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Chinese Journal of Chemical Engineering 2003年第2期11卷 220-223页

作者： Longan SHANG Jin Hwan Do 范代娣姜岷 ho nam CHANG Department Department of Chemical and Biomolecular Englneering Department of Chemical Engineering Northwest University Department of Chemical and Biomolecular Engineering

The feeding method of propionic acid for production ofpoly(3-hydroxybutyrate-co-3-hydro xyvalerate) [P(3HB-co-3HV)] by fed-batch culture of Ralstoniaeutropha was optimized to achieve high cell density and high 3HV yield. Effects of different feedingstrategies of propionic acid on the production of P(3HB-co-3HV) were investigated. A decline ofspecific synthesis rate of copolymer and the yield of 3HV unit from propionic acid were observed dueto the propionic acid accumulation in culture broth when the feeding solution with highP/G(propionic acid to glucose) ratio was employed. It was further confirmed by controlling propionicacid concentration at a low level in the separate feeding of propionic acid. An optimal feedingstrategy was demonstrated to reduce the propionic acid accumulation. The cell concentration,P(3HB-co-3HV) productivity and 3HV unit fraction reached to 163.9kg·m^(-3), 1.8kg·m^(-3)·h^(-1),and 10.6%(by mass), respectively, resulting in a yield of 0.33g HV per g propionic acid.

关键词： biodegradable polyester feeding strategy P(3HB-co-3HV) propionic acid ralstonia eutropha

Effects of feeding a diet containing Gymnema sylvestre extract: attenuating progression of obesity in C57BL/6J mice

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Asian Pacific Journal of Tropical Medicine 2016年第5期9卷 425-431页

作者： Hyeon-Jeong Kim Seong-ho hong Seung-Hee Chang Sanghwa Kim Ah Young Lee Yoonjeong Jang Orkhonselenge Davaadamdin Kyeong-nam Yu Ji-Eun Kim Myung-Haing Cho Laboratory of Toxicology College of Veterinary Medicine Seoul National University Graduate Group of Tumor Biology Seoul National University Graduate School of Convergence Science and Technology Seoul National University Advanced Institutes of Convergence Technology Seoul National University Institute of Green Bio Science Technology Seoul National University

Objective: To investigate the effect of Gymnema sylvestre extract(GS) on initial anti-obesity, liver injury, and glucose homeostasis induced by a high-fat diet(HFD). Methods: The dry powder of GS was extracted with methanol, and gymnemic acid was identified by high performance liquid chromatography as deacyl gymnemic acid. Male C57BL/6J mice that fed on either a normal diet, normal diet containing 1 g/kg GS(CON+GS) HFD, or HFD containing 1.0 g/kg GS(HFD+GS) for 4 weeks were used to test the initial anti-obesity effect of GS. Body weight gain and food intake, and serum levels about lipid and liver injury markers were measured. Histopathology of adipose tissue and liver stained with hematoxylin and eosin(H&E) and oil-red O were analyzed. After 4 weeks of GS extract feeding, intraperitoneal glucose tolerance test(IPGTT) was performed. Results: The methanol extracts of GS exerted significant anti-obesity effects in HFD+GS group. They decreased body weight gain, a lower food and energy efficiency ratio, and showed lower serum levels of total cholesterol(TC), triglyceride(TG), low-density lipoprotein(LDL)-cholesterol, very-low density lipoprotein(VLDL)-cholesterol and leptin compared with the HFD group. The decreases of abdominal as well as epididymal fat weight and adipocyte hypertrophy, lipid droplets in liver, and serum levels of aspartate aminotransferase(AST) and alanine transaminase(ALT) were also observed. The CON+GS group showed an effect of glucose homeostasis compared to the CON group. Conclusions: This study shows that GS provide the possibility as a key role in an initial anti-obesity effects feeding with a HFD.

关键词： Gymnema sylvestre extract Obesity Adipocyte Body weight gain High-fat diet Liver injury

Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells

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Cellular & Molecular Immunology 2021年第6期18卷 1395-1411页

作者： Jin-Kwan Lee Seo-Young Koo Hye-Mi nam Jee-Boong Lee Jiwon Ko Kyung-Mo Kim Eun-Ji Park Tae Jin Kim ho Lee Heounjeong Go Chang-Woo Lee Research Institute Curogen TechnologySuwonSouth Korea Department of Molecular Cell Biology Samsung Medical CenterSungkyunkwan University School of MedicineSuwonSouth Korea MOGAM Institute for Biomedical Research GyeonggiSouth Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea Department of Immunology Sungkyunkwan University School of MedicineSeoulSouth Korea Department of Cancer Biomedical Science Graduate School of Cancer Science and PolicyResearch InstituteNational Cancer CenterGyeonggiSouth Korea

The homeostatic balance between effector T cells and regulatory T cells(Tregs)is crucial for adaptive immunity;however,epigenetic programs that inhibit phosphorylation to regulate Treg development,peripheral expression,and suppressive activity are ***,we found that the Ssu72 phosphatase is activated by various T-cell receptor signaling pathways,including the T-cell receptor and IL-2R pathways,and localizes at the cell *** of Ssu72 in T cells disrupts CD4+T-cell differentiation into Tregs in the periphery via the production of high levels of the effector cytokines IL-2 and IFNγ,which induce CD4+T-cell activation and differentiation into effector cell *** also found a close correlation between downregulation of Ssu72 and severe defects in mucosal tolerance in ***,Ssu72 forms a complex with PLCγ1,which is an essential effector molecule for T-cell receptor signaling as well as Treg development and ***72 deficiency impairs PLCγ1 downstream signaling and results in failure of Foxp3 ***,our studies show that the Ssu72-mediated cytokine response coordinates the differentiation and function of Treg cells in the periphery.

关键词： Ssu72 Regulatory T cells FoxP3 T cell receptor Autoimmunity

Effects of planting distance and depth on PTO load spectrum of a small riding-type transplanter

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International Journal of Agricultural and Biological Engineering 2020年第2期13卷 57-63页

作者： Wan-Soo Kim Yeon-Soo Kim Taek-Jin Kim Kyu-Chul nam Tae-Bum Kim Tae-ho Han Ryu-Gap Im Yong-Hyeon Kim Yong-Joo Kim Department of Biosystems Machinery Engineering Chungnam National UniversityDaejeon 34134Republic of Korea Department of Smart Agriculture Systems Chungnam National UniversityDaejeon 34134Republic of Korea Convergence Agricultural Machinery Group Korea Institute of Industrial TechnologyGimje 54325Republic of Korea Certification WarrantyInspection and Standardization TeamKorea Agricultural Machinery Industry CooperativeCheonan 31041Republic of Korea Diesel Service Korea Co.Ltd. Daejeon 34357Republic of Korea Agricultural Machinery Certification Team Foundation of Agricultural Technology Commercialization and TransferIksan 54667Republic of Korea Gint Co.Ltd. Suwon 16225Republic of Korea

The aim of this study was to analyze the effects of the planting distance and depth on the power take-off(PTO)load spectrum of a small riding-type transplanter for the optimal design of the *** measure load data during actual planting operation,a load measurement system was developed using a torque sensor,a data acquisition system,and an *** experiments were conducted at four planting distances(26 cm,35 cm,43 cm,and 80 cm)and three planting depths(85 mm,105 mm,and 136 mm)in a field with similar soil *** measured load data were inverted into a load spectrum using rain-flow counting and Smith-Watson-Topper(SWT)*** safety factor of a transplanter according to the planting conditions was analyzed using the converted load spectrum and commercial *** load spectrum for all planting conditions showed torque ratios similar within a high cycle region of 108 to *** torque ratio increased when the planting depth increased and planting distance decreased in the low cycle region under less than 108 *** safety factors of the PTO driving gear and the driven gear increased as the planting distance increased at all planting *** the planting depth decreased at the same planting distance,the safety factor of the PTO gears *** results of this study might provide useful information for a transplanter PTO design considering the working load according to the various planting conditions.

关键词： transplanter planting distance planting depth power take-off load spectrum safety factor

ROLE OF FUNGAL LACCASE AND LOW MOLECULAR MEDIATORS ON DECOLOURIZATION OF AROMATIC DYES IN PAPER MILL EFFLUENTS

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天津科技大学学报 2004年第A2期19卷 148-155页

作者： nam-Seok Cho Tae-ho Choi Woonsup Shin A. Leonowicz Professor School of Forest Resources Chungbuk National University Cheongju 361-763 KoreaProfessor School of Forest Resources Chungbuk National University Cheongju 361-763 KoreaProfessor Department of Chemistry Sogang University Seoul 121-742 KoreaProfessor Department of Biochemistry Marie Curie-Sklodowska University Lublin Poland

Several wood rotting fungi decolourized Remazol brilliant blue R (RBBR) and carminic acid (CA). Parallel activity of laccase in these fungi was studied. The addition of acetovanillone (AV) or acetosyringone (AS) intensified these processes: decolourization was more extensive than in the experiment omitting these compounds. At the presence of AS the decourization was more extensive than AV. however the level of decolorizing was relatively low in comparison to laccase activity on syringaldazine. The highly purified constitutive form of Cerrena unicolor and inducible form of Trametes versicolor laccases also destained both dyes. Anyway the addition of AV and AS improved the efficiency of dyes decolourization by wood rotting fungi and fungal laccase. Nitrogen starvation induced the laccase and decoloration activity in both organisms, irrespective of nitrogen availability. This fact indicates laccase not solely responsible for discoloration, and probably discoloration of dyes involves more than one mechanism.

关键词：真菌虫漆酶脱色芳香染料造纸厂废水处理木蚀真菌低分子真菌

Jeju seaweeds suppress lipopolysaccharide-stimulated proinflammatory response in RAW 264.7 murine macrophages

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Asian Pacific Journal of Tropical Biomedicine 2014年第7期4卷 529-537页

作者： Eun-Jin Yang Ji-Young Moon Sang Suk Kim Kyong-Wol Yang Wook Jae Lee nam ho Lee Chang-Gu Hyun Cosmetic Science Center Department of ChemistryJeju National University Jeju Technopark Ara-1-dongJeju-siJeju 690-121.Korea Citrus Research Station National Institute of Horticultural & Herbal ScienceRDAJeju 699-946.Korea Jeju Love Co. Ltd.542-5 Haengwon-ri.Gujwa-eupJeju 695-975.Korea LINC Agency Jeju National University

Objective:To investigate the anti-inflammatory effects of Jeju seaweeds on macrophage RAW264.7 cells under lipopolysaccharide(LPS)***:Ethyl acetate fractions were prepared from five different types of Jeju seaweeds,Dictyopteris divaricata(***),Dictyopteris prolifera(***),Prioutis cornea(***,Grateloupia laceolata(G,lanceolate,and Cralcloupia filicina(***)They were screened for inhibitory effects on proinflammatory mediators and cytokines such as nitric oxide(NO),prostaglandin E,,tumor necrosis factor-a(TNF-a),and interleukin-6(11.-6).Results:Our results revealed that ***,***,***,***,and *** potently inhibited ***-stimulaled NO production(IC_(50),values were 18.0,38.36,38.43,32.81 and 37.14μg/mL,respectively).Consistent with these findings,***,***,***,and *** also reduced the IPS-induced and prostaglandin E,production in a concentration-dependent ***,they suppressed the expression of inducible NO synthase and cyclooxygenase-2 at the protein level in a dose-dependent manner in the RAW264.7 cells,as detennined by western *** addition,the levels of TNF-a and IL-6,released into the medium,were also reduced by ***,***,***,G,lanceolata,and *** in a dose-dependent manner(IC_(50)values for TNF-a were 16.11,28.21,84.27,45.52 and74.75μg/mL,respectively;IC_(50),values for IL-6 were 37.35,80.08,103.28,62.53 and 84.28μg/mL,respectively).The total phlorotannin content was measured by the Folin-Ciocalteu method and expressed as phloroglucinol *** content was 92.0μg/mg for ***,151.8μg/mg for ***,57.2μg/mg for ***,53.0 pg/mg for ***,and 40.2μg/mg for ***:Thus,these findings suggest that Jeju seaweed extracts have potential therapeutic applications for inflammatory responses.

关键词： Nitrie oxide Inlerleukin-6 Prostaglandin E_2 Tumor necrosis factor-α Seaweeds Proinflammatory mediators

Secure Path Cycle Selection Method Using Fuzzy Logic System for Improving Energy Efficiency in Statistical En-Route Filtering Based WSNs

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Wireless Sensor Network 2011年第11期3卷 357-361页

作者： Su Man nam Chung Il Sun Tae ho Cho 不详

Sensor nodes are easily compromised to malicious attackers due to an open environment. A false injected attack which takes place on application layer is elected by the compromised node. If the false report arrives in a base station, a false alarm is occurred, and the energy of the nodes is consumed. To detect the false report, statistical en-route filtering method is proposed. In this paper, we proposed the secure path cycle selection method using fuzzy rule-based system to consume effective energy. The method makes balanced energy consumption of each node. Moreover, the lifetime of the whole network will be increased. The base station determines the path cycle using the fuzzy rule-based system. The performance of the proposed method is demonstrated using simulation studies with the three methods.

关键词： Wireless Sensor Network Secure Path Cycle Selection Statistical En-route Filtering Path Selection Method Fuzzy System

LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 869-882页

作者： Shirley Yin-Yu Pang Rachel Cheuk nam Lo Philip Wing-Lok ho Hui-Fang Liu Eunice Eun Seo Chang Chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi Wing Yan Wong Michelle Hiu-Wai Kung David Boyer Ramsden Shu-Leong ho Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong KongChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongChina Institute of Metabolism and Systems Research University of BirminghamBirminghamUK.

Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. Phosphorylation of Rab GTPases by LRRK2 regulates lysosomal homeostasis and endosomal trafficking. Mutant LRRK2 impairs chaperone-mediated autophagy, resulting in α-syn binding and oligomerization on lysosomal membranes. Mutations in GBA reduce glucocerebrosidase (GCase) activity, leading to glucosylceramide accumulation, α-syn aggregation and broad autophagic abnormalities. LRRK2 and GBA influence each other: GCase activity is reduced in LRRK2 mutant cells, and LRRK2 kinase inhibition can alter GCase activity in GBA mutant cells. Clinically, LRRK2 G2019S mutation seems to modify the effects of GBA mutation, resulting in milder symptoms than those resulting from GBA mutation alone. however, dual mutation carriers have an increased risk of PD and earlier age of onset compared with single mutation carriers, suggesting an additive deleterious effect on the initiation of PD pathogenic processes. Crosstalk between LRRK2 and GBA in PD exists, but its exact mechanism is unclear. Drugs that inhibit LRRK2 kinase or activate GCase are showing efficacy in pre-clinical models. Since LRRK2 kinase and GCase activities are also altered in idiopathic PD (iPD), it remains to be seen if these drugs will be useful in disease modification of iPD.

关键词： Parkinson’s disease Interaction LRRK2 GBA GCase Mutation Autophagy α-Synuclein

Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea

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World Journal of Gastroenterology 2015年第46期21卷 13064-13072页

作者： Suk Pyo Shin nam Keun Kim Ju Hwan Kim Ju ho Lee Jung Oh Kim Sung Hwan Cho Hana Park Mi Na Kim Kyu Sung Rim Seong Gyu Hwang Department of Internal Medicine CHA Bundang Medical CenterCHA University Institute of Gastroenterology CHA Bundang Medical CenterCHA University Department of Biomedical Science College of Life ScienceCHA University Institute for Clinical Research CHA Bundang Medical CenterCHA University Department of Internal Medicine CHA Gangnam Medical CenterCHA University

AIM: To investigate associations between the tumor necrosis factor alpha(TNF-α)-1031 T>C,-863 C>A,-857 C>T,-308 G>A,and-238 G>A polymorphisms and HCC in ***: Hepatocellular carcinoma(HCC) cases were diagnosed at CHA Bundang Medical Center from June 1996 to August 2008. The association between TNF-α polymorphisms and HCC was analyzed in 157HCC patients and 201 controls using a polymerase chain reaction-restriction fragment length polymorphism assay. We investigated five TNF-α polymorphisms,which are TNF-α-1031 T>C,-863 C>A,-857 C>T,-308 G>A,and-238 G>A. The TNF-α genotype frequencies,genotype combinations and haplotypes were analyzed to disclose the association with ***: None of the TNF-α polymorphisms was significantly associated with HCC. however,nine genotype combinations had associations with increased likelihood of HCC. Among them,TNF-α-1031/-857/-238 TT/CC/GA(AOR = 18.849,95%CI: 2.203-161.246,P = 0.007),TNF-α-1031/-308/-238 TT/GG/GA(AOR = 26.956,95%CI: 3.071-236.584,P = 0.003),and TNF-α-1031/-238 TT/GA(AOR = 21.576,95%CI: 2.581-180.394,P = 0.005) showed marked association with HCC. There were five haplotypes of TNF-α polymorphisms which were significantly associated with HCC. They are TNF-α-1031/-863/-857/-308/-238 T-C-C-G-A(OR = 25.824,95%CI: 1.491-447.223,P = 0.0005),TNF-α-1031/-857/-308/-238 T-C-G-A(OR = 12.059,95%CI: 2.747-52.950,P hose with the TT genotype(AOR = 5.795,95%CI: 1.145-29.323). CONCLUSION: Although no single TNF-α polymorphism is associated with HCC in this study,some TNF-α genotype combinations and haplotypes are associated with HCC. In addition,HCC Okuda stage Ⅲ cases with the TNF-α-1031 TT genotype may have a better pr

关键词： Tumor necrosis factor-alpha Polymorphism Single nu

Realizing High Thermoelectric Performance in n-Type Se-Free Bi_(2)Te_(3)Materials by Spontaneous Incorporation of FeTe_(2)Nanoinclusions

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Energy & Environmental Materials 2024年第4期7卷 344-354页

作者： Jamil Ur Rahman Woo Hyun nam Yong-Jae Jung Jong ho Won Jong-Min Oh Nguyen Van Du Gul Rahman Víctor M.García-Suárez Ran He Kornelius Nielsch Jung Young Cho Won-Seon Seo Jong Wook Roh Sang-il Kim Soonil Lee Kyu Hyoung Lee Hyun Sik Kim Weon ho Shin Leibniz Institute for Solid State and Materials Research Dresden 01069Germany Advanced Materials Convergence R&D Division Korea Institute of Ceramic Engineering&TechnologyJinju 52861South Korea Department of Electronic Materials Engineering Kwangwoon UniversitySeoul 01897South Korea Department of Energy Engineering Dankook UniversityCheonan 31116South Korea Faculty of Fundamental Science Phenikaa UniversityHanoi 10000Vietnam Department of Physics Quaid-i-Azam UniversityIslamabad 45320Pakistan Departamento de FAısica Universidad de OviedoOviedo 33007Spain Nanomaterials and Nanotechnology Research Center-CINN El Entrego 33940Spain Department of Materials Science and Engineering Yonsei UniversitySeoul 03722South Korea School of Nano&Materials Science and Engineering Kyungpook National UniversitySangju 37224South Korea Department of Materials Science and Engineering University of SeoulSeoul 02504South Korea School of Materials Science and Engineering Changwon National UniversityChangwon 51140South Korea

Bi_(2)Te_(3)-based materials have drawn much attention from the thermoelectric community due to their excellent thermoelectric performance near room ***,the stability of existing n-type Bi_(2)(Te,Se)_(3)materials is still low due to the evaporation energy of Se(37.70 kJ mol^(-1))being much lower than that of Te(52.55 kJ mol^(-1)).The evaporated Se from the material causes problems in interconnects of the module while degrading the ***,we have developed a new approach for the high-performance and stable n-type Se-free Bi_(2)Te_(3)-based materials bymaximizing the electronic transport while suppressing the phonon transport,at the same *** generated FeTe_(2)nanoinclusions within the matrix during the melt-spinning and subsequent spark plasma sintering is the key to simultaneous engineering of the power factor and lattice thermal *** nanoinclusions change the fermi level of the matrix while intensifying the phonon scattering via *** a fine-tuning of the fermi level with Cu doping in the n-type Bi_(2)Te_(3)-0.02FeTe_(2),a high power factor of∼41×10^(-4)Wm^(-1)K^(-2)with an average zT of 1.01 at the temperature range 300-470 K are achieved,which are comparable to those obtained in n-type Bi_(2)(Te,Se)_(3)*** proposed approach enables the fabrication of high-performance n-type Bi_(2)Te_(3)-based materials without having to include volatile Se element,which guarantees the stability of the ***,widespread application of thermoelectric devices utilizing the n-type Bi_(2)Te_(3)-based materials will become possible.

关键词： Bi_(2)Te_(3) energy harvesting FeTe_(2) nanoinclusion n-type materials thermoelectric