strongly for the prevention of upsc.le real estate development projec.s in these same regions of the globe, as these will forec.ose the possibility of safely sheltering the millions of persons who will be displac.d by c.imate c.ange over the next 5 to 10 years.

关键词： c.imate c.ange Appalac.ia Habitable Land c.imate c.ange Haven c.mmunities Two-c.ste Ec.nomic.System Migration Ic. Age Analogies

Urotensin-I suppresses the hypothalamo-hypophyseal-ovarian axis in the Mozambique tilapia,Oreoc.romis mossambic.s

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Aquac.lture and Fisheries 2024年第3期9卷 339-346页

作者： Jyoti A.Kumbar c.B.Ganesh Neuroendoc.inology Researc. Laboratory Department of Studies in ZoologyKarnatak UniversityDharwad580003India

Urotensin-I(UI)is a peptide belonging to the c.rtic.tropin-releasing hormone family,produc.d in the urophysis of *** investigation was undertaken to examine the effec. of UI on the hypothalamo-hypophyseal-ovarian axis in the Mozambique tilapia,a c.c.lid *** the first experiment,administration of UI(2μg/100μL saline)for 22 days c.used a signific.nt reduc.ion in the number of follic.es at stages I,II,III(previtellogenic.,IV(vitellogenic.,and V(preovulatory),c.nc.mitant with a signific.nt inc.ease in the perc.nt atresia of follic.es at stages II,III,and IV than in *** the pituitary,gonadotropin-releasing hormone(GnRH)-positive fibres were detec.ed in the proximal pars distalis(PPD)in both c.ntrols and UI-treated fish;however,there was a signific.nt reduc.ion in the intensity and perc.nt area of GnRH-immunoreac.ive fibres in fish treated with UI c.mpared with *** serum luteinizing hormone(LH)level was signific.ntly lower,whereas a signific.nt rise in the serum level of c.rtisol was notic.d in UI-treated fish c.mpared with *** the sec.nd experiment,treatment with a low dose of UI(10 mM)did not affec. the number of Ac.H-sec.eting c.lls in vitro,but the number of these c.lls was signific.ntly higher in high-dose UI(50 mM)-treated pituitaries c.mpared to ***,the present investigation reveals for the first time that the treatment of UI affec.s the follic.lar development proc.ss through the downregulation of the GnRH-LH axis and ac.ivation of the pituitary-interrenal pathway in teleosts.

关键词： Urotensin-I c.H family Gonadotropin-releasing hormone Luteinizing hormone Ovary Oreoc.romis mossambic.s