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Detection rate of clinically insignificant prostate cancer ncreases with repeat prostate biopsies

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Asian Journal of Andrology 2013年第2期15卷 236-240,I0007页

作者： Bumsoo Park Seong-Soo Jeon Sung-Ho Ju byong-chang jeong Seong-II Seo Hyun-Moo Lee Han-Yong Choi Department of Urology Sungkyunkwan University School of Medicine Seoul 135-710 Korea institute for Refractory Cancer Research Samsung Medical Center Sungkyunkwan University School of Medicine Seou1135-710 Korea Department of Urology Kangnam General Hospital Yongin 446-597 Korea

To analyze if clinically insignificant prostate cancer （CIPC） is more frequently detected with repeat prostate biopsies, we retrospectively analyzed the records of 2146 men diagnosed with prostate cancer after one or more prostate biopsies. The patients were divided into five groups according to the number of prostate biopsies obtained, e.g, group I had one biopsy, group 2 had two biopsies and group 3 had three biopsies. Of the 2146 patients diagnosed with prostate cancer, 1956 （91,1%）, 142 （6.6%）, 38 （1.8%）, 9 （0.4%） and 1 （0.1%） men were in groups 1, 2, 3, 4 and 5, respectively. Groups 4 and 5 were excluded because of the small sample sizes. The remaining three groups （groups 1, 2 and 3） were statistically analyzed. There were no differences in age or prostate-specific antigen level among the three groups. CIPC was detected in 201 （10.3%）, 28 （19.7%） and 9 （23.7%） patients in groups 1, 2 and 3, respectively （P〈O.O01）. A multivariate analysis showed that the number of biopsies was an independent predictor to detect ClPC （0R=2.688 for group 2; 0R=4.723 for group 3）. In conclusion, patients undergoing multiple prostate biopsies are more likely to be diagnosed with CIPC than those who only undergo one biopsy. However, the risk still exists that the patient could have clinically significant prostate cancer. Therefore, when counseling patients with regard to serial repeat biopsies, the possibility of prostate cancer overdiagnosis and overtreatment must be balanced with the continued risk of clinically significant disease.

关键词： clinically insignificant prostate cancer (CIPC) clinically significant prostate cancer (CSPC) biopsy early detection ofcancer prostatic neoplasms

Evaluating the role of large language models in inflammatory bowel disease patient information

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World Journal of Gastroenterology 2024年第29期30卷 3538-3540页

作者： Eun jeong Gong chang Seok Bang Department of Internal Medicine Hallym University College of MedicineChuncheon 24253Gangwon-doSouth Korea

This letter evaluates the article by Gravina et al on ChatGPT’s potential in providing medical information for inflammatory bowel disease *** promising,it highlights the need for advanced techniques like reasoning+action and retrieval-augmented generation to improve accuracy and *** that simple question and answer testing is insufficient,it calls for more nuanced evaluation methods to truly gauge large language models’capabilities in clinical applications.

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Chat generative pre-trained transformer Large language model Artificial intelligence

Impact of Warm Ischemia during Partial Nephrectomy under Pneumoperitoneum on Recovery of Renal Function Prospective 1 year outcome

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Impact of Warm Ischemia during Partial Nephrectomy under Pne...

Flexible mica films coated by magnetron sputtered insulating layers for high-temperature capacitive energy storage

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作者： Seong Soo Jeon Seo Yong Park Jae Duck Choi byong chang jeong Seong Il Seo Han Yong Choi Purpose To identify the effects of the warm ischemic time (WIT) on the recovery of renal

Purpose To identify the effects of the warm ischemic time(WIT) on the recovery of renal function after partial nephrectomy under the pneumoperitoneum. Materials and methods Thirty seven consecutive patients underwent ...

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SusMat 2024年第5期4卷 154-162页

作者： Chao Yin Tiandong Zhang changhai Zhang Yue Zhang chang Kyu jeong Geon-Tae Hwang Qingguo Chi Key Laboratory of Engineering Dielectrics and its Application Ministry of EducationHarbin University of Science and TechnologyHarbinChina School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbinChina Division of Advanced Materials Engineering Jeonbuk National UniversityJeonjuSouth Korea Department of Materials Science and Engineering Pukyong National UniversityBusanSouth Korea

High-temperature energy storage performance of dielectric capacitors is cru-cial for the next generation of power electronic ***,conduction losses rise sharply at elevated temperature,limiting the application of energy storage ***,the mica films magnetron sputtered by different insulating layers are specifically investigated,which exhibit the excellent high-temperature energy storage *** experimental results revealed that the PbZrO3/Al2O3/PbZrO3(PZO/AO/PZO)interface insulating layers can effec-tively reduce the high-temperature leakage current and conduction loss of the composite ***,the ultrahigh energy storage density(Wrec)and charge‒discharge efficiency(η)can be achieved simultaneously in the flexi-ble mica-based composite ***,PZO/AO/PZO/mica/PZO/AO/PZO(PAPMPAP)films possess excellent Wrec of 27.5 J/cm3 andηof 87.8%at 200◦C,which are significantly better than currently reported high-temperature capaci-tive energy storage dielectric *** with outstanding power density and electrical cycling stability,the flexible films in this work have great appli-cation potential in high-temperature energy storage ***,the magnetron sputtering technology can deposit large-area nanoscale insulating layers on the surface of capacitor films,which can provide technical support for the industrial production of capacitors.

关键词： energy storage high temperature insulating layer magnetron sputtering mica

Oxygen vacancy engineering for tuning the catalytic activity of LaCoO_(3) perovskite

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Journal of Rare Earths 2024年第3期42卷 506-514,I0003页

作者： jeong Hyun Cho Minjae Kim Inchan Yang Kyung Tae Park chang Houn Rhee Hai Woong Park Ji Chul Jung Department of Chemical Engineering Myongji UniversityYongin 17058Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and TechnologyWanju-gunJeollabuk-do 55324Republic of Korea Iron&Steel Process Engineering Research Group POSCOPohang 37859Republic of Korea Hydrogen Research Center Research Institute of Industrial Science&Technology(RIST)Pohang 37673Republic of Korea

Herein, we attempted to engineer oxygen vacancies on the surface of LaCoO_(3) perovskite through simple post-treatments(acid or reductive thermal treatments). Acid treatment induces oxygen vacancies through the selective etching of the La cations, whereas thermal treatment in a reducing atmosphere generates oxygen vacancies by directly removing lattice oxygen. The characterization results confirm that the number of surface oxygen vacancies, which are crucial in various catalytic oxidation reactions,considerably increases in the LaCoO_(3) catalysts treated with acid or reducing gas. Acid treatment enriches the oxygen vacancies while maintaining the structure of the LaCoO_(3) catalysts, which can not be achieved through reductive thermal treatment. Therefore, the acid treatment is considered a promising technique for oxygen vacancy engineering of perovskite catalysts for tuning their catalytic activities. Furthermore,the catalytic activities of the posttreated LaCoO_(3) catalysts for CO oxidation were evaluated and are noted to be considerably better than those of the pristine LaCoO_(3) catalyst due to their abundant oxygen vacancies. Consequently, we conclude that the oxygen vacancies of perovskite catalysts can be effectively engineered via two simple methods and play a significant role in CO oxidation.

关键词： LaCoO_(3)perovskite Acid treatment Reductive thermal treatment Oxygen vacancy CO oxidation Rare earths

Stable immobilization of lithium polysulfides using three-dimensional ordered mesoporous Mn_(2)O_(3) as the host material in lithium-sulfur batteries

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Carbon Energy 2024年第6期6卷 99-112页

作者： Sung Joon Park Yun jeong Choi Hyun-seung Kim Min Joo Hong Hongjun chang Janghyuk Moon Young-Jun Kim Junyoung Mun Ki Jae Kim Department of Energy Science Sungkyunkwan UniversitySuwonGyeonggi-doRepublic of Korea Department of Energy Engineering Konkuk UniversitySeoulRepublic of Korea Advanced Batteries Research Center Korea Electronic Technology InstituteSeongnamRepublic of Korea Department of Future Energy Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Department of Energy Systems Engineering Chung-Ang UniversitySeoulRepublic of Korea SKKU Advanced Institute of Nanotechnology Sungkyunkwan UniversitySuwonGyeonggi-doRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwonRepublic of Korea

Lithium-sulfur batteries(LSBs)have drawn significant attention owing to their high theoretical discharge capacity and energy ***,the dissolution of long-chain polysulfides into the electrolyte during the charge and discharge process(“shuttle effect”)results in fast capacity fading and inferior electrochemical *** this study,Mn_(2)O_(3)with an ordered mesoporous structure(OM-Mn_(2)O_(3))was designed as a cathode host for LSBs via KIT-6 hard templating,to effectively inhibit the polysulfide shuttle ***-Mn_(2)O_(3)offers numerous pores to confine sulfur and tightly anchor the dissolved polysulfides through the combined effects of strong polar-polar interactions,polysulfides,and sulfur chain *** OM-Mn_(2)O_(3)/S composite electrode delivered a discharge capacity of 561 mAh g^(-1) after 250 cycles at 0.5 C owing to the excellent performance of OM-Mn_(2)O_(3).Furthermore,it retained a discharge capacity of 628mA h g^(-1) even at a rate of 2 C,which was significantly higher than that of a pristine sulfur electrode(206mA h g^(-1)).These findings provide a prospective strategy for designing cathode materials for high-performance LSBs.

关键词： host material lithium-sulfur battery ordered mesoporous structure shuttle effect transition-metal oxides

Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

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Research 2024年第1期2023卷 637-649页

作者： Hyun-Kyung So Hyebeen Kim Jinwoo Lee chang-Lim You Chae-Eun Yun Hyeon-Ju jeong Eun-Ju Jin Yunju Jo Dongryeol Ryu Gyu-Un Bae Jong-Sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

Advancements and challenges in gastrointestinal imaging

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World Journal of Clinical Cases 2024年第33期12卷 6591-6594页

作者： Eun jeong Gong chang Seok Bang Department of Internal Medicine Hallym University College of MedicineChun-cheon 24253Gangwon-doSouth Korea Department of Internal Medicine Hallym University College of MedicineChuncheon Sacred Heart HospitalChuncheon 24253Gangwon-doSouth Korea

A recent review by Gulinac et al,provides an in-depth analysis of current clinical issues and challenges in gastrointestinal *** editorial highlights the advancements in imaging techniques,including the integration of artificial intelligence and functional imaging modalities,and discusses the ongoing relevance of traditional nuclear medicine *** future of gastrointestinal imaging looks promising,with continuous improvements in resolution,enhanced ability to analyze color and texture beyond visual diagnosis,faster image processing,and the application of molecular imaging and nanoparticles expected to enhance diagnostic accuracy and clinical outcomes.

关键词： Imaging methods Gastrointestinal diseases Gastrointestinal tract Radiology Tumors of the gastrointestinal tract

Light-Material Interactions Using Laser and Flash Sources for Energy Conversion and Storage Applications

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Nano-Micro Letters 2024年第12期16卷 468-514页

作者： Jung Hwan Park Srinivas Pattipaka Geon-Tae Hwang Minok Park Yu Mi Woo Young Bin Kim Han Eol Lee chang Kyu jeong Tiandong Zhang Yuho Min Kwi-Il Park Keon Jae Lee Jungho Ryu Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering)Kumoh National Institute of Technology61Daehak-RoGumiGyeongbuk 39177Republic of Korea Department of Materials Science and Engineering Pukyong National University45Yongso-RoNam-GuBusan 48513Republic of Korea Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea Division of Advanced Materials Engineering Jeonbuk National UniversityJeonju 54896JeonbukRepublic of Korea School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbin 150080People’s Republic of China Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbin 150080People’s Republic of China Department of Materials Science and Metallurgical Engineering Kyungpook National University80 Daehak-RoBuk-GuDaegu 41566Republic of Korea School of Materials Science and Engineering Yeungnam UniversityDaehak-RoGyeongsan-Si 38541Gyeongsangbuk-doRepublic of Korea

This review provides a comprehensive overview of the progress in light-material interactions(LMIs),focusing on lasers and flash lights for energy conversion and storage *** discuss intricate LMI parameters such as light sources,interaction time,and fluence to elucidate their importance in material *** addition,this study covers various light-induced photothermal and photochemical processes ranging from melting,crystallization,and ablation to doping and synthesis,which are essential for developing energy materials and ***,we present extensive energy conversion and storage applications demonstrated by LMI technologies,including energy harvesters,sensors,capacitors,and *** the several challenges associated with LMIs,such as complex mechanisms,and high-degrees of freedom,we believe that substantial contributions and potential for the commercialization of future energy systems can be achieved by advancing optical technologies through comprehensive academic research and multidisciplinary collaborations.

关键词： Light Light-material interaction Nanomaterials Energy conversion and storage devices