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Mesenchymal stem cells for enhancing biological healing after meniscal injuries

World Journal of Stem Cells 2021年第8期13卷 1005-1029页

作者： Hye Chang Rhim Ok Hee Jeon Seung-Beom Han ji hoon Bae Dong Won Suh Ki-Mo Jang T.H.Chan School of Public Health Harvard UniversityBostonMA 02115United States Department of Biomedical Sciences Korea University College of MedicineSeoul 02841SeoulSouth Korea Department of Orthopaedic Surgery Anam HospitalKorea University College of MedicineSeoul 02841SeoulSouth Korea Department of Orthopaedic Surgery Guro HospitalKorea University College of MedicineSeoul 08308SeoulSouth Korea Department of Orthopaedic Surgery Barunsesang HospitalSeongnam 13497South Korea

The meniscus is a semilunar fibrocartilage structure that plays important roles in maintaining normal knee biomechanics and *** roles of the meniscus,including load distribution,force transmission,shock absorption,joint stability,lubrication,and proprioception,have been well *** to the meniscus can disrupt overall joint stability and cause various symptoms including pain,swelling,giving-way,and *** treated properly,it can lead to early degeneration of the knee *** meniscal injuries remain a significant challenge due to its low intrinsic healing potential,most notably in avascular and aneural inner two-thirds of the area,more efficient repair methods are *** stem cells(MSCs)have been investigated for their therapeutic potential in vitro and in *** far,the application of MSCs,including bone marrow-derived,synovium-derived,and adipose-derived MSCs,has shown promising results in preclinical studies in different animal *** preclinical studies could be categorized into intra-articular injection and tissueengineered construct application according to delivery *** promising results in preclinical studies,there is still a lack of clinical *** review describes the basic knowledge,current treatment,and recent studies regarding the application of MSCs in treating meniscal *** directions for MSC-based approaches to enhance meniscal healing are suggested.

关键词： Meniscus Meniscus healing Cell-based treatment Mesenchymal stem cell Tissue engineering

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Complete recovery of herpes zoster radiculopathy based on electrodiagnostic study:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4303-4309页

作者： Hyeon Seong Kim ji Won Jung You jin Jung Young Suck Ro Si-Bog Park Kyu hoon Lee Department of Rehabilitation Medicine Hanyang University HospitalSeoul 04763South Korea Department of Dermatology Hanyang University HospitalSeoul 04763South Korea

BACKGROUND Herpes zoster is a painful infectious disease caused by the varicella zoster *** zoster radiculopathy,which is a type of segmental zoster paresis,can complicate the disease and cause motor *** complication should be considered when a patient with a rash complains of acute-onset motor weakness,and the diagnosis can be verified via electrodiagnostic *** SUMMARY A 64-year-old female with a history of asthma presented to the emergency department with stabbing pain,an itching sensation,and a rash on the right anterior shoulder that had begun 5 d *** examination revealed multiple erythematous grouped vesicles in the right C4-5 and T1 dermatome *** herpes zoster was suspected,the patient immediately received intravenous *** the third hospital day,she complained of motor weakness in the right upper *** resonance imaging of the cervical spine revealed mild intervertebral disc herniation at C4-C5 without evidence of nerve root *** the 12th hospital day,electrodiagnostic study revealed right cervical radiculopathy,mainly in the C5/6 *** months later,monoparesis resolved,and follow-up electrodiagnostic study was *** This case emphasizes that clinicians should consider the possibility of postherpetic paresis,such as herpes zoster radiculopathy,and that electrodiagnostic study is useful for diagnosis and follow-up.

关键词： Herpes zoster Radiculopathy Electrodiagnosis Varicella zoster virus Monoparesis Case report

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Parameterization of below-cloud scavenging for polydisperse fine mode aerosols as a function of rain intensity

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Journal of Environmental Sciences 2023年第10期132卷 43-55页

作者： Chang hoon Jung Hyung-Min Lee Dasom Park Young Jun Yoon Yongjoo Choi Junshik Um Seoung Soo Lee ji Yi Lee Yong Pyo Kim Department of Health Management Kyungin Women’s UniversityIncheon 21041Korea Department of Environmental Science and Engineering Ewha Woman’s UniversitySeoulKorea Department of Environmental Engineering Konkuk UniversitySeoulKorea Korea Polar Research Institute IncheonKorea Department of Environment Hankuk University of Foreign StudiesYonginKorea Department of Atmospheric Sciences Pusan National UniversityBusanKorea Earth System Science Interdisciplinary Center University of MarylandCollege ParkMDUSA Research Center for Climate Sciences Pusan National UniversityBusanKorea Department of Chemical Engineering and Materials Science Ewha Womans UniversitySeoulKorea

The below-cloud aerosol scavenging process by precipitation is one of the most important mechanisms to remove aerosols from the *** to its complexity and dependence on both aerosol and raindrop sizes,wet scavenging process has been poorly treated,especially during the removal of fine *** makes the numerical simulation of below-cloud scavenging in large-scale aerosolmodels *** consider the slip effects of submicron particles,a simplified expression for the diffusion scavenging was developed by approximating the Cunningham slip correction *** derived analytic solution was parameterized as a simple power function of rain intensity under the assumption of the lognormal size distribution of *** resultant approximated expression was compared to the observed data and the results of previous studies including a 3D atmospheric chemical transport model *** with the default GEOS-Chem coefficient of 0.00106R0.61 and the observation-based coefficient of 0.0144R0.9268,the coefficient of a and b in∧m=aRb spread in the range of 0.0002-0.1959 for a and 0.3261-0.525 for b over a size distribution of GSD of 1.3–2.5 and a geometric mean diameter of 0.01-2.5μ***,this study showed that the scavenging coefficient varies widely by orders of magnitude according to the size distribution of particles and rain *** study also demonstrated that the obtained simplified expression could consider the theoretical approach of aerosol *** proposed analytic approach showed that results can be effectively applied for reduced computational burden in atmospheric modeling.

关键词： Below-cloud scavenging Polydisperse aerosol Parameterization Cunningham correction factor Scavenging coefficient

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Epstein-Barr virus-associated lymphoepithelioma-like early gastric carcinomas and endoscopic submucosal dissection: Case series

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World Journal of Gastroenterology 2014年第5期20卷 1365-1370页

作者： ji Young Lee Kyoung-Mee Kim Byung-hoon Min Jun Haeng Lee Poong-Lyul Rhee Jae Jun Kim Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine

Epstein-Barr virus (EBV)-associated lymphoepithelioma-like gastric carcinoma (LELC) is characterized by a lower lymph node (LN) metastasis rate and a higher survival rate than other forms of gastric cancer. Although current prognosis for LELC is favorable, the most common approach is radical gastrectomy involving an extensive D2 lymph node dissection. Here, we report four cases of EBV-associated early LELC that were treated by an alternative approach, endoscopic submucosal dissection (ESD). The long-term outcome of this procedure is discussed. All patients were treated by ESD en bloc, and all ESD specimens showed tumor-free lateral resection margins. None of the lesions showed lymphovascular invasion. A pathological examination of ESD specimens revealed submucosal invasion of more than 500 μm in all four cases. One patient underwent additional radical surgery post-ESD; no residual tumor or LN metastasis was noted in the surgical specimen. The other three patients did not undergo additional surgery, either because of severe comorbidity or their refusal to undergo operation, but were subjected to medical follow-up. None of the ESD-treated patients reported local recurrence or distant metastases during the 27-32 mo of follow-up after ESD.

关键词： Endoscopic submucosal dissection Epstein-Barr virus Lymph node Lymphoepithelioma-like gastric carcinoma Prognosis

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Post-Translational Regulation of FLOWERING LOCUS T Protein in Arabidopsis

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Molecular Plant 2016年第2期9卷 308-311页

作者： Soo-jin Kim Sung Myun Hong Seong Jeon Yoo Suhyun Moon Hye Seung Jung ji hoon Ahn Creative Research Initiatives Department of Life Sciences Korea University Seoul 136-701 Korea

Dear Editor,Here, we report the developmental regulation of proteolytic cleavage of the FLOWERING LOCUS T （FT） protein. FT, a mem- ber of the phosphatidylethanolamine-binding protein （PEBP） family, functions as a florigen or a component of florigen. PEBP binds phosphoethanolamine, and its ligand-binding domain is evolutionarily conserved from bacteria to plants and animals （Schoentgen and Jolles, 1995; Bradley et al., 1996）. PEBPs regulate important signaling pathways to control growth and differentiation （Chautard et al., 2004）. Some animal PEBP homologs undergo post-translational regulation. For example,

关键词： cleavage functions phosphoethanolamine

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Is mannitol combined with furosemide a new treatment for refractory lymphedema?A case report

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World Journal of Clinical Cases 2021年第29期9卷 8804-8811页

作者： Hyeon Seong Kim Jae Young Lee ji Won Jung Kyu hoon Lee Mi Jung Kim Si-Bog Park Department of Rehabilitation Medicine Hanyang University HospitalSeoul 04763South Korea

BACKGROUND Mannitol is a hyperosmolar agent and the combination of mannitol and furosemide is a widely used treatment for intracranial pressure *** the hypertonic properties of mannitol to move water out of intracellular spaces,we hypothesized that mannitol combined with furosemide could relieve focal tissue swelling in refractory *** SUMMARY A 90-year-old female had been diagnosed with intracranial hemorrhage and received a combination of mannitol and furosemide for intracranial pressure *** of the intracranial hemorrhage,she had refractory lymphedema of the left lower extremity since ***,after receiving the mannitol and furosemide,the patient’s lower extremity lymphedema improved *** the mannitol and furosemide were discontinued,the lymphedema worsened in spite of complete decongestive therapy(CDT)and intermittent pneumatic compression treatment(IPC).To identify the presumed effect of mannitol and furosemide on the lymphedema,these agents were resumed,and the lymphedema improved *** The present case raises the possibility that a combination of mannitol and furosemide might be considered another effective therapeutic option for refractory lymphedema when CDT and IPC are ineffective.

关键词： Lymphedema Mannitol Furosemide Rehabilitation Intermittent pneumatic compression Case report

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Identifying and Verifying Vulnerabilities through PLC Network Protocol and Memory Structure Analysis

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Computers, Materials & Continua 2020年第10期65卷 53-67页

作者： Joo-Chan Lee Hyun-Pyo Choi Jang-hoon Kim Jun-Won Kim Da-Un Jung ji-Ho Shin Jung-Taek Seo Department of Information Security Engineering Soonchunhyang UniversityAsan31538Korea

Cyberattacks on the Industrial Control System(ICS)have recently been increasing,made more intelligent by advancing *** such,cybersecurity for such systems is attracting *** a core element of control devices,the Programmable Logic Controller(PLC)in an ICS carries out on-site control over the ICS.A cyberattack on the PLC will cause damages on the overall ICS,with Stuxnet and Duqu as the most representative ***,cybersecurity for PLCs is considered essential,and many researchers carry out a variety of analyses on the vulnerabilities of PLCs as part of preemptive efforts against *** this study,a vulnerability analysis was conducted on the XGB *** vulnerabilities were identified by analyzing the network protocols and memory structure of PLCs and were utilized to launch replay attack,memory modulation attack,and FTP/Web service account theft for the verification of the *** on the results,the attacks were proven to be able to cause the PLC to malfunction and disable it,and the identified vulnerabilities were defined.

关键词： Industrial control system programmable logic controller cybersecurity network protocol vulnerability

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CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease: multi-institutional case series

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1231-1237页

作者： Roh-Eul Yoo Sun-Won Park Jung Hyo Rhim ji Eun Kim Soo Chin Kim ji-Young Choe Ho-Kyung Choung Sang In Khwarg ji-hoon Kim Jeong Hyun Lee Bo Eun Lee Yeonah Kang Department of Radiology Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Radiology Seoul National University HospitalSeoul 03080Republic of Korea Department of Radiology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061Republic of Korea Department of Pathology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061Republic of Korea Department of Pathology Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Radiology Asan Medical CenterSeoul 05505Republic of Korea Department of Pathology Hallym University Sacred Heart HospitalAnyang14068Republic of Korea Department of Ophthalmology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061Republic of Korea Department of Ophthalmology Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Radiology Ulsan University College of MedicineSeoul 05505Republic of Korea Department of Radiology Inje University Haeundae Paik HospitalBusan 47392Republic of Korea

AIM:To report CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease(IgG4-MALT lymphoma),a rare but clinically important complication of ocular adnexal IgG4-related ***:We retrospectively reviewed all cases of histologically confirmed ocular adnexal IgG4-related disease at three ter tiary and one secondary referral centers,between February 2003 and December *** cases of histopathologically diagnosed IgG4-MALT lymphoma were *** and MR images were analyzed by consensus of two experienced head and neck ***:Lacrimal glands were the main site of involvement in all seven *** lesions typically showed well-demarcated margins,iso-to hyperattenuation on precontrast CT,T2 hypo-to isointensity,T1 isointensity,and homogenous internal architecture with homogenous enhancement *** were mostly hyperdense and isointense to normal extraocular muscles on postcontrast CT and MR images,***:Unlike in typical ocular adnexal IgG4-related disease,T2 isointensity and hyperattenuation on precontrast CT images were noted in some IgG4-MALT lymphoma *** the findings may be nonspecific,the possibility of accompanying MALT lymphoma may need to be considered,when ocular adnexal lesions in patients clinically suspected of having IgG4-related disease are refractory to glucocorticoids and show T2 isointensity and hyperattenuation on precontrast CT for the optimal management of the ***,this is a case series of a very rare complication of ocular adnexal IgG4-related disease,and thus caution is warranted to generalize the conclusion.

关键词： CT IgG4-related disease MR ocular adnexal mucosa-associated lymphoid tissue lymphoma

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Cambrian Stem-group Cnidarians with a New Species from the Cambrian Series 3 of the Taebaeksan Basin, Korea

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Acta Geologica Sinica(English Edition) 2016年第3期90卷 827-837页

作者： Tae-Yoon S.PARK ji-hoon KIHM Jusun WOO Yong-Yi ZHEN Michael ENGELBRETSEN Jongsun HONG Suk-Joo CHOH Dong-jin LEE Division of Polar-Earth System Sciences Korea Polar Research Institute Geological Survey of New South Wales W.B.Clarke Geoscience Centre Research Affiliate Biological Sciences Macquarie University Department of Earth and Environmental Sciences Korea University Department of Earth and Environmental Sciences Andong National University

Five species, Lipopora lissa Jell and Jell, 1976, Lipopora daseia Jell and Jell, 1976, Tretocylichne perplexa Engeibretsen, 1993 from Australia, Cambroctoconus orientalis Park, Woo, Lee, Lee, Lee, Han and Chough, 2011 from China, and Cambroctoconus kyrgyzstanicus Peel, 2014 from Kyrgyzstan, belonging to the Cambrian stem-group cnidarians have been documented in the fossil record. Cambroctoconus coreaensis sp. nov., interpreted here as a stem-group cnidarian, from the Seokgaejae section in the Daegi Formation, Taebaek Group （Cambrian Series 3）, Taebaeksan Basin, central-eastern Korean Peninsula, has a slender cup-shaped skeleton. A cladistic analysis produced 21 most parsimonious trees, which invariably placed the six stem-group cnidarians below the crown-group, but their relationships within the stem-group are unresolved. Nine out of the 21 trees suggest a monophyletic relationship for the Cambrian stem-group cnidarians, whereas in six other trees a monophyly of Cambroctoconus and Tretocylichne appeared as the sister-group to the crown-group cnidarians with Lipopora at the most basal branch. This result may reflect the fact that crown-group cnidarians evolved in the Precambrian, and suggests that the diversity of stem-group cnidarians was a result of an independent radiation in the Cambrian.

关键词： Phylogeny Cnidaria Cambrian Drumian Taebaeksan Basin Korea

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Hydrangeae Dulcis Folium Attenuates Physical Stress by Supressing ACTH-Induced Cortisol in Zebrafish

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Chinese Journal of Integrative Medicine 2020年第2期26卷 130-137页

作者： Junyoung Oh Dong Hyun Kim Gi-young Kim Eun-jin Park Jong hoon Ryu ji Wook Jung Se jin Park Gwang-Woo Kim Seungheon Lee Department of Marine Life Science College of Ocean ScienceJeju National UniversityJeju(63243)Republic of Korea Departme nt of Medicinal Biotech no logy College of Health SciencesDong-A UniversityBusan(604-714)Republic of Korea Department of Food Bioengineering Jeju National UniversityJeju(63243)Republic of Korea Institute of Convergence BioHealth Dong-A UniversityBusan(604-714)Republic of Korea Department of Oriental Pharmaceutical Science College of PharmacyKyung Hee UniversityHoeki-dongDongdaemoon・KuSeoul(130-701)Republic of Korea Kyung Hee East-West Pharmaceutical Research Institute College of PharmacyKyung Hee UniversityHoeki-dongDongdaemoorvKuSeoul(130-701)Republic of Korea Department of Herbal Medicinal Pharmacology College of Herbal Bio-industryDaegu Haany UniversityYugok-dongGyeongsan(712-715)Republic of Korea School of Natural Resources and Environmental Sciences Kangwon National UniversityChuncheon(24341)Republic of Korea Marine Bio Con verge nee Center Gangneung Science&In dustry Promotion AgencyGangneung(25440)Republic of Korea

Objective:To determine the effects of Hydrangeae Dulcis Folium(EHDF)on physical stress,changes in the whole-body cortisol level and behaviour in zebrafish(Danio rerio).Methods:One hundred and seventy-four fish were randomly divided into 4[adrenocorticotropin hormone(ACTH)challenge test:4 fish per group]or 6 groups(behavioural test:10–12 fish per group,whole-body cortisol:4 fish per group).Net handling stress(NHS)was used to induce physical *** were treated with vehicle or EHDF(5–20 mg/L)for 6 min before they were exposed to *** then,fish were sacrificed for collecting body fluid from whole-body or conducted behavioural tests,including novel tank test and open field test,and were evaluated to observe anxiety-like behaviours and *** addition,to elucidate the mode of action of the anti-stress effects of EHDF,ACTH(0.2 IU/g,i.p.)challenge test was ***:The increased anxiety-like behaviours in novel tank test and open field test under stress were prevented by treatment with EHDF at 5–20 mg/L(P<0.05).Moreover,compared with the unstressed group,which was not treated with NHS,the whole-body cortisol level was significantly increased by treatment with NHS(P<0.05).Compared with the NHS-treated stressed control group,pre-treatment with EHDF at concentrations of 5–20 mg/L for 6 min significantly prevented the NHS-increased whole-body cortisol level(P<0.05).In addition,ACTH challenge test showed that EHDF completely blocked the effects of ACTH on cortisol secretion(P<0.05).Conclusion:EHDF may be a good antistress candidate and its mechanism of action may be related to its positive effects on cortisol release.

关键词： net handling stress zebrafish Hydrangeae Dulcis Folium whole-body cortisol behavioural tests

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