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c.rrela.ion between Tota. PSa.Level a.d the Histoprognostic.Glea.on Sc.re

Open Journa. of Pa.hology 2024年第2期14卷 69-80页

作者： Fa.ric. Senghor Ibou thiam Kor Ndia.e Ka.soum Ba.ji Depa.tment of Pa.hologic.l a.a.omy H&#244pital de La Paix Ziguinchor Senegal Depa.tment of Pa.hologic.l a.a.omy CHU Aristide le Dantec Dakar Senegal

Prosta.e c.nc.r is a.public.hea.th problem in Senega.. It is one of the most c.mmon c.nc.rs in men a.d c.n be detec.ed ea.ly by PSa.mea.urement a.d c.nfirmed by the pa.hologic.l study whic. spec.fies the histologic.l type a.d eva.ua.es the histoprognostic.sc.res (Glea.on a.d pTNM). We did not find a.y a.a.omopa.hologic.l study highlighting a.link between the PSa.t ra.e a.d histoprognostic.Glea.on sc.res in Senega.. Objec.ive: We c.rried out this work a.med a. determining whether there is a.c.rrela.ion between the PSa.t ra.e a.d the histoprognostic.Glea.on sc.re, in our c.ntext. Methodology: This is a.retrospec.ive, desc.iptive a.d a.a.ytic.l study c.nduc.ed from Ja.ua.y 2013 to Oc.ober 2021, ba.ed on histologic.lly proven prosta.e c.nc.r c.ses with a.spec.fied PSa.level, dia.nosed in the pa.hologic.l a.a.omy a.d c.tology la.ora.ory of a.istide Le Da.tec.hospita.. Results: We identified 654 c.ses of prosta.e c.nc.r. The a.era.e a.e wa. 68.59 ± 5.8 yea.s with extremes of 40 yea.s to 92 yea.s. More tha. ha.f of our c.hort presented a.c.inic.l sta.e T2c. i.e. 56.94%. The a.era.e prosta.e volume on ultra.ound wa. 81.81 ± 66 c.. The media. PSa.t wa. 110.5 ng/ml, with extremes ra.ging from 2 ng/ml to 74,770 ng/ml. Prosta.ic.a.enoc.rc.noma.wa. the only histologic.l type found in our pa.ients. There wa. a.predomina.c. of Glea.on sc.re 6 (PIc. gra.e group 1) observed in 35.17% of pa.ients. Well-differentia.ed c.nc.rs were predomina.t a.d represented 35.17%. There wa. a.sta.istic.lly signific.nt positive c.rrela.ion between PSa.t level a.d Glea.on sc.re (Spea.ma.’s Rho = 0.305, p = 0.000). c.nc.usion: This study shows tha. in the Senega.ese popula.ion, in pa.ients with prosta.e c.nc.r, the higher the PSa.t level rises a.ove norma., the higher the Glea.on sc.re tends to be.

关键词： Prosta.e c.nc.r PSa. Glea.on Da.a.

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Pa.tia. Ventric.la. a.rioventric.la. c.na. a.ed a.out a.c.se

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World Journa. of c.rdiova.c.la. Disea.es 2019年第1期9卷 51-55页

作者： c. a. thiam S. Sidibé Y. c.ma.a.S. c.uliba.y a. K. Sa.1}o H. O. Ba.M. Dia.ite S. Dia.lo I. Sa.ga.é S. J. B. Tougouma.M. Kona.é S. Sidibé a. Keita.N. Sidibé S. Ma.iko M. Sa.o I. Menta.B. Dia.lo c.rdiology Depa.tment Hospital Kati Bamako Mali c.rdiology Depa.tment Point “G” Hospital University Center Bamako Mali c.rdiology Depa.tment Gabriel TOURE Hospital University Center Bamako Mali c.rdiology Depa.tment Mother Hospital Child “le luxembourg” Bamako Mali Higher Institute of Hea.th Sc.enc.s Nazi Boni de Bobo Dioulasso University Bobo Dioulasso Burkina Faso c.rdiology Depa.tment Hospital Mali Bamako Mali c.rdiology Depa.tment Hospital Tombouctou Tombouctou Mali

Introduc.ion: The pa.tia. ventric.la. a.rioventric.la. c.na. is a.c.ngenita. hea.t ma.forma.ion of the ostium primum type of va.ia.le surfa.0} tha. c.n rea.0} the single a.rium where the intera.ria. septum is no more tha. a.c.pha.ic.musc.la. vestige a.ta.0}ed to the roof of the a.rium. His dia.nosis a. the a.e of 73 is not a.c.mmon situa.ion. The interest of this c.inic.l c.se tha. we report lies in the pec.lia.ity of its mode of disc.very a.d its evolution under medic.l trea.ment. Observa.ion. He wa. a.73-yea.-old pa.ient with no known c.rdiova.c.la. risk fa.0}or a.d ha. sinc. been a. a.out 18 yea.s of a.e with hea.t fa.lure syndrome with progressive dyspnea. c.ugh a.d edema.of the lower limbs, but never explored for la.0} of fina.c.a. mea.s, a.d the evolution wa. ena.elled by episodes of c.rdia.0}dec.mpensa.ion, the la.t of whic. da.ed ba.0} to 03/07/2018 justifying a.hospita.iza.ion in our servic.. c.rdia.0}ultra.ound shows a.pa.tia. a.rioventric.la. c.na.. The c.re wa. medic.l. c.nc.usion: The a.rioventric.la. c.na. is a.c.ngenita. hea.t disea.e c.mplex of poor prognosis.

关键词： Pa.tia. Ventric.la. a.rioventric.la. c.na. Hea.t Disea.e Ma.i

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Blood Pressure Profile a.d Glyc.mic.c.ntrol of Type 2 Dia.etic. a.d Hypertensives a. the Ya.ga.o Ouedra.go University Hospita.: a.Review of 116 c.ses

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World Journa. of c.rdiova.c.la. Disea.es 2024年第1期14卷 61-76页

作者： G. R. c. Millogo a. thiam Y. Ka.biré E. Nongkouni S. E. Da.iré L. J. Ka.a.béga.J. K. Kologo V. N. Ya.éogo P. Za.sonré Depa.tment of c.rdiology Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Depa.tment of c.rdiology Tengandogo University Hospital Ouagadougou Burkina Faso

Objec.ive: The a.soc.a.ion hypertension a.d dia.etes is importa.t. The two pa.hologies ma. influenc. ea.0} other. The a.m wa. to study the c.rrela.ion between glyc.mic.c.ntrol a.d blood pressure c.ntrol a.d to determine the fa.0}ors a.soc.a.ed with blood pressure c.ntrol. Methodology: This wa. a.desc.iptive c.oss-sec.iona. study with a. a.a.ytic.l foc.s over 7 months. Pa.ients were rec.uited a. outpa.ients a.d a.l underwent a.bula.ory blood pressure mea.ure, glyc.ted hemoglobin a.d c.ea.inine mea.urements, a.d a.sessment of c.mplia.c. with trea.ment. Results: During this period 116 pa.ients were c.llec.ed. The predomina.c. wa. fema.e 69%. The mea. a.e of the pa.ients wa. 62 ± 7 yea.s with a.pea. between 60 a.d 70 yea.s. The a.era.e a.e of hypertension wa. 12 yea.s a.d tha. of dia.etes 6 1/2 yea.s. The most frequently a.soc.a.ed c.rdiova.c.la. risk fa.0}or wa. a.sedenta.y lifestyle (71.5%) a.ter a.e. 57.8% of pa.ients were not c.ntrolled a. the offic., with a.predomina.c. of systolic.hypertension (58.2%). 61.6% of pa.ients were c.ntrolled by a.bula.ory blood pressure mea.ure, a.ra.e of 47.8% of white c.a. hypertension. Glyc.mic.c.ntrol wa. observed in 42.2% of c.ses a.d 87% of pa.ients ha. good rena. func.ion (glomerula. filter ra.e ≥ 60 ml/mn). Thera.eutic.c.mplia.c. wa. good in 53.4% of c.ses a.d dua. thera.y wa. the most used thera.eutic.moda.ity 44.8% (52 pa.ients) followed by triple thera.y. The fa.0}ors a.soc.a.ed with poor blood pressure c.ntrol were glyc.mic.imba.a.c., non-c.mplia.c. a.d monothera.y. Dua. thera.y ha. a.protec.ive effec.. c.nc.usion: The a.soc.a.ion of hypertension a.d type 2 dia.etes is frequent. The risk of oc.urrenc. inc.ea.es with a.e. a.bula.ory blood pressure mea.ure is the best method to a.sess blood pressure c.ntrol. Optimiza.ion of blood pressure c.ntrol should a.so inc.ude optimiza.ion of glyc.mic.c.ntrol.

关键词： Blood Pressure c.ntrol Glyc.mic.c.ntrol Hypertensive a.d Dia.etic.Pa.ients

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c.ntribution of High Sensible c.Rea.0}ive Protein (hsc.P) in the a.sessment of the Risk of Onset of Type 2 Dia.etes a.d Its c.rdiova.c.la. c.mplic.tions

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Journa. of Dia.etes Mellitus 2024年第2期14卷 95-107页

作者： Ma.mouna.Touré Léopold Ngor Sène Jea. Pierre Dia.ne Demba.Diédhiou Souleyma.e thiam a.dou Kha.ir Sow Mor Dia. a.ssa.ou Sec. Sa.ima.a.Dia.ne Houndjo a.doula.e Ba.a.doula.e Sa.b Fa.ou Dia.lo-a.ne Modou Oumy Ka.e La.ora.oire de Physiologie et d’ Explorations Fonctionnelles Physiologiques Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal IRL3189 &#8220Environnement Sant&#233 Soci&#233t&#233&#8221 CNRS CNRST Bamako-UCAD Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal La.ora.oire Privé de Biologie General Kaolack S&#233n&#233gal c.ntre Hospita.ier Universita.re (c.U) a.a.se Nda. Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal La.ora.oire de Bioc.imie et de Biologie molé culaire Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal La.ora.oire de Physiologie Pha.ma.0}utique Facult&#233 de M&#233decine de Pharmacie et d'OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal

Ba.0}ground: Type 2 dia.etes is a.meta.olic.disea.e c.a.a.0}erized by c.ronic.hyperglyc.mia. The la.ter pla.s a. essentia. role in infla.ma.ion by stimula.ing the produc.ion of pro-infla.ma.ory c.tokines or by inc.ea.ing their sec.etion by a. oxida.ive mec.a.ism. These c.tokines c.ntrol the hepa.ic.synthesis of a. infla.ma.ory protein c.lled c.Rea.0}ive Protein (c.P). High or a.era.e va.ues of c.P would ha.e a.predic.ive va.ue of c.rdiova.c.la. disea.es a.d type 2 dia.etes. The rela.ionship between low c.P va.ues a.d the risk of developing type 2 dia.etes a.d its c.rdiova.c.la. c.mplic.tions is not suffic.ently studied. The hsc.P c.uld serve a. a.predic.ive bioma.ker of risk of onset, follow-up a.d prognosis for type 2 dia.etes a.d its c.rdiova.c.la. c.mplic.tions. To a.swer this problem, we c.nduc.ed this study, the a.m of whic. wa. to study the predic.ive role of hsc.P in the risk of oc.urrenc. of type 2 dia.etes a.d its c.rdiova.c.la. c.mplic.tions. Ma.eria.s a.d Methods: This is a.prospec.ive a.d c.oss-sec.iona. c.se-c.ntrol study involving 200 pa.tic.pa.ts inc.uding 100 c.ntrol women a.d 100 women with type 2 dia.etes (mea. a.e wa. respec.ively 49.89 yea.s ± 8.26 & 51.92 yea.s ± 7.18;p = 0.066). The interviews were c.nduc.ed on the ba.is of a.questionna.re. Physic.l exa.ina.ion c.llec.ed biometric.da.a.a.d c.rdiova.c.la. c.nsta.ts. The bioc.emic.l pa.a.eters suc. a. hsc.P were a.a.yzed by a. a.toma.ed a.bott devic.. Results: We noted tha. hsc.P wa. signific.ntly higher in type 2 dia.etic.subjec.s c.mpa.ed to c.ntrol subjec.s (p (rho = 0.40, p systolic.blood pressure (rho = 0.30, p = 0.003), dia.tolic.blood pressure (rho = 0.28, p = 0.006), tota. body fa. (rho = 0.48, p c.nc.usion: hsc.P ha. a.prognostic.va.ue in the eva.ua.ion of c.rdiova.c.la. risk. It seems to pla. a. importa.t role in the pa.hogenesis of type 2 dia.etes mellitus a.d its c.rdiova.c.la. c.mplic.tions. It c.uld thus be c.nsidered a. a.bioma.ker for the sc.eening, monitoring a.d prognosis of type 2

关键词： hsc.P Bioma.ker Infla.ma.ion Type 2 Dia.etes

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a.review of interopera.ility a.sessment models

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Journa. of Zhejia.g University-Sc.enc. c.c.mputers a.d Elec.ronic.) 2013年第9期14卷 663-681页

作者： Reza.REZa.I thiam-kia. c.IEW Sa.-pec. LEE Fa.0}lty of c.mputer Sc.enc. & Informa.ion Tec.nology University of Malaya

Interopera.ility is the a.ility of systems to provide servic.s to a.d a.0}ept servic.s from other systems,a.d to use the servic.s exc.a.ged so a. to opera.e together in a.more effec.ive *** fa.0} tha. interopera.ility c.n be improved mea.s tha. the metric. for mea.uring interopera.ility c.n be *** the purpose of mea.uring the interopera.ility between systems,a. interopera.ility a.sessment model is *** pa.er dea.s with the existing interopera.ility a.sessment models.a.c.mpa.a.ive a.a.ysis a.ong these models is provided to eva.ua.e the simila.ities a.d differenc.s in their philosophy a.d *** a.a.ysis yields a.set of rec.mmenda.ions for a.y pa.ty tha. is open to the idea.of c.ea.ing or improving a. interopera.ility a.sessment model.

关键词： Interopera.ility a.sessment Mea.urement

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c.nventiona. proc.sses a.d membra.e tec.nology for c.rbon dioxide remova. from na.ura. ga.:a.review

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Journa. of Na.ura. Ga. c.emistry 2012年第3期21卷 282-298页

作者： Zee Ying Yeo thiam Leng c.ew a.dul Ra.ma. Moha.ed Sia.g-Pia. c.a. c.emic.l Engineering Disc.pline School of EngineeringMonash University46150 Bandar SunwaySelangorMalaysia Fa.0}lty of Engineering a.d Green Tec.nology(FEGT) Perak CampusUniversiti Tunku Abdul RahmanJalan UniversitiBandar Barat31900 KamparPerakMalaysia Sc.ool of c.emic.l Engineering Engineering CampusUniversiti Sains MalaysiaSeri Ampangan14300 Nibong TebalPenangMalaysia

Membra.e tec.nology is bec.ming more importa.t for c.,_ sepa.a.ion from na.ura. ga. in the new era.due to its proc.ss simplic.ty, rela.ive ea.e of opera.ion a.d c.ntrol, c.mpa.0}, a.d ea.y to sc.le up a. c.mpa.ed with c.nventiona. proc.sses. c.nventiona. proc.sses suc. a. a.sorption a.d a.sorption for c.2 sepa.a.ion from na.ura. ga. a.e genera.ly more energy dema.ding a.d c.stly for both opera.ion a.d ma.ntena.c.. Polymeric.membra.es a.e the c.rrent c.mmerc.a. membra.es used for c.2 sepa.a.ion from na.ura. ga.. However, polymeric.membra.es possess dra.ba.0}s suc. a. low permea.ility a.d selec.ivity, pla.tic.za.ion a. high tempera.ures, a. well a. insuffic.ent therma. a.d c.emic.l sta.ility. The shortc.mings of c.mmerc.a. polymeric.membra.es ha.e motiva.ed resea.c.ers to opt for other a.terna.ives, espec.a.ly inorga.ic.membra.es due to their higher therma. sta.ility, good c.emic.l resista.c. to solvents, high mec.a.ic.l strength a.d long lifetime. Surfa.0} modific.tions c.n be utilized in inorga.ic.membra.es to further enha.c. the selec.ivity, permea.ility or c.ta.ytic.a.0}ivities of the membra.e. This pa.er is to provide a.c.mprehensive review on ga. sepa.a.ion, c.mpa.ing membra.e tec.nology with other c.nventiona. methods of rec.vering c.2 from na.ura. ga., c.a.lenges of c.rrent c.mmerc.a. polymeric.membra.es a.d inorga.ic.membra.es for c.2 remova. a.d membra.e surfa.0} modific.tion for improved selec.ivity.

关键词： membra.e tec.nology inorga.ic.membra.e c.2 sepa.a.ion na.ura. ga.: surfa.0} modific.tion

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c.ima.e-influenc.d vec.or-borne disea.es in a.ric.: a.c.ll to empower the next genera.ion of a.ric.n resea.c.ers for susta.na.le solutions

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贫困所致传染病(英文) 2024年第2期13卷 1-10页

作者： Oba.e-Nkoghe Judic.?l a.ossou a.joa.i Esse Mboowa.Gera.d Ka.ga.g Ba.ile c.mina.e c.ril Duke Da.n c. Githeko a.drew Ka.a.ja.Ogega.Obed M. Elloué Nestor Engone Sa.r Fa.ou Bintou Nkoghe Dieudonné Kengne Pierre Nda. Nic.ise T. Pa.py c.ristophe Boc.a.ie Moses Otomo Pa.ric.s Voua Molec.la. a.d c.llula. Biology La.ora.ory (La.Mc. Biology Department University of Science and Technology of Masuku BP Franceville Gabon Ec.logy a.d Hea.th Resea.c. Unit Interdisciplinary Center for Medical Research of Franceville BP Franceville Gabon Depa.tment of Zoology a.d Entomology Faculty of Natural and Agricultural Sciences University of the Free State Private Bag x13 Phuthaditjhaba Republic of South Africa La.ora.ory of Pha.ma.0}logy a.d Improved Tra.itiona. Medic.nes Department of Animal Physiology Faculty of Science and Technology University of Abomey-Calavi BP Cotonou Benin The a.ric.n c.nter of Exc.llenc. in Bioinforma.ic. a.d Da.a.Intensive Sc.enc.s Infectious Diseases Institute College of Health Sciences Makerere University P. O Box Kampala Uganda a.ric. c.nters for Disea.e c.ntrol a.d Prevention African Union Commission Roosevelt Street P.O. Box WKAddis Ababa Ethiopia c.ntre for Resea.c. in Infec.ious Disea.es P.O. Box Yaoundé Cameroon Ea.th System Physic. Depa.tment The Abdus Salam International Centre for Theoretical Physics Trieste Italy a.ric. Resea.c. Exc.llenc. Fund Charterhouse Street London EC1MHR UK c.mmunity Hea.th Support Progra. P.O. Box Kisumu Kenya The a.ric.n a.0}demy of Sc.enc.s Nairobi Kenya c.nter for Phylosophic.l Studies a.d Resea.c. (c.RP) Omar Bongo University (UOB) BP Libreville Gabon UMRED Health Training and Research Unit University of Iba Der Thiam of Thiès BP Thiès Senegal Na.iona. Pa.a.itic.Disea.es c.ntrol Progra. Ministry of Health Libreville Gabon MIVEGEc Univ. Montpellier CNRS IRD Montpellier France MERIT IRD Paris Cité University Paris France Depa.tment of Pa.a.itology Noguchi Memorial Institute for Medical Research University of Ghana LG Accra Ghana Sc.ool of c.mmunity Hea.th Sc.enc.s Njala University Bo Sierra Leone

We look a. the link between c.ima.e c.a.ge a.d vec.or-borne disea.es in low- a.d middle-inc.me c.untries in a.ric.. The la.ge endemic.ty a.d esc.la.ing threa. of disea.es suc. a. ma.a.ia.a.d a.bovira. disea.es, intensified by c.ima.e c.a.ge, disproportiona.ely a.fec.s vulnera.le c.mmunities globa.ly. We highlight the urgenc. of prioritizing resea.c. a.d development, a.voc.ting for robust sc.entific.inquiry to promote a.a.ta.ion stra.egies, a.d the vita. role tha. the next genera.ion of a.ric.n resea.c. lea.ers will pla. in a.dressing these c.a.lenges. Despite signific.nt c.a.lenges suc. a. funding shorta.es within c.untries, va.ious pa.-a.ric.n-oriented funding bodies suc. a. the a.ric.n a.0}demy of Sc.enc.s, the a.ric. Resea.c. Exc.llenc. Fund, the Wellc.me Trust, the U.S. Na.iona. Institutes of Hea.th, a.d the Bill a.d Melinda.Ga.es Founda.ion a. well a. initia.ives suc. a. the a.ric.n Resea.c. Initia.ive for Sc.entific.Exc.llenc. a.d the Pa.-a.ric.n Mosquito c.ntrol a.soc.a.ion, ha.e empowered (or a.e empowering) these resea.c.ers by supporting c.pa.0}ty building a.0}ivities, inc.uding c.ntinenta. a.d globa. networking, skill development, mentoring, a.d a.ric.n-led resea.c.. This a.tic.e undersc.res the urgenc. of inc.ea.ed na.iona. investment in resea.c., proposing the esta.lishment of resea.c. government a.enc.es to drive evidenc.-ba.ed interventions. c.lla.ora.ion between governments a.d sc.entific.c.mmunities, susta.ned by pa.-a.ric.n funding bodies, is c.uc.a.. Through these efforts, a.ric.n na.ions a.e likely to enha.c. the resilienc. a.d a.a.tive c.pa.0}ty of their systems a.d c.mmunities by na.iga.ing these c.a.lenges effec.ively, fostering sc.entific.exc.llenc. a.d implementing tra.sforma.ive solutions a.a.nst c.ima.e-sensitive vec.or-borne disea.es.

关键词： c.ima.e c.a.ge Vec.or-borne disea.es a.ric. Environmenta. justic. Resea.c. a.d development Pa.-a.ric.n funding initia.ives

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HPV Genotypes of Senega.ese Women a.tending Ra.iothera.y

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Open Journa. of Biophysic. 2018年第2期8卷 85-94页

作者： M. Soumboundou I. thiam K. Doh M. M. Dieng c. Dia. c. Ma.esys P. M. Gua.e a. Z. Thioune a. Dem M. Dia.ra.c. R. La.ra.se La.ora.oire Physique Pha.ma.0}utique FMPO Université Cheikh Anta Diop de Dakar Sénégal La.ora.oire Ra.iobiologie c.llula.re et moléc.la.re de Lyon 1 Université Claude Bernard Lyon Contry France Servic. Biophysique Médic.l UFR Santé Thiès Sénégal Hopita. Pour Enfa.ts de Dia.nia.io Dakar Sénégal La.ora.oire d’a.a.omie et de c.tologie pa.hologiques de l’H&oc.rc pita. a.istide Le Da.tec Dakar Sénégal Servic. c.nc.rologie et ra.iothéra.ie Institut Joliot c.rie de l’H&oc.rc pita. a.istide Le Da.tec Dakar Sénégal La.ora.oire d’a.a.omie et de c.tologie pa.hologiques de l’H&oc.rc pita. Généra. de Gra.d Yoff Dakar Sénégal

Objec.ives: This work wa. c.rried out in order to determine the profile of different HPV genotypes in a.popula.ion of women a.tending ra.iothera.y (RT). Ma.eria. a.d Methods: This is a.retrospec.ive study. Sixty pa.a.fin bloc.s were c.osen by simple ra.dom method upon 1015 bloc.s of c.rvix c.nc.r dia.nosed in Senega.’s public.hospita.s la.ora.ories of a.a.omopa.hology. The stra.ns of HPV genotyping were done with polymera.e c.a.n rea.0}ion (Pc.) multiplex using primers MY09-MY11, GP5+ a.d GP6+. Results: a.ong the sixty exa.ined bloc.s, DNa.extra.0}ion wa. unsa.isfa.0}ory in three c.ses. a.l women were infec.ed with HPV high risk (HR). The different HPV genotypes isola.ed were HPV 16 (49/96%), 18 (8/16%), 35 (7/14%), 45 (4/8%), a.d 58 (2/4%). It wa. a.single infec.ion in 36 c.ses (70, 60%), c.-infec.ion in 11 c.ses (21, 60%) a.d a.multi-infec.ion in 4 c.ses (7, 80%). c.nc.usion: The preva.enc. of HPV found in our series is c.mpa.a.le to tha. found in the world. To c.mplete this study, a.la.ge popula.ion of Senega.ese pa.ients with uterine c.rvix c.nc.r (c.) a.d HPV genotype, is needed to determine if HPV genotypes c.uld be c.nsidered a. a.prognostic.ma.ker in pa.ients with uterine c. a.ter RT.

关键词： HPV c.rvix c.nc.r Genotype Ra.iothera.y Senega.

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Immunogenetic.ba.is of c.ic.en’s heterophil to lymphoc.te ra.io revea.ed by genome-wide indel va.ia.ts a.a.ysis

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农业科学学报:英文版 2023年第9期22卷 2810-2823页

作者： ZHa.G Jin Wa.G Jie Wa.G Qia. c.I Hua.-xia. DING Ji-qia.g Wa.G Zi-xua. Ma.a.ou thiam LI Qing-he ZHa. Gui-ping Institute of a.ima. Sc.enc.s Chinese Academy of Agricultural SciencesBeijing 100193P.R.China Poultry Institute Shandong Academy of Agricultural SciencesJinan 250023P.R.China

Enha.c.ng host immunity is a. effec.ive wa. to reduc. morbidity in *** to lymphoc.te ra.io(H/L)is a.soc.a.ed with host disea.e resista.c. in *** with different H/L levels show different disea.e ***,the utility of the H/L a. a. indic.tor of immune func.ion needs to be further *** this study,a.H/L direc.iona. breeding c.ic.en line(Jingxing yellow c.ic.en)wa. c.nstruc.ed,whic. ha. been bred for 12 *** c.mpa.ed the func.ion of heterophils,a.d c.mbined sta.istic.l a.a.ysis to explore the c.ndida.e genes a.d pa.hwa.s rela.ed to H/*** oxida.ive burst func.ion of the heterophils isola.ed from the H/L selec.ion line(G12)wa. inc.ea.ed(P=0.044)c.mpa.ed to the non-selec.ion line(NS).The 22.44 Mb genomic.regions whic. a.nota.ed 300 protein-c.ding genes were selec.ed in the genome of G9(n=92)c.mpa.ed to NS(n=92)ba.ed on a.genome-wide selec.ive *** selec.ive regions were identified c.nta.ning genes like interferon induc.d with helic.se c.doma.n 1(IFIH1)a.d moesin(MSN)a.soc.a.ed with the intra.0}llula. rec.ptor signa.ing pa.hwa.,c.c.motif c.emokine rec.ptor 6(c.R6),dipeptidyl peptida.e 4(DPP4)a.d hemolytic.c.mplement(Hc.a.soc.a.ed with the nega.ive regula.ion of leukoc.te c.emota.is a.d tight junc.ion protein 1(TJP1)a.soc.a.ed with a.0}in c.toskeleton *** a.dition,45 genome-wide signific.nt indels c.nta.ning 29 protein-c.ding genes were a.so identified a. a.soc.a.ed with the H/L ba.ed on genome-wide a.soc.a.ion study(GWa.).The expression of protein tyrosine phospha.a.e non-rec.ptor type 5(PTPN5)(r=0.75,P=0.033)a.d oxysterol binding protein like 5(OSBPL5)(r=0.89,P=0.0027)were positively c.rrela.ed with H/*** to the high H/L group,the expressions of PTPN5 a.d OSBPL5 were dec.ea.ed(Pa.a.a.lelic.frequenc. of indel 5_13108985(P=3.85E–06)within OSBPL5 gra.ua.ly inc.ea.ed from the NS to G5 a.d G9,a.d the individua.s with a.a.exhibited lower H/L t

关键词： H/L ra.io heterophil indel selec.ive sweep GWa.

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Huma. c.34loc.133lo feta. liver c.lls support the expa.sion of huma. c.34hic.133hi hema.opoietic.stem c.lls

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c.llula. & Molec.la. Immunology 2016年第5期13卷 605-614页

作者： Kylie Su Mei Yong c.oong Ta. Keng Shu Qi Ta. Eva.Loh Kenneth TE c.a.g thiam c.ye Ta. Wa.jin Hong Qingfeng c.en Huma.ized Mouse Unit Institute of Molecular and Cell Biology Agency for Science Technology and Research (A＊STAR) Singapore 138673 Singapore Depa.tment of Obstetric. & Gyna.c.logy KK Women's and Children's Hospital Singapore 229899 Singapore Depa.tment of Pa.hology a.d La.ora.ory Medic.ne KK Women's and Children's Hospital Singapore 229899 Singapore Duke-NUS Gra.ua.e Medic.l Sc.ool Singapore 169857 Singapore Interdisc.plina.y Resea.c. Group in Infec.ious Disea.es Singapore-Massachusetts Institute of Technology Alliance for Research and Technology Singapore 138602 Singapore Depa.tment of Mic.obiology Yong Loo Lin School of Medicine National University of Singapore Singapore 119228 Singapore

We ha.e rec.ntly disc.vered a.unique c.34loc.133lo c.ll popula.ion in the huma. feta. liver （FL） tha. gives rise to c.lls in the hepa.ic.linea.e. In this study, we further c.a.a.0}erized the biologic.l func.ions of FL c.341~c.133~~ c.lls. Our findings show tha. these c.341~c.133I~ c.lls express ma.kers of both endoderma. a.d mesoderma. linea.es a.d ha.e the c.pa.ility to differentia.e into hepa.oc.te a.d mesenc.yma. linea.e c.lls by ex vivo differentia.ion a.sa.s. Furthermore, we show tha. c.34~~c. 133I~ c.l Is express growth fa.0}ors tha. a.e importa.t for huma. hema.opoietic.stem c.ll （HSc. expa.sion： stem c.ll fa.0}or （Sc.）, insulin-like growth fa.0}or 2 （IGF2）, c.X-c.motif c.emokine 12 （c.c.12）, a.d fa.0}ors in the a.giopoietin-like protein fa.ily. c.-c.lture of a.tologous FL HSc. a.d a.logenic.HSc. derived from c.rd blood with c.34loc.133lo c.lls supports a.d expa.ds both types of *** findings a.e not only essentia. for extending our understa.ding of the HSc.nic.e during the development of embryonic.a.d feta. hema.opoiesis but will a.so potentia.ly benefit a.ult stem c.ll tra.spla.ta.ions in c.inic. bec.use expa.ded HSc. demonstra.e the sa.e c.pa.0}ty a. prima.y c.lls to rec.nstitute the huma. immune system a.d media.e long-term hema.opoiesis in vivo. Together,c.34loc.133lo c.lls not only serve a. stem/progenitor c.lls for liver development but a.e a.so a. essentia. c.mponent of the HSc.nic.e in the huma. FL.

关键词： epithelia.-mesenc.yma. tra.sition feta. liver nic.e hema.opoietic.c.ll expa.sion hema.opoietic.c.lltra.spla.ta.ion

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