检索结果-南通市图书馆

Phosphatic microspherules and their geobiological implications from the Frasnian-Famennian transition at the Yangdi section, Guilin, South china

引用

Science china Earth Sciences 2014年第6期57卷 943-956页

作者： huang cheng GONG YiMing State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences

Abundant perfectly-preserved phosphatic microspherules have been discovered across the Frasnian-Famennian （F-F） transition from the Yangdi section in Guilin, Guangxi, South china. They are mostly spherical or elliptical in shape and about 150 gin in diameter with smooth exterior surfaces. Each microspherule consistently possesses a small dimple on the surface. The internal texture of microspherules consists of concentric light-colored apatite and dark-colored organic matter bands alternating around a central core. conodonts have also been found preserved together with phosphatic microspherules in the same horizon, and the abundance of the former is obviously higher than that of the latter. Laser Raman spectral studies show close similarities in spectral patterns between the outer shells of phosphatic microspherules and the blade of the conodont genus Palmatolepis sp., as well as between the microspherule nucleus and the platform of the same conodont genus. Furthermore, the statistical results and geochemical data demonstrate that the elevated abundance of phosphatic microspherules roughly coincides with the blooms of bacteria and algae, but is later than the sharp increase of oceanic nutrients. The phosphatic microspherules are inter- preted here to be the ＇otoliths＇ secreted by conodont animals based on the compositional similarities between phosphatic mi- crospherules and conodonts and their interrelated abundances. In addition, an analogous study reveals morphological and tex- tural similarities between fish otoliths and phosphatic microspherules. The formation of phosphatic microspherules is probably related to seawater eutrophication. We speculate that the explosive growth of bacteria and algae is probably caused by the en- richment of nutrients that is most likely associated with the increase of terrestrial inputs, submarine hydrothermal activities or the upwelling anoxic bottom waters in the late Devonian, which would stimulate the conodont animals to secrete

关键词： microspherules conodont animal otoliths eutrophication Devonian F-F South china

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study of the mechanisms of acupuncture and moxibustion treatmentfor ulcerative colitis ratsinview of the gene expression of cytokines

引用

World Journal of Gastroenterology 1999年第6期5卷 515-517页

作者： Wu HG Zhou LB Pan YY huang c chen HP Shi Z Hua XG Shanghai Inst Acupuncture Moxibust & Meridians Shanghai 200030 Peoples R China

AIM:To observe the effect of acupuncture and moxibustion on the expression of IL-1beta and IL-6 mRNA in ulcerative colitis ***:The SD rat ulcerative colitis model was created by immunological method associated with local stimulation. colonic mucosa was prepared from human fresh surgical colonic specimens, homogenized by adding appropriate amount of normal saline and centrifuged at 3000r/min. The supernatant was collected for measurement of protein conentration and then mixed with Freund adjuvant. This antigen fluid was first injected into the plantae of the model group rats, and then into their plantae, dorsa, inguina and abdominal cavities (noFreund adjuvant for the last injection) again on the 10th, 17th, 24th and 31st day. When a certain titer of serum anti colonic antibody was reached, 2% formalin and antigen fluid (no Freund adjuvant) were administered separately by enema. The ulcerative colitis rat model was thus set up. The animals were randomly divided into four groups: model control group (Mc, n = 8), electro acupuncture group (EA, n = 8), herbs partition moxibustion group (HPM 8), normal control group (Nc,n = 8). HPM: Moxa cones made of refined mugwort floss were placed on the medicinal pad (medicinal pad dispensing: Radix Aconiti praeparata, cortex cinnamomi, etc) for Qihai (RN 6) and Tianshu (ST 25, bilateral) and ignited. Two moxa cones were used for each acupoint once a day and 14 times in all. EA: Tianshu (bilateral) and Qihai were stimulated by the intermittent pulse with 2Hz frequency, 4mA intensity for 20 minutes once a day and 14 times in all. After treatment, rats of all four groups were killed simultaneously. The spleen was separated and the distal colon was dissected. Total tissue RNA was isolated by the guanidinium thiocyanate phenol chloroform extraction method. RT-PcR technique was used to study the expression of IL-1 beta and IL-6 ***:IL-1 beta and IL-6 mRNAs were not detected in the spleen and colonic mucosa of the Nc rat

关键词： colitis, ulcerative/therapy acupuncture and moxibustion therapy gene expression cytokines interleukin-1 beta interleukin-6

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The contemporary role of metastasectomy in the management of metastatic Rcc

引用

Journal of cancer Metastasis and Treatment 2021年第1期7卷 926-937页

作者： Zachary Feuer Jacob I.Taylor William c.huang Department of Urology New York University Langone Health New York 10016 NY United States

Metastasectomy was initially described in the 1970s as a therapeutic strategy for patients with metastatic renal cell *** that time,systemic therapy options have grown exponentially,most recently with the introduction of *** aimed to review the contemporary literature regarding the role of metastasectomy in the era of targeted therapy and ***,metastasectomy has benefited patients with small volume,single-organ metastases,with favorable outcomes amongst younger,healthier patients with metastases to specific *** interplay between the employment of metastasectomy and systemic therapy has been limited to small,retrospective series with significant patient selection *** recently,investigators have conducted randomized controlled trials exploring the use of targeted therapies in the adjuvant setting after *** randomized data suggested no benefit in using sorafenib in this setting,and a subsequent study demonstrated possible harm in using pazopanib after ***,the role of other novel systemic therapies,including immunotherapy,nor the timing of use,have been meaningfully *** appears to be a valuable therapeutic option in the properly selected patient,requiring a multi-disciplinary management strategy and,pending future trials,a multimodal treatment approach.

关键词： clear-cell metastatic renal cell carcinoma metastasectomy immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent upper gastrointestinal panendoscopy increases the risk of pyogenic liver abscess

引用

World Journal of Gastroenterology 2017年第16期23卷 2948-2956页

作者： Ming-Jen Tsai chin-Li Lu Ying c huang chung Hsien Liu Wan-Ting huang Kai-Yuan cheng Solomon chih-cheng chen Department of Emergency Medicine Ditmanson Medical Foundation Chia-Yi Christian HospitalChiayi 60002Taiwan Department of Sports Management Chia Nan University of Pharmacy and ScienceTainan 71710Taiwan Department of Public Health College of MedicineNational Cheng-Kung UniversityTainan 70101Taiwan Department of Emergency Medicine Medical Center and School of MedicineKaohsiung Medical UniversityKaohsiung 807Taiwan Department of Medical Research Ditmanson Medical Foundation Chia-Yi Christian HospitalChiayi 60002Taiwan Heng chun christian Hospital Pingtung County 946Taiwan

AIM To investigate the association between a recent gastrointestinal(GI) endoscopy and the subsequent risk of pyogenic liver abscess(PLA).METHODS We designed a nested case control study. Using the Taiwan National Health Insurance Research Database, 2135 patients with a first diagnosis of PLA were identified from 1998 to 2011. Another 10675 patients without PLA matched by age and sex were selected as reference controls. We identified and compared the possible risk factors for PLA and GI endoscopies performed before the index date(when PLA was diagnosed) between the two cohorts. Multivariate analysis was conducted to examine the risk of PLA within the 90 d after the GI *** Patients with a history of diabetes [adjusted odds ratio(a OR) = 4.92, 95%cI: 1.78-13.61], end-stage renal disease(a OR = 3.98, 95%cI: 1.45-10.91), biliary tract infection(a OR = 2.68, 95%cI: 2.11-3.40), liver cirrhosis(a OR = 2.19, 95%cI: 1.39-3.46), GI malignancies(a OR = 5.68, 95%cI: 4.23-7.64), appendicitis(a OR = 3.16, 95%cI: 2.27-4.41), diverticulitis(a OR = 1.64, 95%cI: 1.01-2.64), and recent endoscopic retrograde cholangiopancreatography(a OR = 27.04, 95%cI: 11.65-62.72) were significantly associated with an increased risk of PLA. After adjusting for the above risk factors and the frequency of outpatient department visits and abdominal ultrasounds during 90 d before the index date, an upper GI panendoscopy(a OR = 2.75, 95%cI: 2.05-3.69) but not a lower GI endoscopy(a OR = 1.07, 95%cI: 0.62-1.86) was significantly associated with *** An upper GI panendoscopy performed before 90 d may increase the risk of PLA.

关键词： Appendicitis colonoscopy Diverticulitis Gastrointestinal endoscopy Panendoscopy Pyogenic liver abscess

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Real-time four-dimensional scanning transmission electron microscopy through sparse sampling

引用

chinese Physics B 2024年第11期33卷 34-38页

作者： A W Robinson J Wells A Moshtaghpour D Nicholls c huang A Velazco-Torrejon G Nicotra A I Kirkland N D Browning 无 SenseAI Innovations Ltd. LiverpoolUK centre for Doctoral Training University of LiverpoolLiverpoolUK correlative Imaging Group Rosalind Franklin InstituteOxfordUK cNR-IMM Z.I.VIII Strada 5Catania95121Italy Department of Mechanical Materialsand Aerospace EngineeringUniversity of LiverpoolLiverpoolUK

Four-dimensional scanning transmission electron microscopy(4-D STEM)is a state-of-the-art image acquisition mode used to reveal high and low mass elements at atomic *** acquisition of the electron momenta at each real space probe location allows for various analyses to be performed from a single dataset,including virtual imaging,electric field analysis,as well as analytical or iterative extraction of the object induced phase ***,the limiting factor in 4-D STEM is the speed of acquisition which is bottlenecked by the read-out speed of the camera,which must capture a convergent beam electron diffraction(cBED)pattern at each probe position in the *** developments in sparse sampling and image inpainting(a branch of compressive sensing)for STEM have allowed for real-time recovery of sparsely acquired data from fixed monolithic detectors,Further developments in compressive sensing for 4-D STEM have also demonstrated that acquisition speeds can be increased,i.e.,live video rate 4-D imaging is now *** this work,we demonstrate the first practical implementations of compressive 4-D STEM for real-time inference on two different scanning transmission electron microscopes.

关键词： compressive sensing 4-D STEM inpainting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Natural cerebrolysin induces neuronal differentiation in bone marrow mesenchymal stem cells

引用

Neural Regeneration Research 2009年第3期4卷 178-185页

作者： Zhengzhi Wu Yinghong Li Andrew c. J. huang Ming Li Min Yang Manyin chen Shenzhen Hospital Southern Medical University Shenzhen 518035 Guangdong Province China Larry Hillblom Islet Research center David Geffen School of Medicine UCLA Los Angeles CA 90024 USA

BAcKGROUND： Bone marrow mesenchymal stem cells （MScs） have been shown to differentiate into neuronal-like cells through the use of several factors, such as 2-mercaptoethanol, dimethyl sulfoxide, or monothioglycero However, these factors are not suitable for human use due to toxicity. Theoretically speaking, traditional chinese medicine could be used as potential and safe factors. OBJEcTIVE： To investigate the effect of natural cerebrolysin on neuronal-like differentiation of MScs, based on protein and mRNA analyses. DESIGN, TIME AND SETTING： A parallel controlled, in vitro experiment was performed at the Institute of Integrated chinese and Western Medicine, Shenzhen Hospital, Southern Medical University, between June 2006 and April 2008. MATERIALS： Natural cerebrolysin was provided by Shenzhen Institute of Integrated chinese and Western Medicine, china. It primarily consisted of Renshen （Radix Ginseng）, Tianma （Rhizoma Gastrodiae）, and Yinxingye （Ginkgo Leaf） at a proportion of 1：2：2. Natural cerebrolysin extract （1：20） was prepared using conventional water extraction methodology. Each gram of extract equaled 20 grams of the crude drug. Twelve adult, male, New Zealand rabbits were included, six of which underwent intragastric administration of natural cerebrolysin extract （0.976 g/kg per day） for 1 month for natural cerebrolysin-containing serum. The remaining six rabbits received intragastric administration of equal volumes of physiological saline for normal blank serum. METHODS： Sprague Dawley male rats, 6-8 weeks old, were used to harvest tibial and femoral bone marrow. Isolation and purification of MScs were established from the whole bone marrow by removing the non-adherent cells in primary and passage cultures. For cellular identification, MScs from four to five passages were co-cultured with LG-DMEM media containing 10% natural cerebrolysin. Simultaneously, MScs cultured in/G-DMEM media containing 10% blank rabbit serum served as the control group. MAIN OUTcO

关键词： natural cerebrolysin bone marrow mesenchymal stem cells differentiation neuronal-like cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of serum containing natural cerebrolysin on glucose-regulated protein 78 and ccAAT enhancer-binding protein homologous protein expression in neuronal Pc12 cells following tunicamycin-induced endoplasmic reticulum stress

引用

Neural Regeneration Research 2009年第2期4卷 92-97页

作者： Zhengzhi Wu Ming Li Andrew c.J. huang O Xiuqing Jia Yinghong Li Manyin chen Shenzhen Hospital Southern Medical University Shenzhen 518033 Guangdong Province China Larry Hiflblom Islet Research center David Geffen School of Medicine UCLA Los Angeles CA 90024 USA

BAcKGROUND： Glucose-regulated protein 78 （GRP78）, a marker of endoplasmic reticulum stress, can prolong cell survival. Alternatively, ccAAT enhancer-binding protein homologous protein （cHOP）, a transcription factor specific for endoplasmic reticulum stress, can cause cell cycle arrest and cell apoptosis. OBJEcTIVE： To study the protective effects of serum containing natural cerebrolysin on endoplasmic reticulum stress in tunicamycin-induced neuronal Pc12 cells, and analyze the influence on GRP78 and cHOP expressions. DESIGN, TIME AND SETTING： A parallel controlled study was performed at the Institute of Integrated Western and Traditional chinese Medicine, Shenzhen Hospital, Southern Medical University, between March 2006 and August 2008. MATERIALS： Adult Sprague-Dawley rats were perfused with natural cerebrolysin aqueous extract （0.185 g/kg/d） to produce serum containing natural cerebrolysin. Physiological saline was used to produce blank serum. Pc12 cell line was provided by Shanghai Institute of cell Biology, chinese Academy of Science. Tunicamycin was provided by Sigma （St. Louis, USA）, and natural cerebrolysin, containing ginseng, rhizoma gastrodiae, and gingko leaf （1：2：2）, by Shengzhen Institute of Integrated Western and Traditional chinese Medicine. METHODS： Pc12 cells were treated with DMEM culture media containing 10% blank serum （normal control group）, tunicamycin （1 μg/mL; model group）, and 5%, 10%, and 15% serum containing natural cerebrolysin and tunicamycin （1 μ g/mL; low-, moderate-, and high-dose serum containing natural cerebrotysin groups）, for 2 hours. MAIN OUTcOME MEASURES： Pc12 cells were treated with tunicamycin for 48 hours after which apoptosis was measured using the TUNEL method to calculate apoptotic index. GRP78 expression was detected using immunocytochemistry. After 24 hours of treatment with tunicamycin, GRP78 and cHOP mRNA expressions were measured using RT-PcR. RESULTS： The apoptotic index and cHOP mRNA expression were in th

关键词： natural cerebrolysin Pc12 cell strain endoplasmic reticulum stress tunicamycin glucose regulated protein 78 ccAAT/enhancer-binding protein homologous protein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

THERMODYNAMIc PARAMETERS IN THE NUcLEATION OF LIQUID IRON

引用

Acta Metallurgica Sinica(English Letters) 2003年第6期16卷 519-523页

作者： c.huang B.Song J.H.Mao Q.Lin P.Zhao UniversityofScienceandTechnologyBeijing Beijing100083China centralIronandSteelResearchInstitute Beijing100081China

By using of electrolytic pure iron, the specimens containing different oxide content were made in a Mo wire furnace. The DTA method was employed to measure the undercooling of liquid iron during solidification. The relations between the cleanness of liquid iron and undercooling, thermodynamic driving force of nucleation, the nucleus forming energy, as well as the critical radius of nucleus have been investigated. The results showed that with the increase of cleanness of liquid iron the undercooling and thermodynamic driving force increased, while the nucleus forming energy and critical radius of nucleus decreased.

关键词： pure iron cleanness undercooling thermodynamic parameter

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Energy Efficient Run-Time Incremental Mapping for 3-D Networks-on-chip

引用

Journal of computer Science & Technology 2013年第1期28卷 54-71页

作者： Xiao-Hang Wang Peng Liu Mei Yang Maurizio Palesi Ying-Tao Jiang Michael c huang Intelligent chips and Systems Research centre Guangzhou Institute of Advanced Technology Chinese Academy of Sciences Guangzhou 511458 China Department of Information Science and Electronic Engineering Zhejiang University Hangzhou 310027 China Department of Electrical and computer Engineering University of Nevada Las Vegas Nevada U.S.A. Faculty of Engineering Kore University Catania Italy Department of Electrical and computer Engineering University of Rochester Rochester New York U.S.A.

3-D Networks-on-chip （Noc） emerge as a potent solution to address both the interconnection and design complexity problems facing future Multiprocessor System-on-chips （MPSocs）. Effective run-time mapping on such 3-D Noc-based MPSocs can be quite challenging, as the arrival order and task graphs of the target applications are typically not known a priori, which can be further complicated by stringent energy requirements for Noc systems. This paper thus presents an energy-aware run-time incremental mapping algorithm （ERIM） for 3-D Noc which can minimize the energy consumption due to the data communications among processor cores, while reducing the fragmentation effect on the incoming applications to be mapped, and simultaneously satisfying the thermal constraints imposed on each incoming application. Specifically, incoming applications are mapped to cuboid tile regions for lower energy consumption of communication and the minimal routing. Fragment tiles due to system fragmentation can be gleaned for better resource utilization. Extensive experiments have been conducted to evaluate the performance of the proposed algorithm ERIM, and the results are compared against the optimal mapping algorithm （branch-and-bound） and two heuristic algorithms （TB and TL）. The experiments show that ERIM outperforms TB and TL methods with significant energy saving （more than 10%）, much reduced average response time, and improved system utilization.

关键词： energy efficiency Networks-on-chip multiprocessor System-on-chips run-time incrementa] mapping

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Management of postoperative spinal infections

引用

World Journal of Orthopedics 2012年第11期3卷 182-189页

作者： Vishal Hegde Dennis S Meredith christopher K Kepler Russel c huang Department of Orthopedic Surgery Weill Cornell Medical CollegeNew YorkNY 10021United States Department of Orthopedic Surgery Spine and Scoliosis ServiceHospital for Special SurgeryWeill Cornell Medical CenterNew YorkNY 10021United States Department of Orthopedic Surgery Rothman InstituteThomas Jefferson UniversityPhiladelphiaPA 19107United States

Postoperative surgical site infection(SSI) is a common complication after posterior lumbar spine surgery. This review details an approach to the prevention,diagnosis and treatment of SSIs. Factors contributing to the development of a SSI can be split into three categories:(1) microbiological factors;(2) factors related to the patient and their spinal pathology; and(3) factors relating to the surgical procedure. SSI is most commonly caused by Staphylococcus aureus. The virulence of the organism causing the SSI can affect its presentation. SSI can be prevented by careful adherence to aseptic technique,prophylactic antibiotics,avoiding myonecrosis by frequently releasing retractors and preoperatively optimizing modifiable patient factors. Increasing pain is commonly the only symptom of a SSI and can lead to a delay in diagnosis. c-reactive protein and magnetic resonance imaging can help establish the diagnosis. Treatment requires acquiring intra-operative cultures to guide future antibiotic therapy and surgical debridement of all necrotic tissue. A SSI can usually be adequately treated without removing spinalinstrumentation. A multidisciplinary approach to SSIs is important. It is useful to involve an infectious disease specialist and use minimum serial bactericidal titers to enhance the effectiveness of antibiotic therapy. A plastic surgeon should also be involved in those cases of severe infection that require repeat debridement and delayed closure.

关键词： Surgical site infection Spine surgery Discitis Postoperative infection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：