检索结果-南通市图书馆

SARS-coV-2 variants are associated with different clinical courses in children with MIS-c

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia Bainto Helen Harvey Adriana H.Tremoulet Jane c.Burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑coV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-c).SARS‑coV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-c at Rady children’s Hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-c waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to c,20G,21c(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22c).MIS-c presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PIcU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-coV-2 triggered MIS-c with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： complications cOVID-19 MIS-c SARS-coV-2 variants

SUV39H1-driven NFATc1 methylation is essential for the c-cbl-mediated degradation of NFATc1 in an osteoclast lineage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第4期11卷 86-89页

作者： Do-Won Jeong Hye-Jin Kim Jong-Wan Park Seulbee Lee Hyeryeon Jung Eugene c.Yi Nacksung Kime Yang-Sook chun Department of Biomedical Sciences Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Physiology Seoul National University College of MedicineSeoul 03080Republic of Korea Ischemic/Hypoxic Disease Institute Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science and Technology and College of Medicine Or College of PharmacySeoul National UniversitySeoul 03080Republic of Korea Department of Pharmacology Chonnam National University Medical SchoolGwangju 61469Republic of Korea

Bone undergoes continuous remodeling by tightly-coordinated actions of bone-resorbing osteoclasts and boneforming osteoblasts.1 Recent studies document that the dysregulation of histone methylation profiles is associated with the progression of ***,the specific epigenetic modifiers are incompletely *** this study,we demonstrate an inhibitory role of a variegation 3-9 homolog 1(SUV39H1)in osteoclast formation.

关键词： osteoclast remodeling incomplete

Tropical cyclone activities in the Western North Paci fi c in 2022

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

TROPIcAL cYcLONE RESEARcH AND REVIEW 2024年第2期13卷 125-135页

作者： Huang, Xin Bai, Lina Yu, Zifeng chan, Johnny c. L. Yu, Hui Tang, Jie Guo, Rong Wan, Rijin china Meteorol Adm Shanghai Typhoon Inst Shanghai 200030 Peoples R China Asia Pacific Typhoon collaborat Res ctr Shanghai Peoples R China city Univ Hong Kong Sch Energy & Environm Hong Kong Peoples R China

Based on the best-track dataset from the Shanghai Typhoon Institute/china Meteorological Administration, the paper provides a comprehensive summary and analysis of tropical cyclone (Tc) activities in the Western North Pacific (WNP) and the South china Sea (ScS) for 2022. Using the historical climatology from 1951 to 2020, the anomalous conditions during 2022 in Tc frequency, origin locations, tracks, intensity, and duration for the entire ocean basin as well as landfall events in china are examined. Results show that the overall Tc frequency is slightly lower than normal, but the multiple Tc events have a very high frequency of occurrence. Origin locations of Tcs, which mark the starting points of their paths, show a large westward and northward deviation from climatology. Around 40% of the named Tcs exhibit a shift in their direction of movement from westerly to easterly. Additionally, comparisons of the means, medians, upper and lower quartiles all indicate that the intensity of Tcs in 2022 is generally lower than the climatology, with the duration of Tcs at tropical storm intensity or above being shorter than usual. A notable observation is the fewer incidence of Tc landfalls in china, but with a geographical concentration in Guangdong Province. These anomalous annual Tc activities are influenced by related atmospheric and oceanic environmental conditions modulated by multi-scale climate variability. The findings provide useful information for enhancing disaster mitigation strategies in the Asia-Pacific region. (c) 2024 The Shanghai Typhoon Institute of china Meteorological Administration. Publishing services by Elsevier B.V. on behalf of KeAi communication co. Ltd. This is an open access article under the cc BY-Nc-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： Tropical cyclone Western North Paci fi c Anomalous characteristics Annual report TYPHOON cOMMITTEE REGION EL-NINO INTERANNUAL VARIABILITY INTERDEcADAL VARIATIONS GENESIS FREQUENcY 3RD ASSESSMENT cLIMATE-cHANGE ENSO OScILLATION INTENSITY

Electrocatalytic synthesis of c-N coupling compounds from cO_(2) and nitrogenous species

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SusMat 2024年第2期4卷 51-74页

作者： Zheng Zhang Danyang Li Yunchuan Tu Jiao Deng Huiting Bi Yongchao Yao Yan Wang Tingshuai Li Yongsong Luo Shengjun Sun Dongdong Zheng Sónia A.c.carabineiro Zhou chen Junjiang Zhu Xuping Sun Hubei Key Laboratory of Biomass Fibers and Eco-Dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile UniversityWuhanHubeiChina School of chemistry and chemical Engineering Chongqing UniversityChongqingChina i-Lab Vacuum Interconnected NanotechWorkstation(Nano-X)Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhouJiangsuChina Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengduSichuanChina college of chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinanShandongChina LAQV-REQUIMTE Department of ChemistryNOVA School of Science and TechnologyUniversidade NOVA de Lisboa2829-516 CaparicaPortugal college of Materials Xiamen UniversityXiamenFujianChina

The electrocatalytic synthesis of c-N coupling compounds from cO_(2) and nitrogenous species not only offers an effective avenue to achieve carbon neutral-ity and reduce environmental pollution,but also establishes a route to synthesize valuable chemicals,such as urea,amide,and *** innovative approach expands the application range and product categories beyond simple carbona-ceous species in electrocatalytic cO_(2) reduction,which is becoming a rapidly advancing *** review summarizes the research progress in electrocatalytic urea synthesis,using N_(2),NO_(2)^(-),and NO_(3)^(-)as nitrogenous species,and explores emerging trends in the electrosynthesis of amide and amine from cO_(2) and nitro-gen ***,the future opportunities in this field are highlighted,including electrosynthesis of amino acids and other compounds containing c-N bonds,anodic c-N coupling reactions beyond water oxidation,and the catalytic mechanism of corresponding *** critical review also captures the insights aimed at accelerating the development of electrochemical c-N coupling reactions,confirming the superiority of this electrochemical method over the traditional techniques.

关键词： c-N coupling cO_(2) reduction electrocatalysis nitrogenous species reaction mechanism

Single atom cu-N-c catalysts for the electro-reduction of cO_(2) to cO assessed by rotating ring-disc electrode

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy chemistry 2024年第1期88卷 169-182,I0004页

作者： S.Pérez-Rodríguez M.Gutiérrez-Roa c.Giménez-Rubio D.Ríos-Ruiz P.Arévalo-cid M.V.Martínez-Huerta A.Zitolo M.J.Lázaro D.Sebastián Instituto de carboquímica(cSIc) Miguel Luesma Castán 450018 ZaragozaSpain Instituto de catálisis y Petroleoquímica(cSIc) Marie Curie 228049 MadridSpain Synchrotron SOLEIL L’Orme des MerisiersDépartementale 12891190France

The electrochemical cO_(2) reduction reaction(cO_(2)RR) to controllable chemicals is considered as a promising pathway to store intermittent renewable energy. Herein, a set of catalysts based on copper-nitrogendoped carbon xerogel(cu-N-c) are successfully developed varying the copper amount and the nature of the copper precursor, for the efficient cO_(2)RR. The electrocatalytic performance of cu-N-c materials is assessed by a rotating ring-disc electrode(RRDE), technique still rarely explored for cO_(2)RR. For comparison, products are also characterized by online gas chromatography in a H-cell. The as-synthesized cu-Nc catalysts are found to be active and highly cO selective at low overpotentials(from -0.6 to -0.8 V ***) in 0.1 M KHcO_(3), while H_(2) from the competitive water reduction appears at larger overpotentials(-0.9 V vs. RHE). The optimum copper acetate-derived catalyst containing cu-N_(4) moieties exhibits a cO_(2)-to-cO turnover frequency of 997 h^(-1) at -0.9 V vs. RHE with a H_(2)/cO ratio of 1.8. These results demonstrate that RRDE configuration can be used as a feasible approach for identifying electrolysis products from cO_(2)RR.

关键词： cu-N-c carbon xerogel Rotating ring disc electrode carbon dioxide reduction reaction carbon monoxide

ca^(2+) binding to the c_(2)E domain of otoferlin is required for hair cell exocytosis and hearing

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protein & cell 2024年第4期15卷 305-312页

作者： Han chen Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef Shashank S.chepurwar Regina célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,Jr. Fritz Benseler Nils Brose Kathrin Kusch carolin Wichmann Nicola Strenzke Barbara Vona Julia Preobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany collaborative Research center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synaptic Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of Synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems Physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genética e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIc Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging cluster of Excellence(MBExc) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synapses of cochlear inner hair cells(IHcs)employ a unique molecular machinery(see extended background in Supplementary Materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(Moser and Starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-c_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(Pangršičet al.,2012),also see Supplementary *** is distributed broadly within IHcs(Fig.2Ai-Aiii;Pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

Spatial assessment of the areas sensitive to degradation in the rural area of the municipality (c)ukarica

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Soil and Water conservation Research 2019年第1期7卷 71-80页

作者： Natalija Momirovi(c) Ratko Kadovi(c) Veljko Perovi(c) Milo(s)Marjanovi(c) Aleksandar Baumgertel Institute of Forestry Kneza Vi(s)eslava 311030 BelgradeSerbia Faculty of Forestry University of BelgradeKneza Vi(s)eslava 111030 BelgradeSerbia Institute for Biological Research'Sini(s)a Stankovi(c)' University of BelgradeBulevar despota Stefana 14211060 BelgradeSerbia Faculty of Mining and Geology University of BelgradeDu(s)ina 711000 BelgradeSerbia

In this paper,the assessment of the sensitivity of the soil in the rural area of (c)ukarica municipality to the processes of degradation is *** areas,especially in the vicinity of large cities,are exposed to numerous processes of degradation:soil erosion,urban and industrial zone expansion at the expense of fertile agricultural soils,activation of landslides and a number of other significant ecological *** on the characteristics of the research area,the MEDALUS (Mediterranean Desertification and Land Use) model was applied,and for the assessment of sensitivity to the processes of degradation the main quality indicators were considered:soil,climate,vegetation and *** each of the analyzed quality indicators,parameter groups were *** parameter is quantified according to the defined method by giving them a sensitivity coefficient between 1.0 and *** 10.0 has been applied to analyze and prepare layers of quality ***,the geometric mean for all four quality indicators was used to generate the map of environmental sensitivity to *** results obtained show that 41.54% of the study area is classified as critical;22.34% of the surface as fragile;8.47% of the areas are potentially endangered and 9.58% not threatened to degradation *** results have also shown that MEDALUS model is a functional tool for simulations which support sustainable land management in the areas prone to degradation.

关键词： MEDALUS Land degradation Landslides Human pressures GIS mapping

Hepatitis c Virus, Insulin Resistance, and Steatosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of clinical and Translational Hepatology 2016年第1期4卷 66-75页

作者： Dominik Kralj Lucija Virovi(c) Juki(c) Sanja Stojsavljevi(c) Marko Duvnjak Martina Smoli(c) Ines Bili(c) (c)ur(c)i(c) Department of Gastroenterology and Hepatology Sisters of Charity University Hospital Center Zagreb Croatia Department of Pharmacology Faculty of Medicine University of Osijek Osijek Croatia Department of Pharmacology Faculty of MedicineUniversity of Osijek Department of Endocrinology and metabolism disorders University Hospital Center Osijek Osijek Croatia

Hepatitis c virus (HcV) is one of the main causes of liver disease *** steatosis is a common finding in many hepatic and extrahepatic disorders,the most common being metabolic syndrome (MS).Overtime,it has been shown that the frequent coexistence of these two conditions is not coincidental,since many epidemiological,clinical,and experimental studies have indicated HcV to be strongly associated with liver steatosis and numerous metabolic ***,we present an overview of publications that provide clinical evidence of the metabolic effects of HcV and summarize the available data on the pathogenetic mechanisms of this *** has been shown that HcV infection can induce insulin resistance (IR) in the liver and peripheral tissues through multiple *** research has suggested that HcV interferes with insulin signaling both directly and indirectly,inducing the production of several proinflammatory *** replication,assembly,and release from hepatocytes require close interactions with lipid droplets and host *** modulation of lipid metabolism in host cells can induce hepatic steatosis,which is more pronounced in patients with HcV genotype *** risk of steatosis depends on several viral factors (including genotype,viral load,and gene mutations) and host features (visceral obesity,type 2 diabetes mellitus,genetic predisposition,medication use,and alcohol consumption).HcV-related IR and steatosis have been shown to have a remarkable clinical impact on the prognosis of HcV infection and quality of life,due to their association with resistance to antiviral therapy,progression of hepatic fibrosis,and development of hepatocellular ***,HcV-induced IR,oxidative stress,and changes in lipid and iron metabolism lead to glucose intolerance,arterial hypertension,hyperuricemia,and atherosclerosis,resulting in increased cardiovascular mortality.

关键词： Hepatitis c virus Metabolic syndrome Insulin resistance Steatosis

Treatment modalities for hypersplenism in liver transplant recipients with recurrent hepatitis c

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第40期15卷 5010-5013页

作者： Lena Sibulesky Justin H Nguyen Ricardo Paz-Fumagalli c Burcin Taner Rolland c Dickson Division of Transplant Surgery and Transplant Hepatology Division of Interventional Radiology

Hepatitis c is the most common indication for orthotopic liver transplantation in the United States. Unfortunately, hepatitis c recurs universally in the transplanted liver and is the major cause of decreased graft and patient survival. The combination therapy of interferon and ribavirin has been shown to be the most effective therapy for recurrent hepatitis c. However, pre-and post-transplant hypersplenism often precludes patients from receiving the antiviral therapy. Splenectomy and partial splenic embolization are the two invasive modalities that can correct the cytopenia associated with hypersplenism. In this report we review the two treatment options, their associated outcomes and complications.

关键词： Hypersplenism Leukopenia Recurrenthepatitis c Thrombocytopenia Liver transplant