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Intestinal challenge with enterotoxigenic Escherichia coli in pigs,and nutritional intervention to prevent postweaning diarrhea

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Animal Nutrition 2017年第4期3卷 322-330页

作者： Yawang sun sung Woo kim Department of Animal Science North Carolina State University College of Animal Science and Technology Southwest University

Gut health of nursery pigs immediately after weaning is tightly associated with their growth performance and economic values. Postweaning diarrhea(PWD) is one of the major concerns related to gut health of nursery pigs which often is caused by infections of enterotoxigenic Escherichia coli(ETEC),mainly including F4(K88)^+ and F18^+ E. coli. The main virulence factors of ETEC are adhesins(fimbriae or pili) and enterotoxins. The common types of fimbriae on ETEC from PWD pigs are F18^+ and F4^+. Typically, PWD in pigs is associated with both F18^+ and F4^+ ETEC infections whereas pre-weaning diarrhea in pigs is associated with F4+ ETEC infection. Enterotoxins including heat-labile enterotoxins(LT) and heatstable peptide toxins(ST) are associated with causing diarrhea in pigs. At least 109 to 1010 ETEC are required to induce diarrhea in nursery pigs typically lasting 1 to 5 days after ETEC infection. Antibiotics used to be the most effective way to prevent PWD, however, with the increased bacterial resistance to antibiotics, alternatives to the use of antibiotics are urgently needed to prevent PWD. Immunopropylaxis and nutritional intervention of antimicrobial minerals(such as zinc oxide and copper sulfate), organic acids, functional feedstuffs(such as blood plasma and egg yolk antibodies), direct fed microbials, phytobiotics, and bacteriophage can potentially prevent PWD associated with ETEC. Some other feed additives such as nucleotides, feed enzymes, prebiotic oligosaccharides, and clay minerals can enhance intestinal health and thus indirectly help with preventing PWD. Numerous papers show that nutritional intervention using selected feed additives can effectively prevent PWD.

关键词： Enterotoxigenic Escherichia coli Feed additives Immunopropylaxis Nutritional intervention Pigs Postweaning diarrhea

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Korean red ginseng promotes hippocampal neurogenesis in mice

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Neural Regeneration Research 2020年第5期15卷 887-893页

作者： sun Ryu Hyongjun Jeon Hee-Young kim sungtae Koo Seungtae kim Korean Medicine Research Center for Healthy Aging Pusan National University49 Busandaehak-roMulgeum-eupYangsan-siGyeongsangnam-do 50612Republic of Korea Department of Korean Medical Science School of Korean MedicinePusan National University49 Busandaehak-roMulgeum-eupYangsan-siGyeongsangnam-do 50612Republic of Korea

Neurogenesis in the adult hippocampus plays a major role in cognitive ability of animals including learning and *** red ginseng (KRG) has long been known as a medicinal herb with the potential to improve learning and memory;however,the mechanisms are still ***,we evaluated whether KRG can promote cognitive function and enhance neurogenesis in the ***-week-old male C57BL/6 mice received 50 mg/kg of 5-bromo-2′-deoxyuridine (BrdU) intraperitoneally and 100 mg/kg of KRG or vehicle orally once a day for 14 ***,Rotarod and Morris water maze tests were performed and the brains were collected after the last behavioral *** in the numbers of BrdU- and BrdU/ doublecortin (DCX;a marker for neuronal precursor cells and immature neurons)-positive cells in the dentate gyrus and the gene expression of proliferating cell nuclear antigen (a marker for cell differentiation),cerebral dopamine neurotrophic factor and ciliary neurotrophic factor in the hippocampus were then ***-treated mice came down the pole significantly faster and stood on the rotarod longer than vehicle-treated *** Morris water maze test showed that KRG administration enhanced the learning and memory abilities *** also significantly increased BrdU- and BrdU/DCX-positive cells in the dentate gyrus as well as the proliferating cell nuclear antigen,cerebral dopamine neurotrophic factor and ciliary neurotrophic factor mRNA expression levels in the hippocampus compared to *** of KRG promotes learning and memory abilities,possibly by enhancing hippocampal *** study was approved by the Pusan National University Institutional Animal Care and Use Committee (approval ***-2016-1071) on January 19,2016.

关键词： bromodeoxyuridine cerebral dopamine neurotrophic factor ciliary neurotrophic factor doublecortin ginseng hippocampus Korean red ginseng learning memory neurogenesis proliferating cell nuclear antigen red ginseng

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Hurst’s Memory for Chaotic, Tree Ring, and SOI Series

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Applied Mathematics 2014年第1期5卷 175-195页

作者： byung-Sik kim Hung-Soo kim sun-Hong Min Department of Civil Engineering Inha University Incheon South Korea Department of Urban Environmental Prevention Engineering School of Disaster Prevention Kangwon National University Gangwon South Korea

Hurst’s memory that roots in early work of the British hydrologist H.E. Hurst remains an open problem in stochastic hydrology. Today, the Hurst analysis is widely used for the hydrological studies for the memory and characteristics of time series and many methodologies have been developed for the analysis. So, there are many different techniques for the estimation of the Hurst exponent (H). However, the techniques can produce different characteristics for the persistence of a time series each other. This study uses several techniques such as adjusted range, rescaled range (RR) analysis, modified rescaled range (MRR) analysis, 1/f power spectral density analysis, Maximum Likelihood Estimation (MLE), detrended fluctuations analysis (DFA), and aggregated variance time (AVT) method for the Hurst exponent estimation. The generated time series from chaos and stochastic systems are analyzed for the comparative study of the techniques. Then, this study discusses the advantages and disadvantages of the techniques and also the limitations of them. We found that DFA is the most appropriate technique for the Hurst exponent estimation for both the short term memory and long term memory. We analyze the SOI (Southern Oscillations Index) and 6 tree-ring series for USA sites by means of DFA and the BDS statistic is used for nonlinearity test of the series. From the results, we found that SOI series is nonlinear time series which has a long term memory of H = 0.92. Contrary to earlier work, all the tree ring series are not random from our analysis. A certain tree ring series show a long term memory of H = 0.97 and nonlinear property. Therefore, we can say that the SOI series has the properties of long memory and nonlinearity and tree ring series could also show long memory and non-linearity.

关键词： Hurst’s Memory DFA Chaotic Series Tree-Ring Series SOI BDS Statistic

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Amomum villosum induces longitudinal bone growth in adolescent female rats

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Journal of Traditional Chinese Medicine 2012年第3期32卷 453-458页

作者： sun Haeng Lee Ji Young kim Hocheol kim Seul Ki Park Cho Young kim sun Yong Chung Gyu Tae Chang Department of Pediatrics of Korean Medicine Kyung Hee University Hospital at Gang-dong892 Dongnam-roGangdong-guSeoul 134-727Republic of Korea Department of Herbal Pharmacology College of Korean MedicineKyung Hee University26 Kyungheedae-roDongdaemoon-guSeoul 130-701Republic of Korea Department of Neuropsychiatry of Korean Medicine Kyung Hee University Hospital at Gang-dong892 Dongnam-roGangdong-guSeoul 134727Republic of Korea

OBJECTIVE:This study was conducted to evaluate the effect of Amomum villosum on longitudinal bone ***:Adolescent female Sprague-Dawley rats were divided into 3 groups and treated for 4 days:control(distilled water,p.o.),recombinant human growth hormone(rhGH;100 μg/kg,s.c.),and ***(500 mg/kg,p.o.) *** day 3,tetracycline(20 g/kg,i.p.) was injected for growth plate *** days 2,3 and 4,5-bromo-2'-deoxyuridine(BrdU)(50 mg/kg,i.p.) was injected to label proliferating *** day 5,tibias were dissected and fixed in 4% paraformaldehyde,dehydrated,and sectioned for immunohistochemistry and ***:The rate of bone growth in the *** and rhGH groups increased to(410 ± 44) and(389 ± 46) μm/day(P<0.01),respectively,as compared with the control(330.7 ± 34.7) μm/*** thickness of the growth plates also increased to(591 ± 37) and(598 ± 32) μm,respectively,as compared with the control(524± 89) μm(P<0.001).The number of BrdU-positive cells in the chondrocytes of the *** and rhGH groups was also significantly higher(126±24) and(143±18) cells/mm 2,respectively) than in the control(109 ± 25) mm 2(P<0.05).Insulin-like growth factor-1 and bone morphogenetic protein-2 in the *** and rhGH groups were highly expressed in the growth plate as compared with the control samples,indicating increased bone ***:*** could be used to treat growth retardation during adolescence.

关键词： Amomum villosum Growth plate Bone Development Recombinant human growth hormone

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Detection and treatment of synchronous lesions in colorectal cancer: The clinical implication of perioperative colonoscopy

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World Journal of Gastroenterology 2007年第30期13卷 4108-4111页

作者： Min sun kim Young Jin Park Department of Surgery Dongguk University International Hospital Dongguk University School of Medicine Goyang Korea Department of Surgery Ilsanpaik Hospital Inje University School of Medicine Goyang Korea

AIM： To evaluate the clinical significance of preand intra-operative colonoscopy for the detection of synchronous lesions in colon cancer.METHODS： Two hundred and sixty-five pre-operative and 51 intra-operative colonoscopic evaluations were performed in 316 colorectal cancer patients who underwent curative resection from January 2001 to June 2006. The incidence and characteristics of synchronous lesions and their influence on surgery were evaluated.RESULTS： Two hundred and eighty-two synchronous lesions were detected in 124 （39.2%） of 316 patients including all lesions regardless of their histologic type. True adenomatous polyps were found in 91 （28.8%） of 326 patients, and 27 （5.4% of all patients） patients had synchronous colon cancers. The preoperative identification of synchronous lesions altered the planned surgery in 37 （14.0%） of 265 patients. In 18 patients among the surgically removed cases, the lesions were removed by extending the resection range. Further segmental resection or polypectomy through enterotomy was necessary in 29 patients. Nineteen （37.2%） of 52 intraoperative colonoscopy cases had synchronous lesions. Additional surgical procedures including segmental bowel resection and polypectomy with enterotomy were necessary in 7 （23.7%） of 52 intraoperative colonoscopy cases to remove the lesions.CONCLUSION： Synchronous colorectal polyps or cancer are frequent and their preoperative detection is important for optimal surgical planning and treatment. Intraoperative colonoscopy is a useful option in cases where a preoperative colonoscopy is not feasible.

关键词： Colon cancer Synchronous colon polyp Intraoperative colonoscopy

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Comparison of Missing Data Imputation Methods in Time Series Forecasting

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Computers, Materials & Continua 2022年第1期70卷 767-779页

作者： Hyun Ahn Kyunghee sun Kwanghoon Pio kim Division of Software Convergence Hanshin UniversityGyeonggi18101Korea Contents Convergence Software Research Institute Kyonggi UniversityGyeonggi16227Korea Division of AI Computer Science and Engineering Kyonggi UniversityGyeonggi16227Korea

Time series forecasting has become an important aspect of data analysis and has many real-world ***,undesirable missing values are often encountered,which may adversely affect many forecasting *** this study,we evaluate and compare the effects of imputationmethods for estimating missing values in a time *** approach does not include a simulation to generate pseudo-missing data,but instead perform imputation on actual missing data and measure the performance of the forecasting model created *** an experiment,therefore,several time series forecasting models are trained using different training datasets prepared using each imputation ***,the performance of the imputation methods is evaluated by comparing the accuracy of the forecasting *** results obtained from a total of four experimental cases show that the k-nearest neighbor technique is the most effective in reconstructing missing data and contributes positively to time series forecasting compared with other imputation methods.

关键词： Missing data imputation method time series forecasting LSTM

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3D cellular visualization of intact mouse tooth using optical clearing without decalcification

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International Journal of Oral Science 2019年第3期11卷 223-230页

作者： Sujung Hong Jingu Lee Jin Man kim sun-Young kim Hyung-Ryong kim Pilhan kim Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and Technology (KAIST)291 Daehak-roYuseong-guRepublic of Korea KI for Health Science and Technology (KIHST) Korea Advanced Institute of Science and Technology (KAIST)291 Deahak-roYuseong-guRepublic of Korea Department of Dentistry CHA Bundang Medical CenterCHA UniversitySeongnamRepublic of Korea Department of Conservative Dentistry and Dental Research Institute Seoul National University School of Dentistry101 Daehak-roJongno-guRepublic of Korea College of Dentistry Institute of Tissue Regeneration Engineering (ITREN)Dankook UniversityCheonanRepublic of Korea Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST)291 Daehak-roYuseong-guRepublic of Korea

Dental pulp is composed of nerves,blood vessels,and various types of cells and surrounded by a thick and hard enamel-dentin *** to its importance in the maintenance of tooth vitality,there have been intensive efforts to analyze the complex cellularlevel organization of the dental pulp in *** conventional histologic analysis has provided microscopic images of the dental pulp,3-dimensional (3D) cellular-level visualization of the whole dental pulp in an intact tooth has remained a technically challenging *** is mainly due to the inevitable disruption and loss of microscopic structural features during the process of mechanical sectioning required for the preparation of the tooth sample for histological *** accomplish 3D microscopic observation of thick intact tissue,various optical clearing techniques have been developed mostly for soft tissue,and their application for hard tissues such as bone and teeth has only recently started to be *** this work,we established a simple and rapid optical clearing technique for intact mouse teeth without the time-consuming process of *** achieved 3D cellular-level visualization of the microvasculature and various immune cell distributions in the whole dental pulp of mouse teeth under normal and pathologic *** technique could be used to enable diverse research methods on tooth development and regeneration by providing 3D visualization of various pulpal cells in intact mouse teeth.

关键词： blood vessels Dental pulp soft tissue

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Controllable substitutional vanadium doping in wafer-scale molybdenum disulfide films

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Nano Research 2023年第2期16卷 3415-3421页

作者： Jihyung Seo Eunbin Son Jiha kim sun-Woo kim Jeong Min Baik Hyesung Park Department of Materials Science and Engineering Graduate School of Semiconductor Materials and Devices EngineeringGraduate School of Carbon NeutralityLow Dimensional Carbon Materials CenterUlsan National Institute of Science and TechnologyUlsan 44919Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea SKKU Institute of Energy Science and Technology Sungkyunkwan UniversitySuwon 16419Republic of Korea

Substitutional atomic doping of transition metal dichalcogenides(TMDs)in the chemical vapor deposition(CVD)process is a promising and effective strategy for modifying their physicochemical ***,the conventional CVD method only allows narrow-range modulation of the dopant concentration owing to the low reactivity of the ***,the growth of wafer-scale monolayer TMD films with high dopant concentrations is much more ***,we report a facile doping approach based on liquid precursor-mediated CVD process for achieving high vanadium(V)doping in the MoS_(2)lattice with excellent doping uniformity and *** lateral growth of the host MoS_(2)lattice and the reactivity of the V precursor were simultaneously improved by introducing an alkali metal halide as a reaction *** metal halide promoter enabled the wafer-scale synthesis of V-incorporated MoS_(2)monolayer film with excessively high doping *** excellent wafer-scale uniformity of the highly V-doped MoS_(2)film was confirmed through a series of microscopic,spectroscopic,and electrical analyses.

关键词： doping concentration reaction promoter substitutional doping transition metal dichalcogenides wafer-scale growth

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Use of a clinical pathway in laparoscopic gastrectomy for gastric cancer

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World Journal of Gastroenterology 2015年第48期21卷 13507-13517页

作者： Hee sung kim sun Oak kim byung Sik kim Department of Gastric Surgery Asan Medical CenterUlsan University School of Medicine Department of Clinical Epidemiology and Biostatistics Asan Medical CenterUlsan University School of Medicine

AIM: To evaluate the implementation of a clinical pathway and identify clinical factors affecting the clinical pathway for laparoscopic ***: A standardized clinical pathway for gastric cancer(GC) patients was developed in 2001 by the GC surgery team at the Asan Medical Center. We reviewed the collected data of 4800 consecutive patients treated using the clinical pathway following laparoscopic gastrectomy with lymph node dissection for GC involving intracorporeal and extracorporeal anastomosis. The patients were treated between August 2004 and October 2013 in a single institution. To evaluate the rate of completion and risk factors affecting dropout from the clinical pathway, we used a multivariate logistic regression ***: The overall completion rate of the clinical pathway for laparoscopic gastrectomy was 84.1%(n = 4038). In the comparison between groups of intracorporeal anastomosis and extracorporeal anastomosis patients, the completion rates were 8 3. 8 8 %(n = 1 7 4 0) a n d 8 4. 3 6 %(n = 2 0 7 1), respectively, showing no statistically significant difference. The main reasons for dropping out were postoperative complications(n = 463, 9.7%) and the need for patient observation(n = 299, 6.2%). Among the discharged patients treated using the clinical pathway, the number of patients who were readmitted within 30 d due to postoperative complications was 54(1.1%). In a multivariate analysis, the intraoperative events(OR = 2.558) were the most predictable risk factors for dropping out of the clinical pathway. Additionally, being male(OR = 1.459), advanced age(OR = 1.727), total gastrectomy(OR = 2.444), combined operation(OR = 1.731), and ASA score(OR = 1.889) were significant risk factors affecting the dropout rate from the clinical ***: Laparoscopic gastrectomy appears to be a good indication for the application of a clinical pathway. For successful application, patients with risk factors should be managed carefully.

关键词： Clinical pathway Laparoscopic gastrectomy Gastric cancer Extracorporeal anastomosis Intracorporealanastomosis

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K2Ti6O13 Nanoparticle-Loaded Porous rGO Crumples for Supercapacitors

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Nano-Micro Letters 2020年第1期12卷 115-123页

作者： Chongmin Lee sun Kyung kim Hankwon Chang Hee Dong Jang Department of Nanomaterials Science and Engineering University of Science and TechnologyYuseong‑guDaejeon 34113Republic of Korea Resources Utilization Research Center Korea Institute of Geoscience and Mineral ResourcesYuseong‑guDaejeon 34132Republic of Korea

One-dimensional alkali metal titanates containing potassium,sodium,and lithium are of great concern owing to their high ion mobility and high specific surface *** those titanates are combined with conductive materials such as graphene,carbon nanotube,and carbon nanofiber,they are able to be employed as efficient electrode materials for *** hexa-titanate(K2Ti6O13,KTO),in particular,has shown superior electrochemical properties compared to other alkali metal titanates because of their large lattice parameters induced by the large radius of potassium ***,we present porous rGO crumples(PGC)decorated with KTO nanoparticles(NPs)for application to *** KTO NP/PGC composites were synthesized by aerosol spray pyrolysis and post-heat *** NPs less than 10 nm in diameter were loaded onto PGCs ranging from 3 to 5μ*** porous structure of the composites was obtained by the activation of rGO by adding an excessive amount of KOH to the *** KTO NP/PGC composite electrodes fabricated at the GO/KOH/TiO2 ratio of 1:3:0.25 showed the highest performance(275 F g−1)in capacitance with different KOH concentrations and cycling stability(83%)after 2000 cycles at a current density of 1 A g−1.

关键词： Potassium hexa-titanate Porous graphene crumples Supercapacitors

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