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Association between Helicobacter pylori status and metachronous gastric cancer after endoscopic resection

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World Journal of Gastroenterology 2016年第44期22卷 9794-9802页

作者： Sung Bum kim Si Hyung Lee Seung Il Bae Yo Han Jeong Se Hoon Sohn Kyeong Ok kim byung ik Jang Tae Nyeun kim Department of Internal Medicine Yeungnam University College of Medicine

AIM To investigate the effect of Helicobacter pylori(H. pylori) status test and H. pylori eradication on the occurrence of metachronous gastric cancer(MGC) after endoscopic submucosal dissection(ESD) of early gastric cancer(EGC) and risk factors of MGC. METHODS The authors retrospectively reviewed the medical records of 433 patients(441 lesions) who underwent ESD for EGC from January 2005 to January 2015 in Yeungnam University Hospital. Patients were categorized into two groups; the H. pylori tested group(n = 257) and the H. pylori non-tested group(n = 176) based on performance of H. pylori status test after ESD of EGC. The H. pylori tested group was further categorized into three subgroups based on H. pylori status; the H. pylori-eradicated subgroup(n = 120), the H. pylori-persistent subgroup(n = 42), and the H. pylori-negative subgroup(n = 95). Incidences of MGC and risk factors of MGC were *** Median follow-up duration after ESD was 30.00 mo(range, 6-107 mo). Total 15 patients developed MGC during follow-up. MGC developed in 11 patients of the H. pylori tested group(7 in the H. pylori-negative subgroup, 3 in the H. pylori-eradicated subgroup, and 1 in the H. pylori-persistent subgroup) and 4 patients of the H. pylori non-tested group(P > 0.05). The risk factors of MGC were endoscopic mucosal atrophy in the H. pylori tested group and intestinal metaplasia in all patients. CONCLUSION H. pylori eradication and H. pylori status test seems to have no preventive effect on the development of MGC after ESD for EGC. The risk factors of MGC development were endoscopic mucosal atrophy in the H. pylori tested group alone and intestinal metaplasia in all patients.

关键词： Metachronous gastric cancer Endoscopic submucosal dissection Helicobacter pylori

Carbon nanotube formation using zeolite template and applications

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Journal of Advanced Ceramics 2012年第3期1卷 179-193页

作者： Wei ZHAO Bijay BASNET ik Jin kim Institute for Processing and Application of Inorganic Materials(PAIM) Department of Materials Science and EngineeringHanseo UniversitySeosan city 356-706Korea

Carbon nanotubes(CNTs)have attracted intensive interests of researchers for a long time due to their fascinating physical and chemical properties promising for various potential applications,including advanced ceramics,nanoelectronic devices,nanoscale sensors,solar cells,battery electrode,field emitters,etc..This review summarized the synthetic methods of CNTs,with an emphasis on the chemical vapor deposition(CVD)method,especially catalytic *** there still are some challenges in the way,with the development of the technology,a hope for widespread applications always exists.

关键词： carbon nanotubes catalytic chemical vapor deposition zeolite template catalyst

Our works on conservation of wooden objects in Korea

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江汉考古 2014年第S1期 33-38页

作者： kim ik Joo

韩国木质文物的系统保护始于1976年新安沉船出土后,新安沉船保护方法的研究促进了饱水木保护技术的发展,是韩国木质文物保护的转折点,为木质文物保护新方法、新技术的研究搭建了一个平台。二十世纪九十年代以后韩国出土了大量木质文物,... 详细信息

韩国木质文物的系统保护始于1976年新安沉船出土后,新安沉船保护方法的研究促进了饱水木保护技术的发展,是韩国木质文物保护的转折点,为木质文物保护新方法、新技术的研究搭建了一个平台。二十世纪九十年代以后韩国出土了大量木质文物,这些文物的出土提供了很多新信息,是重要的历史资源。这一趋势促使了韩国保护工作人员对木质文物保护新方的研究。韩国的木质文物实际上是埋藏在沼泽、湖底和海底的饱水木,这些环境限制了微生物的生长。遗址中出土的木质器物是糟朽木或是碳化木。因此,韩国木质文物的保护分两类:一类是用传统工艺修复木建筑和漆器,另一类是保护处理饱水木器。文中介绍了韩国文物保护实验室保护修复木质文物的几个实例。

关键词： Our works on conservation of wooden objects in Korea

Mechanically resilient,alumina-reinforced carbon nanotube arrays for in-plane shock absorption in micromechanical devices

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Microsystems & Nanoengineering 2023年第3期9卷 73-81页

作者： Eunhwan Jo Hojoon Lee Jae-ik Lee Jongbaeg kim School of Mechanical Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Department of Neurosurgery Massachusetts General HospitalHarvard Medical School25 Shattuck StBostonMA 02115USA

Microelectromechanical systems(MEMS)are of considerable interest due to their compact size and low power consumption when used in modern *** devices intrinsically incorporate three-dimensional(3D)microstructures for their intended operations;however,these microstructures are easily broken by mechanical shocks accompanying high-magnitude transient acceleration,inducing device *** various structural designs and materials have been proposed to overcome this limit,developing a shock absorber for easy integration into existing MEMS structures that effectively dissipates impact energy remains ***,a vertically aligned 3D nanocomposite based on ceramic-reinforced carbon nanotube(CNT)arrays is presented for in-plane shock-absorbing and energy dissipation around MEMS *** geometrically aligned composite consists of regionally-selective integrated CNT arrays and a subsequent atomically thick alumina layer coating,which serve as structural and reinforcing materials,*** nanocomposite is integrated with the microstructure through a batch-fabrication process and remarkably improves the in-plane shock reliability of a designed movable structure over a wide acceleration range(0-12,000g).In addition,the enhanced shock reliability through the nanocomposite was experimentally verified through comparison with various control devices.

关键词： shock plane arrays

Cathepsin B-responsive prodrugs for cancer-targeted therapy:Recent advances and progress for clinical translation

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Nano Research 2022年第8期15卷 7247-7266页

作者： Seong ik Jeon Suah Yang Man Kyu Shim Kwangmeyung kim Biomedical Research Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea

The cathepsin B-responsive prodrugs are promising strategies to reduce the serious adverse effects of anticancer drugs by improving the cancer selectivity that can be specifically activated by overexpressed cathepsin B in targeted cancer ***,clinical translation of such therapeutic approaches has been restricted by low antitumor efficacy that is mainly attributable to undesirable pharmacokinetic profiles and inefficient tumor-targeting of cathepsin B-responsive prodrugs,due to their small-molecule *** recent decades,many researchers have widely investigated the drug delivery system(DDS)to improve the in vivo pharmacokinetic profiles and tumor-targeting efficiency of cathepsin B-responsive prodrugs via the application of polymers,dendrimers,antibodies,lipids,and inorganic nanoparticles as drug *** addition,the potential therapeutic efficacy of DDS for cathepsin B-responsive prodrugs is demonstrated in multiple studies and combinatorial treatment with typical therapeutic modalities can effectively overcome the challenges of tumor heterogeneity and multidrug *** this review,recent advances and progress of new DDS for cathepsin B-responsive prodrugs are outlined,and their clinical trials are ***,potential challenges and the outlooks for clinical translation of cathepsin B-responsive prodrugs are highlighted.

关键词： cathepsin B prodrug chemotherapy drug delivery system targeted cancer therapy

ARMA–GARCH model with fractional generalized hyperbolic innovations

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Financial Innovation 2022年第1期8卷 1407-1431页

作者： Sung ik kim Department of Economics and Finance College of BusinessLouisiana State University ShreveportOne University PlaceShreveportLA 71115USA

In this study,a multivariate ARMA–GARCH model with fractional generalized hyperbolic innovations exhibiting fat-tail,volatility clustering,and long-range dependence properties is *** define the fractional generalized hyperbolic process,the non-fractional variant is derived by subordinating time-changed Brownian motion to the generalized inverse Gaussian process,and thereafter,the fractional generalized hyperbolic process is obtained using the Volterra *** on the ARMA–GARCH model with standard normal innovations,the parameters are estimated for the high-frequency returns of six ***,the residuals extracted from the estimated ARMA–GARCH parameters are fitted to the fractional and non-fractional generalized hyperbolic *** results show that the fractional generalized hyperbolic process performs better in describing the behavior of the residual process of high-frequency returns than the non-fractional processes considered in this study.

关键词： Generalized hyperbolic process Time-changed Brownian motion Long-range dependence Fractional Brownian motion ARMA-GARCH model

Site-Specific Zonation of Seismic Site Effects by Optimization of the Expert GIS-Based Geotechnical Information System for Western Coastal Urban Areas in South Korea

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International Journal of Disaster Risk Science 2019年第1期10卷 117-133页

作者： Han-Saem kim Chang-Guk Sun Hyung-ik Cho Earthquake Research Center Korea Institute of Geoscience and Mineral Resources Geological Research Division Korea Institute of Geoscience and Mineral Resources

Earthquake-induced disasters are often more severe over soft soils than over firm soils or rocks owing to the seismic site effects related to the amplification of ground motion. On a regional scale, such differences can be estimated by spatially predicting the subsurface soil thickness over the entire target area. Generally, soil deposits are deeper in coastal or riverside areas than in inland regions. In this study, the seismic site effects in the coastal metropolitan areas of Incheon and Bucheon, South Korea, were assessed to provide information on seismic hazards. Spatial prediction of geotechnical layers was performed for the entire study area within an advanced GIS framework. Approximately 7500 existing borehole records in the Incheon and Bucheon areas were gathered and archived into a GIS database. Surface geotechnical data were acquired from a walk-over survey. Based on the optimized geo-data, spatial zoning maps of site-specific seismic response parameters, based on multiscale geospatial modeling, were created and presented for use in a regional seismic mitigation strategy. Seismic zonation was also performed to determine site coefficients for seismic design over the entire target area and to compare them with each other. We verified that the geotechnical data based spatial zonation would be useful for seismic hazard mitigation.

关键词： Coastal urban areas Geodata Geostatistical spatial zonation Seismic site effects Site classification South Korea

Development and Experimental Evaluation of Strip Shape Prediction Model for Sendzimir Rolling Mills

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Journal of Iron and Steel Research International 2013年第12期20卷 25-32页

作者： SHIN Jong-min HAN Seong-ik kim Jong-shik School of Mechanical Engineering Pusan National University School of Electrical Engineering Pusan National University

It is difficult to obtain the desired strip shape using Sendzimir rolling mills because small diameter work rolls can be easily deformed by the roiling force. To control the strip shape effectively, it is important to understand the relationship between the behavior of the shape actuator and the variation of the strip shape. A numerical model based on the contact element method was proposed for the prediction of strip shape. In this numerical model, the re- lationships between the actuating forces, the roll deflections, the thickness profiles of the entry and exit sides, and the strip shape were considered. The proposed numerical model for strip shape prediction was evaluated by computer simulation and experiment with respect to various AS-U roll and first intermediate roll positions.

关键词： Sendzimir rollingmill double acting AS-U roll strip shape prediction model contact element method

Update of sentinel lymph node mapping assessment in endometrial cancer

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Gynecology and Obstetrics Clinical Medicine 2023年第1期3卷 1-6页

作者： Se ik kim Jae-Weon kim Department of Obstetrics and Gynecology Seoul National University College of MedicineSeoul03080Republic of Korea

Endometrial cancer is the most common gynecologic malignancy in developed *** confirmation of lymph node metastasis is important for risk stratification and the administration of adjuvant ***,comprehensive,systematic lymphadenectomy has been routinely performed but has been associated with various ***,the concept of sentinel lymph node(SLN)mapping and biopsy has emerged and is now accepted as an alternative to conventional systematic lymphadenectomy in early-stage endometrial *** better management of endometrial cancer,we conducted a literature review to summarize the role and diagnostic accuracy of the SLN mapping strategy in endometrial *** from the monumental and recent literature and ongoing clinical trials will be introduced.

关键词： Endometrial cancer Sentinel lymph node Lymph node metastasis Accuracy Prognosis Survival