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API2-MALT1 oncoprotein promotes lymphomagenesis via unique program of substrate ubiquitination and proteolysis

World Journal of Biological chemistry 2016年第1期7卷 128-137页

作者： Shaun Rosebeck Megan S Lim Kojo SJ Elenitoba-Johnson Linda MMcAllister-lucas Peter c lucas Department of Medicine University of Chicago Department of Pathology and Laboratory Medicine Stellar-Chance LaboratoriesUniversity of Pennsylvania Perelman School of Medicine Department of Pediatrics Division of Hematology/OncologyUniversity of Pittsburgh School of Medicine children’s Hospital of Pittsburgh of UPMc Department of Pathology and Pediatrics University of Pittsburgh School of Medicine

Lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is the most common extranodal B cell tumor and accounts for 8% of non-Hodgkin’s lymphomas. Gastric MALT lymphoma is the best-studied example and is a prototypical neoplasm that occurs in the setting of chronic inflammation brought on by persistent infection or autoimmune disease. cytogenetic abnormalities are commonly acquired during the course of disease and the most common is chromosomal translocation t(11;18)(q21;q21), which creates the API2-MALT1 fusion oncoprotein. t(11;18)-positive lymphomas can be clinically aggressive and have a higher rate of dissemination than t(11;18)-negative tumors. Many cancers, including MALT lymphomas, characteristically exhibit deregulated over-activation of cellular survival pathways, such as the nuclear factor-κB (NF-κB) pathway. Molecular characterization of API2-MALT1 has revealed it to be a potent activator of NF-κB, which is required for API2-MALT1-induced cellular transformation, however the mechanisms by which API2-MALT1 exerts these effects are only recently becoming apparent. The API2 moiety of the fusion binds tumor necrosis factor (TNF) receptor associated factor (TRAF) 2 and receptor interacting protein 1 (RIP1), two proteins essential for TNF receptor-induced NF-κB activation. By effectively mimicking ligand-bound TNF receptor, API2-MALT1 promotes TRAF2-dependent ubiquitination of RIP1, which then acts as a scaffold for nucleating and activating the canonical NF-κB machinery. Activation occurs, in part, through MALT1 moiety-dependent recruitment of TRAF6, which can directly modify NF-κB essential modulator, the principal downstream regulator of NF-κB. While the intrinsic MALT1 protease catalytic activity is dispensable for this canonical NF-κB signaling, it is critical for non-canonical NF-κB activation. In this regard, API2-MALT1 recognizes NF-κB inducing kinase (NIK), t

关键词： Oncogene Fusion oncoprotein Lymphoma chromosomal translocation Ubiquitination Apoptosis Nuclear factor-κ B caspases

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Indian medicinal plants are effective in the treatment and management of cOVID-19

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BIOcELL 2023年第4期47卷 677-695页

作者： SUBHASH cHANDRA SANTWANA PALAI EDINARDO FAGNER FERREIRA-MATIAS IVO cAVALcANTE PITA-NETO cÍcERO lucas GOMES-RAMALHO EDLANE MARTINS DE ANDRADE RAY SILVA DE ALMEIDA MARcELLO IRITI HENRIQUE DOUGLAS MELO-cOUTINHO Department of Pharmaceutical chemistry SGRR UniversityUttarakhand248001India Department of Pharmaceutical chemistry HNB Garhwal UniversitySrinagar246174India Department of Veterinary Pharmacology&Toxicology College of Veterinary Science and Animal HusbandryBhubaneswar751003India cEcAPE—college of Dentistry Juazeiro do Norte63050-203Brazil Department of Biological chemistry Regional University of CaririCrato63105-000Brazil Department of Biomedical Surgical and Dental SciencesUniversitàdegli Studi di MilanoMilan20133Italy National Interuniversity consortium of Materials Science and Technology Florence50121Italy

Indian medicinal plants are referred to as the“nectar of life”owing to their phytochemicals and bioactive complexes that are beneficial in treating *** disease 2019(cOVID-19)is a global health issue without any proper *** indigenous plants of India can be exploited to control the precise signs of *** Ministry of AYUSH(Ayurveda,Yoga and Naturopathy,Unani,Siddha,and Homeopathy)has advised routine usage of medicinal plants for *** plants like Zingiber officinalis,Azadirachta indica,Ocimum sanctum,Nigella sativa,Withania somnifera,curcuma longa,Piper nigrum,Allium sativum,Tinospora cordifolia,*** immunity-boosting,antiviral,antibacterial,antioxidant and anti-inflammatory actions that can suppress and treat symptoms of *** vitro,in vivo as well as in silico validation,these phytochemicals can help us to manage and treat cOVID-19 *** integration of traditional knowledge in the prophylaxis of corona infection and current skills validating it for the development of precise and powerful therapeutic approaches will more efficiently resolve different clinical aspects of *** review focuses on both traditional and emergent methods to prevent and treat cOVID-19 with various Indian medicinal plants along with their phytochemicals.

关键词： Antiviral corona virus Diagnosis Immunity Herbs

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重危病人的体液问题

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国外医学.麻醉学与复苏分册 1984年第6期5卷 280-285页

作者： lucas c E 赵维庆

人体的含水量在一个70公斤的男性为42升,约占总体重的60%。其中血浆占3升,组织间隙占11升,细胞内液占28升。这三个不同部分相互间保持着恒定的平衡,并各有表现独特的生理功能。其中血浆部分容量最少,被限于血管系统内,最易于研究,所以... 详细信息

人体的含水量在一个70公斤的男性为42升,约占总体重的60%。其中血浆占3升,组织间隙占11升,细胞内液占28升。这三个不同部分相互间保持着恒定的平衡,并各有表现独特的生理功能。其中血浆部分容量最少,被限于血管系统内,最易于研究,所以已有广泛的研究。因此,液体治疗往往只依据血浆容量变化,而没有把间隙液与细胞内液的变化考虑在内。正常情况血浆内的水及其溶质在前毛细

关键词：重危病人低血压血管内低血容量休克组织间隙血管外液血浆容量白蛋白生理性分流出血性休克血源性休克机械呼吸少尿乏尿症液体治疗

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Health 2020年第10期12卷 1360-1370页

作者： lucas Lima de carvalho lucas Rodrigues claro Amanda dos Santos cabral Marcela Pereira da Silva Mello Bruna Liane Passos lucas Marcelly Valadares Souza Simone Fonseca lucas Alexandre Oliveira Tellles Ravini Fernandez dos Santos Vieira dos Santos Marcia Augusta Pereira dos Santos claudia Lima campos Alzuguir Maria cristina Dias da Silva Antonio Eduardo Vieira dos Santos Maria Antonieta Rubio Tyrrell Eduardo Alexander Júlio césar Fonseca lucas Anna Nery School of Nursing Federal University of Rio de Janeiro Rio de Janeiro Brazil celso Lisboa University center Rio de Janeiro Brazil State Secretariat of Education of Rio de Janeiro Rio de Janeiro Brazil Department of Medicine in Primary Health care Faculty of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil Department of Maternal and child Nursing Faculty of Nursing State University of Rio de Janeiro Rio de Janeiro Brazil Department of Maternal-child Nursing Faculty of Nursing Fernandez Figueira Institute of the Oswaldo Cruz Foundation State University of Rio de Janeiro Rio de Janeiro Brazil

This documentary research aimed to describe the results of an epidemiological survey that sought to determine the prevalence of Infections Related to Health care (IRHc) in newborns admitted to a Neonatal Intensive care Unit (NIcU) at the city of Rio de Janeiro. For methodology, the existing data in the original research database were used as the primary source. The method used was the case study in a quantitative approach. The data have been statistically arranged by odds ratio, which measured the possibility of IRHc development at the 102 newborns, by exposition at the risk factors. Results: IRHc prevalence with pneumonias, sepsis, navel’s infection and ocular infections predominance rises. Prematures are 4.10 more susceptible. Twelve hours after amniotic rupture there are 1.77 more chances of infections. Babies with more than 10 days of hospitalization are 4.70 more susceptible than those with 10 days. The registers examined were incipient at the IRHc’s characterization, beginning and duration, which make the IRHc’s diagnostic/notification difficult.

关键词： Neonatal Nursing cross Infection Data Interpretation Statistical

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智能多分支井作业的近井模拟

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国外石油动态 2002年第23期 7-10页

作者： c.lucas 廉抗利

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Associations between partial foot amputation level,gait parameters,and minimum impairment criteria in para-sport:A research study protocol

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Sports Medicine and Health Science 2022年第1期4卷 70-73页

作者： Fabio c.lucas de Oliveira Samuel Williamson clare L.Ardern Neil Heron Dina christa Janse van Rensburg Marleen G.T.Jansen Sean O'connor Linda Schoonmade Jane Thornton Babette M.Pluim center for Interdisciplinary Research in Rehabilitation and Social Integration CIUSSS-CNUniversite LavalQuebec CityQuebecCanada Research Unit in Sport and Physical Activity(cIDAF) Faculty of Sport Sciences and Physical EducationUniversity of CoimbraCoimbraPortugal English Institute of Sport LondonUK Division of Physiotherapy Karolinska InstituteStockholmSweden center for Public Health Queen's University BelfastBelfastUK Department of General Practice Keele UniversityStaffordshireUK Section Sports Medicine Faculty of Health SciencesUniversity of PretoriaPretoriaSouth Africa Royal Dutch Lawn Tennis Association(KNLTB) Amstelveenthe Netherlands centre for Human Movement Sciences University Medical Centre GroningenUniversity of GroningenGroningenthe Netherlands School of Medicine Dentistry and Biomedical Sciences Centre for Public HealthQueen's University BelfastBelfastUK Medical Library Vrije Universiteit AmsterdamAmsterdamthe Netherlands Department of Family Medicine Schulich School of Medicine&DentistryUniversity of Western OntarioLondonOntarioCanada Department of Epidemiology&Biostatistics Schulich School of Medicine&DentistryUniversity of Western OntarioLondonOntarioCanada AMc/VUmc IOc Research center of Excellence Amsterdam Collaboration on Health&Safety in Sports(ACHSS)AmsterdamNetherlands

Altered biomechanics due to amputation can contribute to substantial limitations,influencing sporting *** with lower extremity amputations or congenital lower limb deficiency are encouraged to participate in ***,to compete in Paralympic sports,the candidate must have an impairment that results in lower extremity loss of function and meets or exceeds the sport's minimum impairment criteria(MIc).This review will focus on the MIc for competitive wheelchair *** deficiency is known as one of the MIc used to regulate participation in competitive para-sports since it impacts gait,kinematics,and biomechanics of both the upper and lower ***,it is questionable whether the MIc concerning limb deficiency is set at the correct level for determining eligibility for participating in Paralympic *** study aims to provide an overview of the evidence examining the impact of different partial foot amputation(PFA)levels on gait as a proxy for sporting *** scoping review will be based on a 6-step methodological framework and Preferred Reporting Items for Systematic Reviews and Meta-Analysis,extension for scoping reviews(PRISMA-ScR).Studies will be selected from PubMed,Embase,cINAHL,and *** authors will screen the titles/abstracts *** studies will be scrutinised,and the same authors will extract *** will be relevant to informing the evidence-based development of MIc for lower limb impairment after PFA and may be extrapolated to specific Paralympic sports,including wheelchair *** will be disseminated through scientific publications and conferences to audiences interested in Paralympic sports.

关键词： Amputees congenital deficiency Gait analysis Paralympic sport Partial foot amputation Wheelchair tennis

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危重病人的液体问题

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新乡医学院学报 1985年第S1期 60-65页

作者： lucas c E Ledgerwood A M 薛福善

人的体液状态主要由总体含水量所反映。体重70公斤的健康人,平均约含42升体液或占体重的60%。42升体液是分布在血浆(3升)、组织间(11升)和细胞内(28升)。三部分体液的流速和构成处于动态平衡状态。每部分体液均有自己特定的部位和独特... 详细信息

人的体液状态主要由总体含水量所反映。体重70公斤的健康人,平均约含42升体液或占体重的60%。42升体液是分布在血浆(3升)、组织间(11升)和细胞内(28升)。三部分体液的流速和构成处于动态平衡状态。每部分体液均有自己特定的部位和独特的功能。在三部分体液中,血浆容量最小,且局限于血管系统内。因为血浆最易接近,大

关键词：危重病人白蛋白 PWP cVP 患者液体治疗低血容量休克平衡液组织间液血容量脓毒血症充盈压血管外液

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang Wei Kang Zhou Xin Huang Xing Zhou Jie Xu Taoyi Kong Junwei lucas Bao Xiaoli Dong Yonggang Wang Department of chemistry and Shanghai Key Laboratory of Molecular catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like c,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDc） has been developed with low redox potential （cellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDc-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDc anode material for SIBs.

关键词： Organic anode material Low redox potential composite anode Sodium-ion batteries

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使用层状复合探测器中的caF2（Eu）进行低本底β射线计数

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世界核地质科学 1984年第3期 58-61页

作者： M.R.Mayhugh A.c.lucas B.K.Utts 曾菱

用薄caF2（Eu）闪烁体与厚NaI（T1）辅助闪烁体（起保护作用）相组合,便可构成用于低本底β射线计数的层状探测器。在反符合计数线路中,采用caF2（Eu）与NaI（T1）结合的探测器能减少本底大约2倍。这是因为可以抑制康普顿散射,并且NaI... 详细信息

用薄caF2（Eu）闪烁体与厚NaI（T1）辅助闪烁体（起保护作用）相组合,便可构成用于低本底β射线计数的层状探测器。在反符合计数线路中,采用caF2（Eu）与NaI（T1）结合的探测器能减少本底大约2倍。这是因为可以抑制康普顿散射,并且NaI（T1）晶体是一个有效的屏蔽层。如果探测器结构本身的放射性很低,采用薄caF2（Eu）则可减少本底,其降低值与探测器厚度成正比。概述如果两个闪烁体的闪烁衰减时间有明显差别,那么将两个层状闪烁体光学地耦合在一起,就可以分辨出不同闪烁体中产生的辐射事件。为此,采用一个普通的光电倍增管与这种层状复合闪烁体相组合,便可根据脉冲形状区

关键词：探测器厚度本底计数 caF2 层状复合低本底 Eu

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采用近井筒模拟技术管理多分支智能井

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国外油田工程 2003年第3期19卷 28-29页

作者： c.lucas 刘凤姣范建敏戴启栋杨利平中原油山分公司采油工程技术研究院中原油田分公司井下特种作业处

针对一口大位移双分支井的两年生产历程进行了研究。为了减少产水,优化大功率电潜泵的举升能力,该井中分支段地开采采用井下流量控制阀加以控制。研究中模拟了井下流量控制对生产动态的影响,评价了在变换完井方式的情况下,生产动态变化... 详细信息

针对一口大位移双分支井的两年生产历程进行了研究。为了减少产水,优化大功率电潜泵的举升能力,该井中分支段地开采采用井下流量控制阀加以控制。研究中模拟了井下流量控制对生产动态的影响,评价了在变换完井方式的情况下,生产动态变化的模拟情况。该模型也可用来选择井下流量控制阀的设置深度,使其处于最利于生产的位置。

关键词：近井筒模拟多分支智能井油井管理油藏模拟计算机软件应用

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