The contemporary role of metastasectomy in the management of metastatic RCC
作者机构：Department of Urology New York University Langone Health New York 10016 NY United States
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2021年第7卷第1期
页 面：926-937页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Clear-cell metastatic renal cell carcinoma metastasectomy immunotherapy
摘 要：Metastasectomy was initially described in the 1970s as a therapeutic strategy for patients with metastatic renal cell *** that time,systemic therapy options have grown exponentially,most recently with the introduction of *** aimed to review the contemporary literature regarding the role of metastasectomy in the era of targeted therapy and ***,metastasectomy has benefited patients with small volume,single-organ metastases,with favorable outcomes amongst younger,healthier patients with metastases to specific *** interplay between the employment of metastasectomy and systemic therapy has been limited to small,retrospective series with significant patient selection *** recently,investigators have conducted randomized controlled trials exploring the use of targeted therapies in the adjuvant setting after *** randomized data suggested no benefit in using sorafenib in this setting,and a subsequent study demonstrated possible harm in using pazopanib after ***,the role of other novel systemic therapies,including immunotherapy,nor the timing of use,have been meaningfully *** appears to be a valuable therapeutic option in the properly selected patient,requiring a multi-disciplinary management strategy and,pending future trials,a multimodal treatment approach.
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