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Risk Assessment Using Two Different Diagnostic Tools: Metabolic Syndrome and Cardiovascular Risk Score (SCORE)—Data from a Weight Reduction Intervention Study

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Food and Nutrition Sciences 2013年第10期4卷 1028-1036页

作者： Janina Willers Andreas hahn Institute of Food Science and Human Nutrition Leibniz University Hannover Hannover Germany.

Objective: Risk score models and the diagnosis of a metabolic syndrome are useful for cardiovascular (CV) risk prediction. The identification of individuals with high CV and metabolic risk is essential to provide appropriate prevention and therapy. The present study aims at clarifying whether these indicators are altered by a weight reduction programme. Additionally, which diagnostic tool has a better predictive value is examined. Method: One hundred and twenty overweight and obese subjects aged 30 60 years were included in a 12-week weight reduction programme. The CV risk was assessed by means of German multiple-used risk charts (SCORE) at baseline and at the end of the trial. Furthermore, the prevalence of the metabolic syndrome (three out of five risk factors) was quantified. Results: The initial prevalence of the metabolic syndrome was 63.3% (n = 76) and decreased to 41.7% (n = 50) by the end of the intervention. The SCORE also decreased significantly after twelve weeks (p 5%) was comparatively low (t0: 7.4%, n = 7;t12: 5.3%, n = 5). Conclusion: The weight reduction concept was applicable to improve the CV risk SCORE and decrease the prevalence of the metabolic syndrome. The CV 10-year risk calculated using German risk charts (SCORE) probably underestimated the risk of CV diseases in this collective. In this case, the diagnosis of a metabolic syndrome is more meaningful than risk SCORE calculations.

关键词： Weight Reduction Cardiovascular Risk Score Metabolic Syndrome

Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis

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World Journal of Gastroenterology 2005年第40期11卷 6322-6329页

作者： Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek Department of Physiology

AIM： To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-y （PPART） ligand, on the development of acute pancreatitis （AP） and on the expression of heat shock protein 70 （HSP70） in the pancreas. METHODS： AP was induced in rats by subcutaneous infusion of ceruw was measured by laser Dopplein for 5 h. Pancreatic blood floler flowmetry. Plasma lipase activity, intedeukin-1β （IL-1β） and IL-10 were determined. Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS： Pioglitazone administered （10-100 mg/kg i.g.） 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis （tiP） as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION： Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-infiammatory activities, to the suppression of IL-1β and to the overexpression of HSP70. PPART ligands could represent a new therapeutic optionin the treatment of AP.

关键词： Cerulein-induced pancreatitis PPARy, ligand Heat shock protein 70

聚硅氯化铝(PASiC)混凝剂的特性及絮凝动态过程

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中国环境科学 2002年第3期22卷 227-230页

作者：岳钦艳高宝玉 H.H.hahn E.Hoffmann 山东大学环境科学与工程学院山东济南250100 InstituteofAquaticEnvironmentalEngineering

采用共聚与复合两种制备工艺,分别制备出具有不同碱化度(B)和不同Al/Si摩尔比系列的商用聚硅氯化铝(PASiC)混凝剂,并分别采用颗粒粒径测定方法和流动电流(SC)测定技术研究比较了PASiC和聚合氯化铝(PAC)混凝剂的颗粒大小、电动特性和凝... 详细信息

采用共聚与复合两种制备工艺,分别制备出具有不同碱化度(B)和不同Al/Si摩尔比系列的商用聚硅氯化铝(PASiC)混凝剂,并分别采用颗粒粒径测定方法和流动电流(SC)测定技术研究比较了PASiC和聚合氯化铝(PAC)混凝剂的颗粒大小、电动特性和凝聚絮凝动态过程.结果表明,Al/Si摩尔比、B值和制备工艺影响PASiC的聚合和带电特性.Al/Si摩尔比越小和B值越大,PASiC的颗粒就越大;在相同的B值下,PASiC较PAC具有更大的颗粒粒径.PASiC的电中和能力较PAC有所下降,且Al/Si摩尔比越小,PASiC的电中和能力下降越多;与PAC相比,PASiC具有更快的凝聚絮凝速度和形成更大的絮体;且Al/Si摩尔比越小,PASiC形成的絮体就越大.

关键词：聚硅氯化铝 PASiC 混凝剂特性絮凝动态过程颗粒大小流动电流

Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways

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World Journal of Gastroenterology 2005年第41期11卷 6450-6458页

作者： Tomasz Brzozowski Peter C Konturek Danuta Drozdowicz Stanislaw J Konturek Oxana Zayachivska Robert Pajdo Slawomir Kwiecien Wieslaw W Pawlik Eckhart G hahn Department of Physiology Jagiellonian University Medical College CracowPoland Department of Medicine Ⅰ University of Erlangen-Nuremberg ErlangenGermany Oxana Zayachivska National Medical University LvivUkraine

AIM： Grapefruit-seed extract （GSE） containing flavonoids, possesses antibacterial and antioxidative properties but whether it influences the gastric defense mechanism and gastroprotection against ethanol- and stress-induced gastric lesions remains unknown. METHODS： We compared the effects of GSE on gastric mucosal lesions induced in rats by topical application of 100% ethanol or 3.5 h of water immersion and restraint stress （WRS） with or without （A） inhibition of cyclooxygenase （COX）-1 activity by indomethacin and rofecoxib, the selective COX-2 inhibitor, （B） suppression of NO-synthase with L-NNA （20 mg/kg ip）, and （C） inactivation by capsaicin （125 mg/kg sc） of sensory nerves with or without intragastric （ig） pretreatment with GSE applied 30 min prior to ethanol or WRS. One hour after ethanol and 3.5 h after the end of WRS, the number and area of gastric lesions were measured by planimetry, the gastric blood flow （GBF） was assessed by H2-gas clearance technique and plasma gastrin levels and the gastric mucosal generation of PGE2, superoxide dismutase （SOD） activity and malonyldialdehyde （MDA） concentration, as an index of lipid peroxidation were determined. RESULTS： Ethanol and WRS caused gastric lesions accompanied by the significant fall in the GBF and SOD activity and the rise in the mucosal MDA content. Pretreatment with GSE （8-64 mg/kg i g） dose- dependently attenuated gastric lesions induced by 100% ethanol and WRS; the dose reducing these lesions by 50% （ID50） was 25 and 36 mg/kg, respectively, and this protective effect was similar to that obtained with methyl PGE2 analog （5 μg/kg i g）. GSE significantly raised the GBF, mucosal generation of PGE2, SOD activity and plasma gastrin levels while attenuating IVlDA content. Inhibition of PGE2 generation with indomethacin or rofecoxib and suppression of NO synthase by L-NNA or capsaicin denervation reversed the GSE-induced protection and the accompanying hyperemia. Cotreatment of exogenous calcitonine gene-rel

关键词： Grapefriut-seed extract Gastroprotection Gastric blood flow Superoxide dismutase Prostaglandin Calcitonine gene-related peptide

Fast stereo matching based on edge energy information

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Journal of Measurement Science and Instrumentation 2012年第2期3卷 129-132页

作者： Youngjoon Han Hernsoo hahn Dept.of Electronic Engineering Soongsil University

A new improvement is proposed for stereo matching which gives a solution to disparity map in terms of edge *** decompose the stereo matching into three parts:sparse disparity estimation for image-pairs,edge energy model and final disparity refinement.A three-step procedure is proposed to solve them *** the first step,we perform an initial disparity model using the ordering constraint and interpolation to obtain a more efficient sparse disparity *** the second step,we apply the energy function by the edge constraints that exist in both *** last step is a kind of disparity *** determine disparity values in target regions based on global *** proposed three-step simple stereo matching procedure yields excellent quantitative and qualitative results with Middlebury data sets in a fast way.

关键词： stereo matching disparity space edge energy model disparity filling

Outdoor travel-aids using bird-eye view virtual camera

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Journal of Measurement Science and Instrumentation 2012年第3期3卷 219-223页

作者： Hernsoo hahn Youngjoon Han Dept.of Electronic Engineering Soongsil University

This paper presents a travel-aid system for sight-impaired pedestrians in outdoor *** many existing travel-aid systems that rely on stereo-vision,the proposed system aims to detect generic obstacles in a cluttered road environment by using just the single camera attached to user's *** achieve this goal,the original image is re-sampled and mapped to a bird-eye view virtual plane,on which background edges are sub-sampled while obstacle edges are *** filters with connected component analysis are used to enhance obstacle edges as edge-blobs with larger size,whereas sparse edges from background are filtered *** on the identified obstacles,safe walking areas are estimated by calculating a polar edge *** algorithm is tested in different sidewalk scenes with complex pavements,and its efficiency has been confirmed.

关键词： travel-aids monocular vision bird-eye view re-sampling polar edge histogram

Phase separations in graded-indium content InGaN/GaN multiple quantum wells and its function to high quantum efficiency

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Journal of Semiconductors 2012年第5期33卷 13-16页

作者：郭洪英孙元平 Yong-Hoon Cho Eun-Kyung Suh Hai-Joon Lee Rak-Jun Choi Yoon-Bong hahn Institute of Science and Technology for Opto-Electronic Information Yantai University Department of Physics Korea Advanced Institute of Science and Technology School of Semiconductor and Chemical Engineering Semiconductor Physics Research CenterChonbuk National University School of Chemical Engineering Chonbuk National University

Phase separations have been studied for graded-indium content In_xGa_（1-x）N/GaN multiple quantum wells（MQWs） with different indium contents by means of photoluminescence（PL）,cathodeluminescence（CL） and time-resolved PL（TRPL） *** the main emission peaks,all samples show another 2 peaks at the high and low energy parts of the main peaks in PL when excited at 10 *** images show a clear contrast for 3 samples,which indicates an increasing phase separation with increasing indium *** spectra at 15 K of the main emissions show an increasing delay of rising time with indium content,which means a carrier transferring from low indium content structures to high indium content structures.

关键词： carrier transfer phase separation graded-indium content multiple quantum wells

Ultrahard BCC-AlCoCrFeNi bulk nanocrystalline high-entropy alloy formed by nanoscale diffusion-induced phase transition

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Journal of Materials Science & Technology 2022年第20期115卷 29-39页

作者： Junjie Wang Zongde Kou Shu Fu Shangshu Wu Sinan Liu Mengyang Yan Zhiqiang Ren Di Wang Zesheng You Si Lan Horst hahn Xun-Li Wang Tao Feng Herbert Gleiter Institute of Nanoscience School of Material Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Institute of Nanotechnology Karlsruhe Institute of TechnologyKarlsruhe 76021Germany Department of Physics City University of Hong KongHong KongChina Center for Neutron Scattering Shenzhen Research InstituteCity University of Hong KongShenzhen 518057China

In the current work,the BCC-AlCoCrFeNi bulk nanocrystalline high-entropy alloy(nc-HEA)with ultrahigh hardness was formed by nanoscale diffusion-induced phase transition in a ***,a dual-phase Al/CoCrFeNi nanocrystalline high-entropy alloy composite(nc-HEAC)was prepared by a laser source inert gas condensation equipment(laser-IGC).The as-prepared nc-HEAC is composed of well-mixed FCC-Al and FCC-CoCrFeNi ***,the heat treatment was used to trigger the interdiffusion between Al and CoCrFeNi nanocrystals and form an FCC-AlCoCrFeNi *** the increase of the annealing temperature,element diffusion intensifies,and the Al Co Cr Fe Ni phase undergoes a phase transition from FCC to BCC ***,the BCC-AlCoCrFe Ni bulk nc-HEA with high Al content(up to 50 at.%)was obtained for the first ***,the nc-HEAC(Al-40%)sample exhibits an unprecedented ultra-high hardness of 1124 HV after annealing at 500℃ for 1 *** present a systematic investigation of the relationship between the microstructure evolution and mechanical properties during annealing,and the corresponding micro-mechanisms in different annealing stages are *** enhanced nanoscale thermal diffusion-induced phase transition process dominates the mechanical performance evolution of the nc-HEACs,which opens a new pathway for the design of high-performance nanocrystalline alloy materials.

关键词： High-entropy alloy Nanocrystalline Composites Diffusion-induced phase transition Mechanical Inert gas condensation

Excellent long-term reactivity of inhomogeneous nanoscale Fe-based metallic glass in wastewater purification

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Science China Materials 2020年第3期63卷 453-466页

作者： Shuang-Qin Chen Ke-Zhen Hui Liang-Zheng dong Zhun Li Qing-hua Zhang Lin Gu Wei Zhao Si Lan Yubin Ke Yang Shao Horst hahn Ke-Fu Yao School of Material Science and Engineering Tsinghua UniversityBeijing 100084China Herbert Gleiter Institute of Nanoscience Nanjing University of Science and TechnologyNanjing 210094China China Iron&Steel Research Institute Group Beijing 100081China Beijing Laboratory for Electron Microscopy Institute of PhysicsCASBeijing 100190China Institute of Nanotechnology Karlsruhe Institute of Technology76344 Eggenstein-LeopoldshafenGermany China Spallation Neutron Source Institute of High Energy PhysicsChinese Academy of SciencesDongguan 523803China

Metallic glasses(MGs)have attracted great attention in wastewater treatment because of their high reactivity arising from amorphous structure,large residual stress and high density of low coordination ***,the reactivity of MGs would gradually slow down with time due to the passivation of active sites by corrosion products,resulting in limited long-term reactivity,which is also an unsolved key issue for established crystalline zero valent iron(ZVI)***,such problems are successfully overcome by introducing nanoscale chemical inhomogeneities in Fe-based MG(Fe-MGI),which apparently contributes to local galvanic cell effect and accelerates electron transfer during degradation *** importantly,the selective depletion of Fe0 causes local volume shrinkage and crack formation,leading to self-peeling of precipitated corrosion products and reacted *** fresh low coordination sites could be continuously provided,counteracting the mass transport and reactivity deteriorating ***,Fe-MGI demonstrates excellent long-term reactivity and self-refreshing properties even in neutral *** present results provide not only a new candidate but also a new route of designing ZVI materials for wastewater treatment.

关键词： Fe-based metallic glass inhomogeneity self-refreshing wastewater treatment catalysis