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chronic hepatitis c infection in a patient with bone marrow hypoplasia

World Journal of Gastroenterology 2008年第26期14卷 4238-4240页

作者： S Bethlen K chandrikakumari L de Leval JB Giot D Mukeba P Leonard F Frippiat c meuris J Delwaide M Moutschen centre Hospitalier Universitaire de Liege Liege 4000Belgium Medical Student Department of Infectious Diseases and Internal Medicine Centre Hospitalier Universitaire de LiegeLiege 4000Belgium Department of Pathology Centre Hospitalier Universitaire de LiegeLiege 4000Belgium Department of Gastroenterology and Hepatology Centre Hospitalier Universitaire de LiegeLiege 4000Belgium

chronic hepatitis c virus(HcV) infection is associated with multifarious extra-hepatic manifestations;the most described and discussed being mixed cryoglob-ulinemia which is strongly related to B-cell lympho-proliferative disorders(LPDs).We present a case of chronic HcV infection and mixed cryoglobulinemia,with minimal liver *** case is a 53-year-old patient who was diagnosed as having bone marrow hypoplasia at the age of *** received several blood transfusions to normalize her *** the age of 31,she was diagnosed with rheumatoid ar-thritis on account of her diffuse joint pain and inflam-mation,elevated rheumatoid factor(RF) and Raynaud's *** years later,monoclonal gam-mopathy of IgG Lambda(one year later,changed to IgM Kappa) was detected during a routine examina-tion.A bone marrow biopsy showed hypoplasia,Kappa positive B-lymphocytes and low-grade malignant lym-phoma *** of the bone marrow aspirate was not *** treatment was initiated owing to herpoor bone marrow function and she is under regular follow-up.

关键词： chronic hepatitis c infection Mixed cryoglobulinemia Prognosis

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Development of mucoadhesive sericin/alginate particles loaded with ibuprofen for sustained drug delivery

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Particuology 2018年第6期16卷 65-73页

作者： Emanuelle D.Freitas Jacyara M.M.Vidart Edson A.Silva meuris G.c.da Silva Melissa G.A.Vieira Department of Processes and Products Design School of Chemical EngineeringUniversity of Campinas-UNICAMPAlbert Einstein Avenue50013083-852CampinasSPBrazil School of chemical Engineering State University of West Parana-UNIOESTEFaculdade Street64585903-000ToledoPRBrazil

A sericin/alginate blend was successfully applied as a matrix for incorporation of *** provided a sustained release formulation,which could improve the therapeutic efficacy of ibuprofen and patient adherence to *** increased the proportion of drug incorporated into the particles (i.e., the drug incorporation efficiency),with incorporation rates between 73.01%±1.70%and 94.15%±4.21%. Alginate affected the drug release,and the particles with the maximum alginate mass fraction tested (2.8%)showed sustained release through a dissolution mechanism,reaching equilibrium after about *** of the incorporation efficiency and the drug release time showed the best results were for formulations with a high alginate *** electron microscopy,Fourier transform infrared spectroscopy,and X-ray diffraction analysis were used for particle characterization to study the incorporation of *** particle size range was 0.80±0.13to 1.08±*** size distributions of sericin-containing particles showed a good fit with the Gaussian model.

关键词： Sericin Alginate Ibuprofen Sustained drug release

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基于硅的锗外延技术实现高性能cMOS器件

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集成电路应用 2006年第11期23卷 35-37页

作者： c.Werkhoven c.Arena M.Bauer P.Brabant M.meuris T.Valentina L.Souriau ASM America IMEc

相对于采用选择性锗硅外延的应变硅而言,基于锗工艺制造的 PMOS 能够进一步提高其驱动能力。将适当的锗前驱物安装在标准硅外延设备上就可以生产锗硅(GOS)晶圆。

关键词： cMOS器件应变硅锗硅技术实现性能驱动能力 PMOS 工艺制造

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