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Diffusion-weighted imaging of biliopancreatic disorders:Correlation with conventional magnetic resonance imaging

World Journal of Gastroenterology 2012年第31期18卷 4102-4117页

作者： nam Kyung Lee Suk Kim Gwang Ha Kim Dong Uk Kim Hyung Il Seo Tae Un Kim Dae Hwan Kang ho Jin Jang Department of Radiology Biomedical Research InstitutePusan National University HospitalSchool of MedicinePusan National UniversityBusan 602-739South Korea Department of Internal Medicine Biomedical Research InstitutePusan National University HospitalSchool of MedicinePusan National UniversityBusan 602-739South Korea Department of Surgery Biomedical Research InstitutePusan National University HospitalSchool of MedicinePusan National UniversityBusan 602-739South Korea Department of Radiology Yangsan Pusan National University HospitalSchool of MedicinePusan National UniversityYangsan 626-770South Korea Department of Internal Medicine Yangsan Pusan National University HospitalSchool of MedicinePusan National UniversityYangsan 626-770South Korea Department of Obstetrics and Gynecology Armed Forces Seoul HospitalSeoul 110-200South Korea

Diffusion-weighted magnetic resonance imaging(DWI)is a well established method for the evaluation of intracranial diseases,such as acute *** for extracranial application is more difficult due to physiological motion artifacts and the heterogeneous composition of the ***,thanks to the newer technical development of DWI,DWI has become increasingly used over the past few years in extracranial organs including the abdomen and *** previous studies of DWI have been limited to the evaluation of diffuse parenchymal abnormalities and focal lesions in abdominal organs,whereas there are few studies about DWI for the evaluation of the biliopancreatic *** further studies are needed to determine its performance in evaluating bile duct,gallbladder and pancreas diseases,DWI has potential in the assessment of the functional information on the biliopancreatic tract concerning the status of tissue cellularity,because increased cellularity is associated with impeded diffusion,as indicated by a reduction in the apparent diffusion *** detection of malignant lesions and their differentiation from benign tumor-like lesions in the biliopancreatic tract could be improved using DWI in conjunction with findings obtained with conventional magnetic resonance ***,DWI can be useful for the assessment of the biliopancreatic tract in patients with renal impairment because contrast-enhanced computed tomography or magnetic resonance scans should be avoided in these patients.

关键词： Magnetic resonance imaging Diffusion-weighted imaging Biliary tract Gallbladder Pancreas

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Function-regeneration of non-porous hydrolyzed-MOF-derived materials

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Nano Research 2019年第8期12卷 1921-1930页

作者： Yo Chan Jeong Jin Weon Seo Jae ho Kim Seunghoon nam Min Chang Shin Young Shik Cho Jin Syul Byeon Chong Rae Park Seung Jae Yang Carbon Nanomaterials Design Laboratory Research Institute of Advanced Materials and Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Advanced Nanohybrids Lab. Department of Chemical Engineering Inha UniversityIncheon 22212Republic of Korea School of Advanced Materials Engineering College of Engineering Andong National University Andong Gyeongsangbuk-do 36729Republic of Korea

A facile synthetic strategy based on a water-based process is developed for the preparation of metal-organic framework (MOF)-derived materials by revisiting the hydrolyzed non-porous metal-organic frameworks (h-MOF). The poor water stability of MOF has been recognized as key limitations for its commercialization and large-scale applications because the hydrolysis resulted in the complete loss of their functionalities. however, we found that the negative effect of hydrolysis on MOF can be nullified during the heat treatment. As similar to the intact MOF, h-MOF can be used as a precursor for the preparation of MOF-derived materials from porous MOF-derived carbons (MDCs) to MDC@ZnO composites. The property of h-MOF-derived materials is almost equivalent to that of MOF-derived materials. In addition, h-MOF turned the weakness of water instability to the strength of facile water-based process for hybridization. With the demonstration of the hybrid composite between h-MDC@ZnO and reduced graphene oxide (rGO) as a prototype example, it exhibited superior electrochemical performance when evaluated as an electrode material for lithium-ion batteries.

关键词： nanomaterials metal-organic framework (MOF) porous materials MOF-derived carbon hydrolyzed MOF

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Incidental renal cell carcinoma post bilateral nephrectomy in autosomal dominant polycystic kidney disease

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World Journal of Clinical Cases 2024年第28期12卷 6187-6194页

作者： Min-ho Shin nam-Kyu Choi Division of General Surgery Department of Hepato-Bilio-Pancreatic Surgery and Transplantation SurgeryChosun University College of MedicineGwangju 61453South Korea

BACKGROUND Renal cell carcinoma(RCC)is more common in patients with autosomal dominant polycystic kidney disease(ADPKD)than in the general *** RCC in ADPKD is challenging due to the presence of multiple renal cysts,often leading to delays and difficulties in distinguishing RCC from cyst infection or hemorrhage.A total of 38 kidneys were excised from 19 patients,with a mean age of 56.8 years and an average hemodialysis duration of 84.2 *** patients underwent open nephrectomies,and 11 underwent hand-assisted laparoscopic *** was detected in 15.8%of kidneys,affecting 21.1%of *** patients had multifocal RCC in both *** RCC cases were pT1 stage,with the largest lesion averaging 16.5 mm in *** average operative duration was 120 minutes,with intraoperative blood loss averaging 184.2 *** patients required blood *** complications occurred in five patients,with a mean hospital stay of 17.1 *** mean follow-up period was 28.1 *** The prevalence of RCC is higher in patients with ADPKD with ESRD than in those with ESRD ***,clinicians should be cautious and implement surveillance programs to monitor the development of RCC in patients with ADPKD,particularly those on dialysis.

关键词： Renal cell carcinoma Autosomal dominant polycystic kidney disease End-stage renal disease Kidney transplantation Nephrectomy

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Influence of the Kerr Effect on the Optical Force Acting on the Dielectric Particle

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Journal of Physical Science and Application 2012年第10期2卷 414-419页

作者： Quang Quy ho Van nam hoang NEWTECHPRO Vietnam Academy of Science and Technology Hanoi Vietnam Council of Science and Technology Hatinh Vietnam

Basing on the necessary condition for the trapping dielectric particle by the Gaussian beam, the Kerr effect in the tweezers with the nonlinear particle or the nonlinear medium is proposed to concern. The expressions of the optical forces concerned with the Kerr effect, which affects the refractive index of the medium, are presented. The distribution of the optical forces in the trapping region is simulated and discussed. The results show that the stability of the tweezers depends on the nonlinear coefficient of refractive index, and the optical tweezers could be broken down with a critical value of the nonlinear coefficient of refractive index of the surrounding medium, or with a critical value of the laser intensity, duration of laser pulse, and radius of beam waist. Moreover, these results give us the explanation the stability of the optical tweezers used for the trapped object as biological molecule embedded in the fluid, which is sensitive with Kerr effect.

关键词： Optical tweezers optical force Kerr effect nonlinear medium.

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Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第5期11卷 315-322页

作者： Eun-Jin YANG Ji-Young MOON Min-Jin KIM Dong Sam KIM Chan-Shick KIM Wook Jae LEE nam ho LEE Chang-Gu HYUN Jeju Biodiversity Research Institute(JBRI) Jeju High-Tech Development Institute(HiDI) Jeju 699-943Korea Jeju Seaweed Industry Development Agency Cheju National UniversityJeju 690-756Korea Faculty of Biotechnology Cheju National UniversityJeju 690-756Korea Department of Chemistry Cheju National UniversityJeju 690-756Korea

Seaweed has been used in traditional cosmetics and as a herbal medicine in treatments for cough,boils,goiters,stomach ailments,and urinary diseases,and for reducing the incidence of tumors,ulcers,and *** the fact that seaweeds are frequently used in the practice of human health,little is known about the role of seaweed in the context of *** study aimed to investigate the influence of Jeju endemic seaweed on a mouse macrophage cell line(RAW 264.7) under the stimulation of lipopolysaccharide(LPS).Ethyl acetate extracts obtained from 14 different kinds of Jeju seaweeds were screened for inhibitory effects on pro-inflammatory *** results revealed that extracts from five seaweeds,Laurencia okamurae,Grateloupia elliptica,Sargassum thun-bergii,Gloiopeltis furcata,and Hizikia fusiformis,were potent inhibitors of the production of pro-inflammatory mediators such as nitric oxide(NO),prostaglandin E2(PGE2),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α).Based on these results,the anti-inflammatory effects and low cell toxicity of these seaweed extracts suggest potential thera-peutic applications in the regulation of the inflammatory response.

关键词： Nitric oxide Interleukin-(IL-) Prostaglandin E(PGE) Tumor necrosis factor-α(TNF-α) Seaweeds Pro-inflammatory mediators

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Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第15期14卷 2394-2400页

作者： Yeon Seok Seo Jin nam Kim Bora Keum Sanghoon Park Yong Dae Kwon Yong Sik Kim Yoon Tae Jeen hoon Jai Chun Chul Yong Kim Chang Duck Kim ho Sang Ryu Soon ho Um Department of Internal Medicine Korea University College of Medicine Seoul 136-705 Korea Department of Radiation Oncology Korea University College of Medicine Seoul 136-705 Korea

AIM: To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC). METhoDS: A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage Ⅲ and Ⅳ-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate 1 mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT. RESULTS: The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, α-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m ≥ 20% than in those with TRR1m < 20% (P < 0.001). CONCLUSION: RT is effective in treating advanced HCC with a tumor response rate of 56.9%.

关键词： Hepatocellular carcinoma Radiotherapy Treatment response Survival

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Brain physiome:A concept bridging in vitro 3D brain models and in silico models for predicting drug toxicity in the brain

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Bioactive Materials 2022年第7期7卷 135-148页

作者： Yoojin Seo Seokyoung Bang Jeongtae Son Dongsup Kim Yong Jeong Pilnam Kim Jihun Yang Joon-ho Eom Nakwon Choi hong nam Kim Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul02792Republic of Korea Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon34141Republic of Korea Next&Bio Inc. Seoul02841Republic of Korea Medical Device Research Division National Institute of Food and Drug Safety EvaluationCheongju28159Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul03722Republic of Korea Yonsei-KIST Convergence Research Institute Yonsei UniversitySeoul03722Republic of Korea

In the last few decades,adverse reactions to pharmaceuticals have been evaluated using 2D in vitro models and animal ***,with increasing computational power,and as the key drivers of cellular behavior have been identified,in silico models have *** models are time-efficient and cost-effective,but the prediction of adverse reactions to unknown drugs using these models requires relevant experimental ***,the physiome concept has emerged to bridge experimental datasets with in silico *** brain physiome describes the systemic interactions of its components,which are organized into a multilevel *** of the limitations in obtaining experimental data corresponding to each physiome component from 2D in vitro models and animal models,3D in vitro brain models,including brain organoids and brain-on-a-chip,have been *** this review,we present the concept of the brain physiome and its hierarchical organization,including cell-and tissue-level *** also summarize recently developed 3D in vitro brain models and link them with the elements of the brain physiome as a guideline for dataset *** connection between in vitro 3D brain models and in silico modeling will lead to the establishment of cost-effective and time-efficient in silico models for the prediction of the safety of unknown drugs.

关键词： Brain physiome In vitro 3D platform Brain organoid Brain-on-a-chip In silico model

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Production of Poly(3-Hydroxybutyrate)by Fed-Batch Culture of Alcaligenes Eutrophus at Phosphorus Limitation in 50 L fermenter

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Chinese Journal of Chemical Engineering 1999年第4期7卷 368-371页

作者：李红旗沈忠耀 ParkbyungGeon ChangYongKeun Changhonam DepartmentofChemicalEngineering TsinghuaUniversityBeijing100084 BioprocessEngineeringResearchCenterandDepartmentofChemicalEnineering KoreaAdvancedInstituteofScienceandTechnologyTaejon305-701Korea

Poly(3-hydroxybutyrate) (PHB) is an intracellular carbon and energy storage material accumulated by many kinds of microorganism under unfavorable growth conditions. For the production of PHB, Alcaligenes eutrophus has been widely used because it is easy to grow, and its physiological and biochemical changes during the PHB synthesis is understood in details. A very high concentration and productivity of PHB could be obtained by fed-batch culture of Alcaligenes eutrophus with phosphate limitation in 50 L fermenter.

关键词： poly(3-hydroxybutyrate) Alcaligenes eutrophus scale-up fermentation

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Modeling and Adaptive Self-Tuning MVC Control of PAM Manipulator Using Online Observer Optimized with Modified Genetic Algorithm

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Engineering（科研） 2011年第2期3卷 130-143页

作者： ho Pham Huy Anh Nguyen Thanh nam 不详

In this paper, the application of modified genetic algorithms (MGA) in the optimization of the ARX Model-based observer of the Pneumatic Artificial Muscle (PAM) manipulator is investigated. The new MGA algorithm is proposed from the genetic algorithm with important additional strategies, and consequently yields a faster convergence and a more accurate search. Firstly, MGA-based identification method is used to identify the parameters of the nonlinear PAM manipulator described by an ARX model in the presence of white noise and this result will be validated by MGA and compared with the simple genetic algorithm (GA) and LMS (Least mean-squares) method. Secondly, the intrinsic features of the hysteresis as well as other nonlinear disturbances existing intuitively in the PAM system are estimated online by a Modified Recursive Least Square (MRLS) method in identification experiment. Finally, a highly efficient self-tuning control algorithm Minimum Variance Control (MVC) is taken for tracking the joint angle position trajectory of this PAM manipulator. Experiment results are included to demonstrate the excellent performance of the MGA algorithm in the NARX model-based MVC control system of the PAM system. These results can be applied to model, identify and control other highly nonlinear systems as well.

关键词： Modified Genetic Algorithm (MGA) Online System Identification ARX Model Pneumatic Artificial Muscle (PAM) PAM Manipulator Minimum Variance Controller (MVC)

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Brain Activity Associated with Memory and Cognitive Function During Jaw-Tapping Movement in Healthy Subjects Using Functional Magnetic Resonance Imaging*

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Chinese Journal of Integrative Medicine 2013年第6期19卷 409-417页

作者： Seung-Yeon Cho Ae-Sook Shin byung-Jo Na Geon-ho Jahng Seong-Uk Park Woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Department of Cardiovascular and Neurological Diseases College of Korean MedicineKyung Hee UniversitySeoulKorea Department of Internal Medicine Kang-Nam Korean HospitalKyung Hee UniversitySeoulKorea Department of Radiology Kyung Hee University Hospital at GangdongSchool of MedicineKyuna Hee UniversitySeoulKorea

Objective： TO determine whether jaw-tapping movement, a classically described as an indication of personal well-being and mental health, stimulates the memory and the cognitive regions of the brain and is associated with improved brain performance. Methods： Twelve healthy right-handed female subjects completed the study. Each patient performed a jaw-tapping task and an n-back task during functional magnetic resonance imaging （fMRI）. The subjects were trained to carry out the jaw-tapping movement at home twice a day for 4 weeks. The fMRI was repeated when they returned. Results： During the first and second jaw-tapping session, both sides of precentral gyrus and the right middle frontal gyrus （BA 6） were activated. And during the second session of the jaw-tapping task, parts of frontal lobe and temporal lobe related to memory function were more activated. In addition, the total percent task accuracy in n-beck task significantly increased after 4 weeks of jaw- tapping movement. After jaw-tapping training for 4 weeks, brain areas related to memory showed significantly increased blood oxygen level dependent signals. Conclusion： Jaw-tapping movement might be a useful exercise for stimulating the memory and cognitive regions of the brain.

关键词： Jaw-tapping movement functional magnetic resonance imaging memory cognitive function dementia

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